Tnfaip8l1 (TNF alpha induced protein 8 like 1) - Rat Genome Database

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Gene: Tnfaip8l1 (TNF alpha induced protein 8 like 1) Rattus norvegicus
Analyze
Symbol: Tnfaip8l1
Name: TNF alpha induced protein 8 like 1
RGD ID: 1588574
Description: Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of TOR signaling. Predicted to be active in cytoplasm. Orthologous to human TNFAIP8L1 (TNF alpha induced protein 8 like 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC301131; similar to tumor necrosis factor, alpha-induced protein 8-like 1; tumor necrosis factor alpha-induced protein 8-like protein 1; tumor necrosis factor, alpha-induced protein 8-like 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,075,724 - 1,088,256 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,055,801 - 1,092,803 (+)EnsemblGRCr8
mRatBN7.29988,587 - 999,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9988,594 - 1,002,254 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx91,434,803 - 1,445,487 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.096,782,342 - 6,793,017 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.095,739,840 - 5,750,524 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,894,949 - 10,905,647 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,896,680 - 10,897,240 (-)Ensemblrn6Rnor6.0
Rnor_5.099,884,059 - 9,894,791 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera97,508,214 - 7,518,912 (-)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3,4-dichloroaniline  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diallyl trisulfide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofurans  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
diuron  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
folic acid  (ISO)
furan  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
inulin  (ISO)
kojic acid  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
resveratrol  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21600655  


Genomics

Comparative Map Data
Tnfaip8l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,075,724 - 1,088,256 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,055,801 - 1,092,803 (+)EnsemblGRCr8
mRatBN7.29988,587 - 999,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9988,594 - 1,002,254 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx91,434,803 - 1,445,487 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.096,782,342 - 6,793,017 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.095,739,840 - 5,750,524 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,894,949 - 10,905,647 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,896,680 - 10,897,240 (-)Ensemblrn6Rnor6.0
Rnor_5.099,884,059 - 9,894,791 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera97,508,214 - 7,518,912 (-)NCBICelera
Cytogenetic Map9q11NCBI
TNFAIP8L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,639,516 - 4,655,568 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,639,511 - 4,655,568 (+)Ensemblhg38GRCh38
GRCh37194,639,528 - 4,655,580 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,590,530 - 4,604,953 (+)NCBIBuild 36Build 36hg18NCBI36
Celera194,576,202 - 4,592,255 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef194,399,685 - 4,415,736 (+)NCBIHuRef
CHM1_1194,639,369 - 4,655,413 (+)NCBICHM1_1
T2T-CHM13v2.0194,623,667 - 4,639,725 (+)NCBIT2T-CHM13v2.0
Tnfaip8l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,469,439 - 56,491,249 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,469,477 - 56,480,955 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381756,162,439 - 56,184,249 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,162,477 - 56,173,955 (+)Ensemblmm10GRCm38
MGSCv371756,301,914 - 56,313,378 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361755,221,848 - 55,233,227 (+)NCBIMGSCv36mm8
MGSCv361755,796,283 - 55,807,662 (+)NCBIMGSCv36mm8
Cytogenetic Map17DNCBI
cM Map1729.19NCBI
Tnfaip8l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,334,677 - 4,350,785 (-)Ensembl
ChiLan1.0NW_0049554954,334,443 - 4,344,283 (-)NCBIChiLan1.0ChiLan1.0
TNFAIP8L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2209,032,772 - 9,048,810 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,262,570 - 8,278,601 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,658,205 - 3,674,237 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,609,415 - 4,622,987 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,621,902 - 4,622,462 (+)EnsemblpanPan2panpan1.1
TNFAIP8L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,098,121 - 55,111,228 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,099,873 - 55,110,110 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2054,822,370 - 54,835,478 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02055,752,343 - 55,765,435 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2055,752,343 - 55,756,020 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12054,815,433 - 54,826,919 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,294,304 - 55,307,388 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,492,350 - 55,505,446 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tnfaip8l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,127,445 - 215,139,657 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,698,479 - 2,705,732 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,695,818 - 2,706,089 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFAIP8L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,203,766 - 74,220,816 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1274,203,753 - 74,220,811 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TNFAIP8L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.164,361,598 - 4,371,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl64,370,775 - 4,371,332 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660813,803,544 - 3,816,625 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfaip8l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,129,286 - 5,141,827 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248285,127,265 - 5,141,561 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tnfaip8l1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1487,549,509 - 87,559,834 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tnfaip8l1
25 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:102
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000074502
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631533Iresp3Immunoglobin response QTL316.2blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)916094576Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000074502   ⟹   ENSRNOP00000065435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl910,896,680 - 10,897,240 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097774   ⟹   ENSRNOP00000096639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,075,825 - 1,089,420 (+)Ensembl
mRatBN7.2 Ensembl9988,594 - 999,612 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104672   ⟹   ENSRNOP00000084479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,075,687 - 1,092,803 (+)Ensembl
mRatBN7.2 Ensembl9988,594 - 1,002,254 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109919   ⟹   ENSRNOP00000084648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,055,801 - 1,085,489 (+)Ensembl
mRatBN7.2 Ensembl9994,934 - 999,523 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126064   ⟹   ENSRNOP00000109610
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,075,687 - 1,092,803 (+)Ensembl
RefSeq Acc Id: NM_001399305   ⟹   NP_001386234
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,075,829 - 1,086,508 (+)NCBI
mRatBN7.29988,667 - 999,342 (+)NCBI
RefSeq Acc Id: XM_006244370   ⟹   XP_006244432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,075,727 - 1,088,256 (+)NCBI
mRatBN7.29988,587 - 999,342 (+)NCBI
Rnor_6.0910,894,949 - 10,905,647 (-)NCBI
Rnor_5.099,884,059 - 9,894,791 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063266830   ⟹   XP_063122900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,075,724 - 1,088,256 (+)NCBI
RefSeq Acc Id: XP_006244432   ⟸   XM_006244370
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZY03 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065435   ⟸   ENSRNOT00000074502
Ensembl Acc Id: ENSRNOP00000084648   ⟸   ENSRNOT00000109919
Ensembl Acc Id: ENSRNOP00000084479   ⟸   ENSRNOT00000104672
Ensembl Acc Id: ENSRNOP00000096639   ⟸   ENSRNOT00000097774
RefSeq Acc Id: NP_001386234   ⟸   NM_001399305
- UniProtKB: A0A8I5ZY03 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122900   ⟸   XM_063266830
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZY03 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000109610   ⟸   ENSRNOT00000126064

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7K3-F1-model_v2 AlphaFold M0R7K3 1-186 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588574 AgrOrtholog
BioCyc Gene G2FUF-28556 BioCyc
Ensembl Genes ENSRNOG00000045999 Ensembl
  ENSRNOG00000069635 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097774.2 UniProtKB/TrEMBL
  ENSRNOT00000104672 ENTREZGENE
  ENSRNOT00000104672.2 UniProtKB/TrEMBL
  ENSRNOT00000109919 ENTREZGENE
  ENSRNOT00000109919.2 UniProtKB/TrEMBL
  ENSRNOT00000126064 ENTREZGENE
  ENSRNOT00000126064.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.160 UniProtKB/TrEMBL
InterPro TNFAIP8-like UniProtKB/TrEMBL
  TNFAIP8_sf UniProtKB/TrEMBL
NCBI Gene 301131 ENTREZGENE
PANTHER PTHR12757 UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8-LIKE PROTEIN 1 UniProtKB/TrEMBL
Pfam DUF758 UniProtKB/TrEMBL
PhenoGen Tnfaip8l1 PhenoGen
RatGTEx ENSRNOG00000045999 RatGTEx
  ENSRNOG00000069635 RatGTEx
UniProt A0A8I5ZY03 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Tnfaip8l1  TNF alpha induced protein 8 like 1  Tnfaip8l1  TNF alpha induced protein 8 like 1  Data merged from RGD:149736346 737654 PROVISIONAL
2021-08-09 Tnfaip8l1  TNF alpha induced protein 8 like 1      Symbol and Name status set to provisional 45752 PROVISIONAL
2015-12-02 Tnfaip8l1  TNF alpha induced protein 8 like 1  Tnfaip8l1  tumor necrosis factor, alpha-induced protein 8-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Tnfaip8l1  tumor necrosis factor, alpha-induced protein 8-like 1  LOC301131  similar to tumor necrosis factor, alpha-induced protein 8-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC301131  similar to tumor necrosis factor, alpha-induced protein 8-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL