Marchf4 (membrane associated ring-CH-type finger 4) - Rat Genome Database

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Gene: Marchf4 (membrane associated ring-CH-type finger 4) Rattus norvegicus
Analyze
Symbol: Marchf4
Name: membrane associated ring-CH-type finger 4
RGD ID: 1590797
Description: Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in Golgi membrane. Predicted to be active in Golgi stack and trans-Golgi network. Orthologous to human MARCHF4 (membrane associated ring-CH-type finger 4); INTERACTS WITH 6-propyl-2-thiouracil; endosulfan; 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase MARCH4; E3 ubiquitin-protein ligase MARCHF4; LOC367295; March4; membrane-associated ring finger (C3HC4) 4; membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase; similar to Membrane-associated RING finger protein 4 (Membrane-associated RING-CH protein IV) (MARCH-IV)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8981,527,703 - 81,647,448 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl981,527,703 - 81,647,448 (-)EnsemblGRCr8
mRatBN7.2974,078,437 - 74,196,070 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl974,078,434 - 74,198,199 (-)EnsemblmRatBN7.2
Rnor_6.0979,781,752 - 79,898,726 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl979,782,845 - 79,898,912 (-)Ensemblrn6Rnor6.0
Rnor_5.0979,554,293 - 79,670,966 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4971,617,505 - 71,735,985 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera971,473,921 - 71,591,034 (-)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Golgi membrane  (IEA)
Golgi stack  (IBA,IEA,ISO)
trans-Golgi network  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14722266  


