Isoc2a (isochorismatase domain containing 2A) - Rat Genome Database

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Gene: Isoc2a (isochorismatase domain containing 2A) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Isoc2a
Name: isochorismatase domain containing 2A
RGD ID: 1592677
Description: INTERACTS WITH (1->4)-beta-D-glucan (ortholog); 17beta-estradiol (ortholog); 4,4'-sulfonyldiphenol (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: isochorismatase domain-containing protein 2; isochorismatase domain-containing protein 2A; LOC684270; similar to isochorismatase domain containing 2; uncharacterized protein LOC684270
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8177,967,751 - 77,986,002 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl177,966,549 - 77,986,002 (-)EnsemblGRCr8
mRatBN7.2168,938,916 - 68,957,179 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,937,759 - 68,957,179 (-)EnsemblmRatBN7.2
Rnor_6.0172,491,667 - 72,509,433 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,491,780 - 72,509,431 (-)Ensemblrn6Rnor6.0
Rnor_5.0176,027,564 - 76,044,837 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera168,165,460 - 68,182,583 (+)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Isoc2a
130 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:71
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000071971
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
M81342  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,954,651 - 68,954,790 (+)MAPPERmRatBN7.2
mRatBN7.21476,987,337 - 76,987,476 (+)MAPPERmRatBN7.2
Rnor_6.01482,272,415 - 82,272,553NCBIRnor6.0
Rnor_6.0172,506,586 - 72,506,724NCBIRnor6.0
Rnor_5.01482,961,971 - 82,962,109UniSTSRnor5.0
Rnor_5.0176,029,780 - 76,029,918UniSTSRnor5.0
RGSC_v3.41482,388,771 - 82,388,909UniSTSRGSC3.4
RGSC_v3.41482,682,536 - 82,682,674UniSTSRGSC3.4
Celera1475,910,689 - 75,910,827UniSTS
Celera168,168,300 - 68,168,438UniSTS
Cytogenetic Map14q21UniSTS
RH129229  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,940,249 - 68,940,444 (+)MAPPERmRatBN7.2
Rnor_6.0172,491,740 - 72,491,934NCBIRnor6.0
Rnor_5.0176,044,570 - 76,044,764UniSTSRnor5.0
Celera168,182,316 - 68,182,510UniSTS
RH127661  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,940,283 - 68,940,492 (+)MAPPERmRatBN7.2
Rnor_6.0172,491,774 - 72,491,982NCBIRnor6.0
Rnor_5.0176,044,522 - 76,044,730UniSTSRnor5.0
Celera168,182,268 - 68,182,476UniSTS
RH132281  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,987,464 - 76,987,668 (+)MAPPERmRatBN7.2
mRatBN7.2168,954,457 - 68,954,663 (+)MAPPERmRatBN7.2
Rnor_6.01482,272,542 - 82,272,745NCBIRnor6.0
Rnor_6.0172,506,392 - 72,506,597NCBIRnor6.0
Rnor_5.01482,962,098 - 82,962,301UniSTSRnor5.0
Rnor_5.0176,029,907 - 76,030,112UniSTSRnor5.0
RGSC_v3.41482,682,663 - 82,682,866UniSTSRGSC3.4
Celera1475,910,816 - 75,911,019UniSTS
Celera168,168,427 - 68,168,632UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000071971   ⟹   ENSRNOP00000066553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl172,491,780 - 72,509,431 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097188   ⟹   ENSRNOP00000094488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl177,966,549 - 77,986,002 (-)Ensembl
mRatBN7.2 Ensembl168,937,759 - 68,957,179 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000148451   ⟹   ENSRNOP00000099798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl177,967,751 - 77,986,002 (-)Ensembl
RefSeq Acc Id: NM_001409142   ⟹   NP_001396071
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,967,751 - 77,986,002 (-)NCBI
mRatBN7.2168,938,916 - 68,957,179 (-)NCBI
RefSeq Acc Id: NM_001409143   ⟹   NP_001396072
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,967,751 - 77,986,002 (-)NCBI
mRatBN7.2168,938,916 - 68,957,179 (-)NCBI
RefSeq Acc Id: XM_039100618   ⟹   XP_038956546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,969,012 - 77,985,995 (-)NCBI
mRatBN7.2168,940,177 - 68,957,178 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001396071 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396072 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956546 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75869 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000094488
  ENSRNOP00000094488.1
  ENSRNOP00000099798
  ENSRNOP00000099798.1
Ensembl Acc Id: ENSRNOP00000066553   ⟸   ENSRNOT00000071971
RefSeq Acc Id: XP_038956546   ⟸   XM_039100618
- Peptide Label: isoform X1
- UniProtKB: A6KNQ0 (UniProtKB/TrEMBL),   A0A8I6GL72 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094488   ⟸   ENSRNOT00000097188
RefSeq Acc Id: NP_001396072   ⟸   NM_001409143
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001396071   ⟸   NM_001409142
- Peptide Label: isoform 1
- UniProtKB: A6KNQ0 (UniProtKB/TrEMBL),   A0A8I6GL72 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099798   ⟸   ENSRNOT00000148451
Protein Domains
Isochorismatase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RAK2-F1-model_v2 AlphaFold M0RAK2 1-209 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689709
Promoter ID:EPDNEW_R217
Type:initiation region
Name:LOC684270_1
Description:similar to isochorismatase domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0172,509,364 - 72,509,424EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592677 AgrOrtholog
BioCyc Gene G2FUF-60867 BioCyc
Ensembl Genes ENSRNOG00000050348 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097188 ENTREZGENE
  ENSRNOT00000097188.2 UniProtKB/TrEMBL
  ENSRNOT00000148451 ENTREZGENE
  ENSRNOT00000148451.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.850 UniProtKB/TrEMBL
InterPro Isochorismatase-like UniProtKB/TrEMBL
  Isochorismatase-like_sf UniProtKB/TrEMBL
  Isochorismatase_domain UniProtKB/TrEMBL
NCBI Gene 684270 ENTREZGENE
PANTHER HYDROLASE UniProtKB/TrEMBL
  ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam Isochorismatase UniProtKB/TrEMBL
PhenoGen Isoc2a PhenoGen
RatGTEx ENSRNOG00000050348 RatGTEx
Superfamily-SCOP SSF52499 UniProtKB/TrEMBL
UniProt A0A8I6GL72 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L726_RAT UniProtKB/TrEMBL
  A6KNQ0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-27 Isoc2a  isochorismatase domain containing 2A  Isoc2a  isochorismatase domain containing 2a  Name changed 629549 APPROVED
2022-10-27 Isoc2a  isochorismatase domain containing 2a  LOC684270  similar to isochorismatase domain containing 2  Name and Symbol changed 629549 APPROVED
2006-11-20 LOC684270  similar to isochorismatase domain containing 2      Symbol and Name status set to provisional 70820 PROVISIONAL