Mia3 (MIA SH3 domain ER export factor 3) - Rat Genome Database

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Gene: Mia3 (MIA SH3 domain ER export factor 3) Rattus norvegicus
Analyze
Symbol: Mia3
Name: MIA SH3 domain ER export factor 3
RGD ID: 1591600
Description: Predicted to enable cargo receptor activity. Predicted to be involved in several processes, including COPII-coated vesicle cargo loading; cell migration involved in sprouting angiogenesis; and regulation of leukocyte migration. Predicted to act upstream of or within chondrocyte development; collagen fibril organization; and positive regulation of bone mineralization. Predicted to be located in endoplasmic reticulum exit site and endoplasmic reticulum membrane. Orthologous to human MIA3 (MIA SH3 domain ER export factor 3); INTERACTS WITH 17beta-estradiol; bisphenol A; diuron.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC683007; melanoma inhibitory activity family, member 3; melanoma inhibitory activity protein 3; MIA family member 3, ER export factor; similar to melanoma inhibitory activity 3; transport and Golgi organization protein 1 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81397,502,040 - 97,547,155 (-)NCBIGRCr8
mRatBN7.21394,970,421 - 95,012,071 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,970,424 - 95,011,972 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1397,475,789 - 97,517,336 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01398,875,598 - 98,917,143 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01396,057,744 - 96,099,289 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013101,727,434 - 101,770,127 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13101,727,935 - 101,761,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013100,935,910 - 100,975,638 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1394,497,011 - 94,538,361 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17044017   PMID:17726152   PMID:19269366   PMID:19946888   PMID:21525241   PMID:21606205   PMID:25202031   PMID:27138255   PMID:28341552   PMID:28442536   PMID:31904090  


Genomics

Comparative Map Data
Mia3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81397,502,040 - 97,547,155 (-)NCBIGRCr8
mRatBN7.21394,970,421 - 95,012,071 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,970,424 - 95,011,972 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1397,475,789 - 97,517,336 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01398,875,598 - 98,917,143 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01396,057,744 - 96,099,289 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013101,727,434 - 101,770,127 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13101,727,935 - 101,761,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013100,935,910 - 100,975,638 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1394,497,011 - 94,538,361 (-)NCBICelera
Cytogenetic Map13q26NCBI
MIA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381222,618,097 - 222,668,007 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1222,618,097 - 222,668,007 (+)EnsemblGRCh38hg38GRCh38
GRCh371222,791,439 - 222,841,349 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361220,858,067 - 220,907,974 (+)NCBINCBI36Build 36hg18NCBI36
Celera1196,010,506 - 196,060,426 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1193,465,425 - 193,515,349 (+)NCBIHuRef
CHM1_11224,063,933 - 224,113,866 (+)NCBICHM1_1
T2T-CHM13v2.01221,851,826 - 221,901,751 (+)NCBIT2T-CHM13v2.0
Mia3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,107,091 - 183,151,091 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,107,682 - 183,150,894 (-)EnsemblGRCm39 Ensembl
GRCm381183,326,236 - 183,369,565 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,326,725 - 183,369,553 (-)EnsemblGRCm38mm10GRCm38
Celera1190,326,494 - 190,370,357 (-)NCBICelera
Cytogenetic Map1H5NCBI
Mia3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555201,850,942 - 1,890,390 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555201,853,145 - 1,890,338 (-)NCBIChiLan1.0ChiLan1.0
MIA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2126,654,962 - 26,708,563 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1126,608,370 - 26,662,214 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01198,291,200 - 198,339,502 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11203,307,949 - 203,354,919 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1203,304,237 - 203,354,919 (+)Ensemblpanpan1.1panPan2
MIA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13816,880,411 - 16,936,368 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3816,879,740 - 16,935,844 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3816,935,124 - 16,992,958 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03816,925,143 - 16,982,995 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3816,904,493 - 16,983,727 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13816,930,566 - 16,988,381 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03817,280,373 - 17,337,228 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03817,574,654 - 17,632,475 (+)NCBIUU_Cfam_GSD_1.0
MIA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1011,377,846 - 11,429,015 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11011,362,489 - 11,428,844 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21013,549,341 - 13,583,336 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MIA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,901,891 - 6,954,556 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl256,902,425 - 6,954,526 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660557,140,156 - 7,193,188 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Mia3
195 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
AW526955  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21394,973,102 - 94,973,265 (+)MAPPERmRatBN7.2
Rnor_6.013101,730,115 - 101,730,277NCBIRnor6.0
Rnor_5.013100,938,591 - 100,938,753UniSTSRnor5.0
Celera1394,499,692 - 94,499,854UniSTS
RH 3.4 Map13650.7UniSTS
RH142097  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21394,970,701 - 94,970,911 (+)MAPPERmRatBN7.2
Rnor_6.013101,727,714 - 101,727,923NCBIRnor6.0
Rnor_5.013100,936,190 - 100,936,399UniSTSRnor5.0
Celera1394,497,291 - 94,497,500UniSTS
RH 3.4 Map13651.7UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 41 11 8
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000080170   ⟹   ENSRNOP00000071370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,970,684 - 94,988,012 (-)Ensembl
Rnor_6.0 Ensembl13101,727,935 - 101,748,098 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085600   ⟹   ENSRNOP00000069539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,970,424 - 95,011,972 (-)Ensembl
Rnor_6.0 Ensembl13101,727,935 - 101,761,541 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099629   ⟹   ENSRNOP00000087321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,970,424 - 95,011,972 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113437   ⟹   ENSRNOP00000093846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,970,684 - 95,011,972 (-)Ensembl
RefSeq Acc Id: NM_001398684   ⟹   NP_001385613
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,502,040 - 97,543,587 (-)NCBI
mRatBN7.21394,970,424 - 95,011,975 (-)NCBI
RefSeq Acc Id: NM_001398698   ⟹   NP_001385627
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,502,040 - 97,519,619 (-)NCBI
mRatBN7.21394,970,424 - 94,988,005 (-)NCBI
RefSeq Acc Id: XM_039091493   ⟹   XP_038947421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,502,040 - 97,547,155 (-)NCBI
mRatBN7.21394,970,421 - 95,012,071 (-)NCBI
RefSeq Acc Id: XM_063272603   ⟹   XP_063128673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,502,040 - 97,519,686 (-)NCBI
RefSeq Acc Id: XM_063272604   ⟹   XP_063128674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,502,040 - 97,519,686 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000071370   ⟸   ENSRNOT00000080170
RefSeq Acc Id: ENSRNOP00000069539   ⟸   ENSRNOT00000085600
RefSeq Acc Id: XP_038947421   ⟸   XM_039091493
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AGK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000087321   ⟸   ENSRNOT00000099629
RefSeq Acc Id: ENSRNOP00000093846   ⟸   ENSRNOT00000113437
RefSeq Acc Id: NP_001385613   ⟸   NM_001398684
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A0G2JVM2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385627   ⟸   NM_001398698
- Peptide Label: isoform 2
RefSeq Acc Id: XP_063128673   ⟸   XM_063272603
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063128674   ⟸   XM_063272604
- Peptide Label: isoform X3
Protein Domains
SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVM2-F1-model_v2 AlphaFold A0A0G2JVM2 1-1377 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591600 AgrOrtholog
BioCyc Gene G2FUF-17036 BioCyc
Ensembl Genes ENSRNOG00000059202 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080170 ENTREZGENE
  ENSRNOT00000080170.2 UniProtKB/TrEMBL
  ENSRNOT00000085600 ENTREZGENE
  ENSRNOT00000085600.2 UniProtKB/TrEMBL
  ENSRNOT00000099629.1 UniProtKB/TrEMBL
  ENSRNOT00000113437.1 UniProtKB/TrEMBL
Gene3D-CATH SH3 Domains UniProtKB/TrEMBL
InterPro SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene 683007 ENTREZGENE
PANTHER MELANOMA INHIBITORY ACTIVITY-RELATED UniProtKB/TrEMBL
  TRANSPORT AND GOLGI ORGANIZATION PROTEIN 1 HOMOLOG UniProtKB/TrEMBL
Pfam SH3_2 UniProtKB/TrEMBL
PhenoGen Mia3 PhenoGen
PROSITE SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059202 RatGTEx
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
UniProt A0A0G2JVM2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K0A8_RAT UniProtKB/TrEMBL
  A0A8I6A7R3_RAT UniProtKB/TrEMBL
  A0A8I6AGK4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Mia3  MIA SH3 domain ER export factor 3  Mia3  MIA family member 3, ER export factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-29 Mia3  MIA family member 3, ER export factor  Mia3  melanoma inhibitory activity family, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-13 Mia3  melanoma inhibitory activity family, member 3  LOC683007  similar to melanoma inhibitory activity 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC683007  similar to melanoma inhibitory activity 3      Symbol and Name status set to provisional 70820 PROVISIONAL