Serpina6 (serpin family A member 6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Serpina6 (serpin family A member 6) Rattus norvegicus
Analyze
Symbol: Serpina6
Name: serpin family A member 6
RGD ID: 1595901
Description: Predicted to enable molecular carrier activity; serine-type endopeptidase inhibitor activity; and steroid binding activity. Predicted to act upstream of or within glucocorticoid metabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in corticosteroid-binding globulin deficiency. Orthologous to human SERPINA6 (serpin family A member 6); INTERACTS WITH (+)-schisandrin B; (S)-colchicine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cbg; Corticosteroid binding globulin; corticosteroid-binding globulin; MGC112780; serine (or cysteine) peptidase inhibitor, clade A, member 6; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (mapped); serpin A6; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6; serpin peptidase inhibitor, clade A, member 6; Serpina6_mapped; transcortin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Serpina6em1Glha
Genetic Models: SD-Serpina6em1Glha ; SD-Serpina6em1Glha/Rrrc
Candidate Gene For: Srcrt4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,544,828 - 128,555,064 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6128,544,831 - 128,555,139 (-)EnsemblGRCr8
mRatBN7.26122,780,040 - 122,790,274 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,780,043 - 122,790,349 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6122,920,505 - 122,930,725 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,215,781 - 123,226,001 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,552,673 - 122,562,896 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,523,948 - 127,534,178 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,523,906 - 127,534,247 (-)Ensemblrn6Rnor6.0
Rnor_5.06136,742,720 - 136,752,950 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46127,911,618 - 127,921,851 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6120,260,306 - 120,270,532 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (EXP)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
acetamide  (EXP)
aconitine  (EXP)
aflatoxin B1  (EXP,ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
drospirenone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
fumonisin B1  (ISO)
glafenine  (EXP)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
indometacin  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
Mitotane  (ISO)
Monobutylphthalate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
norgestimate  (ISO)
okadaic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP,ISO)
Triptolide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
withaferin A  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Serum corticosteroid-binding globulin concentration and insulin resistance syndrome: a population study. Fernandez-Real JM, etal., J Clin Endocrinol Metab 2002 Oct;87(10):4686-90.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:2710140   PMID:3347061   PMID:8039711   PMID:12477932   PMID:16502470   PMID:16980625   PMID:17467234   PMID:17644521   PMID:18513745   PMID:19833863   PMID:23141917   PMID:23279724  
PMID:23376485   PMID:23533145   PMID:27418032   PMID:29273683   PMID:36112420   PMID:38015819  


Genomics

Comparative Map Data
Serpina6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,544,828 - 128,555,064 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6128,544,831 - 128,555,139 (-)EnsemblGRCr8
mRatBN7.26122,780,040 - 122,790,274 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,780,043 - 122,790,349 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6122,920,505 - 122,930,725 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,215,781 - 123,226,001 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,552,673 - 122,562,896 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,523,948 - 127,534,178 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,523,906 - 127,534,247 (-)Ensemblrn6Rnor6.0
Rnor_5.06136,742,720 - 136,752,950 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46127,911,618 - 127,921,851 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6120,260,306 - 120,270,532 (-)NCBICelera
Cytogenetic Map6q32NCBI
SERPINA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381494,304,248 - 94,323,336 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1494,304,248 - 94,323,389 (-)Ensemblhg38GRCh38
GRCh371494,770,585 - 94,789,673 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361493,840,338 - 93,859,441 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341493,840,338 - 93,859,426NCBI
Celera1474,824,369 - 74,843,477 (-)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1474,950,383 - 74,969,481 (-)NCBIHuRef
CHM1_11494,708,390 - 94,727,495 (-)NCBICHM1_1
T2T-CHM13v2.01488,531,534 - 88,550,620 (-)NCBIT2T-CHM13v2.0
Serpina6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912103,612,889 - 103,623,477 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12103,612,889 - 103,623,471 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3812103,646,630 - 103,657,218 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12103,646,630 - 103,657,212 (-)Ensemblmm10GRCm38
MGSCv3712104,884,842 - 104,895,281 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612104,047,682 - 104,058,121 (-)NCBIMGSCv36mm8
Celera12104,862,913 - 104,873,376 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1252.98NCBI
Serpina6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543816,356,540 - 16,380,872 (-)Ensembl
ChiLan1.0NW_00495543816,356,600 - 16,380,861 (-)NCBIChiLan1.0ChiLan1.0
SERPINA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21595,461,767 - 95,480,904 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11494,678,417 - 94,688,646 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01474,936,724 - 74,955,799 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11494,269,299 - 94,288,391 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1494,269,299 - 94,288,391 (-)EnsemblpanPan2panpan1.1
SERPINA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,323,896 - 63,341,829 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,323,933 - 63,453,708 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha862,900,449 - 62,925,083 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0863,589,497 - 63,614,157 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl863,589,530 - 63,614,404 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1863,266,111 - 63,290,719 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,318,270 - 63,342,932 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0863,648,530 - 63,673,205 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101973017
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864011,314,687 - 11,325,700 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367332,141,392 - 2,148,151 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367332,141,484 - 2,148,129 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7115,535,697 - 115,554,570 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17115,535,552 - 115,554,536 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27122,544,744 - 122,563,955 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12472,079,084 - 72,098,549 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2472,077,274 - 72,098,154 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605359,312,190 - 59,331,143 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpina6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473410,637,515 - 10,651,033 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473410,638,031 - 10,650,297 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Serpina6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17114,913,894 - 114,924,275 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Serpina6
68 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:24
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000012500
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
RH127840  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26122,780,198 - 122,780,408 (+)MAPPERmRatBN7.2
Rnor_6.06127,524,107 - 127,524,316NCBIRnor6.0
Rnor_5.06136,742,879 - 136,743,088UniSTSRnor5.0
RGSC_v3.46127,911,777 - 127,911,986UniSTSRGSC3.4
Celera6120,260,465 - 120,260,674UniSTS
RH 3.4 Map6832.3UniSTS
Cytogenetic Map6q32UniSTS
BF388405  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26122,784,960 - 122,785,152 (+)MAPPERmRatBN7.2
Rnor_6.06127,528,869 - 127,529,060NCBIRnor6.0
Rnor_5.06136,747,641 - 136,747,832UniSTSRnor5.0
RGSC_v3.46127,916,540 - 127,916,731UniSTSRGSC3.4
Celera6120,265,227 - 120,265,418UniSTS
RH 3.4 Map6816.09UniSTS
Cytogenetic Map6q32UniSTS


