Prr19 (proline rich 19) - Rat Genome Database

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Pathways
Gene: Prr19 (proline rich 19) Rattus norvegicus
Analyze
Symbol: Prr19
Name: proline rich 19
RGD ID: 1595416
Description: Predicted to be located in chromosome and nucleus. Orthologous to human PRR19 (proline rich 19); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; methimazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC681408; LOC681408; MGC188639; proline-rich protein 19
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,012,307 - 90,017,988 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl190,014,027 - 90,017,997 (+)EnsemblGRCr8
mRatBN7.2180,884,529 - 80,890,712 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,887,151 - 80,890,168 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx186,279,368 - 86,282,385 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,830,512 - 94,833,528 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,035,145 - 88,038,162 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,167,027 - 82,172,636 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,169,620 - 82,172,636 (+)Ensemblrn6Rnor6.0
Rnor_5.0183,433,779 - 83,436,807 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,577,805 - 80,578,988 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,330,058 - 75,333,073 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Prr19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,012,307 - 90,017,988 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl190,014,027 - 90,017,997 (+)EnsemblGRCr8
mRatBN7.2180,884,529 - 80,890,712 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,887,151 - 80,890,168 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx186,279,368 - 86,282,385 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,830,512 - 94,833,528 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,035,145 - 88,038,162 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,167,027 - 82,172,636 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,169,620 - 82,172,636 (+)Ensemblrn6Rnor6.0
Rnor_5.0183,433,779 - 83,436,807 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,577,805 - 80,578,988 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,330,058 - 75,333,073 (+)NCBICelera
Cytogenetic Map1q21NCBI
PRR19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381942,302,132 - 42,310,814 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1942,302,098 - 42,310,814 (+)Ensemblhg38GRCh38
GRCh371942,806,284 - 42,814,966 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,498,124 - 47,506,813 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1939,607,080 - 39,615,768 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1939,236,425 - 39,245,114 (+)NCBIHuRef
CHM1_11942,807,935 - 42,816,636 (+)NCBICHM1_1
T2T-CHM13v2.01945,121,505 - 45,130,199 (+)NCBIT2T-CHM13v2.0
Prr19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,000,784 - 25,003,565 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,000,836 - 25,003,557 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38725,301,359 - 25,304,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,301,411 - 25,304,132 (+)Ensemblmm10GRCm38
MGSCv37726,086,378 - 26,089,152 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36725,010,119 - 25,012,893 (+)NCBIMGSCv36mm8
Celera719,916,403 - 19,919,177 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.74NCBI
Prr19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555605,333 - 610,058 (-)Ensembl
ChiLan1.0NW_004955555605,333 - 610,104 (-)NCBIChiLan1.0ChiLan1.0
PRR19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22048,407,301 - 48,415,762 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11950,275,899 - 50,284,394 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01939,189,839 - 39,198,524 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,780,843 - 47,789,689 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,780,843 - 47,789,689 (+)EnsemblpanPan2panpan1.1
PRR19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,074,045 - 112,076,036 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,073,031 - 112,075,316 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1111,500,212 - 111,502,203 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01112,686,667 - 112,688,658 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,686,709 - 112,687,932 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,240,895 - 112,242,886 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,876,841 - 111,878,832 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,803,371 - 112,805,362 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prr19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,861,670 - 15,865,625 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706209,083 - 210,247 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936706209,013 - 210,326 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRR19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,630,832 - 49,635,831 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1649,630,831 - 49,635,831 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,525,227 - 45,529,312 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRR19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,512,360 - 36,515,518 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607314,759,983 - 14,761,354 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prr19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907450,222 - 452,441 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624907450,196 - 454,604 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prr19
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12169,411,318 - 169,414,134 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prr19
35 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:47
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000068251
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 4 36 136 61 56 37 53 37 6 234 111 4 120 70 85 19 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000068251   ⟹   ENSRNOP00000062750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl190,014,027 - 90,017,997 (+)Ensembl
mRatBN7.2 Ensembl180,887,151 - 80,890,168 (+)Ensembl
Rnor_6.0 Ensembl182,169,620 - 82,172,636 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088955   ⟹   ENSRNOP00000072020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl190,015,049 - 90,017,997 (+)Ensembl
mRatBN7.2 Ensembl180,889,216 - 80,890,167 (+)Ensembl
Rnor_6.0 Ensembl182,169,620 - 82,172,635 (+)Ensembl
RefSeq Acc Id: NM_001173428   ⟹   NP_001166899
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,014,971 - 90,017,988 (+)NCBI
mRatBN7.2180,887,150 - 80,890,168 (+)NCBI
Rnor_6.0182,169,620 - 82,172,636 (+)NCBI
Rnor_5.0183,433,779 - 83,436,807 (+)NCBI
Celera175,330,058 - 75,333,073 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228480   ⟹   XP_006228542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,014,907 - 90,017,988 (+)NCBI
mRatBN7.2180,887,073 - 80,890,168 (+)NCBI
Rnor_6.0182,169,518 - 82,172,636 (+)NCBI
Rnor_5.0183,433,779 - 83,436,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090655   ⟹   XP_038946583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,015,147 - 90,017,988 (+)NCBI
mRatBN7.2180,887,317 - 80,890,712 (+)NCBI
RefSeq Acc Id: XM_039090657   ⟹   XP_038946585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,015,143 - 90,017,988 (+)NCBI
mRatBN7.2180,887,317 - 80,890,711 (+)NCBI
RefSeq Acc Id: XM_063273759   ⟹   XP_063129829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,012,307 - 90,017,988 (+)NCBI
RefSeq Acc Id: NP_001166899   ⟸   NM_001173428
- UniProtKB: D3ZED7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228542   ⟸   XM_006228480
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSRNOP00000062750   ⟸   ENSRNOT00000068251
Ensembl Acc Id: ENSRNOP00000072020   ⟸   ENSRNOT00000088955
RefSeq Acc Id: XP_038946583   ⟸   XM_039090655
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946585   ⟸   XM_039090657
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063129829   ⟸   XM_063273759
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZED7-F1-model_v2 AlphaFold D3ZED7 1-364 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595416 AgrOrtholog
BioCyc Gene G2FUF-60392 BioCyc
Ensembl Genes ENSRNOG00000043154 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068251 ENTREZGENE
  ENSRNOT00000068251.4 UniProtKB/TrEMBL
  ENSRNOT00000088955 ENTREZGENE
  ENSRNOT00000088955.3 UniProtKB/TrEMBL
InterPro Pro-rich_19 UniProtKB/TrEMBL
KEGG Report rno:681408 UniProtKB/TrEMBL
NCBI Gene 681408 ENTREZGENE
PANTHER PROLINE-RICH PROTEIN 19 UniProtKB/TrEMBL
  PTHR37346 UniProtKB/TrEMBL
Pfam Pro-rich_19 UniProtKB/TrEMBL
PhenoGen Prr19 PhenoGen
RatGTEx ENSRNOG00000043154 RatGTEx
UniProt A0A0G2K1X4_RAT UniProtKB/TrEMBL
  B5DEK4_RAT UniProtKB/TrEMBL
  D3ZED7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-08 Prr19  proline rich 19  LOC687149  hypothetical protein LOC687149  Data merged from RGD:1588937 1643240 APPROVED
2008-03-31 Prr19  proline rich 19  LOC681408  hypothetical protein LOC681408  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681408  hypothetical protein LOC681408      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687149  hypothetical protein LOC687149      Symbol and Name status set to provisional 70820 PROVISIONAL