Vom2r67 (vomeronasal 2 receptor, 67) - Rat Genome Database

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Gene: Vom2r67 (vomeronasal 2 receptor, 67) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Vom2r67
Name: vomeronasal 2 receptor, 67
RGD ID: 1592277
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane; INTERACTS WITH 6-propyl-2-thiouracil; amitrole; methimazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC689485; similar to vomeronasal 2, receptor, 1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814266,065 - 273,379 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl14266,066 - 273,379 (-)EnsemblGRCr8
mRatBN7.214251,096 - 258,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1174,992,461 - 174,997,330 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl14251,075 - 256,677 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx14268,918 - 276,227 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0141,570,694 - 1,578,000 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014267,369 - 274,683 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd14261,545 - 268,859 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive14260,464 - 267,768 (-)NCBILyon_Normotensive
Lyon_Hypertensive14259,423 - 266,736 (-)NCBILyon_Hypertensive
F344_StmMcwi14327,937 - 335,210 (-)NCBIF344_StmMcwi
Rnor_6.0141,318,061 - 1,323,644 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl141,318,157 - 1,323,644 (+)Ensemblrn6Rnor6.0
Rnor_5.0141,315,284 - 1,320,867 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414441,987 - 447,570 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera14511,803 - 517,386 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
Additional References at PubMed
PMID:17382427  


Genomics

Variants

.
Variants in Vom2r67
116 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:14
Count of miRNA genes:14
Interacting mature miRNAs:14
Transcripts:ENSRNOT00000061889
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat


Expression

RNA-SEQ Expression

appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 4 5 6 3 3 3 19 3 4 12 22 3

Sequence


Ensembl Acc Id: ENSRNOT00000041082   ⟹   ENSRNOP00000040299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1174,992,461 - 174,997,330 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000061889   ⟹   ENSRNOP00000058605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl14266,066 - 273,379 (-)Ensembl
mRatBN7.2 Ensembl14251,075 - 256,677 (-)Ensembl
Rnor_6.0 Ensembl141,318,157 - 1,323,644 (+)Ensembl
RefSeq Acc Id: NM_001099485   ⟹   NP_001092955
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814266,087 - 273,379 (-)NCBI
mRatBN7.214251,096 - 258,386 (-)NCBI
Dahl_SR_JrHsd14261,545 - 268,859 (-)NCBI
Lyon_Normotensive14260,464 - 267,768 (-)NCBI
Lyon_Hypertensive14259,423 - 266,736 (-)NCBI
F344_StmMcwi14327,937 - 335,210 (-)NCBI
Rnor_6.0141,318,061 - 1,323,644 (+)NCBI
Rnor_5.0141,315,284 - 1,320,867 (+)NCBI
RGSC_v3.414441,987 - 447,570 (-)RGD
Celera14511,803 - 517,386 (+)RGD
Sequence:
RefSeq Acc Id: XM_039092469   ⟹   XP_038948397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814266,065 - 273,379 (-)NCBI
mRatBN7.214251,096 - 258,386 (-)NCBI
RefSeq Acc Id: XM_039092473   ⟹   XP_038948401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814266,953 - 273,379 (-)NCBI
mRatBN7.214251,962 - 258,386 (-)NCBI
RefSeq Acc Id: XM_039092474   ⟹   XP_038948402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814266,953 - 273,379 (-)NCBI
mRatBN7.214251,962 - 258,386 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001092955 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948397 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948401 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948402 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058605
  ENSRNOP00000058605.5
RefSeq Acc Id: NP_001092955   ⟸   NM_001099485
- Peptide Label: precursor
- Sequence:
Ensembl Acc Id: ENSRNOP00000058605   ⟸   ENSRNOT00000061889
RefSeq Acc Id: XP_038948397   ⟸   XM_039092469
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948402   ⟸   XM_039092474
- Peptide Label: isoform X3
- UniProtKB: D4AA85 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948401   ⟸   XM_039092473
- Peptide Label: isoform X2
- UniProtKB: D4AA85 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000040299   ⟸   ENSRNOT00000041082

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQ04-F1-model_v2 AlphaFold D3ZQ04 1-647 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592277 AgrOrtholog
BioCyc Gene G2FUF-16711 BioCyc
Ensembl Genes ENSRNOG00000031928 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000069678 Ensembl
Ensembl Transcript ENSRNOT00000061889 ENTREZGENE
  ENSRNOT00000061889.6 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/TrEMBL
  GPCR_3_Ca_sens_rcpt-rel UniProtKB/TrEMBL
  GPCR_3_vmron_rcpt_2 UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
KEGG Report rno:689485 UniProtKB/TrEMBL
NCBI Gene 689485 ENTREZGENE
PANTHER PTHR24061 UniProtKB/TrEMBL
  VOMERONASAL 2, RECEPTOR 10-RELATED UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/TrEMBL
  ANF_receptor UniProtKB/TrEMBL
  NCD3G UniProtKB/TrEMBL
PhenoGen Vom2r67 PhenoGen
PRINTS VOMERONASL2R UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_4 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031928 RatGTEx
  ENSRNOG00000069678 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
UniProt D3ZQ04_RAT UniProtKB/TrEMBL
  D4AA85 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-23 Vom2r67  vomeronasal 2 receptor, 67  LOC689485  similar to vomeronasal 2, receptor, 1  Symbol and Name updated 1299863 APPROVED
2008-01-09 LOC689485  similar to vomeronasal 2, receptor, 1  LOC681856  similar to vomeronasal 2, receptor, 1  Data merged from RGD:1590506 1643240 APPROVED
2006-11-20 LOC689485  similar to vomeronasal 2, receptor, 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC681856  similar to vomeronasal 2, receptor, 1      Symbol and Name status set to provisional 70820 PROVISIONAL