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Gene: Crisp1 (cysteine-rich secretory protein 1) Rattus norvegicus

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Symbol:

Crisp1

Name:

cysteine-rich secretory protein 1

RGD ID:

1590757

Description:

Predicted to enable calcium channel regulator activity. Predicted to be involved in binding activity of sperm to zona pellucida. Predicted to act upstream of or within regulation of acrosome reaction. Predicted to be active in extracellular space. Orthologous to human CRISP1 (cysteine rich secretory protein 1); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Crisp4; cysteine-rich secretory protein 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CRISP1 (cysteine rich secretory protein 1)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, Treefam
Mus musculus (house mouse):	Crisp4 (cysteine-rich secretory protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CRISP1 (cysteine rich secretory protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CRISP1 (cysteine rich secretory protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Crisp1 (cysteine rich secretory protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CRISP1 (cysteine rich secretory protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CRISP1 (cysteine rich secretory protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CRISP1 (cysteine rich secretory protein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Crisp4 (cysteine-rich secretory protein 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PhylomeDB)
Caenorhabditis elegans (roundworm):	scl-13	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PhylomeDB)
Caenorhabditis elegans (roundworm):	scl-14	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PhylomeDB)
Caenorhabditis elegans (roundworm):	scl-5	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PhylomeDB)
Caenorhabditis elegans (roundworm):	scl-15	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PhylomeDB)
Caenorhabditis elegans (roundworm):	scl-10	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PhylomeDB)
Caenorhabditis elegans (roundworm):	scl-20	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PhylomeDB)
Caenorhabditis elegans (roundworm):	scl-6	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG16995	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	CG34049	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	CG4270	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	CG31286	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	CG32313	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	crisp1.6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	28,238,326 - 28,265,344 (-)	NCBI		GRCr8
mRatBN7.2	9	20,741,775 - 20,768,796 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	20,741,777 - 20,768,796 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	29,272,264 - 29,299,315 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	34,375,604 - 34,415,624 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	32,686,420 - 32,726,441 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	24,356,577 - 24,383,679 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	24,356,579 - 24,383,679 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	23,218,716 - 23,245,318 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	16,975,151 - 17,002,149 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	18,378,604 - 18,405,902 (-)	NCBI		Celera
Cytogenetic Map	9	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Crisp1	Rat	(-)-alpha-phellandrene	decreases expression	ISO	CRISP1 (Homo sapiens)	6480464	alpha phellandrene results in decreased expression of CRISP1 mRNA	CTD	PMID:25075043
Crisp1	Rat	1,2-dichloroethane	decreases expression	ISO	Crisp4 (Mus musculus)	6480464	ethylene dichloride results in decreased expression of CRISP4 mRNA	CTD	PMID:28960355
Crisp1	Rat	17beta-estradiol	multiple interactions	EXP		6480464	[bisphenol A co-treated with Estradiol] results in increased expression of CRISP1 mRNA	CTD	PMID:26496021
Crisp1	Rat	2,3',4,4',5-Pentachlorobiphenyl	increases expression	ISO	Crisp4 (Mus musculus)	6480464	2 more ...	CTD	PMID:31388691
Crisp1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	Crisp4 (Mus musculus)	6480464	Tetrachlorodibenzodioxin affects the expression of CRISP4 mRNA	CTD	PMID:21570461
Crisp1	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of CRISP1 mRNA	CTD	PMID:24780913
Crisp1	Rat	6-propyl-2-thiouracil	decreases expression	EXP		6480464	Propylthiouracil results in decreased expression of CRISP1 mRNA	CTD	PMID:30047161
