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Gene: Gcn1 (GCN1 activator of EIF2AK4) Rattus norvegicus

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Symbol:

Gcn1

Name:

GCN1 activator of EIF2AK4

RGD ID:

1593434

Description:

Predicted to enable several functions, including protein serine/threonine kinase activator activity; stalled ribosome sensor activity; and ubiquitin-protein transferase regulator activity. Predicted to be involved in cellular response to amino acid starvation; regulation of translation; and rescue of stalled ribosome. Predicted to act upstream of or within several processes, including GCN2-mediated signaling; protein K6-linked ubiquitination; and protein-RNA covalent cross-linking repair. Predicted to be active in cytosolic ribosome. Orthologous to human GCN1 (GCN1 activator of EIF2AK4); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

eIF-2-alpha kinase activator GCN1; GCN1 eIF2 alpha kinase activator-like 1; GCN1 general control of amino-acid synthesis 1-like 1; GCN1 general control of amino-acid synthesis 1-like 1 (yeast); GCN1, eIF2 alpha kinase activator homolog; Gcn1l1; LOC690632; similar to GCN1 general control of amino-acid synthesis 1-like 1; stalled ribosome sensor GCN1; translational activator GCN1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GCN1 (GCN1 activator of EIF2AK4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Gcn1 (GCN1 activator of EIF2AK4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gcn1 (GCN1 activator of EIF2AK4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GCN1 (GCN1 activator of EIF2AK4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GCN1 (GCN1 activator of EIF2AK4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gcn1 (GCN1 activator of EIF2AK4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GCN1 (GCN1 activator of EIF2AK4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GCN1 (GCN1 activator of EIF2AK4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gcn1 (GCN1 activator of EIF2AK4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gcn1 (GCN1 activator of EIF2AK4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GCN1 (GCN1 activator of EIF2AK4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gcn1 (GCN1 activator of EIF2AK4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gcn1 (GCN1 activator of EIF2AK4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gcn1 (GCN1 activator of EIF2AK4)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GCN1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GCN1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gcn-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gcn-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	l(3)80Fj	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gcn1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gcn1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	46,652,273 - 46,715,119 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	46,652,273 - 46,713,488 (-)	Ensembl				GRCr8
mRatBN7.2	12	40,991,512 - 41,052,661 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	40,991,512 - 41,052,555 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	42,158,685 - 42,219,872 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	42,772,334 - 42,833,527 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	41,832,873 - 41,894,066 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	46,728,684 - 46,789,696 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	46,728,699 - 46,789,726 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	48,527,293 - 48,587,188 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	42,253,048 - 42,313,931 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	42,614,520 - 42,675,976 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

fetal akinesia deformation sequence syndrome 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,6-dimethoxyphenol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

chloropicrin (ISO)

choline (ISO)

chrysene (ISO)

ciglitazone (ISO)

cisplatin (ISO)

clobetasol (ISO)

cobalt dichloride (ISO)

dicrotophos (ISO)

diethylstilbestrol (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

folic acid (ISO)

furfural (ISO)

ivermectin (ISO)

L-methionine (ISO)

methotrexate (ISO)

methoxychlor (EXP)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (EXP)

potassium dichromate (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to amino acid starvation (IBA,IEA,ISO)

GCN2-mediated signaling (IEA,ISO)

protein-RNA covalent cross-linking repair (IEA,ISO)

regulation of translation (IBA,IEA)

rescue of stalled cytosolic ribosome (IEA,ISO)

Cellular Component

cytoplasm (IEA,ISO)

cytosol (IBA,IEA,ISO)

cytosolic ribosome (IEA,ISO)

Molecular Function

molecular adaptor activity (IEA,ISO)

protein binding (ISO)

protein kinase regulator activity (IBA,IEA)

protein serine/threonine kinase activator activity (IEA,ISO)

stalled ribosome sensor activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:19946888	PMID:22681889	PMID:23447528	PMID:24333428	PMID:25002582	PMID:25468996

Genomics

Comparative Map Data

Gcn1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	46,652,273 - 46,715,119 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	46,652,273 - 46,713,488 (-)	Ensembl				GRCr8
mRatBN7.2	12	40,991,512 - 41,052,661 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	40,991,512 - 41,052,555 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	42,158,685 - 42,219,872 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	42,772,334 - 42,833,527 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	41,832,873 - 41,894,066 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	46,728,684 - 46,789,696 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	46,728,699 - 46,789,726 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	48,527,293 - 48,587,188 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	42,253,048 - 42,313,931 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	42,614,520 - 42,675,976 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

GCN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	120,127,202 - 120,194,715 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	120,127,202 - 120,194,976 (-)	Ensembl			hg38	GRCh38
GRCh37	12	120,565,006 - 120,632,518 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	119,049,397 - 119,116,896 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	119,027,735 - 119,095,233	NCBI
Celera	12	120,198,130 - 120,265,628 (-)	NCBI		Celera
Cytogenetic Map	12	q24.23	NCBI
HuRef	12	117,574,069 - 117,641,060 (-)	NCBI		HuRef
CHM1_1	12	120,532,993 - 120,600,505 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	120,114,374 - 120,181,877 (-)	NCBI		T2T-CHM13v2.0

Gcn1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	115,703,177 - 115,760,713 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	115,703,313 - 115,760,713 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	115,565,117 - 115,622,654 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	115,565,254 - 115,622,654 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	116,015,272 - 116,072,663 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	115,826,251 - 115,883,650 (+)	NCBI		MGSCv36	mm8
Celera	5	112,670,413 - 112,723,868 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	56.1	NCBI

Gcn1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	11,416,237 - 11,474,207 (+)	Ensembl
ChiLan1.0	NW_004955455	11,416,222 - 11,474,791 (+)	NCBI	ChiLan1.0	ChiLan1.0

GCN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	128,189,519 - 128,257,684 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	128,185,896 - 128,253,056 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	117,702,791 - 117,769,894 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	121,078,302 - 121,143,180 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	121,078,302 - 121,140,829 (-)	Ensembl			panPan2	panpan1.1

GCN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	16,087,380 - 16,146,865 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	16,087,382 - 16,146,813 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	16,092,431 - 16,151,406 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	16,355,070 - 16,414,547 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	16,355,009 - 16,414,538 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	16,316,165 - 16,375,608 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	16,393,481 - 16,452,480 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	16,434,569 - 16,493,880 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gcn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	146,219,903 - 146,287,212 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936668	724,031 - 785,533 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936668	718,961 - 786,101 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GCN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	40,146,472 - 40,218,107 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	40,151,415 - 40,218,183 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	42,713,772 - 42,738,750 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GCN1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	115,479,321 - 115,545,465 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	115,477,825 - 115,545,418 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	129,561,750 - 129,628,198 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gcn1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	13,446,373 - 13,510,508 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	13,446,352 - 13,510,501 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gcn1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	38,203,167 - 38,258,434 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gcn1
293 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	89
Count of miRNA genes:	76
Interacting mature miRNAs:	82
Transcripts:	ENSRNOT00000001517
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	44139558	52308831	Rat

Markers in Region

D12Rat80

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	12	46,687,954 - 46,688,078 (+)	Marker Load Pipeline
mRatBN7.2	12	41,027,193 - 41,027,317 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	46,764,366 - 46,764,489	NCBI	Rnor6.0
Rnor_5.0	12	48,562,601 - 48,562,724	UniSTS	Rnor5.0
RGSC_v3.4	12	42,288,705 - 42,288,829	RGD	RGSC3.4
RGSC_v3.4	12	42,288,706 - 42,288,829	UniSTS	RGSC3.4
Celera	12	42,650,198 - 42,650,319	UniSTS
RGSC_v3.1	12	42,152,093 - 42,152,217	RGD
RH 2.0 Map	12	534.9	RGD
SHRSP x BN Map	12	48.6499	RGD
Cytogenetic Map	12	q16	UniSTS

BI279846

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	41,051,753 - 41,051,939 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	46,788,919 - 46,789,104	NCBI	Rnor6.0
Rnor_5.0	12	48,586,365 - 48,586,550	UniSTS	Rnor5.0
RGSC_v3.4	12	42,313,154 - 42,313,339	UniSTS	RGSC3.4
Celera	12	42,675,199 - 42,675,384	UniSTS
RH 3.4 Map	12	773.12	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001168664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089791	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC123425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC169100	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001517 ⟹ ENSRNOP00000001517

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	46,652,273 - 46,713,488 (-)	Ensembl
mRatBN7.2 Ensembl	12	40,991,512 - 41,052,555 (-)	Ensembl
Rnor_6.0 Ensembl	12	46,728,699 - 46,789,726 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094827 ⟹ ENSRNOP00000082473

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	46,652,273 - 46,706,547 (-)	Ensembl
mRatBN7.2 Ensembl	12	40,991,512 - 41,045,887 (-)	Ensembl

RefSeq Acc Id:

NM_001168664 ⟹ NP_001162135

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,652,273 - 46,713,289 (-)	NCBI
mRatBN7.2	12	40,991,512 - 41,052,531 (-)	NCBI
Rnor_6.0	12	46,728,684 - 46,789,696 (-)	NCBI
Rnor_5.0	12	48,527,293 - 48,587,188 (-)	NCBI
RGSC_v3.4	12	42,253,048 - 42,313,931 (-)	RGD
Celera	12	42,614,520 - 42,675,976 (-)	RGD

