Enables chromatin binding activity. Involved in several processes, including maternal behavior; regulation of gene expression; and response to estradiol. Located in chromatin. Used to study choline deficiency disease. Biomarker of choline deficiency disease; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MBD2 (methyl-CpG binding domain protein 2); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; DNA modification pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
LOC291525; LOC680172; LOC684150; methyl-CpG-binding domain protein 2; MGC188552; similar to Methyl-CpG-binding domain protein 2 (Methyl-CpG-binding protein MBD2)
[Testosterone co-treated with Estradiol] promotes the reaction [bisphenol A results in increased expression of MBD2 mRNA] and [Testosterone co-treated with Estradiol] promotes the reaction [estradiol-17 beta-benzoate results in increased expression of MBD2 mRNA]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MBD2 mRNA
Decitabine inhibits the reaction [Dust results in increased expression of MBD2 mRNA] and Decitabine inhibits the reaction [Dust results in increased expression of MBD2 protein]
[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of MBD2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of MBD2 mRNA
[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of MBD2 mRNA and [Testosterone co-treated with Estradiol] promotes the reaction [bisphenol A results in increased expression of MBD2 mRNA]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MBD2 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MBD2 mRNA
[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MBD2 gene more ...
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MBD2 mRNA
[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD2 mRNA
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD2 mRNA
resveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]] and resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [MBD2 protein binds to BRCA1 promoter]]
[Testosterone co-treated with Estradiol] promotes the reaction [bisphenol A results in increased expression of MBD2 mRNA] and [Testosterone co-treated with Estradiol] promotes the reaction [estradiol-17 beta-benzoate results in increased expression of MBD2 mRNA]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBD2 mRNA
A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats.
Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout life.