Crisp1	Rat	acrylamide	increases expression	EXP		6480464	Acrylamide results in increased expression of CRISP1 mRNA	CTD	PMID:28959563
Crisp1	Rat	all-trans-retinoic acid	decreases expression	ISO	Crisp4 (Mus musculus)	6480464	Tretinoin results in decreased expression of CRISP1 mRNA	CTD	PMID:16604517
Crisp1	Rat	alpha-phellandrene	decreases expression	ISO	CRISP1 (Homo sapiens)	6480464	alpha phellandrene results in decreased expression of CRISP1 mRNA	CTD	PMID:25075043
Crisp1	Rat	amitrole	decreases expression	EXP		6480464	Amitrole results in decreased expression of CRISP1 mRNA	CTD	PMID:30047161
Crisp1	Rat	ammonium chloride	affects expression	EXP		6480464	Ammonium Chloride affects the expression of CRISP1 mRNA	CTD	PMID:16483693
Crisp1	Rat	benzo[a]pyrene	affects methylation	ISO	CRISP1 (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of CRISP1 5' UTR	CTD	PMID:27901495
Crisp1	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	Crisp4 (Mus musculus)	6480464	Diethylhexyl Phthalate results in decreased expression of CRISP1 mRNA and Diethylhexyl Phthalate results in decreased expression of CRISP4 mRNA	CTD	PMID:32235866 and PMID:34319233
Crisp1	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with Estradiol] results in increased expression of CRISP1 mRNA	CTD	PMID:26496021
Crisp1	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of CRISP1 mRNA	CTD	PMID:25181051
Crisp1	Rat	Butylbenzyl phthalate	decreases expression	ISO	Crisp4 (Mus musculus)	6480464	butylbenzyl phthalate results in decreased expression of CRISP1 mRNA	CTD	PMID:36756972
Crisp1	Rat	cadmium dichloride	decreases methylation	EXP		6480464	Cadmium Chloride results in decreased methylation of CRISP4 promoter	CTD	PMID:22457795
Crisp1	Rat	CGP 52608	multiple interactions	ISO	CRISP1 (Homo sapiens)	6480464	CGP 52608 promotes the reaction [RORA protein binds to CRISP1 gene]	CTD	PMID:28238834
Crisp1	Rat	chlordecone	increases expression	ISO	Crisp4 (Mus musculus)	6480464	Chlordecone results in increased expression of CRISP1 mRNA	CTD	PMID:33711761
Crisp1	Rat	ciguatoxin CTX1B	affects expression	ISO	Crisp4 (Mus musculus)	6480464	Ciguatoxins affects the expression of CRISP4 mRNA	CTD	PMID:18353800
Crisp1	Rat	clotrimazole	decreases expression	EXP		6480464	Clotrimazole results in decreased expression of CRISP1 mRNA	CTD	PMID:30047161
Crisp1	Rat	decabromodiphenyl ether	increases expression	EXP		6480464	decabromobiphenyl ether results in increased expression of CRISP1 mRNA	CTD	PMID:23914054
Crisp1	Rat	delphinidin	increases expression	ISO	Crisp4 (Mus musculus)	6480464	delphinidin results in increased expression of CRISP1 mRNA	CTD	PMID:38291899
Crisp1	Rat	dexamethasone	decreases expression	EXP		6480464	Dexamethasone results in decreased expression of CRISP1 mRNA	CTD	PMID:20032058
Crisp1	Rat	dexamethasone	multiple interactions	EXP		6480464	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of CRISP1 mRNA]	CTD	PMID:20032058
Crisp1	Rat	dextran sulfate	decreases expression	ISO	Crisp4 (Mus musculus)	6480464	Dextran Sulfate results in decreased expression of CRISP1 protein	CTD	PMID:35999755
Crisp1	Rat	flurbiprofen	decreases expression	ISO	Crisp4 (Mus musculus)	6480464	Flurbiprofen results in decreased expression of CRISP1 mRNA	CTD	PMID:16949054
Crisp1	Rat	methimazole	decreases expression	EXP		6480464	Methimazole results in decreased expression of CRISP1 mRNA	CTD	PMID:30047161
Crisp1	Rat	paracetamol	affects expression	ISO	Crisp4 (Mus musculus)	6480464	Acetaminophen affects the expression of CRISP4 mRNA	CTD	PMID:17562736
Crisp1	Rat	phenethyl isothiocyanate	increases expression	EXP		6480464	phenethyl isothiocyanate results in increased expression of CRISP1 mRNA	CTD	PMID:17616710
Crisp1	Rat	quercitrin	decreases expression	ISO	CRISP1 (Homo sapiens)	6480464	quercitrin results in decreased expression of CRISP1 mRNA	CTD	PMID:25193878
Crisp1	Rat	serpentine asbestos	increases methylation	ISO	CRISP1 (Homo sapiens)	6480464	Asbestos and Serpentine results in increased methylation of CRISP1 5' UTR	CTD	PMID:29523930
Crisp1	Rat	sodium fluoride	increases expression	ISO	Crisp4 (Mus musculus)	6480464	Sodium Fluoride results in increased expression of CRISP1 protein	CTD	PMID:28918527
Crisp1	Rat	testosterone	multiple interactions	EXP		6480464	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of CRISP1 mRNA]	CTD	PMID:20032058
Crisp1	Rat	zinc atom	increases expression	ISO	Crisp4 (Mus musculus)	6480464	Zinc deficiency results in increased expression of CRISP1 mRNA	CTD	PMID:20857495
Crisp1	Rat	zinc(0)	increases expression	ISO	Crisp4 (Mus musculus)	6480464	Zinc deficiency results in increased expression of CRISP1 mRNA	CTD	PMID:20857495

