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Gene: Cldn34d (claudin 34D) Rattus norvegicus

Analyze

No known orthologs.

Symbol:

Cldn34d

Name:

claudin 34D

RGD ID:

1592959

Description:

Predicted to enable structural molecule activity. Predicted to be located in membrane. Predicted to be active in bicellular tight junction and plasma membrane. Orthologous to human CLDN34 (claudin 34); INTERACTS WITH Cuprizon.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

hypothetical protein LOC680370; LOC680370; uncharacterized protein LOC680370

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	CLDN34 (claudin 34)	HGNC	EggNOG, Ensembl, OrthoDB, Panther
Alliance orthologs ³
Mus musculus (house mouse):	Cldn34d (claudin 34D)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CLDN34 (claudin 34)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cldn34a (claudin 34a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cldn34	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	44,473,389 - 44,481,870 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	44,473,390 - 44,481,870 (-)	Ensembl				GRCr8
mRatBN7.2	X	40,594,666 - 40,603,146 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	40,594,666 - 40,603,146 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	41,907,081 - 41,915,563 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	45,374,403 - 45,382,885 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	43,058,991 - 43,067,473 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	43,870,402 - 43,878,881 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	43,870,402 - 43,878,881 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	44,172,770 - 44,181,249 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	62,081,939 - 62,090,418 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	41,258,897 - 41,267,377 (-)	NCBI		Celera
Cytogenetic Map	X	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Cuprizon (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

bicellular tight junction (IBA,IEA)

membrane (IEA)

plasma membrane (IBA,IEA)

Molecular Function

structural molecule activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.

Genomics

Variants

Variants in Cldn34d
29 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	26
Count of miRNA genes:	26
Interacting mature miRNAs:	26
Transcripts:	ENSRNOT00000066493
Prediction methods:	Miranda, Pita, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598873	Memor2	Memory QTL 2	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	X	24470360	44931007	Rat
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	4001493	44939387	Rat
2290375	Gluco34	Glucose level QTL 34	2.75		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	24470360	45082063	Rat
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1970440	46970440	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	8111486	53111486	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	mesenchyme	mesoderm	renal system	reproductive system	respiratory system
2	3	1	1	1	3	1	1	20	2

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008773232	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000066493 ⟹ ENSRNOP00000063353

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	44,473,390 - 44,481,870 (-)	Ensembl
mRatBN7.2 Ensembl	X	40,594,666 - 40,603,146 (-)	Ensembl
Rnor_6.0 Ensembl	X	43,870,402 - 43,878,881 (-)	Ensembl

RefSeq Acc Id:

NM_001109402 ⟹ NP_001102872

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	44,473,390 - 44,481,870 (-)	NCBI
mRatBN7.2	X	40,594,666 - 40,603,146 (-)	NCBI
Rnor_6.0	X	43,870,402 - 43,878,881 (-)	NCBI
Rnor_5.0	X	44,172,770 - 44,181,249 (-)	NCBI
RGSC_v3.4	X	62,081,939 - 62,090,418 (-)	RGD
Celera	X	41,258,897 - 41,267,377 (-)	RGD

Sequence:

show sequence

TACCACACACCTGACTATGAAGTCACCATCCATTCTTGAAGGACACTAGGGGAGCCATATTCTC
TTTAGCACTACTGGTCCATCTATCTTCACATTCTGCCACATAAGGGGTTACAAATTCATTTGGA
GACAGCATTATAGGCAATTGACGAGAGATAACTGTCACCGTGATAATGGCCAGAAAACATGCCA
AGCGGCAACTAGGAGGTTTTGCTGCAAGTACCATAGCATGGTTCCTTTGCAGTGTCTCTATGGG
CCTCCCTCAATGGCGAGTGTGGTTCTTTCAAGATCCCATGGAGTCCAAGCCTGGCATGACCTTA
GTAGGCATGTGGAGAACCTGTGTTTACCACCAGAAAAGTAATTCCACCTTTAACAGAGTGTGTT
ACAAATACACCTACCAGGATACCTTCATCCCTCTGGATATTCGAGTTGCCCAACATCTGCTACT
CATCGCAAGCCTACTTGGCATTATTTCCATAATTTCCGTTATCATTGCTCTTTGGAAATTATAC
TCAGGGAGACTCCGGAAGAAAGTCGCCTTCAATCCATTCCGCCTTCCAGGGATTCTGAACGTCA
TTGCTAGCAGCTTTGTCTTACTTTCCATCTTGTACAATTATTTATCGATCATTCGCAAGGATGG
GATTGCCTTCCCTCCATCTTTCCACACACCCTCCTTCCCAGATAGTCAAAAAGTTGGCACTGCA
CTGGCAATGGCAACTCTTTCCTGTTTCTTATTTCTTCTAGGTGGTATAATCCCACTTTCTTTCA
CTCTTCCCCCACGTTGCCGAGTGCGCTATAATACTTAAAAGTAAATTTCCAACTTATATAGACT
TGAAAATCTAAAATTACCATTAGAAATTGCAAGCACTCTTCAAATACCTACTTAAAATTTCCAG
ATGAAAAACCATGCCCAATGATGACAAGTAGGCCTCCTGATATTTCCTGTCTCAGTTGCTCCAT
CAGTTTCATTGGCTTATTGATTTTCATTAAATAAAATCTTTCCCAATT

hide sequence

RefSeq Acc Id:

XM_008773232 ⟹ XP_008771454

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	44,473,389 - 44,481,864 (-)	NCBI
mRatBN7.2	X	40,594,672 - 40,602,432 (-)	NCBI
Rnor_6.0	X	43,870,408 - 43,878,161 (-)	NCBI