Sequence:

show sequence

ATGGCGGCGGACACGCAGGTCTCCGAGACACTGAAGCGCTTTGCAGTGAAGGTGACAACAGCTA
GTGTGAAGGAGCGGAGAGAGATTCTCAGTGAACTGGGGCGATGTATTGCTGGGAAAGATCTGCC
AGAGGGAGCAGTGAAAGGGCTCTGCAAGCTGTTCTGCTTGACCCTGCATCGATACAGGGATGCA
GCTTCTCGCAGAGCCCTGCAGGCAGCCATTCAGCAGCTGGCTGAGGCCCAGCCAGAAGCCACAG
CCAAGAACCTCCTGCACTCTCTTCAGTCCTCAGGGGTCGGCTCCAAAGCGTGTGTTCCCAGCAA
AAGCAGCGGCTCAGCCGCCTTGCTGGCCCTGACCTGGACCTGCCTTCTTGTGCGGATTGTCTTT
CCCCTGAAGGCCAAGCGGCAAGGAGACATCTGGAACAAGCTGGTGGAGGTGCAGTGTCTGCTGC
TGCTGGAGGTGCTGGGCGGCTCCCACAAGCATGCTGTGGACGGCGCTGTGAAGAAACTCACTAA
GCTATGGAAAGAGAACCCTGGGCTGGTGGAGCAGTACTTCTCAGCCATCCTTAGCCTAGAACCC
AACCAAAACTATGCCGGCATGCTGGGGCTGCTCGTGCAGTTCTGTACAAATCACAAAGAGATGG
ACGTGGTCAATCAGCACAAGAGTACCCTGCTGGAGTTCTACGTGAAGCACATTCTGATGAGCAA
AGCCAAGCCTCCCAAGTACTTGTTGGACAACTGCGCCCCGCTGCTCCGGTTCATGTCCCACTCT
GAGTTTAAGGACCTGATTCTGCCTACCATACAGAAGTCCTTGCTGAGGAGCCCGGAGAATGTTA
TAGAGACTATCTCCAGCCTGCTGGCTTCAGTGACACTTGATCTCAGCCAGTATGCCCTGGACAT
CGTGAAAGGCTTGGCAAATCAGCTGAAGTCCAACAGCCCCCGCCTGATGGACGAAGCGGTCCTG
GCACTGCGTAACCTGTCCCGTCAGTGCAGTGACTCGTCCGCCACCGAGGCCCTGACTAAGCATC
TGTTTGCAATCCTTGGAGGCTCCGAAGGGAAGCTGACCATCATAGCCCAGAAGATGAGCGTCCT
TTCAGGGATTGGAAGCCTCAGTCATCATGGGGTATCGGGGCCTTCAGGTCAAGTTCTGAATGGG
TGTGTGGCTGAGCTGTTCATCCCGTTCCTGCAACAGGAAGTGCACGAAGGGACCTTGGTACATG
CTGTCTCTGTCCTGGCGCTCTGGTGCAACCGGTTCACGACAGAAGTGCCCAAGAAGCTCACTGA
CTGGTTCAAGAAAGTTTTCAGCCTTAAAACCTCCACTTCTGCAGTGAGGCACGCCTACCTGCAG
TGCATGCTGGCCTCCTTCCGAGGTGACACACTCTTGCAGGCCTTGGACTTTCTGCCCTTGCTCA
TGCAGACAGTAGAGAAGGCGGCCTCCCAGAGCACTCAGGTCCCCACAGTCACCGAAGGCGTCGC
CGCAGCCCTGTTGGTCTCCAAGCTCTCTGTGGCCGACTCACAAGCTGAGGCCAAACTGAGCAAC
TTTTGGCAGCTGGTTGTGGATGAGAAGAAGCAGATTTTCACATCTGAGAAGTTTCTGCTCCTGG
CTTCAGAGGAGGCCCTGTGTACTGTGCTGCATCTGACCGAGAGGCTTTTCCTTGACCACGCCCA
CAGGCTCACCAACAGCAGAGTACAGCAGTACTACCGGGTCCTGGTGGCTGTGCTCTTGAGCCGC
ACCTGGCATGTGCGCAGGCAGGCCCAGCAGACAGTCCGGAAGCTGCTGTCCTCTCTTGGGGGCA
TTAAGCTAGCCAACGGCCTTTTGGAGGAGCTGAAGACTGTCCTCAACTCTCACAAGGTGCTACC
CTTGGAGACTCTTGTGACAGATGCTGGGGAGGTAATGGAGACAGGCAAGACCTATGTGCCTCCT
CGAGTTCTGCAGGAAGCTCTGTGTGTCATCTCCGGCGTTCCGGGGCTCAAGGGCGACATCACCA
GCACCGAGCAGCTGGCCCAGGAGATGCTGATCATCTCCCACCACCCGTCCTTAGTGGCGGTGCA
GTCTGGACTCTGGCCAGCACTTCTCACCAGGATGAAGATTGACCCTGAAGCCTTTATCACCAGG
