Zfp455l1 (zinc finger protein 455 like 1) - Rat Genome Database

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Gene: Zfp455l1 (zinc finger protein 455 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Zfp455l1
Name: zinc finger protein 455 like 1
RGD ID: 1594231
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF429 (zinc finger protein 429) and ZNF595 (zinc finger protein 595); INTERACTS WITH 17beta-estradiol (ortholog); aflatoxin B1 (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC680200; MGC189378; similar to zinc finger protein 455; zinc finger protein 455-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8136,755,197 - 36,773,283 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl136,755,682 - 36,767,869 (-)EnsemblGRCr8
mRatBN7.2134,866,934 - 34,944,939 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl134,927,303 - 34,944,121 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx134,788,645 - 34,805,378 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0140,779,493 - 40,796,226 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0134,954,190 - 34,971,005 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0137,802,591 - 37,818,879 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl137,802,592 - 37,818,879 (-)Ensemblrn6Rnor6.0
Rnor_5.0139,184,215 - 39,200,806 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4175,146,427 - 5,163,228 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera133,496,779 - 33,513,582 (-)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Zfp455l1
203 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:40
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000043747
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000043747   ⟹   ENSRNOP00000049291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl136,755,682 - 36,767,869 (-)Ensembl
mRatBN7.2 Ensembl134,927,303 - 34,944,121 (-)Ensembl
Rnor_6.0 Ensembl137,802,592 - 37,818,879 (-)Ensembl
RefSeq Acc Id: NM_001139491   ⟹   NP_001132963
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,755,682 - 36,772,502 (-)NCBI
mRatBN7.2134,927,301 - 34,944,121 (-)NCBI
Rnor_6.0137,802,591 - 37,818,879 (-)NCBI
Rnor_5.0139,184,215 - 39,200,806 (-)NCBI
RGSC_v3.4175,146,427 - 5,163,228 (-)RGD
Celera133,496,779 - 33,513,582 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001419516   ⟹   NP_001406445
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,755,682 - 36,772,502 (-)NCBI
mRatBN7.2134,927,301 - 34,944,121 (-)NCBI
RefSeq Acc Id: XM_063273561   ⟹   XP_063129631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,755,197 - 36,772,364 (-)NCBI
RefSeq Acc Id: XM_063273566   ⟹   XP_063129636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,755,197 - 36,773,102 (-)NCBI
RefSeq Acc Id: XM_063273570   ⟹   XP_063129640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,755,197 - 36,773,283 (-)NCBI
RefSeq Acc Id: NP_001132963   ⟸   NM_001139491
- Peptide Label: isoform 2
- UniProtKB: B2RZ85 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049291   ⟸   ENSRNOT00000043747
RefSeq Acc Id: NP_001406445   ⟸   NM_001419516
- Peptide Label: isoform 1
- UniProtKB: B2RZ85 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129640   ⟸   XM_063273570
- Peptide Label: isoform X1
- UniProtKB: B2RZ85 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129636   ⟸   XM_063273566
- Peptide Label: isoform X1
- UniProtKB: B2RZ85 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129631   ⟸   XM_063273561
- Peptide Label: isoform X1
- UniProtKB: B2RZ85 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RZ85-F1-model_v2 AlphaFold B2RZ85 1-470 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689579
Promoter ID:EPDNEW_R104
Type:multiple initiation site
Name:LOC680200_1
Description:similar to zinc finger protein 455
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0137,818,869 - 37,818,929EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594231 AgrOrtholog
BioCyc Gene G2FUF-61851 BioCyc
Ensembl Genes ENSRNOG00000042308 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043747 ENTREZGENE
  ENSRNOT00000043747.6 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9024521 IMAGE-MGC_LOAD
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf-C2H2_11 UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:680200 UniProtKB/TrEMBL
MGC_CLONE MGC:189378 IMAGE-MGC_LOAD
NCBI Gene 680200 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 771 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_11 UniProtKB/TrEMBL
PhenoGen Zfp455l1 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042308 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt B2RZ85 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-23 Zfp455l1  zinc finger protein 455 like 1  LOC680200  similar to zinc finger protein 455  Name and Symbol changed 629549 APPROVED
2006-11-20 LOC680200  similar to zinc finger protein 455      Symbol and Name status set to provisional 70820 PROVISIONAL