Terb2 (telomere repeat binding bouquet formation protein 2) - Rat Genome Database

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Gene: Terb2 (telomere repeat binding bouquet formation protein 2) Rattus norvegicus
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Symbol: Terb2
Name: telomere repeat binding bouquet formation protein 2
RGD ID: 1593334
Description: Predicted to be involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Predicted to act upstream of or within meiosis I; oogenesis; and spermatogenesis. Predicted to be located in chromosome, telomeric region and nuclear envelope. Predicted to be active in nuclear inner membrane. Human ortholog(s) of this gene implicated in spermatogenic failure 59. Orthologous to human TERB2 (telomere repeat binding bouquet formation protein 2); INTERACTS WITH bisphenol A; trichloroethene; aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC691952; LOC691952; telomere repeats-binding bouquet formation protein 2; uncharacterized protein C15orf43 homolog; uncharacterized protein LOC691952
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83129,591,933 - 129,610,293 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3129,591,940 - 129,610,290 (+)EnsemblGRCr8
mRatBN7.23109,138,343 - 109,156,700 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,138,343 - 109,156,683 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3112,811,971 - 112,830,403 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03121,407,491 - 121,425,920 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03119,067,867 - 119,086,302 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03114,129,387 - 114,147,943 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,129,589 - 114,147,926 (+)Ensemblrn6Rnor6.0
Rnor_5.03120,669,991 - 120,688,368 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43108,970,235 - 108,988,403 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3108,036,306 - 108,054,613 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:26548954  


Genomics

Comparative Map Data
Terb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83129,591,933 - 129,610,293 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3129,591,940 - 129,610,290 (+)EnsemblGRCr8
mRatBN7.23109,138,343 - 109,156,700 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,138,343 - 109,156,683 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3112,811,971 - 112,830,403 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03121,407,491 - 121,425,920 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03119,067,867 - 119,086,302 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03114,129,387 - 114,147,943 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,129,589 - 114,147,926 (+)Ensemblrn6Rnor6.0
Rnor_5.03120,669,991 - 120,688,368 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43108,970,235 - 108,988,403 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3108,036,306 - 108,054,613 (+)NCBICelera
Cytogenetic Map3q35NCBI
TERB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381544,956,687 - 44,979,229 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1544,956,687 - 44,979,229 (+)Ensemblhg38GRCh38
GRCh371545,248,885 - 45,271,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361543,036,192 - 43,058,713 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1522,140,500 - 22,163,021 (+)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1522,073,117 - 22,095,638 (+)NCBIHuRef
CHM1_11545,367,211 - 45,389,738 (+)NCBICHM1_1
T2T-CHM13v2.01542,764,694 - 42,787,237 (+)NCBIT2T-CHM13v2.0
Terb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392122,016,753 - 122,036,874 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2122,016,753 - 122,036,878 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382122,186,272 - 122,206,393 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,186,272 - 122,206,397 (+)Ensemblmm10GRCm38
MGSCv372122,012,008 - 122,032,129 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362121,877,713 - 121,897,834 (+)NCBIMGSCv36mm8
MGSCv362123,157,091 - 123,177,029 (+)NCBIMGSCv36mm8
Celera2123,334,753 - 123,355,050 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.56NCBI
Terb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,352,685 - 8,371,529 (-)Ensembl
ChiLan1.0NW_0049554098,352,685 - 8,371,576 (-)NCBIChiLan1.0ChiLan1.0
TERB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21634,193,326 - 34,221,313 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11538,375,582 - 38,399,487 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01523,904,880 - 23,927,325 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11542,170,633 - 42,191,736 (-)NCBIPanPan1.1PanPan1.1panPan2
TERB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13011,414,656 - 11,436,119 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3011,414,737 - 11,436,113 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3011,471,083 - 11,492,529 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03011,551,223 - 11,572,700 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3011,551,303 - 11,572,695 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13011,457,569 - 11,479,021 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03011,580,653 - 11,602,099 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03011,699,657 - 11,721,101 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Terb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864089,865,459 - 89,880,383 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364717,713,543 - 7,727,806 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364717,713,562 - 7,728,720 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TERB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,738,663 - 126,768,126 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11126,738,520 - 126,767,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21141,338,388 - 141,367,348 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TERB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12638,226,041 - 38,247,500 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2638,226,687 - 38,247,076 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048102,812,232 - 102,834,156 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Terb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,203,928 - 14,221,213 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473114,203,324 - 14,220,899 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Terb2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15100,296,579 - 100,314,670 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Terb2
145 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:105
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000056119
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
5 1 1 9 13 1 23 1 31 24 1 3 1 47 12

Sequence


Ensembl Acc Id: ENSRNOT00000056119   ⟹   ENSRNOP00000052967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3129,591,940 - 129,610,290 (+)Ensembl
mRatBN7.2 Ensembl3109,138,343 - 109,156,683 (+)Ensembl
Rnor_6.0 Ensembl3114,129,589 - 114,147,926 (+)Ensembl
RefSeq Acc Id: NM_001109652   ⟹   NP_001103122
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,591,933 - 129,610,293 (+)NCBI
mRatBN7.23109,138,343 - 109,156,700 (+)NCBI
Rnor_6.03114,129,589 - 114,147,943 (+)NCBI
Rnor_5.03120,669,991 - 120,688,368 (+)NCBI
RGSC_v3.43108,970,235 - 108,988,403 (+)RGD
Celera3108,036,306 - 108,054,613 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001103122 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80020 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052967
  ENSRNOP00000052967.2
RefSeq Acc Id: NP_001103122   ⟸   NM_001109652
- UniProtKB: D4A1L6 (UniProtKB/TrEMBL),   A6HPR8 (UniProtKB/TrEMBL),   A6HPR9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052967   ⟸   ENSRNOT00000056119

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1L6-F1-model_v2 AlphaFold D4A1L6 1-218 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593334 AgrOrtholog
BioCyc Gene G2FUF-48106 BioCyc
Ensembl Genes ENSRNOG00000037178 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056119 ENTREZGENE
  ENSRNOT00000056119.6 UniProtKB/TrEMBL
InterPro DUF4557 UniProtKB/TrEMBL
KEGG Report rno:691952 UniProtKB/TrEMBL
NCBI Gene 691952 ENTREZGENE
PANTHER PTHR35345 UniProtKB/TrEMBL
  TELOMERE REPEATS-BINDING BOUQUET FORMATION PROTEIN 2 UniProtKB/TrEMBL
Pfam DUF4557 UniProtKB/TrEMBL
PhenoGen Terb2 PhenoGen
RatGTEx ENSRNOG00000037178 RatGTEx
UniProt A6HPR8 ENTREZGENE, UniProtKB/TrEMBL
  A6HPR9 ENTREZGENE, UniProtKB/TrEMBL
  D4A1L6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-31 Terb2  telomere repeat binding bouquet formation protein 2  LOC691952  hypothetical protein LOC691952  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691952  hypothetical protein LOC691952  LOC688057  hypothetical protein LOC688057  Data merged from RGD:1593606 1643240 APPROVED
2006-11-20 LOC691952  hypothetical protein LOC691952      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC688057  hypothetical protein LOC688057      Symbol and Name status set to provisional 70820 PROVISIONAL