CACCTGGACCAGATCATCCCCAGGATCACTACACAGAGCCCCCTGAACCAGTCTTCCATGAACG
CCATGGGCTCCCTTTCCATCCTGTCTCCTGATCGAGTCCTCCCTCAGCTCATCAGCAGTATCAC
CGCGTCTGTGCAGAATCCTGCGCTGTGCCTCGTGACTCGGGAGGAGTTTGCTGTCATGCAGACC
CCTGCCGGAGAGCTGTTTGATAAATCCATCATCCAGAGTGCCCAGCAGGACAGCATAAAAAAGG
CCAACATGAAGCGAGAGAACAAGGCCTACTCTTTTAAGGAGCAGATCATCGAGCTGGAGCTGAA
GGAGGAAATAAAGAAGAAGAAAGGCATAAAAGAGGAGGTTCAGCTGACGAGTAAGCAGAAGGAG
ATGCTGCAGGCCCAGATGGACAAGGAGGCGCAAATCCGGAGGCGGCTGCAGGAGCTGGATGGGG
AACTAGAAGCAGCGCTTGGACTCCTAGACGCCATTATGACCAGGAACCCACGTGGCCTGACACA
GTACATCCCTGTTCTGGTTGACGCCTTCCTGCCCTTGCTGAAGTCTCCTCTGGCTGCTCCCAGG
GTCAAAGGCCCCTTCCTGTCTTTGGCTGCCTGTGTCATGCCCCCTAGACTCAAGACCTTGGGCA
CCTTGGTGAGTCATGTGACCCTGCGCCTGCTGAAGCCAGAGTGTGCTCTGGATCAGTCCTGGTG
CCAAGAAGAGCTGCCGGTGGCTGTCAGGAGGGCTGTGTCACTGCTGCACACACACACCATTCCC
AGCAGGGTGGGCAAGGGCGAGCCAGATGCTGCACCGCTGTCTGCACCCGCCTTCTCCTTGATCT
TCCCGATGTTAAAGATGGTGCTCACTGAGATGCCCTACCACAGCGAGGAGGAAGAGGAGCAGAT
GGCCCAGATCCTTCAGATCCTCACTGTCCACGCTCAGCTGAGGGCTTCCCCTGACACCCCGCCC
GAGCGGGTGGATGAGAATGGCCCGGAGTTGCTGCCCCGAGTGGCCATGCTACGTCTGCTGACGT
GGGTGATCGGAACGGGCTCCCCTCGCCTACAGGTTCTTGCCTCAGACACTCTGACCGCCCTATG
TGCCAGCAGCAGTGGGGAGGACGGCTGTGCCTTTGCGGAGCAGGAGGAGGTGGATGTGCTGCTC
GCTGCCTTGCAGTCCCCATGTGCCAGCGTGCGCGAGACTGCGCTCCGGGGGCTGATGGAGCTCC
ACCTGGTGTTGCCAGCCCCTGACACTGATGAGAAGAACGGCCTGAACCTGCTGCGGAGACTCTG
GGTTGTGAAGTTTGACAAGGAGGAGGAGATACGGAAGCTGGCTGAGAGGCTTTGGACGACCATG
GGCCTCGATCTGCAGTCAGATCTCTGCTCGTTGCTGATCGATGATGTGATCTATCACGAGGCTG
CTGTGAGGCAGGCTGGGGCTGAAGCCCTTTCGCAGGCAGTGGCACGATACCAGCGGCAAGCAGC
AGAGGTTATGGGCAGGCTCATGGAGATCTACCAGGAGAAGCTCTATCGGCCACCCCCAGTGCTG
GATGCTTTGGGCCGAGTGATTTCAGAATCCCCTCCAGACCAGTGGGAAGCCAGGTGTGGCCTGG
CCTTGGCCCTGAACAAGCTCTCACAGTATTTGGATAGCTCTCAGGTGAAGCCGCTCTTTCAGTT
TTTTGTCCCGGATGCCCTCAATGACCGAAACCCAGATGTGCGGAAGTGCATGTTAGATGCAGCG
CTTGCCACACTCAATGCCCATGGGAAGGAGAATGTCAACTCACTGCTGCCCGTGTTTGAGGAGT
TCCTGAAGGACGCGCCCAATGATGCCAGCTACGACGCCGTGCGACAGAGTGTGGTGGTTCTGAT
GGGCTCTTTGGCCAAGCACCTGGACAAGAGTGACCCCAAAGTGAAACCCATTGTTGCCAAGCTC
ATTGCCGCCCTCTCCACACCTTCTCAGCAGGTCCAGGAGTCAGTCGCCAGCTGCTTACCGCCAC
TTGTGCCTGCCGTCAAGGAGGACGCTGGGGGCATGATTCAGCGGCTCATGCAGCAGCTGCTGGA
GTCAGACAAGTACGCAGAGCGCAAGGGGGCCGCGTACGGGCTGGCGGGCCTGGTGAAAGGCCTG
GGCATCCTTTCCCTGAAGCAGCAGGAAATGATGGCTGCACTCACCGATGCTATCCAGGACAAGA
