Tektl1 (tektin like 1) - Rat Genome Database

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Gene: Tektl1 (tektin like 1) Rattus norvegicus
Analyze
Symbol: Tektl1 (Ensembl: Ccdc105)
Name: tektin like 1 (Ensembl:coiled-coil domain containing 105)
RGD ID: 1594374
Description: Predicted to be active in axonemal B tubule inner sheath. Orthologous to human TEKTL1 (tektin like 1); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; methimazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ccdc105; coiled-coil domain containing 105; coiled-coil domain-containing protein 105; LOC500800; MGC116191; similar to hypothetical protein FLJ40365; tektin-like protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,551,549 - 11,558,258 (+)NCBIGRCr8
mRatBN7.2710,900,449 - 10,907,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,902,182 - 10,907,671 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,722,500 - 13,727,991 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,599,942 - 15,605,433 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,477,759 - 13,483,252 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0713,913,929 - 13,919,420 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl713,913,929 - 13,919,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0714,069,715 - 14,075,206 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,453,332 - 12,458,823 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera79,019,589 - 9,025,080 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:19056867  


Genomics

Comparative Map Data
Tektl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,551,549 - 11,558,258 (+)NCBIGRCr8
mRatBN7.2710,900,449 - 10,907,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,902,182 - 10,907,671 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,722,500 - 13,727,991 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,599,942 - 15,605,433 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,477,759 - 13,483,252 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0713,913,929 - 13,919,420 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl713,913,929 - 13,919,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0714,069,715 - 14,075,206 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,453,332 - 12,458,823 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera79,019,589 - 9,025,080 (+)NCBICelera
Cytogenetic Map7q11NCBI
TEKTL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381915,010,726 - 15,023,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1915,010,726 - 15,023,276 (+)EnsemblGRCh38hg38GRCh38
GRCh371915,121,538 - 15,134,088 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,982,556 - 14,995,081 (+)NCBINCBI36Build 36hg18NCBI36
Celera1915,017,220 - 15,029,771 (+)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,688,706 - 14,701,320 (+)NCBIHuRef
CHM1_11915,120,983 - 15,133,569 (+)NCBICHM1_1
T2T-CHM13v2.01915,135,627 - 15,148,213 (+)NCBIT2T-CHM13v2.0
Tektl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391078,582,758 - 78,623,636 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1078,582,760 - 78,588,899 (-)EnsemblGRCm39 Ensembl
GRCm381078,746,924 - 78,787,802 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,746,926 - 78,753,065 (-)EnsemblGRCm38mm10GRCm38
MGSCv371078,209,669 - 78,215,812 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361078,150,053 - 78,156,196 (-)NCBIMGSCv36mm8
Celera1079,768,758 - 79,774,901 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Tektl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554958,258,095 - 8,264,468 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554958,258,304 - 8,264,462 (-)NCBIChiLan1.0ChiLan1.0
TEKTL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22019,921,513 - 19,936,231 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11918,938,565 - 18,953,278 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01914,555,665 - 14,568,774 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11915,526,703 - 15,539,220 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1915,526,703 - 15,539,220 (+)Ensemblpanpan1.1panPan2
CCDC105
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12047,097,782 - 47,105,104 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2047,097,797 - 47,105,857 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2046,947,387 - 46,954,715 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02047,589,117 - 47,596,439 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2047,589,142 - 47,596,480 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12046,819,992 - 46,827,306 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02047,239,790 - 47,247,120 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02047,510,337 - 47,517,651 (-)NCBIUU_Cfam_GSD_1.0
