Ppp1r26 (protein phosphatase 1, regulatory subunit 26) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ppp1r26 (protein phosphatase 1, regulatory subunit 26) Rattus norvegicus
Analyze
Symbol: Ppp1r26
Name: protein phosphatase 1, regulatory subunit 26
RGD ID: 1595050
Description: Predicted to enable protein phosphatase inhibitor activity. Orthologous to human PPP1R26 (protein phosphatase 1 regulatory subunit 26); INTERACTS WITH bisphenol A; 2,3',4,4',5-Pentachlorobiphenyl (ortholog); 2-hydroxypropanoic acid (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07051376.1; LOC685398; rCG45515-like; similar to 1A6/DRIM (down-regulated in metastasis) interacting protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ppp1r26-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8332,179,686 - 32,188,069 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl332,177,235 - 32,188,264 (+)EnsemblGRCr8
mRatBN7.2311,781,504 - 11,790,076 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl311,781,295 - 11,790,073 (+)EnsemblmRatBN7.2
Rnor_6.037,032,118 - 7,040,615 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,035,169 - 7,038,421 (+)NCBIrn6Rnor6.0
Rnor_5.0312,382,947 - 12,391,430 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.437,439,319 - 7,444,353 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera36,562,270 - 6,571,507 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19389623  


Genomics

Comparative Map Data
Ppp1r26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8332,179,686 - 32,188,069 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl332,177,235 - 32,188,264 (+)EnsemblGRCr8
mRatBN7.2311,781,504 - 11,790,076 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl311,781,295 - 11,790,073 (+)EnsemblmRatBN7.2
Rnor_6.037,032,118 - 7,040,615 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,035,169 - 7,038,421 (+)NCBIrn6Rnor6.0
Rnor_5.0312,382,947 - 12,391,430 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.437,439,319 - 7,444,353 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera36,562,270 - 6,571,507 (+)NCBICelera
Cytogenetic Map3p12NCBI
PPP1R26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389135,479,066 - 135,488,892 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9135,479,073 - 135,488,897 (+)Ensemblhg38GRCh38
GRCh379138,371,628 - 138,380,738 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369137,511,469 - 137,520,560 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349135,597,592 - 135,606,684NCBI
Celera9108,888,779 - 108,897,869 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9107,836,353 - 107,842,565 (+)NCBIHuRef
CHM1_19138,520,166 - 138,529,344 (+)NCBICHM1_1
T2T-CHM13v2.09147,707,139 - 147,716,966 (+)NCBIT2T-CHM13v2.0
Ppp1r26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39228,336,613 - 28,345,520 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl228,336,812 - 28,345,520 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38228,446,493 - 28,455,508 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl228,446,800 - 28,455,508 (+)Ensemblmm10GRCm38
MGSCv37228,303,461 - 28,311,028 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36228,269,950 - 28,277,517 (+)NCBIMGSCv36mm8
Celera228,152,222 - 28,159,789 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.38NCBI
Ppp1r26
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,042,763 - 4,046,467 (+)Ensembl
ChiLan1.0NW_0049555134,039,819 - 4,046,482 (+)NCBIChiLan1.0ChiLan1.0
PPP1R26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2113,823,768 - 3,838,873 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan193,826,926 - 3,841,206 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09106,620,368 - 106,629,655 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19135,613,494 - 135,622,218 (+)NCBIPanPan1.1PanPan1.1panPan2
PPP1R26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1951,196,524 - 51,204,311 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl951,199,252 - 51,202,800 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha950,492,110 - 50,500,625 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0952,086,793 - 52,094,566 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1950,864,889 - 50,873,413 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0951,189,397 - 51,197,905 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0951,269,251 - 51,277,026 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppp1r26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947201,293,186 - 201,300,827 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366692,075,659 - 2,079,459 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366692,074,225 - 2,081,872 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R26
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21308,617,637 - 308,624,955 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R26
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1122,681,538 - 2,690,589 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl122,682,299 - 2,685,943 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660582,467,025 - 2,476,229 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r26