AGAACTTCCGAAGGCGAGAGGGAGCTCTGTTTGCCTTCGAGATGCTCTGCACCATGCTGGGGAA
GCTCTTCGAGCCCTATGTGGTCCACGTGCTGCCCCATCTATTGCTGTGCTTTGGAGATGGCAAT
CAGTACGTACGCGAGGCTGCAGATGACTGTGCCAAAGCTGTGATGAGCAATTTGAGTGCTCATG
GTGTGAAGTTGGTGCTCCCGTCCCTGTTAGCTGCCCTGGAGGAGGAGTCCTGGAGGACCAAAGC
TGGGTCAGTAGAGCTGCTCGGGGCGATGGCGTACTGTGCACCTAAGCAGCTGTCCTCCTGCCTG
CCCAACATTGTGCCCAAGCTGACAGAGGTGCTGACAGACTCCCACGTCAAGGTGCAGAAGGCTG
GGCAGCAAGCCCTCAGGCAGATCGGCTCTGTCATCAGGAACCCGGAGATTCTCGCCATTGCCCC
GGTCCTGCTGGACGCTCTGACGGACCCATCGAGGAAGACTCAGAAGTGCCTGCAGACCCTGCTG
GACACCAAGTTTGTCCACTTCATTGACGCCCCGTCCCTGGCACTCATCATGCCCATTGTCCAGA
GAGCCTTCCAGGATCGCTCCACAGACACACGCAAGATGGCCGCGCAGATTATTGGCAACATGTA
CTCCCTGACAGACCAGAAGGACTTGGCTCCTTACCTGCCCAGTGTGACACCTGGCCTGAAAGCC
TCACTCTTAGACCCTGTCCCTGAGGTGCGCACAGTGTCTGCAAAGGCTCTTGGGGCCATGGTGA
AGGGCATGGGAGAGTCGTGCTTTGAGGACTTGCTGCCGTGGCTGATGGAGACTCTGACATATGA
GCAGAGCTCTGTGGACCGCTCAGGCGCTGCCCAAGGGTTGGCTGAGGTAATGGCTGGCTTAGGA
GTAGAGAAGTTGGAAAAATTGATGCCAGAAATTGTGGCCACTGCCAGCAAAGTGGACATCGCAC
CCCATGTCCGAGACGGCTACATCATGATGTTCAACTACCTGCCTATCACCTTTGGGGACAAGTT
TACCCCTTATGTGGGGCCCATCATCCCTTGTATCCTCAAAGCTCTGGCTGATGAGAATGAGTTC
GTTCGTGACACCGCCCTCCGTGCCGGCCAGCGGGTCATCTCCATGTATGCTGAGACAGCCATTG
CCCTGCTGCTGCCCCAGCTGGAGCAAGGCCTCTTTGATGACCTCTGGAGAATCCGGTTCAGCTC
TGTTCAACTCCTTGGGGACCTCCTGTTCCACATCTCTGGGGTCACTGGGAAAATGACCACAGAA
ACAGCCTCTGAGGATGATAACTTTGGAACTGCTCAGTCTAACAAGGCAATCATCACGGCCCTGG
GGGTCGATCGGCGGAACCGGGTCCTGGCAGGGCTCTATATGGGCCGCTCAGACACCCAGCTGGT
GGTGAGGCAGGCGTCACTGCACGTGTGGAAGATTGTCGTTTCCAACACTCCCCGCACCCTGCGA
GAGATCCTGCCCACTCTCTTTGGTCTGCTGCTGGGTTTCCTGGCTAGCACGTGTGCAGATAAGA
GAACGATTGCAGCCAGGACGTTGGGAGATCTTGTCCGGAAGCTGGGGGAGAAGATCCTCCCTGA
GATCATCCCCATCCTCGAAGAAGGGCTAAGGTCTCAGAAGAGCGATGAGAGGCAGGGCGTGTGC
ATCGGGCTCAGCGAGATCATGAAGTCCACCAGCCGGGATGCTGTGCTCTATTTCTCTGAGTCCC
TTGTGCCCACGGCACGGAAGGCACTATGTGATCCCCTGGAGGAGGTCCGGGAGGCGGCGGCCAA
AACCTTTGAGCAGCTGCACTCCACCATTGGCCACCAGGCTTTGGAGGACATTCTCCCGTTCCTG
CTGAAGCAGCTGGATGACGAGGAGGTGTCAGAATTCGCCCTGGATGGTCTGAAGCAGGTCATGG
CCGTTAAGAGCCGTGTGGTGCTGCCCTATCTGGTACCCAAGCTGACGACACCACCTGTCAACAC
CCGGGTGCTGGCTTTCCTCTCATCTGTGGCTGGCGATGCTCTGACGCGTCACCTTGGTGTGATT
CTCCCAGCAGTCATGTTAGCGCTGAAGGAAAAGCTTGGGACTCCAGACGAGCAGCTGGAGATGG
CCAACTGTCAGGCTGTCATCCTCTCGGTAGAGGATGACACTGGGCACCGGATCATCATTGAGGA
TCTGCTGGAGGCCACTCGAAGCCCTGAGGTGGGCATGAGGCAGGCCGCCGCCATCATCCTCAAC
ATGTACTGCTCCCGCTCCAAGGCTGACTATACCAGCCACCTGCGCAGCCTGGTCTCCGGCTTGA
TCCGCCTCTTCAATGACTCCAGCCCTGTGGTTCTGGGGGAGAGCTGGGATGCTCTCAACGCCAT
CACTAAGAAGCTGGATGCCGGCAACCAGCTGGCCCTGATCGAAGAATTCCATAAGGAAATCCGC
TACATAGGCAACGAGTGCCGAGGGGAGCATGTGCCGGGCTTCTGCCTTCCAAAGAAGGGAGTAA
CCTCCATCCTTCCAGTGCTACGGGAAGGAGTCCTCACAGGCAGTCCTGAGCAAAAGGAAGAAGC
AGCCAAGGCCTTGGGCTTGGTGATCCGCCTGACGTCGGCCGATGCCCTGAGGCCCTCTGTGGTC
AGCATCACTGGCCCTCTGATTCGCATCCTTGGGGACCGGTTCAGCTGGAGTGTGAAGGCGGCCC
TGCTGGAGACACTCAGCCTCTTGCTGGGCAAGGTCGGGATCGCCCTGAAGCCCTTCCTGCCCCA
GCTTCAGACCACCTTCACCAAAGCTCTGCAGGACTCCAATCGGGGCGTACGCCTCAAGGCTGCG
GATGCCCTAGGGAAACTCATTTCCATCCACATCAAGGTGGACCCCCTTTTTACAGAGCTGCTCA
ATGGAATCCGTGTGGTGGAGGACCCAGGTATAAGGGACACCATGTTGCAGGCCCTCAGGTTTGT
GATTCAGGGTGCGGGCGCCAAAGTGGATGCTGCCATCCGGAAAAACATTGTCTCACTCCTGCTG
GGCATGCTGGGCCACGACGAGGACAACACTCGGATCTCTTCAGCCGGGTGCCTTGGGGAGCTGT
GTGCCTTTCTGACTGAGGAGGAGCTCAACACGGTCCTGCAGCAGTGCTTGCTGGCTGACGTATC
TGGCATTGACTGGATGGTTCGGCACGGCCGGAGCTTGGCGCTGTCTGTGGCTGTGAACGTGGCT
CCCAGCAGACTCTGCACAGGCAAATACAGCAATGAGGTTCAGGACATGGTCCTCAGCAACGCTG
TGGCAGACAGGATCCCCATTGCCGTGAGTGGGATTCGGGGCATGGGCTTCCTCATGAAGTATCA
CATCGAGACAGGAGGGGGACAGCTGCCACCCAGACTCTCCACCCTGCTCATTAAGTGTCTGCAG
AACCCGTCCAGTGACATCAGGCTGGTTGCCGAGAAGATGATCTGGTGGGCCAACAAGGAGCCCC
GGCCTGCCCTGGAGCCCCAGGCCATCAAGCCCATCCTGAAGGCTCTACTCGACAACACCAAGGA
CAAGAACACGGTAGTGAGGGCCTACAGCGAGCAGGCCATCGTGAATCTGCTCAAACTGAGGCAG
GGCGAGGAGCTGCTGCAGTCACTCTCCAAGATCCTGGATGTGGCCAGCTTGGAGGCGCTGAATG
AGTGCAGCCGGCGGTCGCTGAAGAAGCTGGCCTGCCAGGCGGACTCTGTGGAGCAGGTGGATGA
CACCATCCTGACGTGACAAGCTGGGTCCGCTACAGCCACACTGCCCCACGTCTGCGCTCACACT
GTTTTCATTTTTGAAAATATGTTTATTCCAAGGGGAGCTCAGGAGATGGTGTTCCCAGAAAGTA
TTTTAGTATATCAGCCAACCAGAGCCAAAGCCTTAAATCCAACCCACACACAACTGAAAATCAC
CTCCTCCATCTCTTGCCCTTATCTCTGGAGAAGAGAAAGAAGCGAGCTCAGCGACCTCAGTGAG
CGTGTGAGCGGCCGCTAGGGGGCCTGACTCACTCTGCCCTGCCAGAGGGATGAGCTCAGGTCCC
TCTTCTGTGCTGGGTGGCCTGTGTCTGCTGGGATCTGAGTGGGGCACAGGCTGCAGAGCTCCGC
CTGACCTGACGCTGTGGCTTGCTTTTCATGTGGCCTGACTGGACCTGACTTGTCTGGAGGAGGT
GATGCTCACGTCTCCTCCTCAGTTCCAGGTCTCGGGATGCAGGCCATTGGAAGGAGGTTTAATA
AAGGCTTTGATTTCATCTTGAAAGAA

