Mcrip2 (MAPK regulated co-repressor interacting protein 2) - Rat Genome Database

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Gene: Mcrip2 (MAPK regulated co-repressor interacting protein 2) Rattus norvegicus
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Symbol: Mcrip2
Name: MAPK regulated co-repressor interacting protein 2
RGD ID: 1592603
Description: Predicted to enable RNA binding activity. Predicted to act upstream of or within several processes, including carboxylic acid metabolic process; cold-induced thermogenesis; and response to cold. Predicted to be located in cytoplasm. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Orthologous to human MCRIP2 (MAPK regulated corepressor interacting protein 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fam195a; family with sequence similarity 195, member A; hypothetical protein LOC685545; LOC360499; LOC685545; MAPK regulated corepressor interacting protein 2; RGD1311273; similar to RIKEN cDNA 9530058B02; uncharacterized protein LOC685545
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,388,325 - 15,393,302 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1015,388,325 - 15,398,730 (-)EnsemblGRCr8
mRatBN7.21014,883,813 - 14,888,784 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,883,813 - 14,894,021 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,622,816 - 19,627,758 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,111,692 - 19,116,634 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,611,978 - 14,616,914 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,230,801 - 15,235,740 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,230,801 - 15,235,740 (-)Ensemblrn6Rnor6.0
Rnor_5.01015,043,744 - 15,048,702 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41015,129,198 - 15,134,137 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,552,689 - 14,557,628 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
cytoplasmic stress granule  (IEA,ISO)
cytosol  (ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:26184334  


Genomics

Comparative Map Data
Mcrip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,388,325 - 15,393,302 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1015,388,325 - 15,398,730 (-)EnsemblGRCr8
mRatBN7.21014,883,813 - 14,888,784 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,883,813 - 14,894,021 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,622,816 - 19,627,758 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,111,692 - 19,116,634 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,611,978 - 14,616,914 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,230,801 - 15,235,740 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,230,801 - 15,235,740 (-)Ensemblrn6Rnor6.0
Rnor_5.01015,043,744 - 15,048,702 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41015,129,198 - 15,134,137 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,552,689 - 14,557,628 (-)NCBICelera
Cytogenetic Map10q12NCBI
MCRIP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816641,828 - 648,474 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16636,817 - 648,474 (+)Ensemblhg38GRCh38
GRCh3716691,828 - 698,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616631,850 - 638,475 (+)NCBIBuild 36Build 36hg18NCBI36
Celera16892,017 - 898,642 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16613,634 - 620,259 (+)NCBIHuRef
CHM1_116691,805 - 698,438 (+)NCBICHM1_1
T2T-CHM13v2.016645,896 - 652,542 (+)NCBIT2T-CHM13v2.0
Mcrip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,082,672 - 26,087,738 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,082,672 - 26,087,738 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381725,863,698 - 25,868,740 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,863,698 - 25,868,764 (-)Ensemblmm10GRCm38
MGSCv371726,000,643 - 26,005,683 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361725,591,298 - 25,596,338 (-)NCBIMGSCv36mm8
Celera1726,396,522 - 26,401,785 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.96NCBI
Mcrip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,554,321 - 16,559,404 (-)Ensembl
ChiLan1.0NW_00495544216,554,321 - 16,559,404 (-)NCBIChiLan1.0ChiLan1.0
MCRIP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218882,882 - 890,109 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,667,170 - 4,674,005 (+)NCBINHGRI_mPanPan1
PanPan1.116649,370 - 662,671 (+)NCBIPanPan1.1PanPan1.1panPan2
MCRIP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,921,947 - 39,922,873 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,185,687 - 41,190,649 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0640,264,222 - 40,269,187 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,264,226 - 40,269,173 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1639,952,769 - 39,957,724 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,912,984 - 39,917,919 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,392,126 - 40,397,089 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mcrip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,262,811 - 112,270,836 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936501360,688 - 365,497 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936501360,671 - 365,512 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCRIP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,123,048 - 41,127,917 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1341,123,037 - 41,133,463 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,343,426 - 41,353,426 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MCRIP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.15557,388 - 568,952 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl5557,607 - 569,675 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606830,568,150 - 30,574,129 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcrip2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,456,432 - 1,461,734 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249131,448,489 - 1,461,734 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mcrip2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v193,129,235 - 3,134,136 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mcrip2
32 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:118
Interacting mature miRNAs:131
Transcripts:ENSRNOT00000027170
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 88 59 6 352 188 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027170   ⟹   ENSRNOP00000027169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1015,388,325 - 15,393,300 (-)Ensembl
mRatBN7.2 Ensembl1014,883,813 - 14,888,753 (-)Ensembl
Rnor_6.0 Ensembl1015,230,801 - 15,235,740 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119177   ⟹   ENSRNOP00000088107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1015,388,325 - 15,398,730 (-)Ensembl
mRatBN7.2 Ensembl1014,883,813 - 14,894,021 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000139815   ⟹   ENSRNOP00000110513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1015,388,325 - 15,390,472 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144924   ⟹   ENSRNOP00000100984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1015,388,325 - 15,395,164 (-)Ensembl
RefSeq Acc Id: NM_001109475   ⟹   NP_001102945
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,388,325 - 15,393,264 (-)NCBI
mRatBN7.21014,883,813 - 14,888,753 (-)NCBI
Rnor_6.01015,230,801 - 15,235,740 (-)NCBI
Rnor_5.01015,043,744 - 15,048,702 (-)NCBI
RGSC_v3.41015,129,198 - 15,134,137 (-)ENTREZGENE
Celera1014,552,689 - 14,557,628 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_039086832   ⟹   XP_038942760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,388,326 - 15,393,302 (-)NCBI
mRatBN7.21014,883,814 - 14,888,784 (-)NCBI
RefSeq Acc Id: XM_063269841   ⟹   XP_063125911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,389,203 - 15,393,066 (-)NCBI
RefSeq Acc Id: XM_063269842   ⟹   XP_063125912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,388,326 - 15,393,066 (-)NCBI
RefSeq Acc Id: NP_001102945   ⟸   NM_001109475
- UniProtKB: D3ZM07 (UniProtKB/TrEMBL),   A6HD70 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027169   ⟸   ENSRNOT00000027170
RefSeq Acc Id: XP_038942760   ⟸   XM_039086832
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000088107   ⟸   ENSRNOT00000119177
RefSeq Acc Id: XP_063125912   ⟸   XM_063269842
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063125911   ⟸   XM_063269841
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000100984   ⟸   ENSRNOT00000144924
Ensembl Acc Id: ENSRNOP00000110513   ⟸   ENSRNOT00000139815