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247603,094,025 - 3,097,699 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247603,090,014 - 3,099,163 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppp1r26
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v158,213,750 - 8,222,228 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppp1r26
79 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:60
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000036601
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH130832  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2311,789,750 - 11,789,946 (+)MAPPERmRatBN7.2
Rnor_6.037,040,290 - 7,040,485NCBIRnor6.0
Rnor_5.0312,391,105 - 12,391,300UniSTSRnor5.0
RGSC_v3.437,444,028 - 7,444,223UniSTSRGSC3.4
Celera36,571,182 - 6,571,377UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 49 60 130 88 11 48 35 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000036601   ⟹   ENSRNOP00000037924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl332,177,235 - 32,188,264 (+)Ensembl
mRatBN7.2 Ensembl311,781,295 - 11,790,073 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102380   ⟹   ENSRNOP00000078859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl332,179,767 - 32,188,264 (+)Ensembl
mRatBN7.2 Ensembl311,781,632 - 11,790,073 (+)Ensembl
RefSeq Acc Id: NM_001427208   ⟹   NP_001414137
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,179,686 - 32,188,069 (+)NCBI
RefSeq Acc Id: XM_039106146   ⟹   XP_038962074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,179,759 - 32,188,066 (+)NCBI
mRatBN7.2311,781,764 - 11,790,076 (+)NCBI
RefSeq Acc Id: XM_039106149   ⟹   XP_038962077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,179,759 - 32,188,066 (+)NCBI
mRatBN7.2311,781,764 - 11,790,076 (+)NCBI
RefSeq Acc Id: XM_039106150   ⟹   XP_038962078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,179,759 - 32,188,066 (+)NCBI
mRatBN7.2311,781,764 - 11,790,076 (+)NCBI
RefSeq Acc Id: XM_063284559   ⟹   XP_063140629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,180,184 - 32,188,066 (+)NCBI
RefSeq Acc Id: XP_038962078   ⟸   XM_039106150
- Peptide Label: isoform X1
- UniProtKB: D3ZPW4 (UniProtKB/TrEMBL),   A6JTN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962077   ⟸   XM_039106149
- Peptide Label: isoform X1
- UniProtKB: D3ZPW4 (UniProtKB/TrEMBL),   A6JTN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962074   ⟸   XM_039106146
- Peptide Label: isoform X1
- UniProtKB: D3ZPW4 (UniProtKB/TrEMBL),   A6JTN0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078859   ⟸   ENSRNOT00000102380
Ensembl Acc Id: ENSRNOP00000037924   ⟸   ENSRNOT00000036601
RefSeq Acc Id: NP_001414137   ⟸   NM_001427208
- UniProtKB: D3ZPW4 (UniProtKB/TrEMBL),   A6JTN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140629   ⟸   XM_063284559
- Peptide Label: isoform X1
- UniProtKB: D3ZPW4 (UniProtKB/TrEMBL),   A6JTN0 (UniProtKB/TrEMBL)
Protein Domains
Protein phosphatase 1 regulatory subunit 26 N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZPW4-F1-model_v2 AlphaFold D3ZPW4 1-956 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595050 AgrOrtholog
BioCyc Gene G2FUF-50283 BioCyc
Ensembl Genes ENSRNOG00000027193 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036601 ENTREZGENE
  ENSRNOT00000036601.6 UniProtKB/TrEMBL
  ENSRNOT00000102380 ENTREZGENE
  ENSRNOT00000102380.2 UniProtKB/TrEMBL
InterPro PPP1R26 UniProtKB/TrEMBL
  PPP1R26_N UniProtKB/TrEMBL
NCBI Gene 685398 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 26 UniProtKB/TrEMBL
  PTHR15724 UniProtKB/TrEMBL
Pfam PPP1R26_N UniProtKB/TrEMBL
PhenoGen Ppp1r26 PhenoGen
RatGTEx ENSRNOG00000027193 RatGTEx
UniProt A6JTN0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZPW4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Ppp1r26  protein phosphatase 1, regulatory subunit 26  AABR07051376.1    Data merged from RGD:15003656 737654 PROVISIONAL
2019-11-08 AABR07051376.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2013-05-24 Ppp1r26  protein phosphatase 1, regulatory subunit 26  LOC100364681  rCG45515-like  Data merged from RGD:2320582 1643240 APPROVED
2011-10-21 Ppp1r26  protein phosphatase 1, regulatory subunit 26  LOC685398  similar to 1A6/DRIM (down-regulated in metastasis) interacting protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100364681  rCG45515-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC685398  similar to 1A6/DRIM (down-regulated in metastasis) interacting protein  LOC687551  similar to 1A6/DRIM (down-regulated in metastasis) interacting protein  Data merged from RGD:1584214 1643240 APPROVED
2006-11-20 LOC685398  similar to 1A6/DRIM (down-regulated in metastasis) interacting protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687551  similar to 1A6/DRIM (down-regulated in metastasis) interacting protein      Symbol and Name status set to provisional 70820 PROVISIONAL