Genomics

Comparative Map Data
Marchf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8981,527,703 - 81,647,448 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl981,527,703 - 81,647,448 (-)EnsemblGRCr8
mRatBN7.2974,078,437 - 74,196,070 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl974,078,434 - 74,198,199 (-)EnsemblmRatBN7.2
Rnor_6.0979,781,752 - 79,898,726 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl979,782,845 - 79,898,912 (-)Ensemblrn6Rnor6.0
Rnor_5.0979,554,293 - 79,670,966 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4971,617,505 - 71,735,985 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera971,473,921 - 71,591,034 (-)NCBICelera
Cytogenetic Map9q33NCBI
MARCHF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382216,257,865 - 216,372,483 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2216,257,865 - 216,372,483 (-)Ensemblhg38GRCh38
GRCh372217,122,588 - 217,237,206 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362216,830,834 - 216,944,995 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342216,948,094 - 217,062,256NCBI
Celera2210,889,243 - 211,003,395 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2208,976,394 - 209,090,552 (-)NCBIHuRef
CHM1_12217,128,106 - 217,242,266 (-)NCBICHM1_1
T2T-CHM13v2.02216,740,406 - 216,854,601 (-)NCBIT2T-CHM13v2.0
Marchf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39172,466,271 - 72,576,454 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl172,466,271 - 72,576,089 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38172,427,112 - 72,537,159 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl172,427,112 - 72,536,930 (-)Ensemblmm10GRCm38
MGSCv37172,473,686 - 72,583,138 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36172,360,322 - 72,470,499 (-)NCBIMGSCv36mm8
Celera172,999,270 - 73,104,429 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.54NCBI
Marchf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545316,820,344 - 16,933,152 (+)Ensembl
ChiLan1.0NW_00495545316,820,344 - 16,933,106 (+)NCBIChiLan1.0ChiLan1.0
MARCHF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213118,884,516 - 118,998,758 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B118,899,480 - 119,013,727 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B103,517,175 - 103,632,197 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B222,121,032 - 222,235,291 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B222,121,032 - 222,235,548 (-)EnsemblpanPan2panpan1.1
MARCHF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13723,218,664 - 23,330,115 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3723,220,458 - 23,330,077 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3724,047,570 - 24,161,054 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03723,245,433 - 23,359,713 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3723,245,431 - 23,357,446 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13723,130,632 - 23,244,121 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03723,083,496 - 23,196,876 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03723,101,072 - 23,215,243 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Marchf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303171,599,517 - 171,701,771 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936586925,192 - 1,029,578 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936586923,254 - 1,026,340 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARCHF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15118,480,239 - 118,587,549 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115118,480,243 - 118,587,548 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215131,361,322 - 131,466,904 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MARCHF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110102,099,296 - 102,213,263 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10102,099,150 - 102,211,499 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604097,188,351 - 97,300,419 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Marchf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248238,748,490 - 8,864,330 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248238,748,487 - 8,864,304 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Marchf4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14146,021,830 - 146,133,128 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Marchf4
657 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:106
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000022076
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
D9Mco17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,147,299 - 74,147,467 (+)MAPPERmRatBN7.2
Rnor_6.0979,850,565 - 79,850,732NCBIRnor6.0
Rnor_5.0979,622,779 - 79,622,946UniSTSRnor5.0
RGSC_v3.4971,685,354 - 71,685,521UniSTSRGSC3.4
Celera971,542,732 - 71,542,897UniSTS
Cytogenetic Map9q33UniSTS
D9Mco12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,130,336 - 74,130,511 (+)MAPPERmRatBN7.2
Rnor_6.0979,833,602 - 79,833,776NCBIRnor6.0
Rnor_5.0979,605,816 - 79,605,990UniSTSRnor5.0
RGSC_v3.4971,667,567 - 71,667,741UniSTSRGSC3.4
Celera971,525,771 - 71,525,945UniSTS
Cytogenetic Map9q33UniSTS
D9Mco13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,130,337 - 74,130,531 (+)MAPPERmRatBN7.2
Rnor_6.0979,833,603 - 79,833,796NCBIRnor6.0
Rnor_5.0979,605,817 - 79,606,010UniSTSRnor5.0
RGSC_v3.4971,667,568 - 71,667,761UniSTSRGSC3.4
Celera971,525,772 - 71,525,965UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 1 19 141 36 35 12 11 12 6 123 59 9 120 35 84 23 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000022076   ⟹   ENSRNOP00000022076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl981,527,703 - 81,647,448 (-)Ensembl
mRatBN7.2 Ensembl974,078,434 - 74,198,199 (-)Ensembl
Rnor_6.0 Ensembl979,782,845 - 79,898,912 (-)Ensembl
RefSeq Acc Id: NM_001427784   ⟹   NP_001414713
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8981,527,703 - 81,647,448 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414713 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022076
  ENSRNOP00000022076.4
Ensembl Acc Id: ENSRNOP00000022076   ⟸   ENSRNOT00000022076
RefSeq Acc Id: NP_001414713   ⟸   NM_001427784
- UniProtKB: D3ZNC9 (UniProtKB/TrEMBL)
Protein Domains
RING-CH-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZNC9-F1-model_v2 AlphaFold D3ZNC9 1-409 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590797 AgrOrtholog
BioCyc Gene G2FUF-27205 BioCyc
Ensembl Genes ENSRNOG00000016472 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022076 ENTREZGENE
  ENSRNOT00000022076.7 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro MARCHF4/9/11 UniProtKB/TrEMBL
  Znf_RING-CH UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene 367295 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE MARCHF4 UniProtKB/TrEMBL
  PTHR46053 UniProtKB/TrEMBL
Pfam RINGv UniProtKB/TrEMBL
PhenoGen Marchf4 PhenoGen
PROSITE ZF_RING_CH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016472 RatGTEx
SMART RINGv UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt D3ZNC9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Marchf4  membrane associated ring-CH-type finger 4  March4  membrane associated ring-CH-type finger 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-02 March4  membrane associated ring-CH-type finger 4  March4  membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-05 March4  membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase  March4  membrane-associated ring finger (C3HC4) 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 March4  membrane-associated ring finger (C3HC4) 4  LOC367295  similar to Membrane-associated RING finger protein 4 (Membrane-associated RING-CH protein IV) (MARCH-IV)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC367295  similar to Membrane-associated RING finger protein 4 (Membrane-associated RING-CH protein IV) (MARCH-IV)      Symbol and Name status set to provisional 70820 PROVISIONAL