Unc5cl (unc-5 family C-terminal like) - Rat Genome Database

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Pathways
Gene: Unc5cl (unc-5 family C-terminal like) Rattus norvegicus
Analyze
Symbol: Unc5cl
Name: unc-5 family C-terminal like
RGD ID: 1587368
Description: Predicted to enable peptidase activity. Predicted to be involved in positive regulation of JNK cascade and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in membrane. Orthologous to human UNC5CL (unc-5 family C-terminal like); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: unc-5 homolog C (C. elegans)-like; unc-5 homolog C-like; UNC5C-like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,025,719 - 20,041,083 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl920,025,719 - 20,039,841 (-)EnsemblGRCr8
mRatBN7.2912,528,109 - 12,543,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,528,246 - 12,542,233 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx921,041,334 - 21,055,444 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,107,538 - 26,121,648 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0924,490,670 - 24,504,827 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0914,494,080 - 14,510,302 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,491,584 - 14,508,235 (-)Ensemblrn6Rnor6.0
Rnor_5.0913,415,190 - 13,431,259 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera910,303,101 - 10,317,112 (-)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO)
membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22158417  


Genomics

Comparative Map Data
Unc5cl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,025,719 - 20,041,083 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl920,025,719 - 20,039,841 (-)EnsemblGRCr8
mRatBN7.2912,528,109 - 12,543,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,528,246 - 12,542,233 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx921,041,334 - 21,055,444 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,107,538 - 26,121,648 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0924,490,670 - 24,504,827 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0914,494,080 - 14,510,302 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,491,584 - 14,508,235 (-)Ensemblrn6Rnor6.0
Rnor_5.0913,415,190 - 13,431,259 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera910,303,101 - 10,317,112 (-)NCBICelera
Cytogenetic Map9q12NCBI
UNC5CL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,026,895 - 41,039,221 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,026,895 - 41,039,221 (-)Ensemblhg38GRCh38
GRCh37640,994,634 - 41,006,960 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,102,749 - 41,114,906 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34641,102,749 - 41,114,906NCBI
Celera642,547,321 - 42,559,619 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef640,712,588 - 40,724,897 (-)NCBIHuRef
CHM1_1640,997,146 - 41,009,444 (-)NCBICHM1_1
T2T-CHM13v2.0640,855,459 - 40,867,785 (-)NCBIT2T-CHM13v2.0
Unc5cl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,761,155 - 48,846,737 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1748,761,929 - 48,846,742 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381748,454,127 - 48,539,709 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,454,901 - 48,539,714 (+)Ensemblmm10GRCm38
MGSCv371748,594,226 - 48,608,011 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361747,920,490 - 47,934,253 (+)NCBIMGSCv36mm8
Celera1751,887,114 - 51,900,869 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1724.14NCBI
Unc5cl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554377,696,971 - 7,710,403 (-)Ensembl
ChiLan1.0NW_0049554377,697,062 - 7,710,240 (-)NCBIChiLan1.0ChiLan1.0
UNC5CL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2555,524,675 - 55,531,447 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1651,393,156 - 51,401,497 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0640,615,697 - 40,627,997 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1641,923,872 - 41,936,198 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl641,923,872 - 41,936,198 (-)EnsemblpanPan2panpan1.1
UNC5CL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1129,782,411 - 9,794,822 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl129,783,963 - 9,794,690 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha129,812,647 - 9,824,932 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01210,261,886 - 10,274,171 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1210,263,438 - 10,272,570 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1129,794,206 - 9,806,475 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0129,876,010 - 9,888,295 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0129,970,656 - 9,982,941 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Unc5cl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,165,113 - 45,176,657 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647618,752,099 - 18,795,070 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647618,787,583 - 18,795,241 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UNC5CL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,332,201 - 36,347,175 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1736,332,183 - 36,347,409 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2741,631,082 - 41,645,880 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UNC5CL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11731,121,777 - 31,130,120 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1731,122,081 - 31,128,771 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604441,027,437 - 41,035,791 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Unc5cl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475417,713,361 - 17,724,276 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475417,713,111 - 17,723,735 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Unc5cl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1481,459,176 - 81,473,783 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Unc5cl
238 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:91
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000073556
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9360535521031556Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
RH139987  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2912,528,324 - 12,528,514 (+)MAPPERmRatBN7.2
Rnor_6.0914,494,313 - 14,494,502NCBIRnor6.0
Rnor_5.0913,415,423 - 13,415,612UniSTSRnor5.0
Celera910,303,180 - 10,303,369UniSTS
RH 3.4 Map928.5UniSTS
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 61 91 90 90 59 87 59 6 340 176 11 64 81 92 31 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000073556   ⟹   ENSRNOP00000064852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl912,528,246 - 12,542,233 (-)Ensembl
Rnor_6.0 Ensembl914,494,234 - 14,508,214 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076531   ⟹   ENSRNOP00000068477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl920,025,719 - 20,039,841 (-)Ensembl
mRatBN7.2 Ensembl912,528,353 - 12,542,233 (-)Ensembl
Rnor_6.0 Ensembl914,494,755 - 14,508,235 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078464   ⟹   ENSRNOP00000069780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl914,491,584 - 14,502,933 (-)Ensembl
RefSeq Acc Id: NM_001106882   ⟹   NP_001100352
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,025,719 - 20,039,841 (-)NCBI
mRatBN7.2912,528,109 - 12,542,233 (-)NCBI
Rnor_6.0914,494,234 - 14,508,214 (-)NCBI
Rnor_5.0913,415,190 - 13,431,259 (-)NCBI
Celera910,303,101 - 10,317,112 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244422   ⟹   XP_006244484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,025,719 - 20,041,083 (-)NCBI
mRatBN7.2912,528,109 - 12,543,382 (-)NCBI
Rnor_6.0914,494,080 - 14,508,777 (-)NCBI
Rnor_5.0913,415,190 - 13,431,259 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006244423   ⟹   XP_006244485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,025,719 - 20,040,401 (-)NCBI
mRatBN7.2912,529,416 - 12,542,794 (-)NCBI
Rnor_6.0914,495,446 - 14,508,777 (-)NCBI
Rnor_5.0913,415,190 - 13,431,259 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083172   ⟹   XP_038939100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,025,719 - 20,034,133 (-)NCBI
mRatBN7.2912,528,109 - 12,536,525 (-)NCBI
RefSeq Acc Id: XM_063266842   ⟹   XP_063122912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,025,719 - 20,040,400 (-)NCBI
RefSeq Acc Id: XM_063266843   ⟹   XP_063122913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,025,719 - 20,041,083 (-)NCBI
RefSeq Acc Id: XR_005488861
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,025,719 - 20,040,400 (-)NCBI
mRatBN7.2912,528,109 - 12,542,793 (-)NCBI
RefSeq Acc Id: XR_005488862
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,027,048 - 20,040,400 (-)NCBI
mRatBN7.2912,529,438 - 12,542,793 (-)NCBI
RefSeq Acc Id: XR_005488863
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,027,054 - 20,040,401 (-)NCBI
mRatBN7.2912,529,444 - 12,542,794 (-)NCBI
RefSeq Acc Id: NP_001100352   ⟸   NM_001106882
- UniProtKB: A0A096MKD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244484   ⟸   XM_006244422
- Peptide Label: isoform X1
- UniProtKB: A0A096MKD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244485   ⟸   XM_006244423
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000064852   ⟸   ENSRNOT00000073556
Ensembl Acc Id: ENSRNOP00000069780   ⟸   ENSRNOT00000078464
Ensembl Acc Id: ENSRNOP00000068477   ⟸   ENSRNOT00000076531
RefSeq Acc Id: XP_038939100   ⟸   XM_039083172
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063122913   ⟸   XM_063266843
- Peptide Label: isoform X1
- UniProtKB: A0A096MKD8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122912   ⟸   XM_063266842
- Peptide Label: isoform X1
Protein Domains
ZU5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MKD8-F1-model_v2 AlphaFold A0A096MKD8 1-518 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696485
Promoter ID:EPDNEW_R7009
Type:single initiation site
Name:Unc5cl_1
Description:unc-5 family C-terminal like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0914,508,235 - 14,508,295EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587368 AgrOrtholog
BioCyc Gene G2FUF-28313 BioCyc
Ensembl Genes ENSRNOG00000046601 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076531 ENTREZGENE
  ENSRNOT00000076531.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  2.60.220.30 UniProtKB/TrEMBL
InterPro DEATH-like_dom UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  UNC5 UniProtKB/TrEMBL
  UPA UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
KEGG Report rno:301225 UniProtKB/TrEMBL
NCBI Gene 301225 ENTREZGENE
PANTHER PTHR12582 UniProtKB/TrEMBL
  UNC5C-LIKE PROTEIN UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  UPA UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
PhenoGen Unc5cl PhenoGen
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046601 RatGTEx
SMART DEATH UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
UniProt A0A096MKD8 ENTREZGENE, UniProtKB/TrEMBL
  A6JID9_RAT UniProtKB/TrEMBL
  A6JIE0_RAT UniProtKB/TrEMBL
  A6JIE2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-26 Unc5cl  unc-5 family C-terminal like  Unc5cl  unc-5 homolog C (C. elegans)-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 Unc5cl  unc-5 homolog C (C. elegans)-like      Symbol and Name status set to provisional 70820 PROVISIONAL