Dnajb7 (DnaJ heat shock protein family (Hsp40) member B7) - Rat Genome Database

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Gene: Dnajb7 (DnaJ heat shock protein family (Hsp40) member B7) Rattus norvegicus
Analyze
Symbol: Dnajb7
Name: DnaJ heat shock protein family (Hsp40) member B7
RGD ID: 1589047
Description: Predicted to enable protein folding chaperone; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in Z disc. Predicted to be active in cytoplasm and nucleus. Orthologous to human DNAJB7 (DnaJ heat shock protein family (Hsp40) member B7); INTERACTS WITH bisphenol A; decabromodiphenyl ether; diclofenac.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DnaJ (Hsp40) homolog, subfamily B, member 7; dnaJ homolog subfamily B member 7; LOC685839; similar to DnaJ homolog subfamily B member 7 (mDJ5)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,812,886 - 114,814,200 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7114,810,853 - 114,814,405 (-)EnsemblGRCr8
mRatBN7.27112,932,736 - 112,934,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,932,616 - 112,945,537 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7114,695,085 - 114,696,399 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,918,586 - 116,919,900 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,887,995 - 116,889,309 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07122,642,740 - 122,644,054 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,642,740 - 122,644,054 (-)Ensemblrn6Rnor6.0
Rnor_5.07122,619,286 - 122,620,600 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47119,735,945 - 119,737,259 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,252,184 - 109,253,498 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
nucleus  (IBA)
Z disc  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21231916  


Genomics

Comparative Map Data
Dnajb7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,812,886 - 114,814,200 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7114,810,853 - 114,814,405 (-)EnsemblGRCr8
mRatBN7.27112,932,736 - 112,934,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,932,616 - 112,945,537 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7114,695,085 - 114,696,399 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,918,586 - 116,919,900 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,887,995 - 116,889,309 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07122,642,740 - 122,644,054 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,642,740 - 122,644,054 (-)Ensemblrn6Rnor6.0
Rnor_5.07122,619,286 - 122,620,600 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47119,735,945 - 119,737,259 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,252,184 - 109,253,498 (-)NCBICelera
Cytogenetic Map7q34NCBI
DNAJB7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,859,549 - 40,862,113 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,859,549 - 40,862,113 (-)Ensemblhg38GRCh38
GRCh372241,255,553 - 41,258,117 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,585,499 - 39,588,076 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342239,580,052 - 39,582,630NCBI
Celera2225,059,224 - 25,061,801 (-)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2224,217,586 - 24,220,163 (-)NCBIHuRef
CHM1_12241,214,305 - 41,216,882 (-)NCBICHM1_1
T2T-CHM13v2.02241,331,741 - 41,334,305 (-)NCBIT2T-CHM13v2.0
Dnajb7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391581,291,289 - 81,292,474 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1581,291,127 - 81,292,500 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381581,407,088 - 81,408,273 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,406,926 - 81,408,299 (-)Ensemblmm10GRCm38
MGSCv371581,237,518 - 81,238,703 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361581,234,343 - 81,235,528 (-)NCBIMGSCv36mm8
Celera1583,525,125 - 83,526,310 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.09NCBI
Dnajb7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541326,511,834 - 26,512,849 (-)Ensembl
ChiLan1.0NW_00495541326,510,844 - 26,512,855 (-)NCBIChiLan1.0ChiLan1.0
DNAJB7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22350,681,614 - 50,692,770 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12253,391,456 - 53,392,656 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02221,754,641 - 21,757,204 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12239,850,575 - 39,853,799 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2239,852,079 - 39,853,008 (-)EnsemblpanPan2panpan1.1
DNAJB7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11024,372,364 - 24,373,715 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1024,372,507 - 24,373,436 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1024,305,603 - 24,307,665 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01025,119,157 - 25,121,219 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11024,834,405 - 24,836,467 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01025,155,295 - 25,157,357 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01025,329,675 - 25,331,737 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dnajb7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,960,172 - 7,961,323 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936492970,645 - 972,294 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAJB7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.157,574,729 - 7,576,224 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.254,751,120 - 4,756,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNAJB7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11923,406,249 - 23,407,805 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045102,154,908 - 102,156,876 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnajb7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11251,159,546 - 251,160,835 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dnajb7
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:156
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000025941
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 25 86 74 74 44 82 44 6 256 130 5 72 59 70 30 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000025941   ⟹   ENSRNOP00000060598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,810,853 - 114,814,405 (-)Ensembl
mRatBN7.2 Ensembl7112,932,616 - 112,945,537 (-)Ensembl
Rnor_6.0 Ensembl7122,642,740 - 122,644,054 (-)Ensembl
RefSeq Acc Id: NM_001130510   ⟹   NP_001123982
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,812,886 - 114,814,200 (-)NCBI
mRatBN7.27112,932,736 - 112,934,050 (-)NCBI
Rnor_6.07122,642,740 - 122,644,054 (-)NCBI
Rnor_5.07122,619,286 - 122,620,600 (-)NCBI
RGSC_v3.47119,735,945 - 119,737,259 (-)RGD
Celera7109,252,184 - 109,253,498 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001123982 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM15725 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060598
  ENSRNOP00000060598.1
RefSeq Acc Id: NP_001123982   ⟸   NM_001130510
- UniProtKB: D3ZN46 (UniProtKB/TrEMBL),   A6HSZ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060598   ⟸   ENSRNOT00000025941
Protein Domains
J

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZN46-F1-model_v2 AlphaFold D3ZN46 1-303 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695510
Promoter ID:EPDNEW_R6035
Type:initiation region
Name:Dnajb7_1
Description:DnaJ heat shock protein family member B7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07122,644,079 - 122,644,139EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589047 AgrOrtholog
BioCyc Gene G2FUF-32678 BioCyc
Ensembl Genes ENSRNOG00000019187 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025941 ENTREZGENE
  ENSRNOT00000025941.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.110 UniProtKB/TrEMBL
InterPro DnaJ_dom_sf UniProtKB/TrEMBL
  DnaJ_N UniProtKB/TrEMBL
  DNJB2/6-like UniProtKB/TrEMBL
  Heat_shock_DnaJ_CS UniProtKB/TrEMBL
KEGG Report rno:685839 UniProtKB/TrEMBL
NCBI Gene 685839 ENTREZGENE
PANTHER DNAJ HOMOLOG SUBFAMILY B MEMBER 2 UniProtKB/TrEMBL
  SIMILAR TO DNAJ HOMOLOG SUBFAMILY B MEMBER 6 (HEAT SHOCK PROTEIN J2) (HSJ-2) (MRJ) (MDJ4) UniProtKB/TrEMBL
Pfam DnaJ UniProtKB/TrEMBL
PhenoGen Dnajb7 PhenoGen
PRINTS DNAJPROTEIN UniProtKB/TrEMBL
PROSITE DNAJ_1 UniProtKB/TrEMBL
  DNAJ_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019187 RatGTEx
SMART DnaJ UniProtKB/TrEMBL
Superfamily-SCOP DnaJ_N UniProtKB/TrEMBL
UniProt A6HSZ8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZN46 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Dnajb7  DnaJ heat shock protein family (Hsp40) member B7  Dnajb7  DnaJ (Hsp40) homolog, subfamily B, member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Dnajb7  DnaJ (Hsp40) homolog, subfamily B, member 7  LOC685839  similar to DnaJ homolog subfamily B member 7 (mDJ5)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC685839  similar to DnaJ homolog subfamily B member 7 (mDJ5)      Symbol and Name status set to provisional 70820 PROVISIONAL