hide sequence

RefSeq Acc Id:

XM_039089790 ⟹ XP_038945718

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,674,894 - 46,715,119 (-)	NCBI
mRatBN7.2	12	41,014,134 - 41,052,661 (-)	NCBI

RefSeq Acc Id:

XM_039089791 ⟹ XP_038945719

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,674,894 - 46,715,119 (-)	NCBI
mRatBN7.2	12	41,014,134 - 41,052,661 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001162135	(Get FASTA)	NCBI Sequence Viewer
	XP_038945718	(Get FASTA)	NCBI Sequence Viewer
	XP_038945719	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI69100	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001517
	ENSRNOP00000001517.7
	ENSRNOP00000082473.2

RefSeq Acc Id:

NP_001162135 ⟸ NM_001168664

- UniProtKB:

F1LRI5 (UniProtKB/TrEMBL), A0A8I6G9H9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAADTQVSETLKRFAVKVTTASVKERREILSELGRCIAGKDLPEGAVKGLCKLFCLTLHRYRDA
ASRRALQAAIQQLAEAQPEATAKNLLHSLQSSGVGSKACVPSKSSGSAALLALTWTCLLVRIVF
PLKAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDGAVKKLTKLWKENPGLVEQYFSAILSLEP
NQNYAGMLGLLVQFCTNHKEMDVVNQHKSTLLEFYVKHILMSKAKPPKYLLDNCAPLLRFMSHS
EFKDLILPTIQKSLLRSPENVIETISSLLASVTLDLSQYALDIVKGLANQLKSNSPRLMDEAVL
ALRNLSRQCSDSSATEALTKHLFAILGGSEGKLTIIAQKMSVLSGIGSLSHHGVSGPSGQVLNG
CVAELFIPFLQQEVHEGTLVHAVSVLALWCNRFTTEVPKKLTDWFKKVFSLKTSTSAVRHAYLQ
CMLASFRGDTLLQALDFLPLLMQTVEKAASQSTQVPTVTEGVAAALLVSKLSVADSQAEAKLSN
FWQLVVDEKKQIFTSEKFLLLASEEALCTVLHLTERLFLDHAHRLTNSRVQQYYRVLVAVLLSR
TWHVRRQAQQTVRKLLSSLGGIKLANGLLEELKTVLNSHKVLPLETLVTDAGEVMETGKTYVPP
RVLQEALCVISGVPGLKGDITSTEQLAQEMLIISHHPSLVAVQSGLWPALLTRMKIDPEAFITR
HLDQIIPRITTQSPLNQSSMNAMGSLSILSPDRVLPQLISSITASVQNPALCLVTREEFAVMQT
PAGELFDKSIIQSAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKE
MLQAQMDKEAQIRRRLQELDGELEAALGLLDAIMTRNPRGLTQYIPVLVDAFLPLLKSPLAAPR
VKGPFLSLAACVMPPRLKTLGTLVSHVTLRLLKPECALDQSWCQEELPVAVRRAVSLLHTHTIP
SRVGKGEPDAAPLSAPAFSLIFPMLKMVLTEMPYHSEEEEEQMAQILQILTVHAQLRASPDTPP
ERVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASDTLTALCASSSGEDGCAFAEQEEVDVLL
AALQSPCASVRETALRGLMELHLVLPAPDTDEKNGLNLLRRLWVVKFDKEEEIRKLAERLWTTM
GLDLQSDLCSLLIDDVIYHEAAVRQAGAEALSQAVARYQRQAAEVMGRLMEIYQEKLYRPPPVL
DALGRVISESPPDQWEARCGLALALNKLSQYLDSSQVKPLFQFFVPDALNDRNPDVRKCMLDAA
LATLNAHGKENVNSLLPVFEEFLKDAPNDASYDAVRQSVVVLMGSLAKHLDKSDPKVKPIVAKL
IAALSTPSQQVQESVASCLPPLVPAVKEDAGGMIQRLMQQLLESDKYAERKGAAYGLAGLVKGL
GILSLKQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGN
QYVREAADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCL
PNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLL
DTKFVHFIDAPSLALIMPIVQRAFQDRSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKA
SLLDPVPEVRTVSAKALGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLG
VEKLEKLMPEIVATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEF
VRDTALRAGQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTE
TASEDDNFGTAQSNKAIITALGVDRRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLR
EILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEIIPILEEGLRSQKSDERQGVC
IGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQALEDILPFL
LKQLDDEEVSEFALDGLKQVMAVKSRVVLPYLVPKLTTPPVNTRVLAFLSSVAGDALTRHLGVI
LPAVMLALKEKLGTPDEQLEMANCQAVILSVEDDTGHRIIIEDLLEATRSPEVGMRQAAAIILN
MYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLGESWDALNAITKKLDAGNQLALIEEFHKEIR
YIGNECRGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQKEEAAKALGLVIRLTSADALRPSVV
SITGPLIRILGDRFSWSVKAALLETLSLLLGKVGIALKPFLPQLQTTFTKALQDSNRGVRLKAA
DALGKLISIHIKVDPLFTELLNGIRVVEDPGIRDTMLQALRFVIQGAGAKVDAAIRKNIVSLLL
GMLGHDEDNTRISSAGCLGELCAFLTEEELNTVLQQCLLADVSGIDWMVRHGRSLALSVAVNVA
PSRLCTGKYSNEVQDMVLSNAVADRIPIAVSGIRGMGFLMKYHIETGGGQLPPRLSTLLIKCLQ
NPSSDIRLVAEKMIWWANKEPRPALEPQAIKPILKALLDNTKDKNTVVRAYSEQAIVNLLKLRQ
GEELLQSLSKILDVASLEALNECSRRSLKKLACQADSVEQVDDTILT

hide sequence

Ensembl Acc Id:

ENSRNOP00000001517 ⟸ ENSRNOT00000001517

RefSeq Acc Id:	XP_038945719 ⟸ XM_039089791
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038945718 ⟸ XM_039089790
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000082473 ⟸ ENSRNOT00000094827

Protein Domains

TOG

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LRI5-F1-model_v2	AlphaFold	F1LRI5	1-2671	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698685

Promoter ID:

EPDNEW_R9210

Type:

multiple initiation site

Name:

Gcn1l1_1

Description:

GCN1 eIF2 alpha kinase activator-like 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	46,789,712 - 46,789,772	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1593434	AgrOrtholog
BioCyc Gene	G2FUF-19007	BioCyc
Ensembl Genes	ENSRNOG00000021871	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001517	ENTREZGENE
	ENSRNOT00000001517.9	UniProtKB/TrEMBL
	ENSRNOT00000094827.2	UniProtKB/TrEMBL
Gene3D-CATH	1.25.10.10	UniProtKB/TrEMBL
InterPro	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	GNC1-like_N	UniProtKB/TrEMBL
	HEAT_GCN1	UniProtKB/TrEMBL
	HEAT_type_2	UniProtKB/TrEMBL
	TOG	UniProtKB/TrEMBL
KEGG Report	rno:690632	UniProtKB/TrEMBL
NCBI Gene	690632	ENTREZGENE
PANTHER	PTHR23346:SF7	UniProtKB/TrEMBL
	TRANSLATIONAL ACTIVATOR GCN1-RELATED	UniProtKB/TrEMBL
Pfam	GNC1_N	UniProtKB/TrEMBL
	HEAT_EF3_GNC1	UniProtKB/TrEMBL
	HEAT_EF3_N	UniProtKB/TrEMBL
	HEAT_GCN1	UniProtKB/TrEMBL
	HEAT_GCN1_C_2	UniProtKB/TrEMBL
PhenoGen	Gcn1	PhenoGen
PROSITE	HEAT_REPEAT	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000021871	RatGTEx
SMART	TOG	UniProtKB/TrEMBL
Superfamily-SCOP	ARM-type_fold	UniProtKB/TrEMBL
UniProt	A0A8I6G9H9	ENTREZGENE, UniProtKB/TrEMBL
	F1LRI5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-10	Gcn1	GCN1 activator of EIF2AK4	Gcn1	GCN1, eIF2 alpha kinase activator homolog	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2018-09-06	Gcn1	GCN1, eIF2 alpha kinase activator homolog	Gcn1l1	GCN1 eIF2 alpha kinase activator-like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-07-09	Gcn1l1	GCN1 eIF2 alpha kinase activator-like 1	Gcn1l1	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Gcn1l1	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	LOC690632	similar to GCN1 general control of amino-acid synthesis 1-like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC690632	similar to GCN1 general control of amino-acid synthesis 1-like 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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