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZM07-F1-model_v2 AlphaFold D3ZM07 1-160 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697064
Promoter ID:EPDNEW_R7589
Type:multiple initiation site
Name:Mcrip2_1
Description:MAPK regulated co-repressor interacting protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01015,235,733 - 15,235,793EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592603 AgrOrtholog
BioCyc Gene G2FUF-25747 BioCyc
Ensembl Genes ENSRNOG00000020029 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027170 ENTREZGENE
  ENSRNOT00000027170.7 UniProtKB/TrEMBL
  ENSRNOT00000119177.2 UniProtKB/TrEMBL
  ENSRNOT00000139815.1 UniProtKB/TrEMBL
  ENSRNOT00000144924 ENTREZGENE
  ENSRNOT00000144924.1 UniProtKB/TrEMBL
InterPro FAM195 UniProtKB/TrEMBL
KEGG Report rno:685545 UniProtKB/TrEMBL
NCBI Gene 685545 ENTREZGENE
Pfam FAM195 UniProtKB/TrEMBL
PhenoGen Mcrip2 PhenoGen
RatGTEx ENSRNOG00000020029 RatGTEx
UniProt A0A8I6A8M7_RAT UniProtKB/TrEMBL
  A0ABK0LHL1_RAT UniProtKB/TrEMBL
  A0ABK0LI24_RAT UniProtKB/TrEMBL
  A6HD70 ENTREZGENE, UniProtKB/TrEMBL
  D3ZM07 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-20 Mcrip2  MAPK regulated co-repressor interacting protein 2  Fam195a  family with sequence similarity 195, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Fam195a  family with sequence similarity 195, member A  LOC682248  hypothetical protein LOC682248  Data merged from RGD:1585743 1643240 APPROVED
2010-04-21 Fam195a  family with sequence similarity 195, member A  LOC685545  hypothetical protein LOC685545  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 LOC685545  hypothetical protein LOC685545  RGD1311273  similar to RIKEN cDNA 9530058B02   Data merged from RGD:1311273 1643240 APPROVED
2008-04-30 RGD1311273  similar to RIKEN cDNA 9530058B02   RGD1311273_predicted  similar to RIKEN cDNA 9530058B02 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC685545  hypothetical protein LOC685545      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682248  hypothetical protein LOC682248      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1311273_predicted  similar to RIKEN cDNA 9530058B02 (predicted)  LOC360499_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC360499_predicted  similar to RIKEN cDNA 9530058B02 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL