Mrpl57 (mitochondrial ribosomal protein L57) - Rat Genome Database

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Gene: Mrpl57 (mitochondrial ribosomal protein L57) Rattus norvegicus
Analyze
Symbol: Mrpl57
Name: mitochondrial ribosomal protein L57
RGD ID: 1594654
Description: Predicted to be a structural constituent of ribosome. Predicted to act upstream of or within translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrial ribosome. Orthologous to human MRPL57 (mitochondrial ribosomal protein L57); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: large ribosomal subunit protein mL63; LOC691814; mitochondrial ribosomal protein 63; Mrp63; ribosomal protein 63, mitochondrial; similar to mitochondrial ribosomal protein 63
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81536,086,457 - 36,087,319 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1536,086,457 - 36,087,298 (+)EnsemblGRCr8
mRatBN7.21531,970,904 - 31,971,766 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1531,970,860 - 31,973,993 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1533,962,231 - 33,963,093 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01535,112,901 - 35,113,763 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01533,370,986 - 33,371,848 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01538,096,994 - 38,097,856 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1538,095,803 - 38,097,835 (+)Ensemblrn6Rnor6.0
Rnor_5.01541,937,785 - 41,938,647 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41536,866,920 - 36,867,782 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1531,681,562 - 31,682,425 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
translation  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11402041   PMID:12477932   PMID:18614015   PMID:28892042  


Genomics

Comparative Map Data
Mrpl57
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81536,086,457 - 36,087,319 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1536,086,457 - 36,087,298 (+)EnsemblGRCr8
mRatBN7.21531,970,904 - 31,971,766 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1531,970,860 - 31,973,993 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1533,962,231 - 33,963,093 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01535,112,901 - 35,113,763 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01533,370,986 - 33,371,848 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01538,096,994 - 38,097,856 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1538,095,803 - 38,097,835 (+)Ensemblrn6Rnor6.0
Rnor_5.01541,937,785 - 41,938,647 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41536,866,920 - 36,867,782 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1531,681,562 - 31,682,425 (+)NCBICelera
Cytogenetic Map15p12NCBI
MRPL57
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381321,176,658 - 21,179,084 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1321,176,647 - 21,179,084 (+)Ensemblhg38GRCh38
GRCh371321,750,797 - 21,753,223 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361320,648,372 - 20,651,223 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341320,648,371 - 20,651,218NCBI
Celera132,812,030 - 2,814,882 (+)NCBICelera
Cytogenetic Map13q12.11NCBI
HuRef132,551,493 - 2,554,345 (+)NCBIHuRef
CHM1_11321,718,059 - 21,720,911 (+)NCBICHM1_1
T2T-CHM13v2.01320,369,738 - 20,372,165 (+)NCBIT2T-CHM13v2.0
Mrpl57
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391458,063,662 - 58,066,544 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1458,063,691 - 58,066,753 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381457,826,228 - 57,829,087 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1457,826,234 - 57,829,296 (+)Ensemblmm10GRCm38
MGSCv371458,445,076 - 58,447,582 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361456,780,349 - 56,782,855 (+)NCBIMGSCv36mm8
Celera1455,622,774 - 55,625,280 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1430.51NCBI
Mrpl57
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554971,896,994 - 1,897,747 (+)NCBIChiLan1.0ChiLan1.0
MRPL57
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12516,979,757 - 16,982,141 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2516,981,590 - 16,981,898 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2517,077,243 - 17,078,817 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02517,116,872 - 17,118,446 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2517,117,195 - 17,118,390 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12516,991,459 - 16,993,027 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02517,003,189 - 17,004,440 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02517,059,007 - 17,060,581 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mrpl57
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945119,038,230 - 119,039,168 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936720585,780 - 586,693 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936720585,785 - 586,712 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRPL57
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl111,321,085 - 1,321,828 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1111,320,846 - 1,321,829 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MRPL57
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1331,741 - 32,560 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl331,742 - 32,566 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605744,584,234 - 44,585,175 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrpl57
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477616,412,064 - 16,412,921 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477616,412,064 - 16,412,919 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mrpl57
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11267,003,935 - 67,004,674 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mrpl57
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:169
Count of miRNA genes:123
Interacting mature miRNAs:138
Transcripts:ENSRNOT00000064635
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH143635  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,970,974 - 31,971,151 (+)MAPPERmRatBN7.2
Rnor_6.01538,097,065 - 38,097,241NCBIRnor6.0
Rnor_5.01541,937,856 - 41,938,032UniSTSRnor5.0
RGSC_v3.41536,866,991 - 36,867,167UniSTSRGSC3.4
Celera1531,681,634 - 31,681,810UniSTS
RH 3.4 Map15216.1UniSTS
Cytogenetic Map15p12UniSTS
AV005697  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,971,421 - 31,971,578 (+)MAPPERmRatBN7.2
Rnor_6.01538,097,512 - 38,097,668NCBIRnor6.0
Rnor_5.01541,938,303 - 41,938,459UniSTSRnor5.0
RGSC_v3.41536,867,438 - 36,867,594UniSTSRGSC3.4
Celera1531,682,081 - 31,682,237UniSTS
Cytogenetic Map15p12UniSTS
RH140624  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,971,391 - 31,971,590 (+)MAPPERmRatBN7.2
Rnor_6.01538,097,482 - 38,097,680NCBIRnor6.0
Rnor_5.01541,938,273 - 41,938,471UniSTSRnor5.0
RGSC_v3.41536,867,408 - 36,867,606UniSTSRGSC3.4
Celera1531,682,051 - 31,682,249UniSTS
Cytogenetic Map15p12UniSTS
RH140692  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,971,287 - 31,971,482 (+)MAPPERmRatBN7.2
Rnor_6.01538,097,378 - 38,097,572NCBIRnor6.0
Rnor_5.01541,938,169 - 41,938,363UniSTSRnor5.0
RGSC_v3.41536,867,304 - 36,867,498UniSTSRGSC3.4
Celera1531,681,947 - 31,682,141UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064635   ⟹   ENSRNOP00000063888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1538,096,994 - 38,097,835 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086854   ⟹   ENSRNOP00000074355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1538,095,803 - 38,097,463 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097941   ⟹   ENSRNOP00000094371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1531,970,860 - 31,973,993 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000165080   ⟹   ENSRNOP00000111579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1536,086,457 - 36,087,298 (+)Ensembl
RefSeq Acc Id: NM_001109649   ⟹   NP_001103119
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81536,086,457 - 36,087,319 (+)NCBI
mRatBN7.21531,970,904 - 31,971,766 (+)NCBI
Rnor_6.01538,096,994 - 38,097,856 (+)NCBI
Rnor_5.01541,937,785 - 41,938,647 (+)NCBI
RGSC_v3.41536,866,920 - 36,867,782 (+)RGD
Celera1531,681,562 - 31,682,425 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001103119 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI67109 (Get FASTA)   NCBI Sequence Viewer  
  EDM14362 (Get FASTA)   NCBI Sequence Viewer  
  EDM14363 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000111579
  ENSRNOP00000111579.1
RefSeq Acc Id: NP_001103119   ⟸   NM_001109649
- UniProtKB: B2RZD0 (UniProtKB/TrEMBL),   A0A8I6AJG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074355   ⟸   ENSRNOT00000086854
Ensembl Acc Id: ENSRNOP00000063888   ⟸   ENSRNOT00000064635
Ensembl Acc Id: ENSRNOP00000094371   ⟸   ENSRNOT00000097941
Ensembl Acc Id: ENSRNOP00000111579   ⟸   ENSRNOT00000165080

