Spmip3 (sperm microtubule inner protein 3) - Rat Genome Database

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Pathways
Gene: Spmip3 (sperm microtubule inner protein 3) Rattus norvegicus
Analyze
Symbol: Spmip3
Name: sperm microtubule inner protein 3
RGD ID: 1588722
Description: Orthologous to human SPMIP3 (sperm microtubule inner protein 3); INTERACTS WITH bisphenol A; aflatoxin B1 (ortholog); aristolochic acid A (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C13h1orf100; hypothetical protein LOC689766; LOC689766; similar to human chromosome 1 open reading frame 100; sperm associated microtubule inner protein 3; uncharacterized protein C1orf100 homolog; uncharacterized protein LOC689766
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81392,272,502 - 92,295,887 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1392,274,854 - 92,296,883 (+)EnsemblGRCr8
mRatBN7.21389,740,464 - 89,771,505 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1389,742,831 - 89,763,817 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1392,248,183 - 92,269,077 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01393,648,302 - 93,669,196 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01390,826,714 - 90,847,628 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01395,885,189 - 95,908,003 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1395,887,708 - 95,908,003 (+)Ensemblrn6Rnor6.0
Rnor_5.013100,327,827 - 100,350,564 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41393,654,716 - 93,675,613 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1389,305,278 - 89,326,149 (+)NCBICelera
Cytogenetic Map13q25NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Spmip3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81392,272,502 - 92,295,887 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1392,274,854 - 92,296,883 (+)EnsemblGRCr8
mRatBN7.21389,740,464 - 89,771,505 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1389,742,831 - 89,763,817 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1392,248,183 - 92,269,077 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01393,648,302 - 93,669,196 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01390,826,714 - 90,847,628 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01395,885,189 - 95,908,003 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1395,887,708 - 95,908,003 (+)Ensemblrn6Rnor6.0
Rnor_5.013100,327,827 - 100,350,564 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41393,654,716 - 93,675,613 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1389,305,278 - 89,326,149 (+)NCBICelera
Cytogenetic Map13q25NCBI
SPMIP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381244,352,635 - 244,389,663 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1244,352,635 - 244,389,663 (+)Ensemblhg38GRCh38
GRCh371244,515,937 - 244,552,965 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361242,582,560 - 242,619,016 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1217,805,882 - 217,842,427 (+)NCBICelera
Cytogenetic Map1q44NCBI
HuRef1214,899,368 - 214,935,708 (+)NCBIHuRef
CHM1_11245,788,408 - 245,824,900 (+)NCBICHM1_1
T2T-CHM13v2.01243,768,961 - 243,806,036 (+)NCBIT2T-CHM13v2.0
Spmip3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391177,555,704 - 177,580,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1177,557,380 - 177,580,890 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381177,728,137 - 177,753,309 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1177,729,814 - 177,753,324 (+)Ensemblmm10GRCm38
MGSCv371179,659,945 - 179,683,436 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361179,566,489 - 179,589,999 (+)NCBIMGSCv36mm8
Celera1184,784,737 - 184,808,217 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map182.8NCBI
Spmip3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554067,651,769 - 7,682,036 (+)Ensembl
ChiLan1.0NW_0049554067,651,785 - 7,682,027 (+)NCBIChiLan1.0ChiLan1.0
SPMIP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214,749,066 - 4,786,509 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114,971,425 - 5,008,854 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01219,964,465 - 220,001,843 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11225,346,231 - 225,382,173 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1225,346,231 - 225,382,166 (+)EnsemblpanPan2panpan1.1
SPMIP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1735,408,365 - 35,433,101 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl735,408,424 - 35,432,743 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha734,883,045 - 34,907,782 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0735,236,162 - 35,260,953 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl735,236,221 - 35,260,598 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1735,072,373 - 35,097,098 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0735,088,763 - 35,113,522 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0735,353,506 - 35,378,263 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spmip3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934448,329,843 - 48,358,504 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365266,388,882 - 6,410,589 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365266,388,687 - 6,410,589 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPMIP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1017,193,994 - 17,215,443 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11017,198,860 - 17,215,195 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21019,618,682 - 19,636,025 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPMIP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12581,382,374 - 81,422,483 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2581,393,609 - 81,422,366 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605583,588,736 - 83,630,798 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spmip3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477115,100,460 - 15,119,688 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477115,100,391 - 15,119,873 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Spmip3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11056,336,485 - 56,361,392 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Spmip3
132 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:31
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000029081
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1302791Stl29Serum triglyceride level QTL 293.30.0011blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)138933312992500981Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 9 13 34 52 52 22 25 22 1 159 53 21 61 69 30 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000029081   ⟹   ENSRNOP00000035768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1392,274,983 - 92,296,883 (+)Ensembl
mRatBN7.2 Ensembl1389,742,919 - 89,763,817 (+)Ensembl
Rnor_6.0 Ensembl1395,887,708 - 95,908,003 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109629   ⟹   ENSRNOP00000089984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1392,274,854 - 92,295,886 (+)Ensembl
mRatBN7.2 Ensembl1389,742,831 - 89,763,817 (+)Ensembl
RefSeq Acc Id: NM_001109549   ⟹   NP_001103019
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81392,274,983 - 92,295,879 (+)NCBI
mRatBN7.21389,742,919 - 89,763,817 (+)NCBI
Rnor_6.01395,887,708 - 95,908,003 (+)NCBI
Rnor_5.013100,327,827 - 100,350,564 (+)NCBI
RGSC_v3.41393,654,716 - 93,675,613 (+)RGD
Celera1389,305,278 - 89,326,149 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250332   ⟹   XP_006250394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81392,272,502 - 92,295,887 (+)NCBI
mRatBN7.21389,740,464 - 89,763,803 (+)NCBI
Rnor_6.01395,885,189 - 95,907,989 (+)NCBI
Rnor_5.013100,327,827 - 100,350,564 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001103019 (Get FASTA)   NCBI Sequence Viewer  
  XP_006250394 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94792 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035768.3
  ENSRNOP00000089984.1
RefSeq Acc Id: NP_001103019   ⟸   NM_001109549
- UniProtKB: D3ZSS7 (UniProtKB/TrEMBL),   A6JGD6 (UniProtKB/TrEMBL),   A0A8I6ACQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250394   ⟸   XM_006250332
- Peptide Label: isoform X1
- UniProtKB: D3ZSS7 (UniProtKB/TrEMBL),   A6JGD6 (UniProtKB/TrEMBL),   A0A8I6ACQ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035768   ⟸   ENSRNOT00000029081
Ensembl Acc Id: ENSRNOP00000089984   ⟸   ENSRNOT00000109629

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZSS7-F1-model_v2 AlphaFold D3ZSS7 1-144 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699044
Promoter ID:EPDNEW_R9569
Type:multiple initiation site
Name:LOC689766_1
Description:hypothetical protein LOC689766
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01395,887,754 - 95,887,814EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588722 AgrOrtholog
BioCyc Gene G2FUF-17182 BioCyc
Ensembl Genes ENSRNOG00000021411 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029081.4 UniProtKB/TrEMBL
  ENSRNOT00000109629.2 UniProtKB/TrEMBL
InterPro C1orf100 UniProtKB/TrEMBL
KEGG Report rno:689766 UniProtKB/TrEMBL
NCBI Gene 689766 ENTREZGENE
PANTHER HYPOTHETICAL PROTEIN LOC689766 UniProtKB/TrEMBL
  PTHR31763 UniProtKB/TrEMBL
Pfam DUF5530 UniProtKB/TrEMBL
PhenoGen Spmip3 PhenoGen
RatGTEx ENSRNOG00000021411 RatGTEx
UniProt A0A8I6ACQ9 ENTREZGENE, UniProtKB/TrEMBL
  A6JGD6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZSS7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-25 Spmip3  sperm microtubule inner protein 3  Spmip3  sperm associated microtubule inner protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-05-05 Spmip3  sperm associated microtubule inner protein 3  C13h1orf100  similar to human chromosome 1 open reading frame 100  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-07-21 C13h1orf100  similar to human chromosome 1 open reading frame 100  LOC689766  hypothetical protein LOC689766  Name and Symbol changed 629549 APPROVED
2006-11-19 LOC689766  hypothetical protein LOC689766      Symbol and Name status set to provisional 70820 PROVISIONAL