Tektl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118205,876,284 - 205,885,385 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365965,425,581 - 5,434,390 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365965,425,461 - 5,434,390 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCDC105
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl262,570,479 - 62,582,755 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1262,569,723 - 62,583,823 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2262,129,934 - 62,141,266 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TEKTL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,597,502 - 13,627,846 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl613,597,954 - 13,627,404 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660745,979,597 - 5,993,262 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tektl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249012,069,084 - 2,078,840 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249012,069,167 - 2,078,414 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tektl1
52 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:29
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000009833
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 7
Low 4
Below cutoff 2 2 20 6 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009833   ⟹   ENSRNOP00000009833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl710,902,182 - 10,907,671 (+)Ensembl
Rnor_6.0 Ensembl713,913,929 - 13,919,420 (+)Ensembl
RefSeq Acc Id: NM_001025774   ⟹   NP_001020945
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,552,765 - 11,558,256 (+)NCBI
mRatBN7.2710,902,182 - 10,907,673 (+)NCBI
Rnor_6.0713,913,929 - 13,919,420 (+)NCBI
Rnor_5.0714,069,715 - 14,075,206 (+)NCBI
RGSC_v3.4712,453,332 - 12,458,823 (+)RGD
Celera79,019,589 - 9,025,080 (+)RGD
Sequence:
RefSeq Acc Id: XM_039079735   ⟹   XP_038935663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,552,079 - 11,558,258 (+)NCBI
mRatBN7.2710,902,219 - 10,907,672 (+)NCBI
RefSeq Acc Id: XM_039079736   ⟹   XP_038935664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,553,402 - 11,558,258 (+)NCBI
mRatBN7.2710,902,823 - 10,907,672 (+)NCBI
RefSeq Acc Id: XM_039079737   ⟹   XP_038935665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,551,549 - 11,558,258 (+)NCBI
mRatBN7.2710,900,449 - 10,907,672 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001020945   ⟸   NM_001025774
- UniProtKB: Q4V7B5 (UniProtKB/Swiss-Prot),   A6K926 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009833   ⟸   ENSRNOT00000009833
RefSeq Acc Id: XP_038935665   ⟸   XM_039079737
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038935663   ⟸   XM_039079735
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038935664   ⟸   XM_039079736
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V7B5-F1-model_v2 AlphaFold Q4V7B5 1-500 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695062
Promoter ID:EPDNEW_R5587
Type:single initiation site
Name:Ccdc105_1
Description:coiled-coil domain containing 105
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0713,913,888 - 13,913,948EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594374 AgrOrtholog
BioCyc Gene G2FUF-34846 BioCyc
Ensembl Genes ENSRNOG00000007375 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055031806 UniProtKB/Swiss-Prot
  ENSRNOG00060032385 UniProtKB/Swiss-Prot
  ENSRNOG00065018674 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009833 ENTREZGENE
  ENSRNOT00000009833.6 UniProtKB/Swiss-Prot
  ENSRNOT00055055037 UniProtKB/Swiss-Prot
  ENSRNOT00060056085 UniProtKB/Swiss-Prot
  ENSRNOT00065031352 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7456481 IMAGE-MGC_LOAD
InterPro CCDC105 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tektin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:500800 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:116191 IMAGE-MGC_LOAD
NCBI Gene 500800 ENTREZGENE
PANTHER COILED-COIL DOMAIN-CONTAINING PROTEIN 105 UniProtKB/Swiss-Prot
  COILED-COIL DOMAIN-CONTAINING PROTEIN 105 UniProtKB/TrEMBL
  COILED-COIL DOMAIN-CONTAINING PROTEIN 105 UniProtKB/TrEMBL
  PTHR35081 UniProtKB/Swiss-Prot
Pfam Tektin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tektl1 PhenoGen
RatGTEx ENSRNOG00000007375 RatGTEx
  ENSRNOG00055031806 RatGTEx
  ENSRNOG00060032385 RatGTEx
  ENSRNOG00065018674 RatGTEx
UniProt A6K926 ENTREZGENE, UniProtKB/TrEMBL
  CC105_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-05 Tektl1  tektin like 1  Ccdc105  coiled-coil domain containing 105  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Ccdc105  coiled-coil domain containing 105  LOC500800  similar to hypothetical protein FLJ40365  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC500800  similar to hypothetical protein FLJ40365      Symbol and Name status set to provisional 70820 PROVISIONAL