Pnpla3 (patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Pnpla3 (patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase) Rattus norvegicus
Analyze
Symbol: Pnpla3
Name: patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase (Ensembl:patatin-like phospholipase domain containing 3)
RGD ID: 1595843
Description: Predicted to enable acylglycerol O-acyltransferase activity; anion binding activity; and lipase activity. Involved in several processes, including cellular response to 3,3',5-triiodo-L-thyronine; cellular response to insulin stimulus; and white fat cell differentiation. Predicted to be active in cytoplasm; lipid droplet; and membrane. Biomarker of hypothyroidism and obesity. Human ortholog(s) of this gene implicated in coronary artery disease; liver disease (multiple); and type 2 diabetes mellitus. Orthologous to human PNPLA3 (patatin like phospholipase domain containing 3); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3; adiponutrin; Adpn; LOC362972; patatin-like phospholipase domain containing 3; patatin-like phospholipase domain-containing protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87117,173,485 - 117,194,065 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7117,173,516 - 117,194,594 (+)EnsemblGRCr8
mRatBN7.27115,293,538 - 115,314,077 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7115,293,538 - 115,314,077 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7117,041,315 - 117,061,957 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07119,267,044 - 119,287,685 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07119,236,507 - 119,257,145 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07125,034,760 - 125,056,165 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7125,034,764 - 125,055,976 (+)Ensemblrn6Rnor6.0
Rnor_5.07125,023,278 - 125,044,677 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47122,152,092 - 122,171,994 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7111,599,483 - 111,620,054 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
CL316243  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (ISO)
genistein  (ISO)
glucose  (ISO)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isosilybin  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
metformin  (EXP)
methotrexate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
quercetin  (ISO)
rotenone  (EXP)
rutin  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
taurodeoxycholic acid  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
lipid droplet  (IBA,IEA,ISO)
membrane  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage. Baulande S, etal., J Biol Chem. 2001 Sep 7;276(36):33336-44. doi: 10.1074/jbc.M105193200. Epub 2001 Jun 28.
2. The impact of PNPLA3 (rs738409 C>G) polymorphisms on liver histology and long-term clinical outcome in chronic hepatitis B patients. Brouwer WP, etal., Liver Int. 2015 Feb;35(2):438-47. doi: 10.1111/liv.12695. Epub 2014 Oct 24.
3. Tri-iodothyronine upregulates adiponutrin mRNA expression in rat and human adipocytes. Calvo RM and Obregon MJ, Mol Cell Endocrinol. 2009 Nov 13;311(1-2):39-46. doi: 10.1016/j.mce.2009.07.006. Epub 2009 Jul 18.
4. Genetic analysis of nonalcoholic fatty liver disease within a Caribbean-Hispanic population. Edelman D, etal., Mol Genet Genomic Med. 2015 Aug 11;3(6):558-69. doi: 10.1002/mgg3.168. eCollection 2015 Nov.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Genetic variants in the PNPLA3 gene are associated with nonalcoholic steatohepatitis. Islek EE, etal., Genet Test Mol Biomarkers. 2014 Jul;18(7):489-96. doi: 10.1089/gtmb.2014.0019. Epub 2014 May 15.
7. PNPLA3 rs738409 polymorphism is associated with liver fibrosis progression in patients with chronic hepatitis C: A repeated measures study. Jiménez-Sousa MÁ, etal., J Clin Virol. 2018 Jun;103:71-74. doi: 10.1016/j.jcv.2018.04.008. Epub 2018 Apr 12.
8. Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals. Lin YC, etal., Am J Clin Nutr. 2014 Apr;99(4):869-74. doi: 10.3945/ajcn.113.079749. Epub 2014 Jan 29.
9. PNPLA3 gene polymorphism in Brazilian patients with type 2 diabetes: A prognostic marker beyond liver disease? Machado CM, etal., Nutr Metab Cardiovasc Dis. 2019 Sep;29(9):965-971. doi: 10.1016/j.numecd.2019.06.002. Epub 2019 Jun 14.
10. Adiponutrin mRNA expression in white adipose tissue is rapidly induced by meal-feeding a high-sucrose diet. Polson DA and Thompson MP, Biochem Biophys Res Commun. 2003 Feb 7;301(2):261-6. doi: 10.1016/s0006-291x(02)03027-9.
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Hepatic steatosis in Wilson disease--Role of copper and PNPLA3 mutations. Stattermayer AF, etal., J Hepatol. 2015 Jul;63(1):156-63. doi: 10.1016/j.jhep.2015.01.034. Epub 2015 Feb 9.
