Il17d (interleukin 17D) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Il17d (interleukin 17D) Rattus norvegicus
Analyze
Symbol: Il17d
Name: interleukin 17D
RGD ID: 1595926
Description: Orthologous to human IL17D (interleukin 17D); INTERACTS WITH bisphenol A; indole-3-methanol; N-acetyl-L-cysteine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: collagen alpha-1(I) chain; interleukin-17D; LOC691799; similar to interleukin 17D precursor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81535,786,898 - 35,804,391 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1535,786,898 - 35,804,391 (+)EnsemblGRCr8
mRatBN7.21531,671,337 - 31,688,833 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1533,662,656 - 33,680,148 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01534,813,340 - 34,830,832 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01533,071,419 - 33,088,912 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01537,790,211 - 37,807,653 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1537,790,141 - 37,807,660 (+)Ensemblrn6Rnor6.0
Rnor_5.01541,634,099 - 41,653,106 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41536,566,010 - 36,583,515 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1531,382,723 - 31,399,559 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Interleukin-17D Promotes Pathogenicity During Infection by Suppressing CD8 T Cell Activity. Lee Y, etal., Front Immunol. 2019 Jun 6;10:1172. doi: 10.3389/fimmu.2019.01172. eCollection 2019.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection. Seelige R, etal., Sci Rep. 2018 Sep 12;8(1):13670. doi: 10.1038/s41598-018-32011-2.
4. Interleukin-17D Aggravates Sepsis by Inhibiting Macrophage Phagocytosis. Yan X, etal., Crit Care Med. 2020 Jan;48(1):e58-e65. doi: 10.1097/CCM.0000000000004070.
Additional References at PubMed
PMID:8889548   PMID:12097364  