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Crisp1	Rat	binding of sperm to zona pellucida	involved_in	IBA	MGI:1925331 and PANTHER:PTN000036190	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Crisp1	Rat	binding of sperm to zona pellucida	acts_upstream_of_or_within	ISO	Crisp4 (Mus musculus)	1624291	MGI:5431546 PMID:21865554	RGD	PMID:21865554
Crisp1	Rat	regulation of acrosome reaction	acts_upstream_of_or_within	ISO	Crisp4 (Mus musculus)	1624291	MGI:4950060 PMID:21482758	RGD	PMID:21482758
Crisp1	Rat	sexual reproduction	involved_in	IBA	FB:FBgn0031412 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Crisp1	Rat	extracellular space	is_active_in	IBA	FB:FBgn0250842 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Crisp1	Rat	calcium channel regulator activity	enables	ISO	Crisp4 (Mus musculus)	1624291	MGI:4950060 PMID:21482758	RGD	PMID:21482758

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:16467491	PMID:21482758	PMID:21630459	PMID:21865554

Crisp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	28,238,326 - 28,265,344 (-)	NCBI		GRCr8
mRatBN7.2	9	20,741,775 - 20,768,796 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	20,741,777 - 20,768,796 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	29,272,264 - 29,299,315 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	34,375,604 - 34,415,624 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	32,686,420 - 32,726,441 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	24,356,577 - 24,383,679 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	24,356,579 - 24,383,679 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	23,218,716 - 23,245,318 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	16,975,151 - 17,002,149 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	18,378,604 - 18,405,902 (-)	NCBI		Celera
Cytogenetic Map	9	q13	NCBI

CRISP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	49,834,257 - 49,877,096 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	49,834,257 - 49,877,096 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	49,801,970 - 49,844,809 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	49,909,929 - 49,942,177 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	6	51,358,053 - 51,390,301 (-)	NCBI		Celera
Cytogenetic Map	6	p12.3	NCBI
HuRef	6	49,532,400 - 49,575,243 (-)	NCBI		HuRef
CHM1_1	6	49,804,885 - 49,847,721 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	49,676,220 - 49,719,057 (-)	NCBI		T2T-CHM13v2.0

Crisp4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	18,185,113 - 18,216,126 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	18,185,415 - 18,216,126 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	18,114,889 - 18,145,902 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	18,115,191 - 18,145,902 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	18,105,272 - 18,127,132 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	18,100,405 - 18,122,265 (-)	NCBI		MGSCv36	mm8
Celera	1	18,019,226 - 18,041,066 (-)	NCBI		Celera
Cytogenetic Map	1	A3	NCBI
cM Map	1	5.65	NCBI

CRISP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	64,319,223 - 64,358,792 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	60,184,866 - 60,221,060 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	49,404,220 - 49,452,287 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	50,665,193 - 50,712,092 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	50,665,204 - 50,712,092 (-)	Ensembl	panpan1.1		panPan2

CRISP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	17,659,446 - 17,696,557 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	17,555,565 - 17,595,087 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	18,153,788 - 18,193,483 (-)	NCBI		ROS_Cfam_1.0
UNSW_CanFamBas_1.0	12	17,779,242 - 17,812,493 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	17,909,484 - 17,942,885 (-)	NCBI		UU_Cfam_GSD_1.0

Crisp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	53,207,268 - 53,230,604 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	10,729,610 - 10,752,933 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	10,729,598 - 10,753,000 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CRISP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	43,883,539 - 43,911,664 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	43,883,536 - 43,911,877 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	50,275,809 - 50,303,939 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CRISP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	22,539,467 - 22,581,428 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	22,551,309 - 22,579,116 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	49,798,950 - 49,845,592 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants in Crisp1
234 total Variants

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain	Variant Page
9	24373649	24373650	A	G	snv	CDS	View more Information
9	24373691	24373692	A	G	snv	CDS	View more Information

Predicted Target Of

	Summary Value
Count of predictions:	66
Count of miRNA genes:	51
Interacting mature miRNAs:	62
Transcripts:	ENSRNOT00000040542
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5109826	50109826	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	1254084	46254084	Rat
7411609	Foco16	Food consumption QTL 16	25.6	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	8952560	53952560	Rat
631680	Cm11	Cardiac mass QTL 11	3.1	0.00089	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	9	20430519	65430519	Rat
61450	Ciaa3	CIA Autoantibody QTL 3	6.5		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	9	7954720	22071169	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	1	37999212	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	1	43718459	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	1254084	46254084	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	40594091	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	5109826	42921101	Rat
70226	Eae4	Experimental allergic encephalomyelitis QTL 4			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	9	1	25661317	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	1	37999212	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
724543	Cm20	Cardiac mass QTL 20	3.9		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	9	16961398	40594091	Rat
1600365	Mcs20	Mammary carcinoma susceptibility QTL 20	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	9	13533770	42791750	Rat
11353947	Bp392	Blood pressure QTL 392			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	7283252	52283252	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	1	37999212	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	1	43718459	Rat
9589133	Insul26	Insulin level QTL 26	17.96	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	9	8952560	53952560	Rat

D9Wox38

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	20,454,551 - 20,454,691 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	24,069,953 - 24,070,092	NCBI	Rnor6.0
Rnor_5.0	9	22,930,514 - 22,930,653	UniSTS	Rnor5.0
RGSC_v3.4	9	16,677,062 - 16,677,201	UniSTS	RGSC3.4
Celera	9	18,102,515 - 18,102,654	UniSTS
Cytogenetic Map	9	q12	UniSTS

BI281439

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	20,471,932 - 20,472,043 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	24,087,334 - 24,087,444	NCBI	Rnor6.0
Rnor_5.0	9	22,947,909 - 22,948,019	UniSTS	Rnor5.0
RGSC_v3.4	9	16,697,307 - 16,697,417	UniSTS	RGSC3.4
Celera	9	18,114,644 - 18,114,754	UniSTS
RH 3.4 Map	9	173.3	UniSTS
Cytogenetic Map	9	q12	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	nervous system	reproductive system
13	1	13	21


RefSeq Transcripts	NM_001039393	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008766935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	DQ200907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000040542 ⟹ ENSRNOP00000048038

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	20,741,777 - 20,768,796 (-)	Ensembl
Rnor_6.0 Ensembl	9	24,356,579 - 24,383,679 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119419 ⟹ ENSRNOP00000084611

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	20,741,777 - 20,757,302 (-)	Ensembl

RefSeq Acc Id:

NM_001039393 ⟹ NP_001034482

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	28,238,326 - 28,265,344 (-)	NCBI
mRatBN7.2	9	20,741,775 - 20,768,796 (-)	NCBI
Rnor_6.0	9	24,356,577 - 24,383,679 (-)	NCBI
Rnor_5.0	9	23,218,716 - 23,245,318 (-)	NCBI
RGSC_v3.4	9	16,975,151 - 17,002,149 (-)	RGD
Celera	9	18,378,604 - 18,405,902 (-)	RGD

Sequence:

show sequence

ATATCCGTTCCTGTTCCTTGATCTGATGAAGCTGGTCCCCTTGTACTAACTGCCTCATTGAGCAGATTGTCTTTGTGAAATGTCATTTAACTCATTAGTACACAATACAAAGACCTGGTTTGTAGCAG
CACAAAATTTTAAGAGCTACATGGATGTGGGTATGGCAATGAAACTCATCTTGTTATTGTTTCTTGCTGCTACTCTTACTGTCTTTGTTCCTGTTGTGACTCTCAGACATCTCAAACTGGATAGAGCT
CTCTATAATCAACTGATCACGGAATCACAAACTGAACCACAGGAAGAAATTGTTGATACACACAATGCCTTCAGGAGAAACGTGTCCCCGCCAGCCAGGAACATGCTGAAAATGAGTTGGAGTTCAGC
TGCTGCAGAAAATGCTAGAATTCTGGCGAGGTACTGCGACAAGTCAGACAGTGACTCACTTGAAAGGAGACTACCAAATACATTTTGTGGAGAAAATATGCATATGGAAAACTATCCCTCTTCCTGGT
CAAATGTAATTGAAATCTGGTACAATGAGTCGAAATATTTCAAATACGGAGAATGGCCATCCACAGATGATGACATTGAAACTTATCACTACACCCAGATGGTCTGGGCCTCTTCCTACCTCATTGGC
TGTGATGTTGCATCATGCCGCAGGCAAAAGGCAGCTACGTATCTCTATGTGTGTCACTATTGCCATGAGGGGAATAGTCAAGACACATTAAACATGCCTTATAAGGAGGGGCCGCCATGTCAAGACTG
TCCAAACAACTGTGAAGATGGACTGTGTACCAACCCCTGCCTTTATTACGATGAATATAACAACTGTGATAAGCAAGTAAAACTTCTTGGATGCTCACATCCAGCAGTCCGGCCATTCTGTAAGGCTT
TTTGTCTGTGTAAAACTGAAATAAAATAACCTATTGCTTGCTGCTATGCTGTGGGGTAAAAGGGTGTTTTCAAGATCATCTATTTCACCTAATGTAATGGACTATAGGACCTTCTACTGAATTTCACT
TGTTTTTAAATTTGTGCTCAATAACTTAATTTTTAAGCATCATTTACAGACATCAGCATATTTCATCAAGACTGTGCCCTTTCCAGGCAGTAAAATAACTTTAAACTTCCTTGTTTAATGAAAGGGCA
AGTCAAATTCTTGCCCCAATTTAATACATGTGATTTGTGTTGTGTAGTTCGACATAACCCCACTAATGCAGGAGCTCTTCATCTATTTACTGGCAGTAAAACAGTCTTTTACATAACCCCTTTTCCTA
ATATCCCCATTTCCCCTACAATCCTAATGTTTTTGTTTAATGTTTCAATTTTCATTCTATTTTGAATCAAGCATTAAAAATATTCAACAAGTGAAAAAAAAAAAAAAAAAAAAA

hide sequence


Protein RefSeqs	NP_001034482	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABB29311	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000048038
	ENSRNOP00000048038.5
	ENSRNOP00000084611.1

RefSeq Acc Id:	NP_001034482 ⟸ NM_001039393
- Peptide Label:	precursor
- UniProtKB:	Q2I7M7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAMKLILLLFLAATLTVFVPVVTLRHLKLDRALYNQLITESQTEPQEEIVDTHNAFRRNVSPPARNMLKMSWSSAAAENARILARYCDKSDSDSLERRLPNTFCGENMHMENYPSSWSNVIEIWYNES KYFKYGEWPSTDDDIETYHYTQMVWASSYLIGCDVASCRRQKAATYLYVCHYCHEGNSQDTLNMPYKEGPPCQDCPNNCEDGLCTNPCLYYDEYNNCDKQVKLLGCSHPAVRPFCKAFCLCKTEIK hide sequence

Ensembl Acc Id:

ENSRNOP00000048038 ⟸ ENSRNOT00000040542

Ensembl Acc Id:

ENSRNOP00000084611 ⟸ ENSRNOT00000119419

Protein Domains

ShKT

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-E9PTT8-F1-model_v2	AlphaFold	E9PTT8	1-254	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13696571

Promoter ID:

EPDNEW_R7094

Type:

single initiation site

Name:

Crisp1_1

Description:

cysteine-rich secretory protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	24,383,580 - 24,383,640	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-28060	BioCyc
Ensembl Genes	ENSRNOG00000013612	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000040542	ENTREZGENE
	ENSRNOT00000040542.5	UniProtKB/TrEMBL
	ENSRNOT00000119419.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.740	UniProtKB/TrEMBL
	3.40.33.10	UniProtKB/TrEMBL
InterPro	Allrgn_V5/Tpx1	UniProtKB/TrEMBL
	CAP_domain	UniProtKB/TrEMBL
	CAP_sf	UniProtKB/TrEMBL
	Crisp-like_dom	UniProtKB/TrEMBL
	Cysteine_rich_secretory	UniProtKB/TrEMBL
	SCP_CRISP	UniProtKB/TrEMBL
	ShKT_dom	UniProtKB/TrEMBL
KEGG Report	rno:654517	UniProtKB/TrEMBL
NCBI Gene	654517	ENTREZGENE
PANTHER	Allrgn_V5/Tpx1	UniProtKB/TrEMBL
Pfam	Crisp	UniProtKB/TrEMBL
	SCP	UniProtKB/TrEMBL
PhenoGen	Crisp1	PhenoGen
PRINTS	V5TPXLIKE	UniProtKB/TrEMBL
PROSITE	SHKT	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000013612	RatGTEx
SMART	SCP	UniProtKB/TrEMBL
Superfamily-SCOP	Crisp domain-like	UniProtKB/TrEMBL
	SCP-like_extracellular	UniProtKB/TrEMBL
UniProt	A0A8I6A1P2_RAT	UniProtKB/TrEMBL
	E9PTT8_RAT	UniProtKB/TrEMBL
	Q2I7M7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-15	Crisp1	cysteine-rich secretory protein 1	Crisp4	cysteine-rich secretory protein 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	Crisp4	cysteine-rich secretory protein 4			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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