Zfp296 (zinc finger protein 296) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Zfp296 (zinc finger protein 296) Rattus norvegicus
Analyze
Symbol: Zfp296
Name: zinc finger protein 296
RGD ID: 1595818
Description: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of dendrite development; regulation of transcription by RNA polymerase II; and spermatogenesis. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF296 (zinc finger protein 296); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC365511; similar to zinc finger protein 296; Znf296
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,356,653 - 88,359,841 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,352,530 - 88,359,840 (+)EnsemblGRCr8
mRatBN7.2179,228,649 - 79,231,866 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,228,401 - 79,231,866 (+)EnsemblmRatBN7.2
Rnor_6.0180,487,193 - 80,491,422 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,487,938 - 80,491,039 (+)Ensemblrn6Rnor6.0
Rnor_5.0181,753,950 - 81,757,459 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera173,687,418 - 73,691,647 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11063263   PMID:24161396  


Genomics

Comparative Map Data
Zfp296
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,356,653 - 88,359,841 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,352,530 - 88,359,840 (+)EnsemblGRCr8
mRatBN7.2179,228,649 - 79,231,866 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,228,401 - 79,231,866 (+)EnsemblmRatBN7.2
Rnor_6.0180,487,193 - 80,491,422 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,487,938 - 80,491,039 (+)Ensemblrn6Rnor6.0
Rnor_5.0181,753,950 - 81,757,459 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera173,687,418 - 73,691,647 (+)NCBICelera
Cytogenetic Map1q21NCBI
ZNF296
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,071,500 - 45,076,478 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,071,500 - 45,076,478 (-)Ensemblhg38GRCh38
GRCh371945,574,758 - 45,579,736 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,266,598 - 50,271,528 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341950,266,598 - 50,271,528NCBI
Celera1942,379,045 - 42,383,975 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,004,983 - 42,009,811 (-)NCBIHuRef
CHM1_11945,578,088 - 45,583,042 (-)NCBICHM1_1
T2T-CHM13v2.01947,896,615 - 47,901,608 (-)NCBIT2T-CHM13v2.0
Zfp296
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,311,212 - 19,314,581 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,311,212 - 19,314,581 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38719,577,287 - 19,580,656 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,577,287 - 19,580,656 (+)Ensemblmm10GRCm38
MGSCv37720,162,636 - 20,166,005 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36718,736,338 - 18,739,177 (+)NCBIMGSCv36mm8
Celera716,983,052 - 16,986,421 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.93NCBI
Znf296
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555552,109,682 - 2,113,922 (-)Ensembl
ChiLan1.0NW_0049555552,109,980 - 2,114,002 (-)NCBIChiLan1.0ChiLan1.0
ZNF296
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,232,109 - 51,238,657 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,103,509 - 53,109,428 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,019,936 - 42,025,304 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,623,782 - 50,630,027 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,623,782 - 50,630,027 (-)EnsemblpanPan2panpan1.1
ZNF296
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,405,643 - 110,411,848 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,408,058 - 110,411,744 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1109,887,079 - 109,893,570 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01110,935,757 - 110,942,247 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,938,446 - 110,942,245 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,611,015 - 110,617,504 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,246,181 - 110,252,672 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,114,986 - 111,121,478 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Znf296
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,276,013 - 17,279,796 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,623,354 - 1,627,140 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,623,386 - 1,627,068 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF296
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,504,388 - 51,508,324 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1651,504,384 - 51,508,284 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ZNF296
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,531,046 - 38,536,746 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,531,146 - 38,536,235 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607318,121,705 - 18,128,622 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf296
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,852,995 - 1,857,150 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249071,853,118 - 1,857,496 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Znf296
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12171,043,063 - 171,046,754 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Zfp296
13 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:154
Count of miRNA genes:130
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000074579
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 64 159 89 88 57 86 57 6 341 183 11 137 78 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000074579   ⟹   ENSRNOP00000064037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,352,530 - 88,359,840 (+)Ensembl
mRatBN7.2 Ensembl179,228,401 - 79,231,866 (+)Ensembl
Rnor_6.0 Ensembl180,487,938 - 80,491,039 (+)Ensembl
RefSeq Acc Id: XM_345065   ⟹   XP_345066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,356,653 - 88,359,841 (+)NCBI
mRatBN7.2179,228,649 - 79,231,866 (+)NCBI
Rnor_6.0180,487,193 - 80,491,422 (+)NCBI
Rnor_5.0181,753,950 - 81,757,459 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001419293 (Get FASTA)   NCBI Sequence Viewer  
  XP_345066 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM08183 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064037
  ENSRNOP00000064037.4
RefSeq Acc Id: XP_345066   ⟸   XM_345065
- Sequence:
Ensembl Acc Id: ENSRNOP00000064037   ⟸   ENSRNOT00000074579
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R3W4-F1-model_v2 AlphaFold M0R3W4 1-450 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689785
Promoter ID:EPDNEW_R298
Type:single initiation site
Name:Zfp296_1
Description:zinc finger protein 296
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,487,883 - 80,487,943EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595818 AgrOrtholog
BioCyc Gene G2FUF-60495 BioCyc
Ensembl Genes ENSRNOG00000049605 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074579 ENTREZGENE
  ENSRNOT00000074579.4 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro BCL-11A_Znf_CCHC UniProtKB/TrEMBL
  Dev/Hematopoietic_TF UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:365511 UniProtKB/TrEMBL
NCBI Gene 365511 ENTREZGENE
PANTHER B-CELL LYMPHOMA/LEUKEMIA 11 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 296 UniProtKB/TrEMBL
Pfam CCHC_BCL-11A UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp296 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049605 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A6J8Q1 ENTREZGENE, UniProtKB/TrEMBL
  M0R3W4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-19 Zfp296  zinc finger protein 296  Znf296  zinc finger protein 296  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Znf296  zinc finger protein 296  Zfp296  zinc finger protein 296  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Zfp296  zinc finger protein 296  LOC365511  similar to zinc finger protein 296  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC365511  similar to zinc finger protein 296      Symbol and Name status set to provisional 70820 PROVISIONAL