Utf1 (undifferentiated embryonic cell transcription factor 1) - Rat Genome Database

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Gene: Utf1 (undifferentiated embryonic cell transcription factor 1) Rattus norvegicus
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Symbol: Utf1
Name: undifferentiated embryonic cell transcription factor 1
RGD ID: 1589375
Description: Predicted to enable HMG box domain binding activity; TBP-class protein binding activity; and transcription coactivator activity. Predicted to be involved in male gonad development and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human UTF1 (undifferentiated embryonic cell transcription factor 1); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC681901; similar to undifferentiated embryonic cell transcription factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81204,169,954 - 204,171,080 (+)NCBIGRCr8
mRatBN7.21194,740,339 - 194,741,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1194,740,339 - 194,741,465 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1203,101,103 - 203,102,229 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,236,142 - 210,237,268 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01202,909,972 - 202,911,098 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01212,281,237 - 212,282,363 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,281,237 - 212,282,363 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,200,178 - 219,201,304 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1192,417,906 - 192,419,032 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Utf1Ratdistal 10q deletion syndrome  ISOUTF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Distal 10q deletion syndromeClinVarPMID:31690835

1 to 20 of 42 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Utf1Rat17alpha-ethynylestradiol increases expressionISOUtf1 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of UTF1 mRNACTDPMID:17942748
Utf1Rat17alpha-ethynylestradiol multiple interactionsISOUtf1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UTF1 mRNACTDPMID:17942748
Utf1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOUtf1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UTF1 mRNACTDPMID:17942748
Utf1Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of UTF1 mRNACTDPMID:30047161
Utf1Ratacetic acid affects expressionISOUtf1 (Mus musculus)6480464Acetic Acid affects the expression of UTF1 proteinCTDPMID:21296659
Utf1Ratall-trans-retinoic acid decreases expressionISOUTF1 (Homo sapiens)6480464Tretinoin results in decreased expression of UTF1 mRNACTDPMID:17138961
Utf1Ratall-trans-retinoic acid multiple interactionsISOUtf1 (Mus musculus)6480464[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of UTF1 mRNACTDPMID:36189433
Utf1Ratall-trans-retinoic acid decreases expressionISOUtf1 (Mus musculus)6480464Tretinoin results in decreased expression of UTF1 mRNACTDPMID:16604517
Utf1Ratamitrole decreases expressionEXP 6480464Amitrole results in decreased expression of UTF1 mRNACTDPMID:30047161
Utf1Ratarsane increases methylationISOUTF1 (Homo sapiens)6480464Arsenic results in increased methylation of UTF1 promoterCTDPMID:21291286
Utf1Ratarsenic atom increases methylationISOUTF1 (Homo sapiens)6480464Arsenic results in increased methylation of UTF1 promoterCTDPMID:21291286
Utf1Ratbelinostat multiple interactionsISOUTF1 (Homo sapiens)6480464[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTF1 mRNACTDPMID:27188386
Utf1Ratbelinostat increases expressionISOUTF1 (Homo sapiens)6480464belinostat results in increased expression of UTF1 mRNACTDPMID:26272509
Utf1Ratbenzo[a]pyrene increases methylationISOUTF1 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of UTF1 exon and Benzo(a)pyrene results in increased methylation of UTF1 promoterCTDPMID:27901495
Utf1Ratbenzo[a]pyrene affects methylationISOUTF1 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of UTF1 3' UTRCTDPMID:27901495
Utf1Ratbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of UTF1 mRNACTDPMID:25181051
Utf1Ratbromochloroacetic acid affects expressionISOUtf1 (Mus musculus)6480464bromochloroacetic acid affects the expression of UTF1 proteinCTDPMID:21296659
Utf1Ratcholine multiple interactionsISOUtf1 (Mus musculus)6480464[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of UTF1 geneCTDPMID:20938992
Utf1Ratcisplatin decreases phosphorylationISOUtf1 (Mus musculus)6480464Cisplatin results in decreased phosphorylation of UTF1 proteinCTDPMID:22006019
Utf1Ratdorsomorphin multiple interactionsISOUTF1 (Homo sapiens)6480464[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...CTDPMID:27188386

1 to 20 of 42 rows

Biological Process

  

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Utf1Ratnucleus located_inISOUTF1 (Homo sapiens)1624291 PMID:18281244RGDPMID:18281244
Utf1Ratnucleus located_inIEAUniProtKB:Q6J1H4 and ensembl:ENSMUSP000001288481600115GO_REF:0000107EnsemblGO_REF:0000107
Utf1Ratnucleus located_inISOUtf1 (Mus musculus)1624291 PMID:18448678RGDPMID:18448678


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:9524124   PMID:9748258   PMID:16582099   PMID:18281244   PMID:18390688   PMID:18448678  



Utf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81204,169,954 - 204,171,080 (+)NCBIGRCr8
mRatBN7.21194,740,339 - 194,741,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1194,740,339 - 194,741,465 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1203,101,103 - 203,102,229 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,236,142 - 210,237,268 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01202,909,972 - 202,911,098 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01212,281,237 - 212,282,363 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,281,237 - 212,282,363 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,200,178 - 219,201,304 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1192,417,906 - 192,419,032 (+)NCBICelera
Cytogenetic Map1q41NCBI
UTF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810133,230,217 - 133,231,558 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10133,230,217 - 133,231,558 (+)EnsemblGRCh38hg38GRCh38
GRCh3710135,043,721 - 135,045,062 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610134,893,768 - 134,895,052 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410134,932,658 - 134,933,942NCBI
Celera10128,471,466 - 128,472,747 (-)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10128,590,264 - 128,591,548 (+)NCBIHuRef
CHM1_110135,324,603 - 135,325,887 (+)NCBICHM1_1
T2T-CHM13v2.010134,185,709 - 134,187,050 (+)NCBIT2T-CHM13v2.0
Utf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397139,523,769 - 139,525,025 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7139,523,702 - 139,525,025 (+)EnsemblGRCm39 Ensembl
GRCm387139,943,856 - 139,945,112 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7139,943,789 - 139,945,112 (+)EnsemblGRCm38mm10GRCm38
MGSCv377147,129,755 - 147,131,011 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367139,795,176 - 139,796,432 (+)NCBIMGSCv36mm8
Celera7139,747,754 - 139,749,010 (+)NCBICelera
Cytogenetic Map7F4NCBI
cM Map784.91NCBI
Utf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495547710,855,471 - 10,857,044 (+)NCBIChiLan1.0ChiLan1.0
UTF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28145,347,730 - 145,352,791 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110145,353,087 - 145,358,148 (+)NCBINHGRI_mPanPan1
UTF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2840,885,694 - 40,887,322 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02841,467,017 - 41,468,705 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2841,467,017 - 41,468,705 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12840,949,347 - 40,950,783 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02840,939,436 - 40,940,952 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02841,341,980 - 41,343,560 (+)NCBIUU_Cfam_GSD_1.0
Utf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072136,215,014 - 6,216,312 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648619,345,059 - 19,346,163 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UTF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.114141,190,170 - 141,193,409 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214153,154,360 - 153,155,863 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UTF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604887,593,456 - 87,595,021 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Utf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473713,512,558 - 13,513,923 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:23
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000075049
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 90 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat

1 to 10 of 90 rows



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 6 35 20 17 1 15 1 3 45 27 26 15 54 16



Ensembl Acc Id: ENSRNOT00000075049   ⟹   ENSRNOP00000066594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1194,740,339 - 194,741,465 (+)Ensembl
Rnor_6.0 Ensembl1212,281,237 - 212,282,363 (+)Ensembl
RefSeq Acc Id: NM_001131032   ⟹   NP_001124504
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81204,169,954 - 204,171,080 (+)NCBI
mRatBN7.21194,740,339 - 194,741,465 (+)NCBI
Rnor_6.01212,281,237 - 212,282,363 (+)NCBI
Rnor_5.01219,200,178 - 219,201,304 (+)NCBI
Celera1192,417,906 - 192,419,032 (+)RGD
Sequence:
Protein RefSeqs NP_001124504 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABY51986 (Get FASTA)   NCBI Sequence Viewer  
  EDM11862 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066594
  ENSRNOP00000066594.1
RefSeq Acc Id: NP_001124504   ⟸   NM_001131032
- UniProtKB: M0RAP1 (UniProtKB/TrEMBL),   A6HXD1 (UniProtKB/TrEMBL),   B3FIB5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066594   ⟸   ENSRNOT00000075049
Myb/SANT-like DNA-binding

Name Modeler Protein Id AA Range Protein Structure
AF-M0RAP1-F1-model_v2 AlphaFold M0RAP1 1-338 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 13 of 13 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-57079 BioCyc
Ensembl Genes ENSRNOG00000050207 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075049 ENTREZGENE
  ENSRNOT00000075049.2 UniProtKB/TrEMBL
InterPro Myb_DNA-bind_4 UniProtKB/TrEMBL
KEGG Report rno:681901 UniProtKB/TrEMBL
NCBI Gene 681901 ENTREZGENE
Pfam Myb_DNA-bind_4 UniProtKB/TrEMBL
PhenoGen Utf1 PhenoGen
RatGTEx ENSRNOG00000050207 RatGTEx
UniProt A6HXD1 ENTREZGENE, UniProtKB/TrEMBL
  B3FIB5 ENTREZGENE, UniProtKB/TrEMBL
  M0RAP1 ENTREZGENE, UniProtKB/TrEMBL
1 to 13 of 13 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-12 Utf1  undifferentiated embryonic cell transcription factor 1  LOC681901  similar to undifferentiated embryonic cell transcription factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC681901  similar to undifferentiated embryonic cell transcription factor 1      Symbol and Name status set to provisional 70820 PROVISIONAL