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TP00-F1-model_v2 AlphaFold Q7TP00 1-425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699726
Promoter ID:EPDNEW_R10250
Type:initiation region
Name:Mrpl57_1
Description:mitochondrial ribosomal protein L57
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01538,096,999 - 38,097,059EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594654 AgrOrtholog
BioCyc Gene G2FUF-13592 BioCyc
Ensembl Genes ENSRNOG00000010855 Ensembl
  ENSRNOG00000062588 Ensembl
  ENSRNOG00000081514 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000165080 ENTREZGENE
  ENSRNOT00000165080.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6919188 IMAGE-MGC_LOAD
InterPro Ribosomal_MRP63_mit UniProtKB/TrEMBL
KEGG Report rno:691814 UniProtKB/TrEMBL
MGC_CLONE MGC:189572 IMAGE-MGC_LOAD
NCBI Gene 691814 ENTREZGENE
PANTHER PTHR14520 UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN 63, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam MRP-63 UniProtKB/TrEMBL
PhenoGen Mrpl57 PhenoGen
PIRSF MRP63 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010855 RatGTEx
  ENSRNOG00000062588 RatGTEx
  ENSRNOG00000081514 RatGTEx
UniProt A0A8I6AJG2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LY63_RAT UniProtKB/TrEMBL
  B2RZD0 ENTREZGENE
  Q7TP00_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-26 Mrpl57  mitochondrial ribosomal protein L57  Mrp63  mitochondrial ribosomal protein 63  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Mrp63  mitochondrial ribosomal protein 63  LOC691814  similar to mitochondrial ribosomal protein 63  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691814  similar to mitochondrial ribosomal protein 63  LOC682467  similar to mitochondrial ribosomal protein 63  Data merged from RGD:1583425 1643240 APPROVED
2006-11-20 LOC691814  similar to mitochondrial ribosomal protein 63      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682467  similar to mitochondrial ribosomal protein 63      Symbol and Name status set to provisional 70820 PROVISIONAL