Cd70 (Cd70 molecule) - Rat Genome Database

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Gene: Cd70 (Cd70 molecule) Rattus norvegicus
Analyze
Symbol: Cd70
Name: Cd70 molecule
RGD ID: 1588573
Description: Predicted to enable receptor ligand activity. Predicted to be involved in several processes, including adaptive immune memory response involving T cells and B cells; extrinsic apoptotic signaling pathway; and lymphocyte proliferation. Predicted to act upstream of or within CD27 signaling pathway and T cell activation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome. Orthologous to human CD70 (CD70 molecule); PARTICIPATES IN cytokine mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; arsenous acid; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD70 antigen; LOC301132; similar to Tumor necrosis factor ligand superfamily member 7 (CD27 ligand) (CD27-L) (CD70 antigen)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr892,093,540 - 2,096,692 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl92,086,848 - 2,096,692 (-)EnsemblGRCr8
mRatBN7.292,006,563 - 2,009,715 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl92,006,563 - 2,009,715 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,440,782 - 2,443,934 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,790,156 - 7,793,308 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,746,009 - 6,749,161 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,842,585 - 9,845,728 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,842,585 - 9,845,728 (+)Ensemblrn6Rnor6.0
Rnor_5.098,844,883 - 8,848,026 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera96,508,540 - 6,511,692 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (EXP,ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper(II) chloride  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furosemide  (EXP)
gardenoside  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflurane  (EXP)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (ISO)
pentanal  (ISO)
PF-3758309  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
triptonide  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
VX nerve agent  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9177220   PMID:11920585   PMID:12777399   PMID:20458337   PMID:28011863   PMID:28011864  


Genomics

Comparative Map Data
Cd70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr892,093,540 - 2,096,692 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl92,086,848 - 2,096,692 (-)EnsemblGRCr8
mRatBN7.292,006,563 - 2,009,715 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl92,006,563 - 2,009,715 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,440,782 - 2,443,934 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,790,156 - 7,793,308 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,746,009 - 6,749,161 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,842,585 - 9,845,728 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,842,585 - 9,845,728 (+)Ensemblrn6Rnor6.0
Rnor_5.098,844,883 - 8,848,026 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera96,508,540 - 6,511,692 (+)NCBICelera
Cytogenetic Map9q11NCBI
CD70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,581,648 - 6,591,150 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,583,183 - 6,604,103 (-)Ensemblhg38GRCh38
GRCh37196,581,659 - 6,591,161 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,536,850 - 6,542,163 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34196,536,850 - 6,542,163NCBI
Celera196,525,685 - 6,531,003 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,346,587 - 6,351,902 (-)NCBIHuRef
CHM1_1196,585,772 - 6,591,088 (-)NCBICHM1_1
T2T-CHM13v2.0196,571,316 - 6,593,751 (-)NCBIT2T-CHM13v2.0
Cd70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,452,997 - 57,456,777 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,452,997 - 57,456,777 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381757,145,997 - 57,149,777 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,145,997 - 57,149,777 (-)Ensemblmm10GRCm38
MGSCv371757,285,420 - 57,289,200 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361756,831,330 - 56,835,110 (-)NCBIMGSCv36mm8
Celera1761,495,459 - 61,499,239 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.69NCBI
CD70
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,993,584 - 11,003,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11910,218,951 - 10,229,120 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,615,056 - 5,621,055 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,535,559 - 6,542,310 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,535,559 - 6,542,310 (-)EnsemblpanPan2panpan1.1
CD70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,639,315 - 53,642,687 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,639,436 - 53,642,319 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2053,386,663 - 53,389,596 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02054,293,471 - 54,296,448 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,293,040 - 54,296,476 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,360,273 - 53,363,248 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,808,582 - 53,811,556 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,037,542 - 54,040,520 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cd70
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,913,063 - 213,916,307 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,918,965 - 3,921,720 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,918,944 - 3,921,720 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,528,400 - 72,532,951 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1272,528,988 - 72,531,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,154,180 - 73,157,142 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD70
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,188,720 - 6,202,212 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl66,188,897 - 6,193,652 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660811,796,679 - 1,810,205 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd70
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248283,720,808 - 3,724,337 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cd70
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1488,545,410 - 88,548,780 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cd70
15 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:56
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000070806
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631533Iresp3Immunoglobin response QTL316.2blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)916094576Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 1 19 88 21 28 6 32 6 4 80 57 83 8 54 22 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000070806   ⟹   ENSRNOP00000064850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl92,086,848 - 2,096,692 (-)Ensembl
mRatBN7.2 Ensembl92,006,563 - 2,009,715 (-)Ensembl
Rnor_6.0 Ensembl99,842,585 - 9,845,728 (+)Ensembl
RefSeq Acc Id: NM_001106878   ⟹   NP_001100348
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr892,093,540 - 2,096,692 (-)NCBI
mRatBN7.292,006,563 - 2,009,715 (-)NCBI
Rnor_6.099,842,585 - 9,845,728 (+)NCBI
Rnor_5.098,844,883 - 8,848,026 (+)NCBI
Celera96,508,540 - 6,511,692 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100348 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83573 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064850
  ENSRNOP00000064850.2
RefSeq Acc Id: NP_001100348   ⟸   NM_001106878
- UniProtKB: A6KQR5 (UniProtKB/TrEMBL),   M0R613 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064850   ⟸   ENSRNOT00000070806
Protein Domains
THD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R613-F1-model_v2 AlphaFold M0R613 1-195 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588573 AgrOrtholog
BioCyc Gene G2FUF-28485 BioCyc
Ensembl Genes ENSRNOG00000051015 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070806 ENTREZGENE
  ENSRNOT00000070806.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro CD70 UniProtKB/TrEMBL
  TNF UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/TrEMBL
KEGG Report rno:301132 UniProtKB/TrEMBL
NCBI Gene 301132 ENTREZGENE
PANTHER CD70 ANTIGEN UniProtKB/TrEMBL
  PTHR15152 UniProtKB/TrEMBL
PhenoGen Cd70 PhenoGen
PROSITE TNF_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051015 RatGTEx
SMART TNF UniProtKB/TrEMBL
Superfamily-SCOP TNF_like UniProtKB/TrEMBL
UniProt A6KQR5 ENTREZGENE, UniProtKB/TrEMBL
  M0R613 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-29 Cd70  Cd70 molecule  Cd70  CD70 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Cd70  CD70 antigen  LOC301132  similar to Tumor necrosis factor ligand superfamily member 7 (CD27 ligand) (CD27-L) (CD70 antigen)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC301132  similar to Tumor necrosis factor ligand superfamily member 7 (CD27 ligand) (CD27-L) (CD70 antigen)      Symbol and Name status set to provisional 70820 PROVISIONAL