Genetic Models
This gene Serpina6 is modified in the following models/strains:
SD-Serpina6em1Glha     SD-Serpina6em1Glha/Rrrc    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
2 8 20 78 91 84 59 28 59 5 180 71 3 57 41 54 25

Sequence


Ensembl Acc Id: ENSRNOT00000012500   ⟹   ENSRNOP00000012500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6128,544,831 - 128,555,139 (-)Ensembl
mRatBN7.2 Ensembl6122,780,043 - 122,790,349 (-)Ensembl
Rnor_6.0 Ensembl6127,523,906 - 127,534,247 (-)Ensembl
RefSeq Acc Id: NM_001009663   ⟹   NP_001009663
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,544,828 - 128,555,064 (-)NCBI
mRatBN7.26122,780,040 - 122,790,274 (-)NCBI
Rnor_6.06127,523,948 - 127,534,178 (-)NCBI
Rnor_5.06136,742,720 - 136,752,950 (-)NCBI
RGSC_v3.46127,911,618 - 127,921,851 (-)RGD
Celera6120,260,306 - 120,270,532 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001009663 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88300 (Get FASTA)   NCBI Sequence Viewer  
  EDL81783 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012500
  ENSRNOP00000012500.4
GenBank Protein P31211 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001009663   ⟸   NM_001009663
- Peptide Label: precursor
- UniProtKB: Q5M822 (UniProtKB/Swiss-Prot),   P31211 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012500   ⟸   ENSRNOT00000012500

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31211-F1-model_v2 AlphaFold P31211 1-396 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694799
Promoter ID:EPDNEW_R5322
Type:initiation region
Name:Serpina6_1
Description:serpin family A member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06127,534,195 - 127,534,255EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595901 AgrOrtholog
BioCyc Gene G2FUF-36406 BioCyc
Ensembl Genes ENSRNOG00000009438 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012500 ENTREZGENE
  ENSRNOT00000012500.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot
  3.30.497.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7323342 IMAGE-MGC_LOAD
InterPro Serpin_CS UniProtKB/Swiss-Prot
  Serpin_dom UniProtKB/Swiss-Prot
  Serpin_fam UniProtKB/Swiss-Prot
  Serpin_sf UniProtKB/Swiss-Prot
  Serpin_sf_1 UniProtKB/Swiss-Prot
  Serpin_sf_2 UniProtKB/Swiss-Prot
KEGG Report rno:299270 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109504 IMAGE-MGC_LOAD
NCBI Gene 299270 ENTREZGENE
PANTHER CORTICOSTEROID-BINDING GLOBULIN UniProtKB/Swiss-Prot
  PTHR11461 UniProtKB/Swiss-Prot
Pfam Serpin UniProtKB/Swiss-Prot
PharmGKB SERPINA6 RGD
PhenoGen Serpina6 PhenoGen
PRINTS LEUSERPINII UniProtKB/Swiss-Prot
PROSITE SERPIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009438 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot
UniProt CBG_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5M822 ENTREZGENE
UniProt Secondary Q5M822 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpina6  serpin family A member 6  Serpina6  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Serpina6  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6  Serpina6  serpin peptidase inhibitor, clade A, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-03-05 Serpina6  serpin peptidase inhibitor, clade A, member 6  Serpina6  serine (or cysteine) peptidase inhibitor, clade A, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Serpina6  serine (or cysteine) peptidase inhibitor, clade A, member 6  Serpina6  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6  Serpina6  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (mapped)  Name updated 737654 APPROVED
2007-04-13 Serpina6  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (mapped)  Serpina6_mapped  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (mapped)  Data merged from RGD:619829 737654 APPROVED
2006-11-20 Serpina6  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Serpina6_mapped  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (mapped)  Serpina6  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6  Symbol and Name updated 1556543 APPROVED
2003-04-09 Serpina6  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6      Symbol and Name updated 629477 APPROVED
2003-03-06 Serpina6  serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6  Cbg  Corticosteroid binding globulin  Data merged from RGD:2284 628472 PROVISIONAL
2002-08-07 Serpina6        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Cbg  Corticosteroid binding globulin      Symbol and Name status set to approved 70586 APPROVED