14. I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease. Valenti L, etal., Hepatology. 2010 Oct;52(4):1274-80. doi: 10.1002/hep.23823.
15. Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C. Valenti L, etal., Hepatology. 2011 Mar;53(3):791-9. doi: 10.1002/hep.24123. Epub 2011 Feb 11.
16. Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B. Viganò M, etal., Hepatology. 2013 Oct;58(4):1245-52. doi: 10.1002/hep.26445. Epub 2013 Aug 6.
Additional References at PubMed
PMID:12477932   PMID:15364929   PMID:17372308   PMID:20034933   PMID:21914237   PMID:22560221   PMID:23398201   PMID:24511104   PMID:28433418   PMID:35908495  


Genomics

Comparative Map Data
Pnpla3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87117,173,485 - 117,194,065 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7117,173,516 - 117,194,594 (+)EnsemblGRCr8
mRatBN7.27115,293,538 - 115,314,077 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7115,293,538 - 115,314,077 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7117,041,315 - 117,061,957 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07119,267,044 - 119,287,685 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07119,236,507 - 119,257,145 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07125,034,760 - 125,056,165 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7125,034,764 - 125,055,976 (+)Ensemblrn6Rnor6.0
Rnor_5.07125,023,278 - 125,044,677 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47122,152,092 - 122,171,994 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7111,599,483 - 111,620,054 (+)NCBICelera
Cytogenetic Map7q34NCBI
PNPLA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382243,923,805 - 43,947,582 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2243,923,781 - 43,964,488 (+)Ensemblhg38GRCh38
GRCh372244,319,685 - 44,343,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362242,650,952 - 42,674,781 (+)NCBIBuild 36Build 36hg18NCBI36
Celera2228,230,136 - 28,255,047 (+)NCBICelera
Cytogenetic Map22q13.31NCBI
HuRef2227,273,880 - 27,298,036 (+)NCBIHuRef
CHM1_12244,278,349 - 44,302,177 (+)NCBICHM1_1
T2T-CHM13v2.02244,406,936 - 44,430,721 (+)NCBIT2T-CHM13v2.0
Pnpla3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391584,052,017 - 84,073,720 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1584,052,038 - 84,071,437 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381584,167,776 - 84,189,521 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1584,167,837 - 84,187,236 (+)Ensemblmm10GRCm38
MGSCv371583,998,246 - 84,019,951 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361583,995,603 - 84,017,280 (+)NCBIMGSCv36mm8
Celera1586,298,497 - 86,320,441 (+)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1539.78NCBI
Pnpla3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541328,879,748 - 28,893,938 (+)Ensembl
ChiLan1.0NW_00495541328,879,646 - 28,896,224 (+)NCBIChiLan1.0ChiLan1.0
PNPLA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22353,752,467 - 53,780,078 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12256,444,968 - 56,473,064 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02224,812,831 - 24,836,161 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12243,004,329 - 43,027,749 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2243,004,499 - 43,027,003 (+)EnsemblpanPan2panpan1.1
PNPLA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11021,708,439 - 21,722,282 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1021,712,378 - 21,722,135 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1021,647,779 - 21,663,038 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01022,455,884 - 22,471,128 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1022,457,538 - 22,471,215 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11022,175,366 - 22,190,635 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01022,495,689 - 22,510,929 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01022,669,488 - 22,684,748 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pnpla3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049455,341,850 - 5,360,187 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367181,619,948 - 1,638,317 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367181,620,034 - 1,638,315 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNPLA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl55,075,622 - 5,092,515 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.155,075,608 - 5,092,599 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PNPLA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11926,435,302 - 26,458,368 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1926,435,599 - 26,462,210 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604598,945,667 - 98,969,751 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnpla3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11253,556,033 - 253,575,213 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pnpla3