Genomics

Comparative Map Data
Il17d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81535,786,898 - 35,804,391 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1535,786,898 - 35,804,391 (+)EnsemblGRCr8
mRatBN7.21531,671,337 - 31,688,833 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1533,662,656 - 33,680,148 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01534,813,340 - 34,830,832 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01533,071,419 - 33,088,912 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01537,790,211 - 37,807,653 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1537,790,141 - 37,807,660 (+)Ensemblrn6Rnor6.0
Rnor_5.01541,634,099 - 41,653,106 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41536,566,010 - 36,583,515 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1531,382,723 - 31,399,559 (+)NCBICelera
Cytogenetic Map15p12NCBI
IL17D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381320,701,513 - 20,723,098 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1320,702,127 - 20,723,099 (+)Ensemblhg38GRCh38
GRCh371321,275,652 - 21,297,237 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361320,175,482 - 20,195,237 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341320,175,481 - 20,195,236NCBI
Celera132,339,416 - 2,359,171 (+)NCBICelera
Cytogenetic Map13q12.11NCBI
HuRef132,080,671 - 2,100,354 (+)NCBIHuRef
CHM1_11321,245,632 - 21,265,326 (+)NCBICHM1_1
T2T-CHM13v2.01319,894,661 - 19,916,241 (+)NCBIT2T-CHM13v2.0
Il17d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391457,762,197 - 57,780,623 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1457,762,234 - 57,780,623 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381457,524,829 - 57,543,166 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1457,524,777 - 57,543,166 (+)Ensemblmm10GRCm38
MGSCv371458,143,666 - 58,162,003 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361456,479,310 - 56,497,275 (+)NCBIMGSCv36mm8
Celera1455,320,839 - 55,338,474 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1430.1NCBI
Il17d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554971,499,700 - 1,506,557 (+)NCBIChiLan1.0ChiLan1.0
IL17D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21420,328,193 - 20,353,096 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11311,445,815 - 11,465,593 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,030,234 - 2,049,965 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11320,343,474 - 20,362,679 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1320,343,537 - 20,361,535 (+)EnsemblpanPan2panpan1.1
IL17D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12517,386,815 - 17,390,315 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2517,419,385 - 17,438,570 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02517,520,985 - 17,545,597 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.12517,397,175 - 17,416,610 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02517,409,033 - 17,428,202 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02517,465,859 - 17,485,089 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il17d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945119,457,556 - 119,482,058 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367201,005,101 - 1,029,617 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367201,005,111 - 1,029,613 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL17D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl111,029,109 - 1,066,085 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1111,029,219 - 1,066,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.211149,861 - 192,581 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL17D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.13401,525 - 421,725 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605744,179,514 - 44,200,905 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il17d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477616,924,085 - 16,941,729 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477616,924,085 - 16,941,141 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Il17d
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11267,287,517 - 67,304,925 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il17d
98 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
AI462269  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,688,183 - 31,688,283 (+)MAPPERmRatBN7.2
Rnor_6.01537,807,014 - 37,807,112NCBIRnor6.0
Rnor_5.01541,652,450 - 41,652,548UniSTSRnor5.0
RGSC_v3.41536,583,040 - 36,583,138UniSTSRGSC3.4
Celera1531,398,920 - 31,399,018UniSTS
Cytogenetic Map15p12UniSTS
RH130901  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,670,771 - 31,670,960 (+)MAPPERmRatBN7.2
Rnor_6.01537,789,628 - 37,789,816NCBIRnor6.0
Rnor_5.01541,635,512 - 41,635,700UniSTSRnor5.0
RGSC_v3.41536,565,663 - 36,565,851UniSTSRGSC3.4
Celera1531,381,624 - 31,381,812UniSTS
RH 3.4 Map15215.3UniSTS
Cytogenetic Map15p12UniSTS
RH136357  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,670,699 - 31,670,907 (+)MAPPERmRatBN7.2
Rnor_6.01537,789,556 - 37,789,763NCBIRnor6.0
Rnor_5.01541,635,440 - 41,635,647UniSTSRnor5.0
RGSC_v3.41536,565,591 - 36,565,798UniSTSRGSC3.4
Celera1531,381,552 - 31,381,759UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 144 90 89 58 43 58 6 289 140 8 126 67 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000076285   ⟹   ENSRNOP00000068381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1537,806,836 - 37,807,660 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076392   ⟹   ENSRNOP00000067985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1537,790,141 - 37,790,286 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091953   ⟹   ENSRNOP00000074427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1537,790,272 - 37,807,142 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143439   ⟹   ENSRNOP00000112503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1535,786,898 - 35,804,391 (+)Ensembl
RefSeq Acc Id: NM_001402485   ⟹   NP_001389414
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81535,786,898 - 35,804,391 (+)NCBI
mRatBN7.21531,671,337 - 31,688,833 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001389414 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000112503
  ENSRNOP00000112503.1
Ensembl Acc Id: ENSRNOP00000068381   ⟸   ENSRNOT00000076285
Ensembl Acc Id: ENSRNOP00000067985   ⟸   ENSRNOT00000076392
Ensembl Acc Id: ENSRNOP00000074427   ⟸   ENSRNOT00000091953
RefSeq Acc Id: NP_001389414   ⟸   NM_001402485
- Peptide Label: precursor
Ensembl Acc Id: ENSRNOP00000112503   ⟸   ENSRNOT00000143439

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K812-F1-model_v2 AlphaFold A0A0G2K812 1-200 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699730
Promoter ID:EPDNEW_R10244
Type:multiple initiation site
Name:Il17d_1
Description:interleukin 17D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01537,790,142 - 37,790,202EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595926 AgrOrtholog
BioCyc Gene G2FUF-13602 BioCyc
Ensembl Genes ENSRNOG00000051120 Ensembl
  ENSRNOG00000079865 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000143439 ENTREZGENE
  ENSRNOT00000143439.1 UniProtKB/TrEMBL
NCBI Gene 691799 ENTREZGENE
PhenoGen Il17d PhenoGen
RatGTEx ENSRNOG00000051120 RatGTEx
  ENSRNOG00000079865 RatGTEx
UniProt A0ABK0M9M6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Il17d  interleukin 17D  LOC691799  similar to interleukin 17D precursor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691799  similar to interleukin 17D precursor  LOC682369  similar to interleukin 17D precursor  Data merged from RGD:1584580 1643240 APPROVED
2006-11-20 LOC691799  similar to interleukin 17D precursor      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682369  similar to interleukin 17D precursor      Symbol and Name status set to provisional 70820 PROVISIONAL