Cldn34e (claudin 34E) - Rat Genome Database

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Gene: Cldn34e (claudin 34E) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cldn34e
Name: claudin 34E
RGD ID: 1591711
Description: Predicted to enable structural molecule activity. Predicted to be located in membrane. Predicted to be active in bicellular tight junction and plasma membrane. Orthologous to human CLDN34 (claudin 34); INTERACTS WITH bisphenol A; trichloroethene; vinclozolin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC680489; LOC680489; similar to claudin 1; uncharacterized protein LOC680489
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X45,620,496 - 45,627,344 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX45,620,496 - 45,627,344 (-)EnsemblGRCr8
mRatBN7.2X41,742,084 - 41,748,930 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX41,742,297 - 41,742,935 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX43,031,664 - 43,032,302 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X46,499,025 - 46,499,663 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X44,163,754 - 44,164,392 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X44,999,482 - 45,006,621 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX44,999,725 - 45,000,363 (-)Ensemblrn6Rnor6.0
Rnor_5.0X45,297,488 - 45,308,594 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X63,403,708 - 63,404,346 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX42,398,669 - 42,399,307 (-)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline

Genomics

Variants

.
Variants in Cldn34e
65 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:20
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000035538
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X4493088389930883Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 2 13 110 17 19 3 17 3 3 71 36 1 107 23 53 16 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000035538   ⟹   ENSRNOP00000035284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX45,620,496 - 45,627,344 (-)Ensembl
mRatBN7.2 EnsemblX41,742,297 - 41,742,935 (-)Ensembl
Rnor_6.0 EnsemblX44,999,725 - 45,000,363 (-)Ensembl
RefSeq Acc Id: NM_001109415   ⟹   NP_001102885
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X45,620,496 - 45,627,344 (-)NCBI
mRatBN7.2X41,742,084 - 41,748,930 (-)NCBI
Rnor_6.0X44,999,725 - 45,000,363 (-)NCBI
Rnor_5.0X45,297,488 - 45,308,594 (-)NCBI
RGSC_v3.4X63,403,708 - 63,404,346 (-)RGD
CeleraX42,398,669 - 42,399,307 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102885 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96085 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035284
  ENSRNOP00000035284.2
RefSeq Acc Id: NP_001102885   ⟸   NM_001109415
- UniProtKB: D4A2S9 (UniProtKB/TrEMBL),   A6IPS8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035284   ⟸   ENSRNOT00000035538

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2S9-F1-model_v2 AlphaFold D4A2S9 1-212 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591711 AgrOrtholog
BioCyc Gene G2FUF-2413 BioCyc
Ensembl Genes ENSRNOG00000026351 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035538 ENTREZGENE
  ENSRNOT00000035538.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.150 UniProtKB/TrEMBL
InterPro Claudin UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/TrEMBL
KEGG Report rno:680489 UniProtKB/TrEMBL
NCBI Gene 680489 ENTREZGENE
PANTHER Claudin UniProtKB/TrEMBL
Pfam Claudin_2 UniProtKB/TrEMBL
PhenoGen Cldn34e PhenoGen
RatGTEx ENSRNOG00000026351 RatGTEx
UniProt A6IPS8 ENTREZGENE, UniProtKB/TrEMBL
  D4A2S9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-28 Cldn34e  claudin 34E  LOC680489  similar to claudin 1  Name and Symbol changed 629549 APPROVED
2008-01-09 LOC680489  similar to claudin 1  LOC681674  similar to claudin 1  Data merged from RGD:1592865 1643240 APPROVED
2006-11-20 LOC680489  similar to claudin 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC681674  similar to claudin 1      Symbol and Name status set to provisional 70820 PROVISIONAL