Cep170b (centrosomal protein 170B) - Rat Genome Database

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Pathways
Gene: Cep170b (centrosomal protein 170B) Rattus norvegicus
Analyze
Symbol: Cep170b
Name: centrosomal protein 170B
RGD ID: 1595689
Description: Orthologous to human CEP170B (centrosomal protein 170B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aconitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: centrosomal protein of 170 kDa protein B; LOC500726; similar to KARP-1 binding protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,602,707 - 137,627,750 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6137,602,707 - 137,627,750 (+)EnsemblGRCr8
mRatBN7.26131,780,935 - 131,806,658 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,778,957 - 131,806,658 (+)EnsemblmRatBN7.2
Rnor_6.06137,283,814 - 137,311,512 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,288,810 - 137,311,932 (+)Ensemblrn6Rnor6.0
Rnor_5.06146,293,198 - 146,317,420 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46137,709,826 - 137,731,513 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6129,325,451 - 129,352,849 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Cep170b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,602,707 - 137,627,750 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6137,602,707 - 137,627,750 (+)EnsemblGRCr8
mRatBN7.26131,780,935 - 131,806,658 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,778,957 - 131,806,658 (+)EnsemblmRatBN7.2
Rnor_6.06137,283,814 - 137,311,512 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,288,810 - 137,311,932 (+)Ensemblrn6Rnor6.0
Rnor_5.06146,293,198 - 146,317,420 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46137,709,826 - 137,731,513 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6129,325,451 - 129,352,849 (+)NCBICelera
Cytogenetic Map6q32NCBI
CEP170B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814104,864,513 - 104,896,747 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14104,864,541 - 104,896,770 (+)Ensemblhg38GRCh38
GRCh3714105,331,605 - 105,363,084 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,402,699 - 104,434,132 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1485,386,210 - 85,417,492 (+)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,529,219 - 85,556,332 (+)NCBIHuRef
CHM1_114105,269,452 - 105,300,570 (+)NCBICHM1_1
T2T-CHM13v2.01499,111,170 - 99,142,641 (+)NCBIT2T-CHM13v2.0
Cep170b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,687,950 - 112,713,026 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,686,889 - 112,713,026 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812112,721,514 - 112,746,592 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,720,455 - 112,746,592 (+)Ensemblmm10GRCm38
MGSCv3712113,960,385 - 113,984,802 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612113,170,042 - 113,194,399 (+)NCBIMGSCv36mm8
Celera12113,936,710 - 113,961,121 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.2NCBI
Cep170b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,261,882 - 3,283,433 (+)Ensembl
ChiLan1.0NW_0049555383,261,900 - 3,283,274 (+)NCBIChiLan1.0ChiLan1.0
CEP170B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215106,049,711 - 106,082,757 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,266,214 - 105,299,254 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,515,684 - 85,548,410 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,305,959 - 105,334,323 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,307,591 - 105,332,523 (+)EnsemblpanPan2panpan1.1
CEP170B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,374,536 - 72,399,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha871,877,926 - 71,903,669 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0872,647,605 - 72,673,546 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,650,002 - 72,860,168 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,332,072 - 72,356,585 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,374,059 - 72,399,912 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,773,550 - 72,799,306 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cep170b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,702,462 - 1,725,404 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936621531,382 - 554,166 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936621531,419 - 554,390 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CEP170B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27131,200,726 - 131,225,088 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CEP170B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,796,088 - 82,826,636 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2482,796,127 - 82,826,789 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605370,222,224 - 70,252,809 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cep170b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624734441,815 - 464,966 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624734442,432 - 466,891 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cep170b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17130,313,833 - 130,337,497 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cep170b
151 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:47
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000030235, ENSRNOT00000030246
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 90 59 6 354 190 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000030246   ⟹   ENSRNOP00000033816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6137,602,707 - 137,627,750 (+)Ensembl
mRatBN7.2 Ensembl6131,778,957 - 131,806,658 (+)Ensembl
Rnor_6.0 Ensembl6137,288,810 - 137,311,932 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109856   ⟹   ENSRNOP00000096003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,778,957 - 131,806,658 (+)Ensembl
RefSeq Acc Id: NM_001427267   ⟹   NP_001414196
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,602,707 - 137,627,750 (+)NCBI
RefSeq Acc Id: XM_063262346   ⟹   XP_063118416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,603,813 - 137,627,747 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414196 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118416 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97420 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000033816
  ENSRNOP00000033816.4
Ensembl Acc Id: ENSRNOP00000033816   ⟸   ENSRNOT00000030246
Ensembl Acc Id: ENSRNOP00000096003   ⟸   ENSRNOT00000109856
RefSeq Acc Id: NP_001414196   ⟸   NM_001427267
- UniProtKB: D4A1G8 (UniProtKB/TrEMBL),   A0A8I6AQA5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118416   ⟸   XM_063262346
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AQA5 (UniProtKB/TrEMBL)
Protein Domains
FHA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1G8-F1-model_v2 AlphaFold D4A1G8 1-1575 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595689 AgrOrtholog
BioCyc Gene G2FUF-35777 BioCyc
Ensembl Genes ENSRNOG00000033688 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030246 ENTREZGENE
  ENSRNOT00000030246.9 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.20 UniProtKB/TrEMBL
InterPro Cent_Immune-Sig_Mod UniProtKB/TrEMBL
  CEP170_C UniProtKB/TrEMBL
  FHA_dom UniProtKB/TrEMBL
  SMAD_FHA_domain UniProtKB/TrEMBL
NCBI Gene 500726 ENTREZGENE
PANTHER CENTROSOMAL PROTEIN OF 170 KDA UniProtKB/TrEMBL
  CENTROSOMAL PROTEIN OF 170 KDA PROTEIN B UniProtKB/TrEMBL
Pfam CEP170_C UniProtKB/TrEMBL
  FHA UniProtKB/TrEMBL
PhenoGen Cep170b PhenoGen
PROSITE FHA_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033688 RatGTEx
SMART FHA UniProtKB/TrEMBL
Superfamily-SCOP SMAD_FHA UniProtKB/TrEMBL
UniProt A0A8I6AQA5 ENTREZGENE
  D4A1G8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-10 Cep170b  centrosomal protein 170B  LOC500726  similar to KARP-1 binding protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC500726  similar to KARP-1 binding protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL