Rpl22l2 (ribosomal protein L22-like 2) - Rat Genome Database

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Gene: Rpl22l2 (ribosomal protein L22-like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rpl22l2 (Ensembl: AABR07053716.1)
Name: ribosomal protein L22-like 2
RGD ID: 1590585
Description: Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Orthologous to human RPL22L1 (ribosomal protein L22 like 1); INTERACTS WITH bisphenol A; indole-3-methanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 60S ribosomal protein L22-like 1; LOC680575; ribosomal protein L22 like 1-like; similar to ribosomal protein L22 like 1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83137,447,321 - 137,447,785 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3137,447,321 - 137,447,785 (+)EnsemblGRCr8
mRatBN7.23116,994,156 - 116,994,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,994,164 - 116,994,532 (+)EnsemblmRatBN7.2
Rnor_6.03122,285,243 - 122,285,664 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03127,730,959 - 127,731,380 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43117,384,474 - 117,384,842 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3115,810,922 - 115,811,375 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24625528  


Genomics

Variants

.
Variants in Rpl22l2
13 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 1 24 32 50 34 2 32 9 16 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000040366   ⟹   ENSRNOP00000042920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3116,994,164 - 116,994,532 (+)Ensembl
Rnor_6.0 Ensembl3122,285,243 - 122,285,611 (+)Ensembl
RefSeq Acc Id: NM_001408857   ⟹   NP_001395786
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,447,321 - 137,447,785 (+)NCBI
mRatBN7.23116,994,156 - 116,994,620 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395786 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000042920
  ENSRNOP00000042920.1
Ensembl Acc Id: ENSRNOP00000042920   ⟸   ENSRNOT00000040366
RefSeq Acc Id: NP_001395786   ⟸   NM_001408857
- UniProtKB: D3ZSF9 (UniProtKB/TrEMBL),   A0A8I6GK43 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZSF9-F1-model_v2 AlphaFold D3ZSF9 1-122 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590585 AgrOrtholog
BioCyc Gene G2FUF-47891 BioCyc
Ensembl Genes ENSRNOG00000029173 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040366 ENTREZGENE
  ENSRNOT00000040366.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1360.210 UniProtKB/TrEMBL
InterPro Ribosomal_L22e UniProtKB/TrEMBL
  Ribosomal_L22e_sf UniProtKB/TrEMBL
NCBI Gene 680575 ENTREZGENE
PANTHER PTHR10064 UniProtKB/TrEMBL
  PTHR10064:SF1 UniProtKB/TrEMBL
Pfam Ribosomal_L22e UniProtKB/TrEMBL
PhenoGen Rpl22l2 PhenoGen
RatGTEx ENSRNOG00000029173 RatGTEx
UniProt A0A8I6GK43 ENTREZGENE
  D3ZSF9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Rpl22l2  ribosomal protein L22-like 2  LOC100365299  ribosomal protein L22 like 1-like  Data merged from RGD:2319375 1643240 APPROVED
2010-05-05 LOC100365299  ribosomal protein L22 like 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-21 Rpl22l2  ribosomal protein L22-like 2  LOC680575  similar to ribosomal protein L22 like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680575  similar to ribosomal protein L22 like 1  LOC688103  similar to ribosomal protein L22 like 1  Data merged from RGD:1592456 1643240 APPROVED
2006-11-20 LOC680575  similar to ribosomal protein L22 like 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC688103  similar to ribosomal protein L22 like 1      Symbol and Name status set to provisional 70820 PROVISIONAL