Bsph1 (binder of sperm protein homolog 1) - Rat Genome Database

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Gene: Bsph1 (binder of sperm protein homolog 1) Rattus norvegicus
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Symbol: Bsph1
Name: binder of sperm protein homolog 1
RGD ID: 1594649
Description: Predicted to enable heparin binding activity. Predicted to be involved in sperm capacitation. Predicted to be located in extracellular region. Predicted to be active in cell surface. Orthologous to human BSPH1 (binder of sperm protein homolog 1); INTERACTS WITH atrazine; arsane (ortholog); arsenic atom (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bovine seminal plasma protein homolog 1-like; LOC100912137; LOC691820; similar to epididymal sperm binding protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8183,549,565 - 83,585,706 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl183,546,660 - 83,586,707 (+)EnsemblGRCr8
mRatBN7.2174,413,976 - 74,450,117 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl174,411,200 - 74,450,120 (+)EnsemblmRatBN7.2
Rnor_6.0175,705,172 - 75,793,950 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl175,748,916 - 75,789,785 (+)Ensemblrn6Rnor6.0
Rnor_5.0177,033,418 - 77,094,538 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4174,045,645 - 74,084,661 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera169,843,118 - 69,942,551 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
permethrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (IBA,IEA,ISO)
extracellular region  (IEA)

Molecular Function
heparin binding  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22539676  


Genomics

Comparative Map Data
Bsph1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8183,549,565 - 83,585,706 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl183,546,660 - 83,586,707 (+)EnsemblGRCr8
mRatBN7.2174,413,976 - 74,450,117 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl174,411,200 - 74,450,120 (+)EnsemblmRatBN7.2
Rnor_6.0175,705,172 - 75,793,950 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl175,748,916 - 75,789,785 (+)Ensemblrn6Rnor6.0
Rnor_5.0177,033,418 - 77,094,538 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4174,045,645 - 74,084,661 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera169,843,118 - 69,942,551 (+)NCBICelera
Cytogenetic Map1q21NCBI
BSPH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381947,967,258 - 47,992,170 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1947,968,046 - 47,992,170 (-)Ensemblhg38GRCh38
GRCh371948,471,303 - 48,495,427 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,163,115 - 53,187,239 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1945,336,802 - 45,361,003 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1944,853,535 - 44,877,476 (-)NCBIHuRef
CHM1_11948,473,221 - 48,497,337 (-)NCBICHM1_1
T2T-CHM13v2.01950,959,608 - 50,984,497 (-)NCBIT2T-CHM13v2.0
Bsph1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39713,184,766 - 13,207,375 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl713,184,766 - 13,207,374 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38713,450,841 - 13,473,450 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl713,450,841 - 13,473,449 (+)Ensemblmm10GRCm38
MGSCv37714,036,190 - 14,058,798 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36712,351,020 - 12,373,628 (+)NCBIMGSCv36mm8
Celera711,068,322 - 11,090,376 (+)NCBICelera
Cytogenetic Map7A1NCBI
cM Map77.89NCBI
Bsph1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955609261,937 - 266,866 (+)Ensembl
ChiLan1.0NW_004955609261,937 - 266,866 (+)NCBIChiLan1.0ChiLan1.0
BSPH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22054,077,554 - 54,096,962 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11955,942,742 - 55,966,781 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01944,907,826 - 44,933,116 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11953,559,937 - 53,583,726 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1953,559,937 - 53,583,726 (-)EnsemblpanPan2panpan1.1
BSPH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11108,187,315 - 108,207,096 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,670,110 - 107,689,899 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01108,713,160 - 108,732,137 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11108,382,792 - 108,402,323 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,026,079 - 108,045,637 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,893,963 - 108,912,977 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101963272
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934920,161,472 - 20,171,703 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366641,779,662 - 1,789,727 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BSPH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,566,667 - 53,569,308 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1653,566,334 - 53,570,282 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,149,649 - 49,164,791 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BSPH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,234,737 - 41,253,039 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607321,017,702 - 21,019,228 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bsph1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248325,823,293 - 5,836,540 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bsph1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12173,542,192 - 173,570,576 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bsph1
332 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
sensory system
visual system
6 8 8 5 3 5 8 3 6 4 3 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000083154   ⟹   ENSRNOP00000068799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl183,546,660 - 83,586,707 (+)Ensembl
mRatBN7.2 Ensembl174,411,200 - 74,450,120 (+)Ensembl
Rnor_6.0 Ensembl175,748,916 - 75,789,785 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089836   ⟹   ENSRNOP00000074764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl183,546,764 - 83,586,707 (+)Ensembl
mRatBN7.2 Ensembl174,411,200 - 74,450,120 (+)Ensembl
Rnor_6.0 Ensembl175,748,916 - 75,789,785 (+)Ensembl
RefSeq Acc Id: XM_039097328   ⟹   XP_038953256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8183,549,565 - 83,585,706 (+)NCBI
mRatBN7.2174,413,976 - 74,450,117 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038953256 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068799.3
  ENSRNOP00000074764.3
Ensembl Acc Id: ENSRNOP00000074764   ⟸   ENSRNOT00000089836
Ensembl Acc Id: ENSRNOP00000068799   ⟸   ENSRNOT00000083154
RefSeq Acc Id: XP_038953256   ⟸   XM_039097328

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JTQ2-F1-model_v2 AlphaFold A0A0G2JTQ2 1-130 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594649 AgrOrtholog
BioCyc Gene G2FUF-60669 BioCyc
Ensembl Genes ENSRNOG00000052287 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083154.3 UniProtKB/TrEMBL
  ENSRNOT00000089836.3 UniProtKB/TrEMBL
Gene3D-CATH 2.10.10.10 UniProtKB/TrEMBL
InterPro FN_type2_dom UniProtKB/TrEMBL
  FN_type2_sf UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
  SP_Capacitation_Regulator UniProtKB/TrEMBL
NCBI Gene Bsph1 ENTREZGENE
PANTHER BINDER OF SPERM PROTEIN HOMOLOG 1 UniProtKB/TrEMBL
  SEMINAL PLASMA PROTEIN UniProtKB/TrEMBL
Pfam fn2 UniProtKB/TrEMBL
PhenoGen Bsph1 PhenoGen
PRINTS FNTYPEII UniProtKB/TrEMBL
PROSITE FN2_1 UniProtKB/TrEMBL
  FN2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052287 RatGTEx
SMART FN2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57440 UniProtKB/TrEMBL
UniProt A0A0G2JTQ2_RAT UniProtKB/TrEMBL
  A0A0G2K8W7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Bsph1  binder of sperm protein homolog 1  LOC100912137  bovine seminal plasma protein homolog 1-like  Data merged from RGD:6488695 737654 PROVISIONAL
2012-07-05 LOC100912137  bovine seminal plasma protein homolog 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-23 Bsph1  binder of sperm protein homolog 1  LOC691820  similar to epididymal sperm binding protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC691820  similar to epididymal sperm binding protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL