Timm8a2 (translocase of inner mitochondrial membrane 8A2)

Gene: Timm8a2 (translocase of inner mitochondrial membrane 8A2) Rattus norvegicus

Analyze

No known orthologs.

Symbol:

Timm8a2

Name:

translocase of inner mitochondrial membrane 8A2

RGD ID:

1588172

Description:

Predicted to be involved in protein transport. Predicted to be located in mitochondrial inner membrane.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC680794; similar to Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1 homolog); translocase of inner mitochondrial membrane 8 homolog a2; translocase of inner mitochondrial membrane 8 homolog a2 (yeast)

RGD Orthologs

Alliance Genes

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	TIMM8A (translocase of inner mitochondrial membrane 8A)	HGNC	OrthoDB, Panther, PhylomeDB, Treefam
Alliance orthologs ³
Mus musculus (house mouse):	Timm8a2 (translocase of inner mitochondrial membrane 8A2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	timm8a (translocase of inner mitochondrial membrane 8 homolog A (yeast))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ddp-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	TIM8	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	105,529,725 - 105,537,745 (+)	NCBI		GRCr8
mRatBN7.2	15	99,123,374 - 99,131,097 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	99,127,384 - 99,131,155 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	103,060,193 - 103,063,884 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	104,152,345 - 104,156,008 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	101,080,171 - 101,083,834 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	108,448,351 - 108,456,834 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	108,453,147 - 108,456,808 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	111,840,703 - 111,844,364 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	107,145,036 - 107,148,697 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	15	97,899,949 - 97,903,743 (+)	NCBI		Celera
Cytogenetic Map	15	q25	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

protein transport (IEA)

Cellular Component

mitochondrial inner membrane (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
2.	Comprehensive gene review and curation	RGD comprehensive gene curation

Genomics

Variants

Variants in Timm8a2
18 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	71
Count of miRNA genes:	56
Interacting mature miRNAs:	66
Transcripts:	ENSRNOT00000018486
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631655	Bp126	Blood pressure QTL 126	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	58156477	101769107	Rat
731177	Uae26	Urinary albumin excretion QTL 26	2.4	0.025	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	15	67588667	101769107	Rat
2300326	Plaw1	Placental weight QTL 1	15	0.005	placenta mass (VT:0004257)	placenta wet weight (CMO:0002088)	15	68327165	100062518	Rat
1641889	Colcr6	Colorectal carcinoma resistance QTL 6	2.9	0.0126	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	15	73690518	99794247	Rat
2317055	Aia10	Adjuvant induced arthritis QTL 10	3.41		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	15	75788062	101769107	Rat
1549844	Bss7	Bone structure and strength QTL 7	6.4		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	15	75788062	101769107	Rat
70155	Gcs1	Gastric cancer susceptibility QTL1	3.8		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	15	76306099	101769107	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium										3	10
Low	2				4				16	21	19	1
Below cutoff		15	17	7	15	7	2	5	50	11	8	8	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599798	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274627	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274628	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC129791	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000018486 ⟹ ENSRNOP00000018486

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	99,127,410 - 99,131,071 (+)	Ensembl
Rnor_6.0 Ensembl	15	108,453,147 - 108,456,808 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000107031 ⟹ ENSRNOP00000078149

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	99,127,384 - 99,131,155 (+)	Ensembl

RefSeq Acc Id:

NM_001109429 ⟹ NP_001102899

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	105,534,058 - 105,537,719 (+)	NCBI
mRatBN7.2	15	99,127,410 - 99,131,071 (+)	NCBI
Rnor_6.0	15	108,453,147 - 108,456,808 (+)	NCBI
Rnor_5.0	15	111,840,703 - 111,844,364 (+)	NCBI
RGSC_v3.4	15	107,145,036 - 107,148,697 (+)	RGD
Celera	15	97,899,949 - 97,903,743 (+)	RGD

Sequence:

show sequence

CATGGAGTCATCCTGGTCTTCACTGGGGGGCAGCCTGGGCTCTGCAGACCCGCAGCTGCAGCGT
TTCATGGAAGCAGAGGTGCAGAAGCAGCGGGTGCAGTTGCTCATCCACCACATGACGGAGCTCT
GCTGGGAGAAGTGCATGGACAAGCCCGGGCCCAAGCTGGACAGCCGAGCCGAGCTCTGCTTGGT
GAACTGCGTCGAGCGCTTCATCGATACGAGCCAGTTCATTTTGAATCGACTGGAGCACACCCAC
AAGGCCAAACCGTTCTTCTCACAAAACCTTTCTGACTGATCTTAACGTTTCCCTCTTTGAAAAA
GGAAGATCCCTGTTCCTTAGGGCTTCAGAGGCCGTGCCAGTGCAAGACTGATGAGAAAATCCCG
AAATCATCTGTGCCTGAAGGAAAACAACACACCTGGAGAGGATGGAGTCGGGAGACGCCGATCT
CTGCCAAGTCACCGTGCACAAGAGCCTCTTCCACGGGGGATGGAGACAGGGCTCAGCAGTGAAG
AGACTTGTTACTCAACCGTTCTTACCCCAGTCAGTTCTGGCTGATTCAACACCCTCTCCTGACC
TCTGGGGCATTCCAGTCACATGGCACACTTACATTCACATAACATCGTGGAAAGACGGCTCCGT
GAGGAAGAGTACCGCTTGCCCTTCCAGAGGACCCACATTAATTCCCCAGCAACCACACGGTGTC
TCACAGCATCTATAACTCCAGTTCCAGGGGATCCGACACGTTCTCCCCTCCTCTGGCATCCACA
GGCACTGCACGCACATGGTGAGCAGACATGCGTGCAGGTAAAATATCCGTGCACACAAAATACA
AATGAAGGTGAAAACACTGAACAT

hide sequence

RefSeq Acc Id:

XM_063274627 ⟹ XP_063130697

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	105,530,465 - 105,537,745 (+)	NCBI

RefSeq Acc Id:

XM_063274628 ⟹ XP_063130698

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	105,529,725 - 105,537,745 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102899	(Get FASTA)	NCBI Sequence Viewer
	XP_063130697	(Get FASTA)	NCBI Sequence Viewer
	XP_063130698	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM02573	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000018486
	ENSRNOP00000018486.3
	ENSRNOP00000078149.1

RefSeq Acc Id:	NP_001102899 ⟸ NM_001109429
- UniProtKB:	D3ZV76 (UniProtKB/TrEMBL), A6HUL0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MESSWSSLGGSLGSADPQLQRFMEAEVQKQRVQLLIHHMTELCWEKCMDKPGPKLDSRAELCLV NCVERFIDTSQFILNRLEHTHKAKPFFSQNLSD hide sequence

RefSeq Acc Id:

ENSRNOP00000018486 ⟸ ENSRNOT00000018486

RefSeq Acc Id:

ENSRNOP00000078149 ⟸ ENSRNOT00000107031

RefSeq Acc Id:	XP_063130698 ⟸ XM_063274628
- Peptide Label:	isoform X1
- UniProtKB:	A6HUL0 (UniProtKB/TrEMBL), D3ZV76 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063130697 ⟸ XM_063274627
- Peptide Label:	isoform X1
- UniProtKB:	A6HUL0 (UniProtKB/TrEMBL), D3ZV76 (UniProtKB/TrEMBL)

Protein Domains

Tim10-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZV76-F1-model_v2	AlphaFold	D3ZV76	1-97	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1588172	AgrOrtholog
BioCyc Gene	G2FUF-12360	BioCyc
Ensembl Genes	ENSRNOG00000013835	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000018486	ENTREZGENE
	ENSRNOT00000018486.4	UniProtKB/TrEMBL
	ENSRNOT00000107031.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.810	UniProtKB/TrEMBL
InterPro	Tim10/FAM136A-like_domain	UniProtKB/TrEMBL
	Tim8/9/10/13_Znf-like	UniProtKB/TrEMBL
KEGG Report	rno:680794	UniProtKB/TrEMBL
NCBI Gene	680794	ENTREZGENE
Pfam	zf-Tim10_DDP	UniProtKB/TrEMBL
PhenoGen	Timm8a2	PhenoGen
RatGTEx	ENSRNOG00000013835	RatGTEx
Superfamily-SCOP	SSF144122	UniProtKB/TrEMBL
UniProt	A6HUL0	ENTREZGENE, UniProtKB/TrEMBL
	D3ZV76	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-11-21	Timm8a2	translocase of inner mitochondrial membrane 8A2	Timm8a2	translocase of inner mitochondrial membrane 8 homolog a2 (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Timm8a2	translocase of inner mitochondrial membrane 8 homolog a2 (yeast)	LOC680794	similar to Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1 homolog)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC680794	similar to Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1 homolog)	LOC687531	similar to Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1 homolog)	Data merged from RGD:1584234	1643240	APPROVED
2006-11-19	LOC680794	similar to Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1 homolog)			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC687531	similar to Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1 homolog)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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