Zfp780b (zinc finger protein 780B) - Rat Genome Database

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Gene: Zfp780b (zinc finger protein 780B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Zfp780b
Name: zinc finger protein 780B
RGD ID: 1592570
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF780A (zinc finger protein 780A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07002774.4; hypothetical protein LOC685578; hypothetical protein LOC687328; LOC102554136; LOC685578; similar to Zinc finger protein 354A (Transcription factor 17) (Renal transcription factor Kid-1) (Kidney, ischemia, and developmentally regulated protein 1); zinc finger protein 59; zinc finger protein 59-like; zinc finger protein 60; zinc finger protein 60-like; zinc finger protein 780A; zinc finger protein 780A-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Related Pseudogenes: Zfp780b-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,247,941 - 92,297,210 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl192,223,984 - 92,268,523 (+)EnsemblGRCr8
mRatBN7.2183,058,993 - 83,182,629 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,094,305 - 83,140,793 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl183,160,399 - 83,183,254 (+)EnsemblmRatBN7.2
Rnor_6.0184,755,811 - 84,763,979 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,685,931 - 84,698,793 (+)Ensemblrn6Rnor6.0
Rnor_5.0185,872,434 - 85,930,098 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4182,961,675 - 82,982,450 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera177,560,251 - 77,583,716 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14760703  


Genomics

Variants

.
Variants in Zfp780b
410 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:57
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000063839
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 83 213 91 90 59 154 59 6 478 280 22 191 108 124 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000032933   ⟹   ENSRNOP00000037471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,059,010 - 83,082,107 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000041861   ⟹   ENSRNOP00000046702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,094,305 - 83,137,431 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000063839   ⟹   ENSRNOP00000062020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,288,011 - 92,311,536 (+)Ensembl
mRatBN7.2 Ensembl183,160,399 - 83,183,254 (+)Ensembl
Rnor_6.0 Ensembl184,685,931 - 84,698,793 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000073966   ⟹   ENSRNOP00000065360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,009,191 - 83,027,748 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101873   ⟹   ENSRNOP00000086019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,009,189 - 83,082,107 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102346   ⟹   ENSRNOP00000083598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,288,004 - 92,313,799 (+)Ensembl
mRatBN7.2 Ensembl183,160,448 - 83,183,254 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112009   ⟹   ENSRNOP00000097737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,009,189 - 83,027,748 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113399   ⟹   ENSRNOP00000079191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,160,399 - 83,183,254 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115669   ⟹   ENSRNOP00000078742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,223,984 - 92,268,523 (+)Ensembl
mRatBN7.2 Ensembl183,094,305 - 83,140,793 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132605   ⟹   ENSRNOP00000105722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,302,678 - 92,323,452 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139397   ⟹   ENSRNOP00000105808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,250,542 - 92,268,523 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000156414   ⟹   ENSRNOP00000107598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,223,984 - 92,268,523 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000157197   ⟹   ENSRNOP00000110471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,296,624 - 92,318,267 (+)Ensembl
RefSeq Acc Id: XM_039100844   ⟹   XP_038956772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,247,942 - 92,269,045 (+)NCBI
mRatBN7.2183,098,948 - 83,141,462 (+)NCBI
RefSeq Acc Id: XM_063277703   ⟹   XP_063133773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,247,941 - 92,269,045 (+)NCBI
RefSeq Acc Id: XM_063277705   ⟹   XP_063133775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,247,941 - 92,274,432 (+)NCBI
RefSeq Acc Id: XM_063277707   ⟹   XP_063133777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,247,941 - 92,297,210 (+)NCBI
RefSeq Acc Id: XM_063277708   ⟹   XP_063133778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,247,941 - 92,297,210 (+)NCBI
Ensembl Acc Id: ENSRNOP00000062020   ⟸   ENSRNOT00000063839
RefSeq Acc Id: XP_038956772   ⟸   XM_039100844
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000079191   ⟸   ENSRNOT00000113399
Ensembl Acc Id: ENSRNOP00000083598   ⟸   ENSRNOT00000102346
Ensembl Acc Id: ENSRNOP00000097737   ⟸   ENSRNOT00000112009
Ensembl Acc Id: ENSRNOP00000078742   ⟸   ENSRNOT00000115669
Ensembl Acc Id: ENSRNOP00000046702   ⟸   ENSRNOT00000041861
Ensembl Acc Id: ENSRNOP00000037471   ⟸   ENSRNOT00000032933
Ensembl Acc Id: ENSRNOP00000065360   ⟸   ENSRNOT00000073966
Ensembl Acc Id: ENSRNOP00000086019   ⟸   ENSRNOT00000101873
RefSeq Acc Id: XP_063133777   ⟸   XM_063277707
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063133778   ⟸   XM_063277708
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063133775   ⟸   XM_063277705
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063133773   ⟸   XM_063277703
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000107598   ⟸   ENSRNOT00000156414
Ensembl Acc Id: ENSRNOP00000105808   ⟸   ENSRNOT00000139397
Ensembl Acc Id: ENSRNOP00000105722   ⟸   ENSRNOT00000132605
Ensembl Acc Id: ENSRNOP00000110471   ⟸   ENSRNOT00000157197

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLR0-F1-model_v2 AlphaFold D3ZLR0 1-251 view protein structure
AF-D3ZR88-F1-model_v2 AlphaFold D3ZR88 1-624 view protein structure
AF-D3ZA43-F1-model_v2 AlphaFold D3ZA43 1-761 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592570 AgrOrtholog
Ensembl Genes ENSRNOG00000018885 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000029805 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000050995 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000063839.5 UniProtKB/TrEMBL
  ENSRNOT00000102346.2 UniProtKB/TrEMBL
  ENSRNOT00000115669.2 UniProtKB/TrEMBL
  ENSRNOT00000123091.1 UniProtKB/TrEMBL
  ENSRNOT00000132605.1 UniProtKB/TrEMBL
  ENSRNOT00000139397 ENTREZGENE
  ENSRNOT00000139397.1 UniProtKB/TrEMBL
  ENSRNOT00000156414.1 UniProtKB/TrEMBL
  ENSRNOT00000157197.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro C2H2-ZF_domain UniProtKB/TrEMBL
  KRAB UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Znf_C2H2-type UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene Zfp780b ENTREZGENE
PANTHER FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED UniProtKB/TrEMBL
  RIKEN CDNA 6720489N17 GENE-RELATED UniProtKB/TrEMBL
  SI:DKEY-15H8.11 PROTEIN-RELATED UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 519 UniProtKB/TrEMBL
  ZNF44 PROTEIN UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp780b PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018885 RatGTEx
  ENSRNOG00000029805 RatGTEx
  ENSRNOG00000050995 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I5ZLT8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GAY4_RAT UniProtKB/TrEMBL
  A0ABK0LP97_RAT UniProtKB/TrEMBL
  A0ABK0LPT7_RAT UniProtKB/TrEMBL
  A0ABK0LRD5_RAT UniProtKB/TrEMBL
  D3ZA43_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Zfp780b  zinc finger protein 780B  AABR07002774.4    Data merged from RGD:15006091 737654 PROVISIONAL
2021-03-09 Zfp780b  zinc finger protein 780B  LOC102554136  zinc finger protein 60-like  Data merged from RGD:7646794 737654 PROVISIONAL
2019-11-08 AABR07002774.4        Symbol and Name status set to provisional 45752 PROVISIONAL
2013-12-18 LOC102554136  zinc finger protein 60-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-05-24 Zfp780b  zinc finger protein 780B  LOC687328  hypothetical protein LOC687328  Data merged from RGD:1586569 1643240 APPROVED
2012-07-02 Zfp780b  zinc finger protein 780B  LOC499110  similar to Zinc finger protein 354A (Transcription factor 17) (Renal transcription factor Kid-1) (Kidney, ischemia, and developmentally regulated protein 1)  Data merged from RGD:1583738 1643240 APPROVED
2010-04-21 Zfp780b  zinc finger protein 780B  LOC685578  hypothetical protein LOC685578  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC685578  hypothetical protein LOC685578      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC499110  similar to Zinc finger protein 354A (Transcription factor 17) (Renal transcription factor Kid-1) (Kidney, ischemia, and developmentally regulated protein 1)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687328  hypothetical protein LOC687328      Symbol and Name status set to provisional 70820 PROVISIONAL