Gstt4 (glutathione S-transferase, theta 4) - Rat Genome Database

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Gene: Gstt4 (glutathione S-transferase, theta 4) Rattus norvegicus
Analyze
Symbol: Gstt4
Name: glutathione S-transferase, theta 4
RGD ID: 1591294
Description: Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm. Orthologous to human GSTT4 (glutathione S-transferase theta 4); INTERACTS WITH 1,2-dimethylhydrazine; bisphenol A; oxybenzone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione S-transferase theta-4; GST class-theta-4; LOC103694880; LOC686922; similar to Glutathione S-transferase theta-1 (GST class-theta-1) (Glutathione transferase T1-1); uncharacterized LOC103694880
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,834,613 - 12,841,730 (+)NCBIGRCr8
mRatBN7.22012,835,178 - 12,842,306 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,835,178 - 12,842,292 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,541,554 - 13,548,873 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,902,481 - 12,909,800 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,374,423 - 13,381,746 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,778,185 - 13,784,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,778,178 - 13,784,827 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,968,093 - 15,975,083 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,238,379 - 13,239,777 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2014,326,728 - 14,333,740 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Gstt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,834,613 - 12,841,730 (+)NCBIGRCr8
mRatBN7.22012,835,178 - 12,842,306 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,835,178 - 12,842,292 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,541,554 - 13,548,873 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,902,481 - 12,909,800 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,374,423 - 13,381,746 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,778,185 - 13,784,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,778,178 - 13,784,827 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,968,093 - 15,975,083 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,238,379 - 13,239,777 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2014,326,728 - 14,333,740 (+)NCBICelera
Cytogenetic Map20p12NCBI
GSTT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,989,115 - 24,005,453 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,998,401 - 24,005,453 (-)EnsemblGRCh38hg38GRCh38
GRCh372224,340,595 - 24,347,350 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,670,595 - 22,677,258 (-)NCBINCBI36Build 36hg18NCBI36
Celera228,141,156 - 8,147,155 (-)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,288,707 - 7,295,363 (-)NCBIHuRef
CHM1_12224,353,110 - 24,360,070 (-)NCBICHM1_1
T2T-CHM13v2.02224,405,779 - 24,412,527 (-)NCBIT2T-CHM13v2.0
Gstt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,650,777 - 75,658,405 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,650,777 - 75,658,377 (-)EnsemblGRCm39 Ensembl
GRCm381075,814,943 - 75,822,566 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,814,943 - 75,822,543 (-)EnsemblGRCm38mm10GRCm38
MGSCv371075,277,688 - 75,285,288 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,258,662 - 75,266,236 (-)NCBIMGSCv36mm8
Celera1076,859,618 - 76,867,219 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.58NCBI
LOC486404
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,553,498 - 28,564,505 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,626,825 - 27,637,840 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02629,959,598 - 29,970,333 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12628,040,792 - 28,052,080 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,657,366 - 27,668,529 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,647,138 - 28,658,218 (-)NCBIUU_Cfam_GSD_1.0
LOC100151901
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,812,019 - 49,819,248 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,812,009 - 49,819,028 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,254,244 - 53,261,383 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Gstt4
81 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:84
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000058314
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 7
Low 4 7 5 9 4
Below cutoff 2 2 6 2 6 2 3 3 11 14 5 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000058314   ⟹   ENSRNOP00000055115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,835,178 - 12,842,292 (+)Ensembl
Rnor_6.0 Ensembl2013,778,178 - 13,784,827 (+)Ensembl
RefSeq Acc Id: NM_001109675   ⟹   NP_001103145
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,834,613 - 12,841,730 (+)NCBI
mRatBN7.22012,835,178 - 12,842,292 (+)NCBI
Rnor_6.02013,778,185 - 13,784,813 (+)NCBI
Rnor_5.02015,968,093 - 15,975,083 (+)NCBI
RGSC_v3.42013,238,379 - 13,239,777 (+)RGD
Celera2014,326,728 - 14,333,740 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001103145 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97423 (Get FASTA)   NCBI Sequence Viewer  
  EDL97183 (Get FASTA)   NCBI Sequence Viewer  
  EDL97184 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000055115
  ENSRNOP00000055115.3
  ENSRNOP00055029094
  ENSRNOP00060023881
  ENSRNOP00065035254
GenBank Protein Q4V8E6 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001103145   ⟸   NM_001109675
- UniProtKB: Q4V8E6 (UniProtKB/Swiss-Prot),   A6JKG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000055115   ⟸   ENSRNOT00000058314
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8E6-F1-model_v2 AlphaFold Q4V8E6 1-240 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701533
Promoter ID:EPDNEW_R12057
Type:initiation region
Name:Gstt4_1
Description:glutathione S-transferase, theta 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,778,184 - 13,778,244EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591294 AgrOrtholog
BioCyc Gene G2FUF-4160 BioCyc
Ensembl Genes ENSRNOG00000038300 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055020987 UniProtKB/Swiss-Prot
  ENSRNOG00060017367 UniProtKB/Swiss-Prot
  ENSRNOG00065025034 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000058314 ENTREZGENE
  ENSRNOT00000058314.5 UniProtKB/Swiss-Prot
  ENSRNOT00055035837 UniProtKB/Swiss-Prot
  ENSRNOT00060029664 UniProtKB/Swiss-Prot
  ENSRNOT00065043055 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7455039 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C_Theta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N_Theta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:686922 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114470 IMAGE-MGC_LOAD
NCBI Gene 686922 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE THETA-4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43917 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gstt4 PhenoGen
PROSITE GST_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038300 RatGTEx
  ENSRNOG00055020987 RatGTEx
  ENSRNOG00060017367 RatGTEx
  ENSRNOG00065025034 RatGTEx
Superfamily-SCOP GST C-terminal domain-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JKG7 ENTREZGENE, UniProtKB/TrEMBL
  A6JKG8_RAT UniProtKB/TrEMBL
  GSTT4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gstt4  glutathione S-transferase, theta 4  LOC103694880  uncharacterized LOC103694880  Data merged from RGD:9452289 737654 PROVISIONAL
2014-08-25 LOC103694880  uncharacterized LOC103694880      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-11-30 Gstt4  glutathione S-transferase, theta 4  LOC686922  similar to Glutathione S-transferase theta-1 (GST class-theta-1) (Glutathione transferase T1-1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC686922  similar to Glutathione S-transferase theta-1 (GST class-theta-1) (Glutathione transferase T1-1)      Symbol and Name status set to provisional 70820 PROVISIONAL