Tmem236 (transmembrane protein 236) - Rat Genome Database

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Gene: Tmem236 (transmembrane protein 236) Rattus norvegicus
Analyze
Symbol: Tmem236
Name: transmembrane protein 236
RGD ID: 1590637
Description: Predicted to be located in membrane. Orthologous to human TMEM236 (transmembrane protein 236); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; N-methyl-4-phenylpyridinium; ochratoxin A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Fam23a; family with sequence similarity 23, member A; LOC680523; similar to Protein FAM23A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81782,075,020 - 82,149,796 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1782,096,528 - 82,148,211 (+)EnsemblGRCr8
mRatBN7.21777,180,919 - 77,241,258 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1777,188,163 - 77,238,671 (+)EnsemblmRatBN7.2
Rnor_6.01781,280,632 - 81,342,112 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1781,280,898 - 81,342,095 (+)Ensemblrn6Rnor6.0
Rnor_5.01783,026,622 - 83,088,976 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41788,343,859 - 88,400,236 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1776,520,805 - 76,573,090 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Tmem236
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81782,075,020 - 82,149,796 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1782,096,528 - 82,148,211 (+)EnsemblGRCr8
mRatBN7.21777,180,919 - 77,241,258 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1777,188,163 - 77,238,671 (+)EnsemblmRatBN7.2
Rnor_6.01781,280,632 - 81,342,112 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1781,280,898 - 81,342,095 (+)Ensemblrn6Rnor6.0
Rnor_5.01783,026,622 - 83,088,976 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41788,343,859 - 88,400,236 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1776,520,805 - 76,573,090 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
TMEM236
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381017,752,201 - 17,800,868 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1017,752,201 - 17,800,868 (+)Ensemblhg38GRCh38
GRCh371017,794,200 - 17,842,867 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361017,834,257 - 17,882,873 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1017,727,726 - 17,776,346 (+)NCBICelera
Cytogenetic Map10p12.33NCBI
HuRef1017,706,988 - 17,755,602 (+)NCBIHuRef
CHM1_11017,789,873 - 18,089,797 (+)NCBICHM1_1
T2T-CHM13v2.01017,771,505 - 17,820,200 (+)NCBIT2T-CHM13v2.0
Tmem236
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39214,179,335 - 14,226,804 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl214,179,334 - 14,226,804 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38214,174,524 - 14,221,993 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl214,174,523 - 14,221,993 (+)Ensemblmm10GRCm38
MGSCv37214,096,151 - 14,143,620 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36214,092,278 - 14,137,224 (+)NCBIMGSCv36mm8
Celera214,077,701 - 14,125,086 (+)NCBICelera
Cytogenetic Map2A2NCBI
cM Map210.42NCBI
Tmem236
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542910,247,459 - 10,289,869 (-)Ensembl
ChiLan1.0NW_00495542910,247,459 - 10,289,869 (-)NCBIChiLan1.0ChiLan1.0
TMEM236
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2830,596,560 - 30,647,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11030,601,617 - 30,650,636 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01018,070,833 - 18,119,838 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11018,341,130 - 18,389,853 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1018,341,130 - 18,389,847 (+)EnsemblpanPan2panpan1.1
TMEM236
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1219,201,977 - 19,257,284 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl219,204,529 - 19,234,522 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha216,303,569 - 16,341,578 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0219,491,243 - 19,529,351 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl219,493,794 - 19,523,802 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1216,694,212 - 16,732,221 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0217,529,767 - 17,567,778 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0218,149,860 - 18,187,892 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmem236
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934418,360,745 - 18,405,156 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365209,557,503 - 9,599,656 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365209,557,308 - 9,604,290 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM236
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1044,055,239 - 44,097,787 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11044,055,111 - 44,097,462 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21048,738,293 - 48,759,155 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM236
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1917,691,602 - 17,738,052 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl917,692,459 - 17,735,814 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605123,338,176 - 23,382,886 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem236
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1149,404,995 - 9,454,205 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmem236
544 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000057785
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)177061350286062352Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176369714782818564Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176456982086954580Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 35 130 68 70 39 83 39 6 285 148 11 110 74 88 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000057785   ⟹   ENSRNOP00000054599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1782,096,528 - 82,148,211 (+)Ensembl
mRatBN7.2 Ensembl1777,188,163 - 77,238,671 (+)Ensembl
Rnor_6.0 Ensembl1781,280,898 - 81,342,095 (+)Ensembl
RefSeq Acc Id: XM_001057551   ⟹   XP_001057551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,075,020 - 82,149,796 (+)NCBI
mRatBN7.21777,188,019 - 77,241,258 (+)NCBI
Rnor_6.01781,280,632 - 81,342,112 (+)NCBI
Rnor_5.01783,026,622 - 83,088,976 (+)NCBI
RGSC_v3.41788,343,859 - 88,400,236 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_001057551 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054599
  ENSRNOP00000054599.2
RefSeq Acc Id: XP_001057551   ⟸   XM_001057551
- UniProtKB: D4A3Y5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054599   ⟸   ENSRNOT00000057785

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A3Y5-F1-model_v2 AlphaFold D4A3Y5 1-346 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700604
Promoter ID:EPDNEW_R11122
Type:initiation region
Name:Tmem236_1
Description:transmembrane protein 236
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01781,280,883 - 81,280,943EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590637 AgrOrtholog
BioCyc Gene G2FUF-8603 BioCyc
Ensembl Genes ENSRNOG00000037982 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057785 ENTREZGENE
  ENSRNOT00000057785.5 UniProtKB/TrEMBL
InterPro Uncharacterised_FAM23-like_TM UniProtKB/TrEMBL
KEGG Report rno:680523 UniProtKB/TrEMBL
NCBI Gene 680523 ENTREZGENE
PANTHER PTHR31453 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 236 UniProtKB/TrEMBL
PhenoGen Tmem236 PhenoGen
RatGTEx ENSRNOG00000037982 RatGTEx
UniProt D4A3Y5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Tmem236  transmembrane protein 236  LOC100364134  hypothetical protein LOC100364134  Data merged from RGD:2321624 1643240 APPROVED
2011-08-02 Tmem236  transmembrane protein 236  Fam23a  family with sequence similarity 23, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100364134  hypothetical protein LOC100364134      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-21 Fam23a  family with sequence similarity 23, member A  LOC680523  similar to Protein FAM23A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC680523  similar to Protein FAM23A      Symbol and Name status set to provisional 70820 PROVISIONAL