Sequence:

show sequence

TTATAAATTGCTAATAACTGTTTGGTTTGGAGTTGGACCCCATGCCCACCTCTTCTTCTCGGAT
TTGAGGCTGGGTGAAACTGATGATTGCTTTGATGATGTAGTTTGAAAGTAGAGTGATCCAGCTT
TCATAGAAGGATATTAAAAGTGCTACTCCTGCTACTATTTGCTGAATAAATTGAGAAATATTGG
CAGTACACCTACTTTGAAAGATCAATAGAGTTCTGCTGTGAATCCATCTGGCTCAGGTTTAAGT
TGACGAGAGATAACTGTCACCGTGATAATGGCCAGAAAACATGCCAAGCGGCAACTAGGAGGTT
TTGCTGCAAGTACCATAGCATGGTTCCTTTGCAGTGTCTCTATGGGCCTCCCTCAATGGCGAGT
GTGGTTCTTTCAAGATCCCATGGAGTCCAAGCCTGGCATGACCTTAGTAGGCATGTGGAGAACC
TGTGTTTACCACCAGAAAAGTAATTCCACCTTTAACAGAGTGTGTTACAAATACACCTACCAGG
ATACCTTCATCCCTCTGGATATTCGAGTTGCCCAACATCTGCTACTCATCGCAAGCCTACTTGG
CATTATTTCCATAATTTCCGTTATCATTGCTCTTTGGAAATTATACTCAGGGAGACTCCGGAAG
AAAGTCGCCTTCAATCCATTCCGCCTTCCAGGGATTCTGAACGTCATTGCTAGCAGCTTTGTCT
TACTTTCCATCTTGTACAATTATTTATCGATCATTCGCAAGGATGGGATTGCCTTCCCTCCATC
TTTCCACACACCCTCCTTCCCAGATAGTCAAAAAGTTGGCACTGCACTGGCAATGGCAACTCTT
TCCTGTTTCTTATTTCTTCTAGGTGGTATAATCCCACTTTCTTTCACTCTTCCCCCACGTTGCC
GAGTGCGCTATAATACTTAAAAGTAAATTTCCAACTTATATAGACTTGAAAATCTAAAATTACC
ATTAGAAATTGCAAGCACTCTTCAAATACCTACTTAAAATTTCCAGATGAAAAACCATGCCCAA
TGATGACAAGTAGGCCTCCTGATATTTCCTGTCTCAGTTGCTCCATCAGTTTCATTGGCTTATT
GATTTTCATTAAATAAAATCTTTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102872	(Get FASTA)	NCBI Sequence Viewer
	XP_008771454	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL96090	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000063353
	ENSRNOP00000063353.1

RefSeq Acc Id:

NP_001102872 ⟸ NM_001109402

- UniProtKB:

D3ZYG4 (UniProtKB/TrEMBL), A6IPS3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARKHAKRQLGGFAASTIAWFLCSVSMGLPQWRVWFFQDPMESKPGMTLVGMWRTCVYHQKSNS
TFNRVCYKYTYQDTFIPLDIRVAQHLLLIASLLGIISIISVIIALWKLYSGRLRKKVAFNPFRL
PGILNVIASSFVLLSILYNYLSIIRKDGIAFPPSFHTPSFPDSQKVGTALAMATLSCFLFLLGG
IIPLSFTLPPRCRVRYNT

hide sequence

RefSeq Acc Id:	XP_008771454 ⟸ XM_008773232
- Peptide Label:	isoform X1
- UniProtKB:	D3ZYG4 (UniProtKB/TrEMBL), A6IPS3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MARKHAKRQLGGFAASTIAWFLCSVSMGLPQWRVWFFQDPMESKPGMTLVGMWRTCVYHQKSNS TFNRVCYKYTYQDTFIPLDIRVAQHLLLIASLLGIISIISVIIALWKLYSGRLRKKVAFNPFRL PGILNVIASSFVLLSILYNYLSIIRKDGIAFPPSFHTPSFPDSQKVGTALAMATLSCFLFLLGG IIPLSFTLPPRCRVRYNT hide sequence

Ensembl Acc Id:

ENSRNOP00000063353 ⟸ ENSRNOT00000066493

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZYG4-F1-model_v2	AlphaFold	D3ZYG4	1-210	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1592959	AgrOrtholog
BioCyc Gene	G2FUF-2427	BioCyc
Ensembl Genes	ENSRNOG00000043402	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066493	ENTREZGENE
	ENSRNOT00000066493.3	UniProtKB/TrEMBL
Gene3D-CATH	1.20.140.150	UniProtKB/TrEMBL
InterPro	Claudin	UniProtKB/TrEMBL
	PMP22/EMP/MP20/Claudin	UniProtKB/TrEMBL
KEGG Report	rno:680370	UniProtKB/TrEMBL
NCBI Gene	680370	ENTREZGENE
PANTHER	Claudin	UniProtKB/TrEMBL
Pfam	Claudin_2	UniProtKB/TrEMBL
PhenoGen	Cldn34d	PhenoGen
RatGTEx	ENSRNOG00000043402	RatGTEx
UniProt	A6IPS3	ENTREZGENE, UniProtKB/TrEMBL
	D3ZYG4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-04-28	Cldn34d	claudin 34D	LOC680370	hypothetical protein LOC680370	Name and Symbol changed	629549	APPROVED
2008-01-09	LOC680370	hypothetical protein LOC680370	LOC681539	hypothetical protein LOC681539	Data merged from RGD:1594097	1643240	APPROVED
2006-11-20	LOC680370	hypothetical protein LOC680370			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-20	LOC681539	hypothetical protein LOC681539			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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