Advanced Search (OLGA)

Gene: Ebf4 (EBF family member 4) Rattus norvegicus

Analyze

Symbol:

Ebf4

Name:

EBF family member 4

RGD ID:

1588215

Description:

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in T cell apoptotic process and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in chromatin. Orthologous to human EBF4 (EBF family member 4); INTERACTS WITH acetamide; bisphenol A; methoxychlor.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

early B-cell factor 4; early B-cell factor 4-like; LOC680751; similar to early B-cell factor 4; transcription factor COE4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EBF4 (EBF family member 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Ebf4 (early B cell factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ebf4 (EBF family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EBF4 (EBF family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EBF4 (EBF family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ebf4 (EBF family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EBF4 (EBF family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EBF4 (EBF family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ebf4 (EBF family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Ebf4 (early B cell factor 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ebf4 (early B cell factor 4)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	EBF4 (EBF family member 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	EBF4 (EBF family member 4)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	kn	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	kn	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	unc-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	coe3l	Alliance	DIOPT (PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	137,951,310 - 138,019,682 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	137,951,335 - 138,019,665 (+)	Ensembl				GRCr8
mRatBN7.2	3	117,498,186 - 117,566,566 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	117,498,319 - 117,566,566 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	121,397,059 - 121,464,363 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	129,992,677 - 130,059,999 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	127,653,184 - 127,720,493 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	122,836,468 - 122,890,663 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	122,836,446 - 122,890,663 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	129,335,419 - 129,391,670 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	117,910,290 - 117,977,045 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	116,315,020 - 116,379,923 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cisplatin (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methoxychlor (EXP)

niclosamide (ISO)

okadaic acid (ISO)

ozone (ISO)

perfluorohexanesulfonic acid (ISO)

potassium dichromate (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of DNA-templated transcription (IEA,ISO)

regulation of transcription by RNA polymerase II (IBA)

T cell apoptotic process (IEA,ISO)

Cellular Component

chromatin (IEA,ISO)

nucleus (IEA)

Molecular Function

DNA binding (IEA,ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA,ISO)

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA,ISO)

DNA-binding transcription factor binding (IEA,ISO)

metal ion binding (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA,ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA,ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12139918	PMID:12477932

Genomics

Comparative Map Data

Ebf4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	137,951,310 - 138,019,682 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	137,951,335 - 138,019,665 (+)	Ensembl				GRCr8
mRatBN7.2	3	117,498,186 - 117,566,566 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	117,498,319 - 117,566,566 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	121,397,059 - 121,464,363 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	129,992,677 - 130,059,999 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	127,653,184 - 127,720,493 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	122,836,468 - 122,890,663 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	122,836,446 - 122,890,663 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	129,335,419 - 129,391,670 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	117,910,290 - 117,977,045 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	116,315,020 - 116,379,923 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

EBF4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	2,692,780 - 2,760,108 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	2,692,780 - 2,760,108 (+)	Ensembl			hg38	GRCh38
GRCh37	20	2,673,426 - 2,740,754 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	2,621,524 - 2,688,754 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	20	2,738,001 - 2,805,248 (+)	NCBI		Celera
Cytogenetic Map	20	p13	NCBI
HuRef	20	2,623,625 - 2,690,263 (+)	NCBI		HuRef
CHM1_1	20	2,674,237 - 2,740,789 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	2,723,172 - 2,790,570 (+)	NCBI		T2T-CHM13v2.0

Ebf4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	130,134,832 - 130,212,402 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	130,137,089 - 130,212,401 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	130,295,126 - 130,370,482 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	130,295,169 - 130,370,481 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	130,121,675 - 130,196,217 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	129,987,380 - 130,061,907 (+)	NCBI		MGSCv36	mm8
Celera	2	131,520,441 - 131,595,152 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	63.21	NCBI

Ebf4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	13,673,700 - 13,734,344 (+)	Ensembl
ChiLan1.0	NW_004955415	13,673,700 - 13,734,344 (+)	NCBI	ChiLan1.0	ChiLan1.0

EBF4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	3,681,660 - 3,749,093 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	3,678,554 - 3,745,911 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	2,800,909 - 2,868,157 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	2,564,871 - 2,631,106 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

EBF4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	18,469,862 - 18,528,305 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	18,470,952 - 18,528,622 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	18,299,310 - 18,357,702 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	18,890,498 - 18,986,190 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	18,890,525 - 18,987,148 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	18,483,667 - 18,542,399 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	18,594,451 - 18,652,904 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	18,923,257 - 18,981,780 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ebf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	167,519,026 - 167,582,156 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	15,951,544 - 16,013,515 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	15,951,546 - 16,013,541 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EBF4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	32,876,089 - 32,944,678 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	17	32,874,807 - 32,944,623 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	37,245,721 - 37,257,739 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EBF4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	53,786,397 - 53,850,935 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	53,794,161 - 53,838,668 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666087	201,821 - 266,607 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ebf4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	3,834,151 - 3,892,353 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624741	3,834,175 - 3,892,347 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Ebf4
399 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	139
Count of miRNA genes:	113
Interacting mature miRNAs:	120
Transcripts:	ENSRNOT00000028816
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582233	Insul10	Insulin level QTL 10	5.4	0.0015	blood insulin amount (VT:0001560)	serum insulin level times blood glucose level (CMO:0002040)	3	133259579	178259579	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	96509147	141509147	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	129154923	182114333	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	49872657	138829559	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	133134628	178134628	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	104545086	149545086	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	81425008	141509147	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	3	93829559	138829559	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	112250810	157250810	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	96509147	141509147	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	117537367	162537367	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	125116475	170116475	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	110225882	155225882	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	3	136091420	155634702	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	122395989	167395989	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	90755164	141509147	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	137114333	182114333	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	131036586	176036586	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	131036586	176036586	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	125814931	139636791	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	110634702	155634702	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	116188400	161188400	Rat

Markers in Region

D3Got257

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	3	137,959,729 - 137,959,957 (+)	Marker Load Pipeline
mRatBN7.2	3	117,506,603 - 117,506,831 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	122,833,650 - 122,833,877	NCBI	Rnor6.0
Rnor_5.0	3	129,332,601 - 129,332,828	UniSTS	Rnor5.0
RGSC_v3.4	3	117,917,833 - 117,918,060	UniSTS	RGSC3.4
Celera	3	116,322,562 - 116,322,789	UniSTS
Cytogenetic Map	3	q36	UniSTS

D3Got287

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	3	137,999,022 - 137,999,154 (+)	Marker Load Pipeline
mRatBN7.2	3	117,545,903 - 117,546,035 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	122,870,956 - 122,871,087	NCBI	Rnor6.0
Rnor_5.0	3	129,372,016 - 129,372,147	UniSTS	Rnor5.0
RGSC_v3.4	3	117,957,359 - 117,957,490	UniSTS	RGSC3.4
Celera	3	116,360,513 - 116,360,648	UniSTS
Cytogenetic Map	3	q36	UniSTS

AW533927

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	117,515,438 - 117,515,612 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	122,842,485 - 122,842,658	NCBI	Rnor6.0
Rnor_5.0	3	129,341,436 - 129,341,609	UniSTS	Rnor5.0
RGSC_v3.4	3	117,926,669 - 117,926,842	UniSTS	RGSC3.4
Celera	3	116,331,116 - 116,331,289	UniSTS
RH 3.4 Map	3	1000.7	UniSTS
Cytogenetic Map	3	q36	UniSTS

AU048104

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	117,560,374 - 117,560,636 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	122,885,425 - 122,885,686	NCBI	Rnor6.0
Rnor_5.0	3	129,386,485 - 129,386,746	UniSTS	Rnor5.0
RGSC_v3.4	3	117,971,832 - 117,972,093	UniSTS	RGSC3.4
Celera	3	116,374,950 - 116,375,211	UniSTS
Cytogenetic Map	3	q36	UniSTS

SHGC-153198

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	3	137,962,594 - 137,962,698 (+)	Marker Load Pipeline
mRatBN7.2	3	117,509,469 - 117,509,572 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	122,836,516 - 122,836,618	NCBI	Rnor6.0
Rnor_5.0	3	129,335,467 - 129,335,569	UniSTS	Rnor5.0
RGSC_v3.4	3	117,920,700 - 117,920,802	UniSTS	RGSC3.4
Celera	3	116,325,428 - 116,325,530	UniSTS
Cytogenetic Map	3	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	159	91	90	59	34	59	6	298	134	11	138	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001415850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105849	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005501982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC130173	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC158597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000028816 ⟹ ENSRNOP00000028816

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	137,951,335 - 138,019,665 (+)	Ensembl
mRatBN7.2 Ensembl	3	117,498,319 - 117,566,566 (+)	Ensembl
Rnor_6.0 Ensembl	3	122,836,446 - 122,890,663 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000151149 ⟹ ENSRNOP00000112705

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	137,951,335 - 138,012,658 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000157960 ⟹ ENSRNOP00000111404

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	137,951,335 - 138,014,511 (+)	Ensembl

RefSeq Acc Id:

NM_001191076 ⟹ NP_001178005

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	137,952,114 - 138,019,682 (+)	NCBI
mRatBN7.2	3	117,498,988 - 117,566,566 (+)	NCBI
Rnor_6.0	3	122,836,468 - 122,890,663 (+)	NCBI
Rnor_5.0	3	129,335,419 - 129,391,670 (+)	NCBI
Celera	3	116,315,020 - 116,379,923 (+)	NCBI

Sequence:

show sequence

ATGTTTCCCGCACAGGACGCTCTGCCCCGCGGTGGGCTCCACTTGAAAGAGGAGCCGCTGCTGC
CCTCCAGCCTGGGCTCCGTGCGCTCCTGGATGCAGAGCGCGGGCATCCTGGACTCCAGCACCGC
GGCGCAGAGTGGCGTGGGCCTGGCAAGAGCACATTTTGAAAAGCAGCCCCCCTCCAACCTCAGG
AAGTCCAACTTCTTCCACTTCGTGCTGGCCATGTACGACCGGCAGGGGCAGCCCGTGGAGGTGG
AGCGCACAGCCTTCATCGACTTCGTGGAAAAGGATCGAGAGCCTGGGACAGAAAAAACAAACAA
CGGGATCCATTACCGTCTTCGGCTGGTGTATAATAATGGACTTCGGACAGAACAAGACCTCTAC
GTACGACTTATTGACTCCATGTCAAAGCAGGCTATCATCTATGAGGGACAGGACAAGAATCCCG
AAATGTGCCGGGTGCTGCTCACTCATGAGATCATGTGCAGTCGGTGCTGTGACCGCAAGAGCTG
TGGTAACCGGAACGAGACGCCTTCTGATCCAGTCATTATTGACAGGTTCTTCCTCAAATTCTTT
CTCAAATGCAACCAGAACTGTTTGAAGAATGCCGGGAATCCCCGAGACATGCGCCGCTTCCAGG
TGGTGGTGTCCACGACAGTGAGTGTGGACGGACACGTGCTGGCTGTGTCAGACAACATGTTTGT
GCACAACAACTCCAAGCATGGACGCAGAGCCCGACGCCTGGACCCTTCTGAAGCTGCCACCCCA
TGCATCAAGGCCATCAGCCCCGGGGAGGGCTGGACCACGGGAGGCGCCACCGTCATTATCATCG
GAGACAACTTCTTCGACGGGTTGCAGGTCGTGTTTGGCAACGTGCTCCTGTGGAGCGAGCTCAT
CACTCCCCATGCTCTCCGGGTGCAGACGCCACCACGACACATACCCGGGGTAGTAGAAGTGACC
CTCTCCTACAAGTCCAAGCAGTTTTGTAAAGGAGCCCCTGGCCGCTTTGTCTACACAGCCCTGA
ATGAACCCACCATTGACTACGGATTCCAGAGGCTACAGAAAGTCATTCCCAGACACCCAGGAGA
CCCTGAGAGGCTACCCAAGGAAGTGCTGTTGAAAAGGGCGGCTGATTTGGCGGAGGCTCTGTAT
GGAGTGCCCAACAGTAACCAGGAGCTCCTCCTGAAACGGGCGGCGGATGTAGCCGAGGCTCTGT
ACAGCGCCCCGCGCGCGCCTGCACCACTCGGACCCCTGGCCCCCAGCCACCCGCACCCCGCTGT
CGTGGGCATCAACGCTTTCAGCAGCCCTCTGGCTATCGCCGTCGGGGATGCCACACCGGAGCCG
GGCTATGCCCGTAGCTGCGGCAGCGCGTCTCCCCGGTTCGCGCCCAGCCCTGGCTCTCAACAAA
GCAGCTATGGCAGTGGTCTTGGAGCCGGCCTCGGTAGCTATGGAGCGCCCGGTGTGACTGGCCT
TGGCGTGCCCGGGTCCCCTAGCTTCCTCAATGGCTCCACTGCAACCTCACCTTTCGCCATCATG
CCCTCTAGCCCCCCGCTGGCGGCTGCCTCCTCCATGTCCCTTCCGGCCGCTGCCCCCACCACCA
GCGTCTTCTCCTTCTCGCCTGTCAACATGATCTGCGCTGTCAAGCAGAGAAGCGCCTTCGCCCC
TGTGCTGCGCCCACCCAGCTCCCCATCGCAGGCCTGCCCCAGAGCCCACAGAGAGGGGCTTCCA
GACCAGCCTTTTGAAGATACTGACAAGTTCCACTCTGCAGCTCGGGGACTCCAGGGCCTGGCAT
ACTCCTAA

hide sequence

RefSeq Acc Id:

NM_001415850 ⟹ NP_001402779

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	137,951,335 - 138,019,665 (+)	NCBI
mRatBN7.2	3	117,498,209 - 117,566,549 (+)	NCBI

RefSeq Acc Id:

XM_039105845 ⟹ XP_038961773

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	137,951,310 - 138,019,682 (+)	NCBI
mRatBN7.2	3	117,498,186 - 117,566,566 (+)	NCBI

RefSeq Acc Id:

XM_039105846 ⟹ XP_038961774

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	137,951,311 - 138,019,682 (+)	NCBI
mRatBN7.2	3	117,498,186 - 117,566,566 (+)	NCBI

RefSeq Acc Id:

XM_039105847 ⟹ XP_038961775

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	137,951,312 - 138,019,682 (+)	NCBI
mRatBN7.2	3	117,498,186 - 117,566,566 (+)	NCBI

RefSeq Acc Id:

XM_039105849 ⟹ XP_038961777

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	137,952,188 - 138,019,682 (+)	NCBI
mRatBN7.2	3	117,498,676 - 117,566,566 (+)	NCBI

RefSeq Acc Id:

XM_039105850 ⟹ XP_038961778

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	137,952,337 - 138,019,682 (+)	NCBI
mRatBN7.2	3	117,499,208 - 117,566,566 (+)	NCBI

RefSeq Acc Id:

XM_039105853 ⟹ XP_038961781

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	137,952,188 - 138,014,610 (+)	NCBI
mRatBN7.2	3	117,498,676 - 117,561,494 (+)	NCBI

RefSeq Acc Id:

XM_063284541 ⟹ XP_063140611

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	137,952,188 - 138,019,682 (+)	NCBI

RefSeq Acc Id:

XR_005501982

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	137,951,311 - 138,019,682 (+)	NCBI
mRatBN7.2	3	117,498,186 - 117,566,566 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001178005	(Get FASTA)	NCBI Sequence Viewer
	NP_001402779	(Get FASTA)	NCBI Sequence Viewer
	XP_038961773	(Get FASTA)	NCBI Sequence Viewer
	XP_038961774	(Get FASTA)	NCBI Sequence Viewer
	XP_038961775	(Get FASTA)	NCBI Sequence Viewer
	XP_038961777	(Get FASTA)	NCBI Sequence Viewer
	XP_038961778	(Get FASTA)	NCBI Sequence Viewer
	XP_038961781	(Get FASTA)	NCBI Sequence Viewer
	XP_063140611	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI58598	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028816
	ENSRNOP00000028816.7
	ENSRNOP00000111404
	ENSRNOP00000111404.1
	ENSRNOP00000112705.1

RefSeq Acc Id:

NP_001178005 ⟸ NM_001191076

- Peptide Label:

isoform 2

- Sequence:

show sequence

MFPAQDALPRGGLHLKEEPLLPSSLGSVRSWMQSAGILDSSTAAQSGVGLARAHFEKQPPSNLR
KSNFFHFVLAMYDRQGQPVEVERTAFIDFVEKDREPGTEKTNNGIHYRLRLVYNNGLRTEQDLY
VRLIDSMSKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDRKSCGNRNETPSDPVIIDRFFLKFF
LKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEAATP
CIKAISPGEGWTTGGATVIIIGDNFFDGLQVVFGNVLLWSELITPHALRVQTPPRHIPGVVEVT
LSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALY
GVPNSNQELLLKRAADVAEALYSAPRAPAPLGPLAPSHPHPAVVGINAFSSPLAIAVGDATPEP
GYARSCGSASPRFAPSPGSQQSSYGSGLGAGLGSYGAPGVTGLGVPGSPSFLNGSTATSPFAIM
PSSPPLAAASSMSLPAAAPTTSVFSFSPVNMICAVKQRSAFAPVLRPPSSPSQACPRAHREGLP
DQPFEDTDKFHSAARGLQGLAYS

hide sequence

Ensembl Acc Id:

ENSRNOP00000028816 ⟸ ENSRNOT00000028816

RefSeq Acc Id:	XP_038961773 ⟸ XM_039105845
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038961775 ⟸ XM_039105847
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038961774 ⟸ XM_039105846
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038961777 ⟸ XM_039105849
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038961781 ⟸ XM_039105853
- Peptide Label:	isoform X7

RefSeq Acc Id:	XP_038961778 ⟸ XM_039105850
- Peptide Label:	isoform X6

RefSeq Acc Id:	NP_001402779 ⟸ NM_001415850
- Peptide Label:	isoform 1 precursor
- UniProtKB:	D3ZW79 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140611 ⟸ XM_063284541
- Peptide Label:	isoform X4

Ensembl Acc Id:

ENSRNOP00000111404 ⟸ ENSRNOT00000157960

Ensembl Acc Id:

ENSRNOP00000112705 ⟸ ENSRNOT00000151149

Protein Domains

IPT/TIG

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZW79-F1-model_v2	AlphaFold	D3ZW79	1-560	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1588215	AgrOrtholog
BioCyc Gene	G2FUF-47860	BioCyc
Ensembl Genes	ENSRNOG00000007408	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000028816	ENTREZGENE
	ENSRNOT00000028816.8	UniProtKB/TrEMBL
	ENSRNOT00000151149.1	UniProtKB/TrEMBL
	ENSRNOT00000157960	ENTREZGENE
	ENSRNOT00000157960.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.4280	UniProtKB/TrEMBL
	2.60.40.10	UniProtKB/TrEMBL
	2.60.40.3180	UniProtKB/TrEMBL
InterPro	COE_DBD	UniProtKB/TrEMBL
	COE_DBD_sf	UniProtKB/TrEMBL
	COE_HLH	UniProtKB/TrEMBL
	COE_IPT	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_E-set	UniProtKB/TrEMBL
	IPT_TIG_rcpt	UniProtKB/TrEMBL
	Transcription_factor_COE	UniProtKB/TrEMBL
	Transcription_factor_COE_CS	UniProtKB/TrEMBL
NCBI Gene	680751	ENTREZGENE
PANTHER	TF_COE	UniProtKB/TrEMBL
Pfam	COE1_DBD	UniProtKB/TrEMBL
	COE1_HLH	UniProtKB/TrEMBL
	TIG	UniProtKB/TrEMBL
PhenoGen	Ebf4	PhenoGen
PROSITE	COE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007408	RatGTEx
SMART	IPT	UniProtKB/TrEMBL
Superfamily-SCOP	Ig_E-set	UniProtKB/TrEMBL
UniProt	A0ABK0M2J2_RAT	UniProtKB/TrEMBL
	A0ABK0M2Y2_RAT	UniProtKB/TrEMBL
	D3ZW79	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-10-03	Ebf4	EBF family member 4	Ebf4	early B-cell factor 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Ebf4	early B-cell factor 4	LOC680751	similar to early B-cell factor 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC680751	similar to early B-cell factor 4	LOC688106	similar to early B-cell factor 4	Data merged from RGD:1592453	1643240	APPROVED
2006-11-20	LOC688106	similar to early B-cell factor 4			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC680751	similar to early B-cell factor 4			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message