Acsbg3 (acyl-CoA synthetase bubblegum family member 3) - Rat Genome Database

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Gene: Acsbg3 (acyl-CoA synthetase bubblegum family member 3) Rattus norvegicus
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Symbol: Acsbg3
Name: acyl-CoA synthetase bubblegum family member 3
RGD ID: 1595856
Description: Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid biosynthetic process. Predicted to be active in cytoplasm; INTERACTS WITH aldehydo-D-glucose (ortholog); D-glucose (ortholog); genistein (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC316124; LOC316124; similar to gonadotropin-regulated long chain acyl-CoA synthetase; uncharacterized protein LOC316124
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,802,729 - 1,814,761 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,802,744 - 1,814,761 (+)EnsemblGRCr8
mRatBN7.291,715,613 - 1,727,637 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,704,674 - 1,727,634 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,133,444 - 2,161,554 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,482,647 - 7,511,230 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,438,638 - 6,466,748 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd92,497,838 - 2,509,859 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive92,302,062 - 2,314,079 (+)NCBILyon_Normotensive
Lyon_Hypertensive91,891,536 - 1,903,553 (+)NCBILyon_Hypertensive
F344_StmMcwi916,496,274 - 16,508,588 (-)NCBIF344_StmMcwi
Rnor_6.0910,158,745 - 10,188,013 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,158,748 - 10,182,676 (-)Ensemblrn6Rnor6.0
Rnor_5.099,157,941 - 9,186,255 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera96,789,486 - 6,817,708 (-)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation

Genomics

Comparative Map Data
Acsbg3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,802,729 - 1,814,761 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,802,744 - 1,814,761 (+)EnsemblGRCr8
mRatBN7.291,715,613 - 1,727,637 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,704,674 - 1,727,634 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,133,444 - 2,161,554 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,482,647 - 7,511,230 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,438,638 - 6,466,748 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd92,497,838 - 2,509,859 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive92,302,062 - 2,314,079 (+)NCBILyon_Normotensive
Lyon_Hypertensive91,891,536 - 1,903,553 (+)NCBILyon_Hypertensive
F344_StmMcwi916,496,274 - 16,508,588 (-)NCBIF344_StmMcwi
Rnor_6.0910,158,745 - 10,188,013 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,158,748 - 10,182,676 (-)Ensemblrn6Rnor6.0
Rnor_5.099,157,941 - 9,186,255 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera96,789,486 - 6,817,708 (-)NCBICelera
Cytogenetic Map9q11NCBI
Acsbg3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,182,453 - 57,195,907 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,182,477 - 57,195,904 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381756,875,452 - 56,889,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,875,477 - 56,888,904 (+)Ensemblmm10GRCm38
MGSCv371757,015,056 - 57,028,261 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361756,560,601 - 56,574,038 (+)NCBIMGSCv36mm8
Celera1761,220,317 - 61,233,519 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.55NCBI

Variants

.
Variants in Acsbg3
72 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:33
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000073048, ENSRNOT00000074894
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631533Iresp3Immunoglobin response QTL316.2blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)916094576Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 9 29 55 44 43 12 55 12 6 156 106 1 37 16 59 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000073048   ⟹   ENSRNOP00000064726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl910,158,937 - 10,170,428 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074894   ⟹   ENSRNOP00000067848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,802,744 - 1,814,761 (+)Ensembl
mRatBN7.2 Ensembl91,704,674 - 1,727,634 (+)Ensembl
Rnor_6.0 Ensembl910,158,748 - 10,182,676 (-)Ensembl
RefSeq Acc Id: NM_001419489   ⟹   NP_001406418
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,802,744 - 1,814,761 (+)NCBI
mRatBN7.291,715,620 - 1,727,637 (+)NCBI
Dahl_SR_JrHsd92,497,838 - 2,509,859 (+)NCBI
Lyon_Normotensive92,302,062 - 2,314,079 (+)NCBI
Lyon_Hypertensive91,891,536 - 1,903,553 (+)NCBI
F344_StmMcwi916,496,274 - 16,508,588 (-)NCBI
RefSeq Acc Id: XM_039083461   ⟹   XP_038939389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,802,730 - 1,814,761 (+)NCBI
mRatBN7.291,715,613 - 1,727,637 (+)NCBI
RefSeq Acc Id: XM_063267060   ⟹   XP_063123130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,808,813 - 1,814,761 (+)NCBI
RefSeq Acc Id: XR_010054588
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,802,729 - 1,809,689 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001406418 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939389 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123130 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83600 (Get FASTA)   NCBI Sequence Viewer  
  EDL83601 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067848
  ENSRNOP00000067848.2
Ensembl Acc Id: ENSRNOP00000064726   ⟸   ENSRNOT00000073048
Ensembl Acc Id: ENSRNOP00000067848   ⟸   ENSRNOT00000074894
RefSeq Acc Id: XP_038939389   ⟸   XM_039083461
- Peptide Label: isoform X1
- UniProtKB: A6KQU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001406418   ⟸   NM_001419489
- UniProtKB: M0RDY4 (UniProtKB/TrEMBL),   A6KQU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123130   ⟸   XM_063267060
- Peptide Label: isoform X2
Protein Domains
AMP-dependent synthetase/ligase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RDY4-F1-model_v2 AlphaFold M0RDY4 1-669 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595856 AgrOrtholog
BioCyc Gene G2FUF-28506 BioCyc
Ensembl Genes ENSRNOG00000047549 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074894 ENTREZGENE
  ENSRNOT00000074894.4 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.12780 UniProtKB/TrEMBL
InterPro AMP-dep_Synth/Lig UniProtKB/TrEMBL
  AMP-dep_Synthh-like_sf UniProtKB/TrEMBL
NCBI Gene 316124 ENTREZGENE
PANTHER LONG-CHAIN-FATTY-ACID--COA LIGASE UniProtKB/TrEMBL
  LONG-CHAIN-FATTY-ACID--COA LIGASE ACSBG2 UniProtKB/TrEMBL
Pfam AMP-binding UniProtKB/TrEMBL
  AMP-binding_C_3 UniProtKB/TrEMBL
PhenoGen Acsbg3 PhenoGen
RatGTEx ENSRNOG00000047549 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/TrEMBL
UniProt A6KQU2 ENTREZGENE, UniProtKB/TrEMBL
  M0RDY4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-20 Acsbg3  acyl-CoA synthetase bubblegum family member 3  LOC316124  similar to gonadotropin-regulated long chain acyl-CoA synthetase  Name and Symbol changed 629549 APPROVED
2006-11-20 LOC316124  similar to gonadotropin-regulated long chain acyl-CoA synthetase      Symbol and Name status set to provisional 70820 PROVISIONAL