H2az2l2 (H2A.Z histone variant 2 like 2) - Rat Genome Database

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Gene: H2az2l2 (H2A.Z histone variant 2 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: H2az2l2
Name: H2A.Z histone variant 2 like 2
RGD ID: 1592352
Description: Predicted to be a structural constituent of chromatin. Predicted to be involved in heterochromatin formation. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human H2AZ2 (H2A.Z variant histone 2).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: H2A histone family, member V-like; histone H2A.V-like; LOC689408; similar to H2A histone family, member V isoform 1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8690,058,040 - 90,058,522 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl690,058,081 - 90,058,519 (+)EnsemblGRCr8
mRatBN7.2684,321,801 - 84,322,513 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl684,321,903 - 84,322,289 (+)EnsemblmRatBN7.2
Rnor_6.0688,013,857 - 88,014,500 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl688,013,879 - 88,014,265 (+)Ensemblrn6Rnor6.0
Rnor_5.0697,496,024 - 97,496,667 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4687,661,358 - 87,661,744 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera682,870,573 - 82,871,216 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
nucleosome  (IBA,IEA)
nucleus  (IBA,IEA)

Molecular Function

References

Genomics

Variants

.
Variants in H2az2l2
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:129
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000040085
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 4 10 37 33 34 14 15 14 4 81 36 1 29 21 24 20 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000040085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl690,058,081 - 90,058,519 (+)Ensembl
mRatBN7.2 Ensembl684,321,903 - 84,322,289 (+)Ensembl
Rnor_6.0 Ensembl688,013,879 - 88,014,265 (+)Ensembl
RefSeq Acc Id: XM_001070681   ⟹   XP_001070681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8690,058,040 - 90,058,522 (+)NCBI
mRatBN7.2684,321,801 - 84,322,513 (+)NCBI
Rnor_6.0688,013,857 - 88,014,500 (+)NCBI
Rnor_5.0697,496,024 - 97,496,667 (+)NCBI
RGSC_v3.4687,661,358 - 87,661,744 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_001070681 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013919
  ENSRNOP00000084538
  ENSRNOP00000084538.1
RefSeq Acc Id: XP_001070681   ⟸   XM_001070681
- UniProtKB: A0A8I5ZZV2 (UniProtKB/TrEMBL),   A0A0A0MXW3 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Histone H2A C-terminal   Histone H2A/H2B/H3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592352 AgrOrtholog
BioCyc Gene G2FUF-37303 BioCyc
Ensembl Genes ENSRNOG00000010306 UniProtKB/TrEMBL
  ENSRNOG00000038771 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013919 UniProtKB/TrEMBL
  ENSRNOT00000040085 ENTREZGENE
  ENSRNOT00000040085.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL
InterPro Histone-fold UniProtKB/TrEMBL
  Histone_H2A UniProtKB/TrEMBL
  Histone_H2A/H2B/H3 UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/TrEMBL
  Histone_H2A_CS UniProtKB/TrEMBL
KEGG Report rno:689408 UniProtKB/TrEMBL
NCBI Gene 689408 ENTREZGENE
PANTHER PTHR23430 UniProtKB/TrEMBL
Pfam Histone UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/TrEMBL
PhenoGen H2az2l2 PhenoGen
PRINTS HISTONEH2A UniProtKB/TrEMBL
PROSITE HISTONE_H2A UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010306 RatGTEx
  ENSRNOG00000038771 RatGTEx
SMART H2A UniProtKB/TrEMBL
Superfamily-SCOP SSF47113 UniProtKB/TrEMBL
UniProt A0A0A0MXW3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZV2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 H2az2l2  H2A.Z histone variant 2 like 2  LOC689408  similar to H2A histone family, member V isoform 1  Symbol and Name Changed 1299863 APPROVED
2013-05-24 LOC689408  similar to H2A histone family, member V isoform 1  LOC100365693  H2A histone family, member V-like  Data merged from RGD:2318592 1643240 APPROVED
2010-05-05 LOC100365693  H2A histone family, member V-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC689408  similar to H2A histone family, member V isoform 1  LOC687799  similar to H2A histone family, member V isoform 1  Data merged from RGD:1597487 1643240 APPROVED
2006-11-20 LOC689408  similar to H2A histone family, member V isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC687799  similar to H2A histone family, member V isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL