Nudt11 (nudix hydrolase 11) - Rat Genome Database

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Gene: Nudt11 (nudix hydrolase 11) Rattus norvegicus
Analyze
Symbol: Nudt11
Name: nudix hydrolase 11
RGD ID: 1594183
Description: Predicted to enable diphosphoinositol-polyphosphate diphosphatase activity. Predicted to be located in cytosol. Orthologous to several human genes including NUDT11 (nudix hydrolase 11); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: diphosphoinositol polyphosphate phosphohydrolase 3-beta; LOC680248; nudix (nucleoside diphosphate linked moiety X)-type motif 11; similar to Diphosphoinositol polyphosphate phosphohydrolase 3 alpha (DIPP-3 alpha) (DIPP3 alpha) (Diadenosine 5,5-P1,P6-hexaphosphate hydrolase 3 alpha) (Nucleoside diphosphate-linked moiety X motif 10) (Nudix motif 10)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X18,998,587 - 19,005,208 (+)NCBIGRCr8
mRatBN7.2X16,326,775 - 16,333,396 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX16,326,598 - 16,333,145 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX21,138,834 - 21,145,463 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X18,937,809 - 18,944,438 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X15,202,740 - 15,209,371 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X17,171,510 - 17,215,108 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX17,171,605 - 17,215,100 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX17,540,458 - 17,540,952 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X17,951,719 - 17,994,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X28,843,464 - 28,844,061 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX16,396,724 - 16,403,440 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12689335  


Genomics

Comparative Map Data
Nudt11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X18,998,587 - 19,005,208 (+)NCBIGRCr8
mRatBN7.2X16,326,775 - 16,333,396 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX16,326,598 - 16,333,145 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX21,138,834 - 21,145,463 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X18,937,809 - 18,944,438 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X15,202,740 - 15,209,371 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X17,171,510 - 17,215,108 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX17,171,605 - 17,215,100 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX17,540,458 - 17,540,952 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X17,951,719 - 17,994,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X28,843,464 - 28,844,061 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX16,396,724 - 16,403,440 (+)NCBICelera
Cytogenetic MapXq12NCBI
NUDT11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X51,490,011 - 51,496,592 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX51,490,011 - 51,496,592 (-)EnsemblGRCh38hg38GRCh38
GRCh37X51,232,863 - 51,239,444 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X51,249,603 - 51,256,199 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X51,065,899 - 51,072,495NCBI
CeleraX55,276,697 - 55,283,279 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX48,674,760 - 48,680,980 (-)NCBIHuRef
CHM1_1X51,312,772 - 51,319,354 (-)NCBICHM1_1
T2T-CHM13v2.0X50,761,304 - 50,767,871 (-)NCBIT2T-CHM13v2.0
Nudt10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X6,080,750 - 6,085,321 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX6,080,750 - 6,085,069 (-)EnsemblGRCm39 Ensembl
GRCm38X6,168,696 - 6,173,009 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX6,168,696 - 6,173,015 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 EnsemblX6,047,453 - 6,055,110 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X5,745,814 - 5,750,109 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X5,344,172 - 5,348,467 (-)NCBIMGSCv36mm8
CeleraX5,231,100 - 5,235,355 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX2.74NCBI
LOC100977487
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X52,880,742 - 52,887,608 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X52,884,347 - 52,891,213 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X43,666,957 - 43,673,542 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X51,376,769 - 51,382,944 (-)NCBIpanpan1.1PanPan1.1panPan2
NUDT11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X43,916,315 - 43,923,410 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX14,534,787 - 14,536,932 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X44,039,211 - 44,046,750 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX44,039,216 - 44,045,390 (+)EnsemblROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 EnsemblX44,185,564 - 44,190,362 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.0X44,030,651 - 44,038,583 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X44,408,760 - 44,416,307 (-)NCBIUU_Cfam_GSD_1.0
NUDT11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X44,912,160 - 44,918,977 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X50,052,555 - 50,059,095 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Nudt11
14 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
DXRat6  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X17,172,384 - 17,172,556NCBIRnor6.0
Rnor_5.0X17,952,593 - 17,952,765UniSTSRnor5.0
RGSC_v3.4X28,843,080 - 28,843,460RGDRGSC3.4
RGSC_v3.4X28,843,081 - 28,843,253UniSTSRGSC3.4
RGSC_v3.1X28,896,550 - 28,896,722RGD
CeleraX16,542,384 - 16,542,556UniSTS
RH 3.4 MapX253.2UniSTS
RH 3.4 MapX253.2RGD
RH 2.0 Map21176.4RGD
SHRSP x BN MapX4.5899RGD
FHH x ACI MapX4.63RGD
Cytogenetic MapXq13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 74 18 34
Low 43 13 8 5 8 8 8 19 16 17 11 8
Below cutoff 3 14 22 19 9 19 3 45 7 18

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000048236   ⟹   ENSRNOP00000051378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX16,326,598 - 16,333,145 (+)Ensembl
RefSeq Acc Id: NM_001401204   ⟹   NP_001388133
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X18,998,587 - 19,005,208 (+)NCBI
mRatBN7.2X16,326,775 - 16,333,396 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388133 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051378
  ENSRNOP00000051378.2
Reference Protein Sequences
RefSeq Acc Id: NP_001388133   ⟸   NM_001401204
- UniProtKB: D3ZYH3 (UniProtKB/TrEMBL),   A6KPC5 (UniProtKB/TrEMBL),   A6IG46 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000051378   ⟸   ENSRNOT00000048236
Protein Domains
Nudix hydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYH3-F1-model_v2 AlphaFold D3ZYH3 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594183 AgrOrtholog
BioCyc Gene G2FUF-2860 BioCyc
Ensembl Genes ENSRNOG00000046053 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000048573 Ensembl
Ensembl Transcript ENSRNOT00000048236 ENTREZGENE
  ENSRNOT00000048236.4 UniProtKB/TrEMBL
Gene3D-CATH Nucleoside Triphosphate Pyrophosphohydrolase UniProtKB/TrEMBL
InterPro DDP-like_NUDIX UniProtKB/TrEMBL
  Nudix_hydrolase UniProtKB/TrEMBL
  NUDIX_hydrolase_CS UniProtKB/TrEMBL
  NUDIX_hydrolase_dom UniProtKB/TrEMBL
  NUDIX_hydrolase_dom-like UniProtKB/TrEMBL
KEGG Report rno:680248 UniProtKB/TrEMBL
NCBI Gene 680248 ENTREZGENE
PANTHER DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE UniProtKB/TrEMBL
  DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 2-RELATED UniProtKB/TrEMBL
  DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 3-BETA UniProtKB/TrEMBL
Pfam NUDIX UniProtKB/TrEMBL
PhenoGen Nudt11 PhenoGen
PRINTS NUDIXFAMILY UniProtKB/TrEMBL
PROSITE NUDIX UniProtKB/TrEMBL
  NUDIX_BOX UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046053 RatGTEx
  ENSRNOG00000048573 RatGTEx
Superfamily-SCOP NUDIX_hydrolase UniProtKB/TrEMBL
UniProt A6IG46 ENTREZGENE, UniProtKB/TrEMBL
  A6KPC5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYH3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-19 Nudt11  nudix hydrolase 11  Nudt11  nudix (nucleoside diphosphate linked moiety X)-type motif 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Nudt11  nudix (nucleoside diphosphate linked moiety X)-type motif 11  LOC683238  similar to Diphosphoinositol polyphosphate phosphohydrolase 3 alpha (DIPP-3 alpha) (DIPP3 alpha) (Diadenosine 5,5-P1,P6-hexaphosphate hydrolase 3 alpha) (Nucleoside diphosphate-linked moiety X motif 10) (Nudix motif 10)  Data merged from RGD:1589245 1643240 APPROVED
2008-03-05 Nudt11  nudix (nucleoside diphosphate linked moiety X)-type motif 11  LOC680248  similar to Diphosphoinositol polyphosphate phosphohydrolase 3 alpha (DIPP-3 alpha) (DIPP3 alpha) (Diadenosine 5,5-P1,P6-hexaphosphate hydrolase 3 alpha) (Nucleoside diphosphate-linked moiety X motif 10) (Nudix motif 10)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC680248  similar to Diphosphoinositol polyphosphate phosphohydrolase 3 alpha (DIPP-3 alpha) (DIPP3 alpha) (Diadenosine 5,5-P1,P6-hexaphosphate hydrolase 3 alpha) (Nucleoside diphosphate-linked moiety X motif 10) (Nudix motif 10)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683238  similar to Diphosphoinositol polyphosphate phosphohydrolase 3 alpha (DIPP-3 alpha) (DIPP3 alpha) (Diadenosine 5,5-P1,P6-hexaphosphate hydrolase 3 alpha) (Nucleoside diphosphate-linked moiety X motif 10) (Nudix motif 10)      Symbol and Name status set to provisional 70820 PROVISIONAL