Rflna (refilin A) - Rat Genome Database

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Gene: Rflna (refilin A) Rattus norvegicus
Analyze
Symbol: Rflna
Name: refilin A
RGD ID: 1588777
Description: Predicted to enable filamin binding activity. Predicted to be involved in several processes, including actin filament bundle organization; negative regulation of bone mineralization involved in bone maturation; and negative regulation of chondrocyte development. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in actin filament bundle. Orthologous to human RFLNA (refilin A); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam101a; family with sequence similarity 101, member A; filamin-interacting protein FAM101A; hypothetical protein LOC689711; LOC689711; refilin-A; uncharacterized protein LOC689711
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,294,643 - 37,323,373 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1237,294,643 - 37,303,535 (-)EnsemblGRCr8
mRatBN7.21231,633,360 - 31,642,313 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,633,361 - 31,642,317 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1232,806,382 - 32,815,296 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,417,705 - 33,426,620 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,469,557 - 32,478,469 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01237,038,732 - 37,047,628 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1237,038,733 - 37,047,628 (-)Ensemblrn6Rnor6.0
Rnor_5.01238,914,965 - 38,923,860 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41232,730,785 - 32,739,680 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1233,324,655 - 33,333,550 (-)NCBICelera
Cytogenetic Map12q15NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24436304  


Genomics

Comparative Map Data
Rflna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,294,643 - 37,323,373 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1237,294,643 - 37,303,535 (-)EnsemblGRCr8
mRatBN7.21231,633,360 - 31,642,313 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,633,361 - 31,642,317 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1232,806,382 - 32,815,296 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,417,705 - 33,426,620 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,469,557 - 32,478,469 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01237,038,732 - 37,047,628 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1237,038,733 - 37,047,628 (-)Ensemblrn6Rnor6.0
Rnor_5.01238,914,965 - 38,923,860 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41232,730,785 - 32,739,680 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1233,324,655 - 33,333,550 (-)NCBICelera
Cytogenetic Map12q15NCBI
RFLNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812123,973,215 - 124,316,024 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12123,973,241 - 124,316,024 (+)Ensemblhg38GRCh38
GRCh3712124,457,762 - 124,800,570 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612123,339,663 - 123,366,521 (+)NCBIBuild 36Build 36hg18NCBI36
Celera12124,374,399 - 124,401,227 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12121,419,911 - 121,763,336 (+)NCBIHuRef
CHM1_112124,278,627 - 124,622,098 (+)NCBICHM1_1
T2T-CHM13v2.012123,974,731 - 124,318,372 (+)NCBIT2T-CHM13v2.0
Rflna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395125,080,512 - 125,089,611 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5125,080,285 - 125,089,611 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385125,003,448 - 125,012,547 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5125,003,221 - 125,012,547 (+)Ensemblmm10GRCm38
MGSCv375125,483,845 - 125,492,917 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365125,292,454 - 125,301,526 (+)NCBIMGSCv36mm8
Celera5122,021,370 - 122,030,413 (+)NCBICelera
Cytogenetic Map5G1.1NCBI
cM Map563.95NCBI
LOC102011120
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554825,033,914 - 5,042,790 (-)Ensembl
ChiLan1.0NW_0049554825,034,075 - 5,044,162 (-)NCBIChiLan1.0ChiLan1.0
RFLNA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210132,050,056 - 132,396,155 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112132,046,434 - 132,392,533 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012121,737,946 - 121,903,635 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112126,027,350 - 126,191,071 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12126,164,592 - 126,191,071 (+)EnsemblpanPan2panpan1.1
RFLNA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111119,497,097 - 119,666,178 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11119,647,606 - 119,668,003 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037125,621,264 - 125,639,698 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rflna
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474723,766,856 - 23,774,397 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474723,766,756 - 23,775,238 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Rflna
204 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:278
Count of miRNA genes:171
Interacting mature miRNAs:201
Transcripts:ENSRNOT00000001337
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)122963663737764351Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 58 135 87 86 55 81 55 6 306 162 4 121 66 90 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000001337   ⟹   ENSRNOP00000001337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1237,038,733 - 37,047,628 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119390   ⟹   ENSRNOP00000089299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1231,633,361 - 31,642,317 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125048   ⟹   ENSRNOP00000108051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1237,294,643 - 37,303,535 (-)Ensembl
RefSeq Acc Id: NM_001109547   ⟹   NP_001103017
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81237,294,643 - 37,303,535 (-)NCBI
mRatBN7.21231,633,360 - 31,642,313 (-)NCBI
Rnor_6.01237,038,733 - 37,047,628 (-)NCBI
Rnor_5.01238,914,965 - 38,923,860 (-)NCBI
RGSC_v3.41232,730,785 - 32,739,680 (-)RGD
Celera1233,324,655 - 33,333,550 (-)RGD
Sequence:
RefSeq Acc Id: XM_063271671   ⟹   XP_063127741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81237,294,647 - 37,323,373 (-)NCBI
RefSeq Acc Id: XM_063271672   ⟹   XP_063127742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81237,294,647 - 37,302,293 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001103017 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127741 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127742 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM13564 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000108051
  ENSRNOP00000108051.1
RefSeq Acc Id: NP_001103017   ⟸   NM_001109547
- UniProtKB: A6J0X5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001337   ⟸   ENSRNOT00000001337
Ensembl Acc Id: ENSRNOP00000089299   ⟸   ENSRNOT00000119390
RefSeq Acc Id: XP_063127741   ⟸   XM_063271671
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063127742   ⟸   XM_063271672
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000108051   ⟸   ENSRNOT00000125048

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXN7-F1-model_v2 AlphaFold D3ZXN7 1-204 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588777 AgrOrtholog
BioCyc Gene G2FUF-19373 BioCyc
Ensembl Genes ENSRNOG00000001011 Ensembl
  ENSRNOG00000063517 Ensembl
  ENSRNOG00000080603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000125048 ENTREZGENE
  ENSRNOT00000125048.1 UniProtKB/TrEMBL
InterPro Refilin UniProtKB/TrEMBL
KEGG Report rno:689711 UniProtKB/TrEMBL
NCBI Gene 689711 ENTREZGENE
PANTHER PTHR31848 UniProtKB/TrEMBL
  REFILIN-A UniProtKB/TrEMBL
Pfam FAM101 UniProtKB/TrEMBL
PhenoGen Rflna PhenoGen
RatGTEx ENSRNOG00000001011 RatGTEx
  ENSRNOG00000063517 RatGTEx
  ENSRNOG00000080603 RatGTEx
UniProt A0ABK0M354_RAT UniProtKB/TrEMBL
  A6J0X5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 Rflna  refilin A  Fam101a  family with sequence similarity 101, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Fam101a  family with sequence similarity 101, member A  LOC687503  hypothetical protein LOC687503  Data merged from RGD:1584261 1643240 APPROVED
2008-03-06 Fam101a  family with sequence similarity 101, member A  LOC689711  hypothetical protein LOC689711  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC689711  hypothetical protein LOC689711      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687503  hypothetical protein LOC687503      Symbol and Name status set to provisional 70820 PROVISIONAL