Hecw2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2) - Rat Genome Database

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Pathways
Gene: Hecw2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2) Rattus norvegicus
Analyze
Symbol: Hecw2
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
RGD ID: 1593244
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in regulation of dendrite morphogenesis; regulation of mitotic metaphase/anaphase transition; and ubiquitin-dependent protein catabolic process. Predicted to be located in mitotic spindle. Predicted to be active in cytoplasm. Orthologous to human HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 ubiquitin-protein ligase HECW2; LOC316395; similar to HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 isoform 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8962,853,904 - 63,247,472 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl962,859,645 - 63,074,758 (-)EnsemblGRCr8
mRatBN7.2955,359,462 - 55,753,106 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl955,365,203 - 55,580,327 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx963,873,173 - 64,095,115 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0968,988,953 - 69,210,905 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0967,284,797 - 67,500,140 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0960,451,476 - 60,843,160 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl960,457,215 - 60,672,246 (-)Ensemblrn6Rnor6.0
Rnor_5.0960,137,069 - 60,526,937 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4952,623,951 - 52,839,918 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera952,860,020 - 53,074,467 (-)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
cocaine  (EXP)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glyphosate  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melphalan  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
mitotic spindle  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24163370  


Genomics

Comparative Map Data
Hecw2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8962,853,904 - 63,247,472 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl962,859,645 - 63,074,758 (-)EnsemblGRCr8
mRatBN7.2955,359,462 - 55,753,106 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl955,365,203 - 55,580,327 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx963,873,173 - 64,095,115 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0968,988,953 - 69,210,905 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0967,284,797 - 67,500,140 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0960,451,476 - 60,843,160 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl960,457,215 - 60,672,246 (-)Ensemblrn6Rnor6.0
Rnor_5.0960,137,069 - 60,526,937 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4952,623,951 - 52,839,918 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera952,860,020 - 53,074,467 (-)NCBICelera
Cytogenetic Map9q31NCBI
HECW2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382196,194,072 - 196,593,554 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2196,189,099 - 196,593,684 (-)Ensemblhg38GRCh38
GRCh372197,058,796 - 197,458,278 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362196,772,222 - 197,165,580 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342196,889,482 - 197,282,841NCBI
Celera2190,819,831 - 191,213,211 (-)NCBICelera
Cytogenetic Map2q32.3NCBI
HuRef2188,916,792 - 189,310,064 (-)NCBIHuRef
CHM1_12197,069,845 - 197,463,246 (-)NCBICHM1_1
T2T-CHM13v2.02196,678,133 - 197,077,648 (-)NCBIT2T-CHM13v2.0
Hecw2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39153,846,031 - 54,234,193 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl153,846,035 - 54,234,327 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38153,806,872 - 54,195,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl153,806,876 - 54,195,168 (-)Ensemblmm10GRCm38
MGSCv37153,863,718 - 54,251,878 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36153,757,767 - 53,985,072 (-)NCBIMGSCv36mm8
Celera154,347,232 - 54,580,782 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.99NCBI
Hecw2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554033,752,461 - 4,090,041 (+)Ensembl
ChiLan1.0NW_0049554033,902,881 - 4,096,189 (+)NCBIChiLan1.0ChiLan1.0
HECW2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21398,821,302 - 99,214,271 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B98,836,292 - 99,228,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B83,445,401 - 83,838,065 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B201,346,145 - 201,736,143 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B201,351,023 - 201,584,044 (-)EnsemblpanPan2panpan1.1
HECW2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1375,850,518 - 6,213,353 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl375,856,513 - 6,213,820 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha376,799,246 - 7,162,228 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0375,738,571 - 6,103,245 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl375,743,029 - 6,060,033 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1375,739,218 - 6,102,898 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0375,705,967 - 6,070,337 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0375,728,026 - 6,091,688 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hecw2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303153,928,957 - 154,281,017 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365062,558,249 - 2,909,110 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365062,704,885 - 2,913,663 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HECW2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15100,092,882 - 100,498,157 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115100,086,724 - 100,499,566 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215111,160,775 - 111,337,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HECW2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11081,739,680 - 82,127,332 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1081,743,021 - 81,974,689 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040117,327,029 - 117,706,765 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hecw2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624854618,262 - 824,178 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624854475,098 - 831,202 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hecw2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14128,531,764 - 128,906,466 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hecw2
2306 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:98
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000017761
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
BF393968  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2955,380,071 - 55,380,204 (+)MAPPERmRatBN7.2
Rnor_6.0960,471,895 - 60,472,027NCBIRnor6.0
Rnor_5.0960,157,386 - 60,157,518UniSTSRnor5.0
RGSC_v3.4952,639,413 - 52,639,545UniSTSRGSC3.4
Celera952,874,766 - 52,874,898UniSTS
RH 3.4 Map4948.71UniSTS
Cytogenetic Map9q31UniSTS
RH138235  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2955,564,831 - 55,565,013 (+)MAPPERmRatBN7.2
Rnor_6.0960,656,751 - 60,656,932NCBIRnor6.0
Rnor_5.0960,341,591 - 60,341,772UniSTSRnor5.0
RGSC_v3.4952,824,423 - 52,824,604UniSTSRGSC3.4
Celera953,058,972 - 53,059,153UniSTS
Cytogenetic Map9q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 86 59 6 349 186 11 144 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017761   ⟹   ENSRNOP00000017761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl962,859,645 - 63,074,758 (-)Ensembl
mRatBN7.2 Ensembl955,365,203 - 55,580,327 (-)Ensembl
Rnor_6.0 Ensembl960,457,215 - 60,672,246 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000172819   ⟹   ENSRNOP00000109167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl962,880,735 - 63,074,758 (-)Ensembl
RefSeq Acc Id: NM_001108218   ⟹   NP_001101688
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8962,859,645 - 63,074,758 (-)NCBI
mRatBN7.2955,365,203 - 55,580,327 (-)NCBI
Rnor_6.0960,457,215 - 60,672,246 (-)NCBI
Rnor_5.0960,137,069 - 60,526,937 (-)NCBI
RGSC_v3.4952,623,951 - 52,839,918 (-)RGD
Celera952,860,020 - 53,074,467 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244912   ⟹   XP_006244974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8962,853,904 - 63,029,371 (-)NCBI
mRatBN7.2955,359,462 - 55,534,918 (-)NCBI
Rnor_6.0960,451,476 - 60,626,137 (-)NCBI
Rnor_5.0960,137,069 - 60,526,937 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596447   ⟹   XP_017451936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8962,853,904 - 63,247,033 (-)NCBI
mRatBN7.2955,359,462 - 55,752,590 (-)NCBI
Rnor_6.0960,451,476 - 60,843,160 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083598   ⟹   XP_038939526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8962,853,904 - 63,246,403 (-)NCBI
mRatBN7.2955,359,462 - 55,752,197 (-)NCBI
RefSeq Acc Id: XM_039083599   ⟹   XP_038939527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8962,853,904 - 63,247,472 (-)NCBI
mRatBN7.2955,359,462 - 55,753,106 (-)NCBI
RefSeq Acc Id: XM_039083600   ⟹   XP_038939528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8962,853,904 - 63,246,786 (-)NCBI
mRatBN7.2955,359,462 - 55,752,328 (-)NCBI
RefSeq Acc Id: XM_039083601   ⟹   XP_038939529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8962,853,904 - 63,028,386 (-)NCBI
mRatBN7.2955,359,462 - 55,531,600 (-)NCBI
RefSeq Acc Id: NP_001101688   ⟸   NM_001108218
- UniProtKB: D4ADD3 (UniProtKB/TrEMBL),   A6INZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244974   ⟸   XM_006244912
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017451936   ⟸   XM_017596447
- Peptide Label: isoform X1
- UniProtKB: D4ADD3 (UniProtKB/TrEMBL),   A6INZ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017761   ⟸   ENSRNOT00000017761
RefSeq Acc Id: XP_038939527   ⟸   XM_039083599
- Peptide Label: isoform X1
- UniProtKB: D4ADD3 (UniProtKB/TrEMBL),   A6INZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939528   ⟸   XM_039083600
- Peptide Label: isoform X1
- UniProtKB: D4ADD3 (UniProtKB/TrEMBL),   A6INZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939526   ⟸   XM_039083598
- Peptide Label: isoform X1
- UniProtKB: D4ADD3 (UniProtKB/TrEMBL),   A6INZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939529   ⟸   XM_039083601
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000109167   ⟸   ENSRNOT00000172819
Protein Domains
C2   HECT   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADD3-F1-model_v2 AlphaFold D4ADD3 1-1578 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593244 AgrOrtholog
BioCyc Gene G2FUF-27551 BioCyc
Ensembl Genes ENSRNOG00000013257 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017761 ENTREZGENE
  ENSRNOT00000017761.7 UniProtKB/TrEMBL
  ENSRNOT00000172819.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  2.60.40.2840 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro C2_Ca-dep UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  C2_HECW UniProtKB/TrEMBL
  E3_ubiq-protein_ligase UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  HECW1_helix UniProtKB/TrEMBL
  HECW_N UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
KEGG Report rno:316395 UniProtKB/TrEMBL
NCBI Gene 316395 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE HECW2 UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  HECW1_helix UniProtKB/TrEMBL
  HECW_N UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PhenoGen Hecw2 PhenoGen
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013257 RatGTEx
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP HECT UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
UniProt A0ABK0LEG3_RAT UniProtKB/TrEMBL
  A6INZ4 ENTREZGENE, UniProtKB/TrEMBL
  D4ADD3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Hecw2  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2  LOC316395  similar to HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 isoform 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC316395  similar to HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL