Slc25a53 (solute carrier family 25, member 53) - Rat Genome Database

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Gene: Slc25a53 (solute carrier family 25, member 53) Rattus norvegicus
Analyze
Symbol: Slc25a53
Name: solute carrier family 25, member 53
RGD ID: 1591860
Description: Predicted to be located in membrane and mitochondrion. Orthologous to human SLC25A53 (solute carrier family 25 member 53); INTERACTS WITH bisphenol A; decabromodiphenyl ether; 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC679135; Mcart1l; MGC187490; mitochondrial carrier triple repeat 1-like; similar to mitochondrial carrier triple repeat 1; solute carrier family 25 member 53
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X105,099,191 - 105,111,936 (-)NCBIGRCr8
mRatBN7.2X100,306,917 - 100,319,662 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX100,306,915 - 100,319,863 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX102,437,076 - 102,449,701 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X105,935,748 - 105,948,373 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X103,504,923 - 103,517,548 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X107,622,504 - 107,632,594 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X107,500,505 - 107,512,866 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX101,134,275 - 101,146,918 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
mitochondrion  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Slc25a53
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X105,099,191 - 105,111,936 (-)NCBIGRCr8
mRatBN7.2X100,306,917 - 100,319,662 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX100,306,915 - 100,319,863 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX102,437,076 - 102,449,701 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X105,935,748 - 105,948,373 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X103,504,923 - 103,517,548 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X107,622,504 - 107,632,594 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X107,500,505 - 107,512,866 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX101,134,275 - 101,146,918 (-)NCBICelera
Cytogenetic MapXq32NCBI
SLC25A53
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X104,099,214 - 104,157,009 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX104,099,214 - 104,157,009 (-)EnsemblGRCh38hg38GRCh38
GRCh37X103,343,898 - 103,401,690 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X103,230,554 - 103,288,364 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX103,818,515 - 103,876,331 (-)NCBICelera
Cytogenetic MapXq22.2NCBI
HuRefX92,971,723 - 93,029,129 (-)NCBIHuRef
CHM1_1X103,254,803 - 103,312,570 (-)NCBICHM1_1
T2T-CHM13v2.0X102,530,406 - 102,588,209 (-)NCBIT2T-CHM13v2.0
Slc25a53
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X135,881,865 - 135,939,051 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX135,881,865 - 135,939,051 (-)EnsemblGRCm39 Ensembl
GRCm38X136,981,116 - 137,038,302 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX136,981,116 - 137,038,302 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X133,515,655 - 133,572,841 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X133,515,655 - 133,572,839 (-)NCBIMGSCv36mm8
CeleraX120,253,064 - 120,323,158 (-)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX59.1NCBI
Slc25a53
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955548947,623 - 1,003,086 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955548947,623 - 1,008,085 (-)NCBIChiLan1.0ChiLan1.0
SLC25A53
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X103,605,854 - 103,619,204 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X103,609,455 - 103,622,805 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X93,227,050 - 93,236,451 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X103,604,254 - 103,615,067 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX103,606,996 - 103,607,919 (-)Ensemblpanpan1.1panPan2
SLC25A53
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X77,444,715 - 77,454,682 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX77,446,280 - 77,447,632 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX63,640,405 - 63,650,597 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X79,062,963 - 79,073,157 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X76,547,117 - 76,557,310 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X78,250,004 - 78,260,197 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X77,982,593 - 77,992,788 (-)NCBIUU_Cfam_GSD_1.0
Slc25a53
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X77,352,379 - 77,363,487 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649910,294,491 - 10,306,003 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC25A53
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX84,861,739 - 84,871,871 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X84,860,180 - 84,871,866 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X98,820,738 - 98,830,864 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC25A53
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X91,813,263 - 91,815,931 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606516,893,765 - 16,904,530 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc25a53
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480313,031,732 - 13,039,898 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480313,031,644 - 13,040,152 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc25a53
27 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat

Markers in Region
AI448995  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,307,065 - 100,307,195 (+)MAPPERmRatBN7.2
Rnor_6.0X107,622,653 - 107,622,782NCBIRnor6.0
Rnor_5.0X107,500,654 - 107,500,783UniSTSRnor5.0
CeleraX101,134,424 - 101,134,553UniSTS
RH140002  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,307,071 - 100,307,278 (+)MAPPERmRatBN7.2
Rnor_6.0X107,622,659 - 107,622,865NCBIRnor6.0
Rnor_5.0X107,500,660 - 107,500,866UniSTSRnor5.0
CeleraX101,134,430 - 101,134,636UniSTS
MCART6  
Rat AssemblyChrPosition (strand)SourceJBrowse
CeleraX101,136,486 - 101,136,653UniSTS
UniSTS:238086  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,321,902 - 100,322,179 (+)MAPPERmRatBN7.2
Rnor_6.0X107,634,970 - 107,635,246NCBIRnor6.0
Rnor_5.0X107,514,540 - 107,514,816UniSTSRnor5.0
CeleraX101,149,279 - 101,149,555UniSTS
UniSTS:479053  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,321,479 - 100,322,108 (+)MAPPERmRatBN7.2
Rnor_6.0X107,634,547 - 107,635,175NCBIRnor6.0
Rnor_5.0X107,514,117 - 107,514,745UniSTSRnor5.0
CeleraX101,148,856 - 101,149,484UniSTS


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000093992   ⟹   ENSRNOP00000092509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX100,306,917 - 100,316,341 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094538   ⟹   ENSRNOP00000095987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX100,306,917 - 100,319,863 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095393   ⟹   ENSRNOP00000095181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX100,306,921 - 100,319,542 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118966   ⟹   ENSRNOP00000084805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX100,306,915 - 100,319,863 (-)Ensembl
RefSeq Acc Id: NM_001127602   ⟹   NP_001121074
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X105,099,191 - 105,111,936 (-)NCBI
mRatBN7.2X100,306,917 - 100,319,662 (-)NCBI
Rnor_6.0X107,622,504 - 107,632,594 (-)NCBI
Rnor_5.0X107,500,505 - 107,512,866 (-)NCBI
CeleraX101,134,275 - 101,146,918 (-)RGD
Sequence:
RefSeq Acc Id: NM_001419570   ⟹   NP_001406499
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X105,099,191 - 105,111,936 (-)NCBI
mRatBN7.2X100,306,917 - 100,319,662 (-)NCBI
RefSeq Acc Id: XM_039100049   ⟹   XP_038955977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X105,099,191 - 105,111,820 (-)NCBI
mRatBN7.2X100,306,917 - 100,319,546 (-)NCBI
RefSeq Acc Id: NP_001121074   ⟸   NM_001127602
- UniProtKB: B2GUW8 (UniProtKB/TrEMBL),   A6KNU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038955977   ⟸   XM_039100049
- Peptide Label: isoform X1
- UniProtKB: B2GUW8 (UniProtKB/TrEMBL),   A6KNU8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092509   ⟸   ENSRNOT00000093992
RefSeq Acc Id: ENSRNOP00000084805   ⟸   ENSRNOT00000118966
RefSeq Acc Id: ENSRNOP00000095987   ⟸   ENSRNOT00000094538
RefSeq Acc Id: ENSRNOP00000095181   ⟸   ENSRNOT00000095393
RefSeq Acc Id: NP_001406499   ⟸   NM_001419570
- UniProtKB: B2GUW8 (UniProtKB/TrEMBL),   A6KNU8 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591860 AgrOrtholog
BioCyc Gene G2FUF-1601 BioCyc
Ensembl Genes ENSRNOG00000069699 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000093992.1 UniProtKB/TrEMBL
  ENSRNOT00000094538 ENTREZGENE
  ENSRNOT00000094538.1 UniProtKB/TrEMBL
  ENSRNOT00000095393 ENTREZGENE
  ENSRNOT00000095393.1 UniProtKB/TrEMBL
  ENSRNOT00000118966 ENTREZGENE
  ENSRNOT00000118966.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7383238 IMAGE-MGC_LOAD
InterPro Mitochondrial_sb/sol_carrier UniProtKB/TrEMBL
  Mt_carrier_dom UniProtKB/TrEMBL
KEGG Report rno:679135 UniProtKB/TrEMBL
MGC_CLONE MGC:187490 IMAGE-MGC_LOAD
NCBI Gene 679135 ENTREZGENE
PANTHER SD08549P UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 25 MEMBER 53 UniProtKB/TrEMBL
Pfam Mito_carr UniProtKB/TrEMBL
PhenoGen Slc25a53 PhenoGen
PROSITE SOLCAR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000069699 RatGTEx
Superfamily-SCOP Mitoch_carrier UniProtKB/TrEMBL
UniProt A6KNU8 ENTREZGENE, UniProtKB/TrEMBL
  B2GUW8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-08-15 Slc25a53  solute carrier family 25, member 53  Mcart1l  mitochondrial carrier triple repeat 1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-05 Mcart1l  mitochondrial carrier triple repeat 1-like  LOC679135  similar to mitochondrial carrier triple repeat 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC679135  similar to mitochondrial carrier triple repeat 1      Symbol and Name status set to provisional 70820 PROVISIONAL