Micos13 (mitochondrial contact site and cristae organizing system subunit 13) - Rat Genome Database

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Gene: Micos13 (mitochondrial contact site and cristae organizing system subunit 13) Rattus norvegicus
Analyze
Symbol: Micos13
Name: mitochondrial contact site and cristae organizing system subunit 13
RGD ID: 1588578
Description: Predicted to be involved in cristae formation. Predicted to be located in mitochondrial inner membrane. Predicted to be part of MICOS complex. Predicted to be active in mitochondrial crista junction. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 37. Orthologous to human MICOS13 (mitochondrial contact site and cristae organizing system subunit 13); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical LOC301124; hypothetical protein LOC301124; LOC301124; MICOS complex subunit MIC13; uncharacterized protein LOC301124
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,526,978 - 1,528,996 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,526,673 - 1,528,928 (-)EnsemblGRCr8
mRatBN7.291,439,841 - 1,441,782 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,439,058 - 1,442,076 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx91,873,264 - 1,875,205 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,223,450 - 7,225,391 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,178,469 - 6,180,410 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,446,567 - 10,449,566 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,446,699 - 10,449,566 (+)Ensemblrn6Rnor6.0
Rnor_5.099,443,465 - 9,446,493 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera97,071,911 - 7,074,778 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cristae formation  (IBA,IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18614015   PMID:25997101  


Genomics

Comparative Map Data
Micos13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,526,978 - 1,528,996 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,526,673 - 1,528,928 (-)EnsemblGRCr8
mRatBN7.291,439,841 - 1,441,782 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,439,058 - 1,442,076 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx91,873,264 - 1,875,205 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,223,450 - 7,225,391 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,178,469 - 6,180,410 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,446,567 - 10,449,566 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,446,699 - 10,449,566 (+)Ensemblrn6Rnor6.0
Rnor_5.099,443,465 - 9,446,493 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera97,071,911 - 7,074,778 (+)NCBICelera
Cytogenetic Map9q11NCBI
MICOS13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38195,678,422 - 5,680,516 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl195,678,421 - 5,680,516 (-)Ensemblhg38GRCh38
GRCh37195,678,433 - 5,680,527 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36195,629,433 - 5,631,911 (-)NCBIBuild 36Build 36hg18NCBI36
Celera195,615,800 - 5,618,278 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef195,439,198 - 5,441,676 (-)NCBIHuRef
CHM1_1195,678,031 - 5,680,509 (-)NCBICHM1_1
T2T-CHM13v2.0195,665,108 - 5,667,202 (-)NCBIT2T-CHM13v2.0
Micos13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,914,452 - 56,916,771 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,914,452 - 56,916,771 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381756,607,452 - 56,609,771 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,607,452 - 56,609,771 (-)Ensemblmm10GRCm38
MGSCv371756,746,875 - 56,749,194 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361756,292,571 - 56,294,890 (-)NCBIMGSCv36mm8
Celera1760,951,651 - 60,953,970 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.42NCBI
Micos13
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,737,296 - 3,739,056 (+)Ensembl
ChiLan1.0NW_0049554953,737,296 - 3,739,056 (+)NCBIChiLan1.0ChiLan1.0
MICOS13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,075,105 - 10,077,273 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,301,284 - 9,303,453 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0194,695,760 - 4,698,236 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1195,631,304 - 5,633,783 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,631,304 - 5,633,783 (-)EnsemblpanPan2panpan1.1
MICOS13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12054,341,571 - 54,343,606 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2054,342,007 - 54,343,607 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2054,068,240 - 54,070,278 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02054,997,233 - 54,999,275 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,997,669 - 54,999,275 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12054,059,623 - 54,061,657 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02054,540,134 - 54,542,170 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,737,396 - 54,739,434 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Micos13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,576,398 - 214,578,164 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,257,070 - 3,258,599 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,256,619 - 3,258,589 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MICOS13
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl273,294,842 - 73,296,836 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1273,295,212 - 73,296,831 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,817,192 - 73,818,811 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MICOS13
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.165,326,821 - 5,338,848 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl65,335,730 - 5,338,432 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660812,764,295 - 2,779,398 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Micos13
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,521,263 - 4,522,912 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248284,521,134 - 4,522,912 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Micos13
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1487,982,335 - 87,984,423 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Micos13
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:252
Count of miRNA genes:164
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000075344
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631533Iresp3Immunoglobin response QTL316.2blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)916094576Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000075344   ⟹   ENSRNOP00000065236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,526,673 - 1,528,928 (-)Ensembl
mRatBN7.2 Ensembl91,439,058 - 1,442,076 (-)Ensembl
Rnor_6.0 Ensembl910,446,699 - 10,449,566 (+)Ensembl
RefSeq Acc Id: NM_001399202   ⟹   NP_001386131
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,526,978 - 1,528,919 (-)NCBI
mRatBN7.291,439,841 - 1,441,782 (-)NCBI
RefSeq Acc Id: XM_063266826   ⟹   XP_063122896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,526,983 - 1,528,996 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386131 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122896 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83625 (Get FASTA)   NCBI Sequence Viewer  
  EDL83626 (Get FASTA)   NCBI Sequence Viewer  
  EDL83627 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065236
  ENSRNOP00000065236.3
Ensembl Acc Id: ENSRNOP00000065236   ⟸   ENSRNOT00000075344
RefSeq Acc Id: NP_001386131   ⟸   NM_001399202
- Peptide Label: precursor
- UniProtKB: M0R719 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122896   ⟸   XM_063266826
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R719-F1-model_v2 AlphaFold M0R719 1-130 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696455
Promoter ID:EPDNEW_R6980
Type:initiation region
Name:LOC301124_2
Description:hypothetical LOC301124
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6981  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,446,700 - 10,446,760EPDNEW
RGD ID:13696457
Promoter ID:EPDNEW_R6981
Type:initiation region
Name:LOC301124_1
Description:hypothetical LOC301124
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6980  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,446,842 - 10,446,902EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588578 AgrOrtholog
BioCyc Gene G2FUF-28523 BioCyc
Ensembl Genes ENSRNOG00000046002 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075344 ENTREZGENE
  ENSRNOT00000075344.3 UniProtKB/TrEMBL
InterPro Mic13 UniProtKB/TrEMBL
NCBI Gene 301124 ENTREZGENE
PANTHER MICOS COMPLEX SUBUNIT MIC13 UniProtKB/TrEMBL
  PTHR31816 UniProtKB/TrEMBL
Pfam QIL1 UniProtKB/TrEMBL
PhenoGen Micos13 PhenoGen
RatGTEx ENSRNOG00000046002 RatGTEx
UniProt M0R719 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-12-04 Micos13  mitochondrial contact site and cristae organizing system subunit 13  LOC301124  hypothetical LOC301124  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC301124  hypothetical LOC301124      Symbol and Name status set to provisional 70820 PROVISIONAL