Fndc10 (fibronectin type III domain containing 10) - Rat Genome Database

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Gene: Fndc10 (fibronectin type III domain containing 10) Rattus norvegicus
Analyze
Symbol: Fndc10 (Ensembl: Rps15al2)
Name: fibronectin type III domain containing 10 (Ensembl:ribosomal protein S15A-like 2)
RGD ID: 1589420
Description: Predicted to be located in membrane. Orthologous to human FNDC10 (fibronectin type III domain containing 10); INTERACTS WITH 17beta-estradiol; bisphenol A; ochratoxin A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fibronectin type III domain-containing protein 10; Fibronectin type-III domain-containing transmembrane protein C1orf233 homolog; hypothetical protein LOC680656; LOC108348319; LOC680656; uncharacterized LOC108348319
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,581,960 - 171,584,519 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5171,580,033 - 171,595,399 (+)EnsemblGRCr8
mRatBN7.25166,299,587 - 166,311,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,300,122 - 166,310,326 (+)EnsemblmRatBN7.2
Rnor_6.05173,139,345 - 173,141,564 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05176,614,303 - 176,616,937 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45172,546,730 - 172,548,701 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5164,500,919 - 164,502,927 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15057822  


Genomics

Comparative Map Data
Fndc10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,581,960 - 171,584,519 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5171,580,033 - 171,595,399 (+)EnsemblGRCr8
mRatBN7.25166,299,587 - 166,311,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,300,122 - 166,310,326 (+)EnsemblmRatBN7.2
Rnor_6.05173,139,345 - 173,141,564 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05176,614,303 - 176,616,937 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45172,546,730 - 172,548,701 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5164,500,919 - 164,502,927 (+)NCBICelera
Cytogenetic Map5q36NCBI
FNDC10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811,598,012 - 1,600,135 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11,598,012 - 1,600,135 (-)Ensemblhg38GRCh38
GRCh3711,533,392 - 1,535,515 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,523,251 - 1,525,333 (-)NCBIBuild 36Build 36hg18NCBI36
Celera11,045,618 - 1,046,671 (+)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1806,717 - 841,794 (-)NCBIHuRef
CHM1_111,520,545 - 1,522,568 (-)NCBICHM1_1
T2T-CHM13v2.011,032,518 - 1,034,641 (-)NCBIT2T-CHM13v2.0
Fndc10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,778,775 - 155,780,942 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,778,799 - 155,780,938 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384155,694,342 - 155,696,485 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,694,342 - 155,696,481 (+)Ensemblmm10GRCm38
MGSCv374155,068,581 - 155,070,594 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364154,538,142 - 154,540,281 (+)NCBIMGSCv36mm8
Celera4157,966,421 - 157,968,460 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map487.03NCBI
Fndc10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554869,301,802 - 9,303,246 (+)NCBIChiLan1.0ChiLan1.0
FNDC10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,620,329 - 226,622,479 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11225,276,347 - 225,278,496 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01359,080 - 361,223 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111,519,622 - 1,521,256 (-)NCBIPanPan1.1PanPan1.1panPan2
FNDC10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,660,721 - 56,662,696 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha556,736,733 - 56,738,756 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0556,862,833 - 56,864,856 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1556,853,453 - 56,855,476 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,745,801 - 56,747,824 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,135,946 - 57,137,969 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fndc10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,797,867 - 27,807,018 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367371,658,932 - 1,668,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FNDC10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,764,815 - 63,765,483 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1663,762,059 - 63,765,483 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,193,842 - 58,203,996 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FNDC10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120129,906,052 - 129,908,148 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20129,906,142 - 129,906,819 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236695272,481 - 4,513 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fndc10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248188,120,230 - 8,122,171 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248188,120,230 - 8,126,439 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fndc10
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v114,934,439 - 4,936,418 (-)NCBIRrattus_CSIRO_v1


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat

Markers in Region
RH137719  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,301,979 - 166,302,194 (+)MAPPERmRatBN7.2
Rnor_6.05173,141,279 - 173,141,493NCBIRnor6.0
Rnor_5.05176,616,652 - 176,616,866UniSTSRnor5.0
RGSC_v3.45172,548,416 - 172,548,630UniSTSRGSC3.4
Celera5164,502,642 - 164,502,856UniSTS
RH 3.4 Map51175.2UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
14 2 29 90 107 228 153 19 91 61 62 27 27

Sequence


Ensembl Acc Id: ENSRNOT00000041753   ⟹   ENSRNOP00000051016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5171,582,420 - 171,592,183 (+)Ensembl
mRatBN7.2 Ensembl5166,300,122 - 166,310,326 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000155533   ⟹   ENSRNOP00000101778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5171,580,033 - 171,595,399 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000170981   ⟹   ENSRNOP00000100986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5171,582,410 - 171,586,122 (+)Ensembl
RefSeq Acc Id: NM_001419679   ⟹   NP_001406608
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,582,366 - 171,584,518 (+)NCBI
mRatBN7.25166,300,112 - 166,302,264 (+)NCBI
RefSeq Acc Id: XM_063288393   ⟹   XP_063144463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,581,960 - 171,584,519 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001406608 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144463 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4A2Q0 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051016.4
  ENSRNOP00000100986
  ENSRNOP00000101778
Ensembl Acc Id: ENSRNOP00000051016   ⟸   ENSRNOT00000041753
RefSeq Acc Id: NP_001406608   ⟸   NM_001419679
- Peptide Label: precursor
- UniProtKB: D4A2Q0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063144463   ⟸   XM_063288393
- Peptide Label: isoform X1
- UniProtKB: D4A2Q0 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000101778   ⟸   ENSRNOT00000155533
Ensembl Acc Id: ENSRNOP00000100986   ⟸   ENSRNOT00000170981
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZS61-F1-model_v2 AlphaFold D3ZS61 1-130 view protein structure
AF-D4A2Q0-F1-model_v2 AlphaFold D4A2Q0 1-225 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589420 AgrOrtholog
BioCyc Gene G2FUF-38911 BioCyc
Ensembl Genes ENSRNOG00000030447 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000041753.6 UniProtKB/Swiss-Prot
  ENSRNOT00000155533 ENTREZGENE
  ENSRNOT00000170981 ENTREZGENE
InterPro Fndc10 UniProtKB/Swiss-Prot
NCBI Gene 680656 ENTREZGENE
PANTHER FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 10 UniProtKB/Swiss-Prot
  PTHR39233 UniProtKB/Swiss-Prot
Pfam DUF5579 UniProtKB/Swiss-Prot
PhenoGen Fndc10 PhenoGen
RatGTEx ENSRNOG00000030447 RatGTEx
UniProt D4A2Q0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fndc10  fibronectin type III domain containing 10  LOC108348319  uncharacterized LOC108348319  Data merged from RGD:11375690 737654 PROVISIONAL
2016-08-02 LOC108348319  uncharacterized LOC108348319      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-06-29 Fndc10  fibronectin type III domain containing 10  LOC680656  hypothetical protein LOC680656  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680656  hypothetical protein LOC680656  LOC687227  hypothetical protein LOC687227  Data merged from RGD:1587751 1643240 APPROVED
2006-11-19 LOC680656  hypothetical protein LOC680656      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687227  hypothetical protein LOC687227      Symbol and Name status set to provisional 70820 PROVISIONAL