140 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:388
Count of miRNA genes:227
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000015767
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7116269196132020414Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
BI277600  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27115,296,694 - 115,296,861 (+)MAPPERmRatBN7.2
Rnor_6.07125,037,972 - 125,038,138NCBIRnor6.0
Rnor_5.07125,026,484 - 125,026,650UniSTSRnor5.0
RGSC_v3.47122,155,256 - 122,155,422UniSTSRGSC3.4
Celera7111,602,640 - 111,602,806UniSTS
RH 3.4 Map7906.9UniSTS
Cytogenetic Map7q34UniSTS
BE097963  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87117,176,960 - 117,177,109 (+)Marker Load Pipeline
mRatBN7.27115,296,970 - 115,297,119 (+)MAPPERmRatBN7.2
Rnor_6.07125,038,248 - 125,038,396NCBIRnor6.0
Rnor_5.07125,026,760 - 125,026,908UniSTSRnor5.0
RGSC_v3.47122,155,532 - 122,155,680UniSTSRGSC3.4
Celera7111,602,916 - 111,603,064UniSTS
RH 3.4 Map7908.6UniSTS
Cytogenetic Map7q34UniSTS
RH141751  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27115,312,901 - 115,313,103 (+)MAPPERmRatBN7.2
Rnor_6.07125,054,396 - 125,054,597NCBIRnor6.0
Rnor_5.07125,042,908 - 125,043,109UniSTSRnor5.0
RGSC_v3.47122,172,254 - 122,172,455UniSTSRGSC3.4
Celera7111,618,878 - 111,619,079UniSTS
RH 3.4 Map7912.1UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 151 91 90 59 81 59 6 344 180 11 130 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015767   ⟹   ENSRNOP00000015767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7117,173,516 - 117,194,594 (+)Ensembl
mRatBN7.2 Ensembl7115,293,538 - 115,314,077 (+)Ensembl
Rnor_6.0 Ensembl7125,034,764 - 125,055,976 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000121663   ⟹   ENSRNOP00000102492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7117,173,516 - 117,192,440 (+)Ensembl
RefSeq Acc Id: NM_001282324   ⟹   NP_001269253
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87117,173,528 - 117,194,065 (+)NCBI
mRatBN7.27115,293,538 - 115,314,077 (+)NCBI
Rnor_6.07125,034,815 - 125,055,571 (+)NCBI
Rnor_5.07125,023,278 - 125,044,677 (+)NCBI
Celera7111,599,483 - 111,620,054 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063263942   ⟹   XP_063120012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87117,173,485 - 117,184,179 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001269253 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120012 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM15608 (Get FASTA)   NCBI Sequence Viewer  
  EDM15609 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015767
  ENSRNOP00000015767.5
  ENSRNOP00000102492.1
RefSeq Acc Id: NP_001269253   ⟸   NM_001282324
- UniProtKB: D3Z9J9 (UniProtKB/TrEMBL),   A6HTB3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015767   ⟸   ENSRNOT00000015767
RefSeq Acc Id: XP_063120012   ⟸   XM_063263942
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000102492   ⟸   ENSRNOT00000121663
Protein Domains
PNPLA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9J9-F1-model_v2 AlphaFold D3Z9J9 1-425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695554
Promoter ID:EPDNEW_R6079
Type:single initiation site
Name:Pnpla3_1
Description:patatin-like phospholipase domain containing 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07125,034,803 - 125,034,863EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595843 AgrOrtholog
BioCyc Gene G2FUF-32582 BioCyc
Ensembl Genes ENSRNOG00000022268 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015767 ENTREZGENE
  ENSRNOT00000015767.9 UniProtKB/TrEMBL
  ENSRNOT00000121663.1 UniProtKB/TrEMBL
Gene3D-CATH Cytosolic phospholipase A2 catalytic domain UniProtKB/TrEMBL
InterPro Acyl_Trfase/lysoPlipase UniProtKB/TrEMBL
  Patatin UniProtKB/TrEMBL
  PLPL UniProtKB/TrEMBL
KEGG Report rno:362972 UniProtKB/TrEMBL
NCBI Gene 362972 ENTREZGENE
PANTHER 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE PNPLA3 UniProtKB/TrEMBL
  PTHR12406 UniProtKB/TrEMBL
Pfam Patatin UniProtKB/TrEMBL
PhenoGen Pnpla3 PhenoGen
PROSITE PNPLA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022268 RatGTEx
Superfamily-SCOP Acyl_Trfase/lysoPlipase UniProtKB/TrEMBL
UniProt A0ABK0LMA4_RAT UniProtKB/TrEMBL
  A6HTB3 ENTREZGENE, UniProtKB/TrEMBL
  D3Z9J9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Pnpla3  patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase  Pnpla3  patatin-like phospholipase domain containing 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Pnpla3  patatin-like phospholipase domain containing 3  LOC362972  similar to adiponutrin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC362972  similar to adiponutrin      Symbol and Name status set to provisional 70820 PROVISIONAL