Tmem278 (transmembrane protein 278) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tmem278 (transmembrane protein 278) Rattus norvegicus
Analyze
Symbol: Tmem278 (Ensembl: Tmem88b)
Name: transmembrane protein 278 (Ensembl:transmembrane protein 88B)
RGD ID: 1588243
Description: Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TMEM88B (transmembrane protein 88B); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC680723; LOC680723; Tmem88b; transmembrane protein 88B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,673,319 - 171,676,143 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5171,673,319 - 171,676,143 (-)EnsemblGRCr8
mRatBN7.25166,391,080 - 166,393,904 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,391,080 - 166,393,904 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5169,095,879 - 169,098,731 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,917,300 - 170,920,152 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,879,831 - 170,882,683 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,230,364 - 173,233,188 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,230,364 - 173,233,188 (-)Ensemblrn6Rnor6.0
Rnor_5.05176,705,977 - 176,708,801 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45172,640,032 - 172,642,856 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5164,591,808 - 164,594,643 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Tmem278
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,673,319 - 171,676,143 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5171,673,319 - 171,676,143 (-)EnsemblGRCr8
mRatBN7.25166,391,080 - 166,393,904 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,391,080 - 166,393,904 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5169,095,879 - 169,098,731 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,917,300 - 170,920,152 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,879,831 - 170,882,683 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,230,364 - 173,233,188 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,230,364 - 173,233,188 (-)Ensemblrn6Rnor6.0
Rnor_5.05176,705,977 - 176,708,801 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45172,640,032 - 172,642,856 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5164,591,808 - 164,594,643 (-)NCBICelera
Cytogenetic Map5q36NCBI
TMEM278
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811,425,871 - 1,430,255 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11,425,871 - 1,430,255 (+)Ensemblhg38GRCh38
GRCh3711,361,251 - 1,365,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,351,425 - 1,353,030 (+)NCBIBuild 36Build 36hg18NCBI36
Celera11,209,262 - 1,238,394 (-)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1633,684 - 633,943 (+)NCBIHuRef
CHM1_111,348,921 - 1,350,553 (+)NCBICHM1_1
T2T-CHM13v2.01857,800 - 864,615 (+)NCBIT2T-CHM13v2.0
Tmem278
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,866,048 - 155,870,331 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,866,048 - 155,870,331 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384155,781,591 - 155,785,874 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,781,591 - 155,785,874 (-)Ensemblmm10GRCm38
MGSCv374155,155,700 - 155,159,983 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364154,627,151 - 154,629,674 (-)NCBIMGSCv36mm8
Celera4158,053,444 - 158,057,690 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map487.36NCBI
Tmem278
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554869,376,707 - 9,379,315 (-)Ensembl
ChiLan1.0NW_0049554869,376,707 - 9,379,315 (-)NCBIChiLan1.0ChiLan1.0
TMEM278
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,796,547 - 226,799,717 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11225,494,806 - 225,497,281 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,849 - 185,020 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111,381,365 - 1,382,070 (+)NCBIPanPan1.1PanPan1.1panPan2
TMEM88B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,569,512 - 56,573,353 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,569,814 - 56,571,310 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha556,645,679 - 56,647,617 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0556,772,105 - 56,774,043 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,772,125 - 56,775,886 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,762,323 - 56,764,261 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,654,578 - 56,656,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,044,927 - 57,046,868 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmem278
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,718,939 - 27,720,169 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367371,746,208 - 1,746,947 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM88B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,686,546 - 63,688,456 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1663,686,542 - 63,689,298 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,290,386 - 58,293,142 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM278
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120130,028,526 - 130,031,739 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20130,026,134 - 130,030,985 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605434,570,455 - 34,572,716 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem278
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248188,215,265 - 8,216,922 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248188,213,876 - 8,217,899 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmem278
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v114,844,234 - 4,846,391 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:508
Count of miRNA genes:248
Interacting mature miRNAs:306
Transcripts:ENSRNOT00000055343
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 55 145 88 86 58 21 58 6 253 104 5 129 68 90 28 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000055343   ⟹   ENSRNOP00000052210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5171,673,319 - 171,676,143 (-)Ensembl
mRatBN7.2 Ensembl5166,391,080 - 166,393,904 (-)Ensembl
Rnor_6.0 Ensembl5173,230,364 - 173,233,188 (-)Ensembl
RefSeq Acc Id: NM_001109426   ⟹   NP_001102896
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,673,319 - 171,676,143 (-)NCBI
mRatBN7.25166,391,080 - 166,393,904 (-)NCBI
Rnor_6.05173,230,364 - 173,233,188 (-)NCBI
Rnor_5.05176,705,977 - 176,708,801 (-)NCBI
RGSC_v3.45172,640,032 - 172,642,856 (-)RGD
Celera5164,591,808 - 164,594,643 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102896 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81324 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052210
  ENSRNOP00000052210.2
RefSeq Acc Id: NP_001102896   ⟸   NM_001109426
- UniProtKB: D4AAB3 (UniProtKB/TrEMBL),   A6IUS3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052210   ⟸   ENSRNOT00000055343

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAB3-F1-model_v2 AlphaFold D4AAB3 1-165 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588243 AgrOrtholog
BioCyc Gene G2FUF-38899 BioCyc
Ensembl Genes ENSRNOG00000036869 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055343 ENTREZGENE
  ENSRNOT00000055343.4 UniProtKB/TrEMBL
InterPro TMEM88 UniProtKB/TrEMBL
KEGG Report rno:680723 UniProtKB/TrEMBL
NCBI Gene 680723 ENTREZGENE
PANTHER PTHR28628 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 88B UniProtKB/TrEMBL
PhenoGen Tmem278 PhenoGen
RatGTEx ENSRNOG00000036869 RatGTEx
UniProt A6IUS3 ENTREZGENE, UniProtKB/TrEMBL
  D4AAB3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-03-06 Tmem278  transmembrane protein 278  Tmem88b  transmembrane protein 88B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-21 Tmem88b  transmembrane protein 88B  LOC680723  hypothetical protein LOC680723  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680723  hypothetical protein LOC680723  LOC687243  hypothetical protein LOC687243  Data merged from RGD:1587735 1643240 APPROVED
2006-11-19 LOC680723  hypothetical protein LOC680723      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687243  hypothetical protein LOC687243      Symbol and Name status set to provisional 70820 PROVISIONAL