Treml2 (triggering receptor expressed on myeloid cells-like 2) - Rat Genome Database

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Gene: Treml2 (triggering receptor expressed on myeloid cells-like 2) Rattus norvegicus
Analyze
Symbol: Treml2
Name: triggering receptor expressed on myeloid cells-like 2
RGD ID: 1587039
Description: Predicted to enable signaling receptor activity. Predicted to be involved in T cell activation. Predicted to be located in membrane. Predicted to be active in cell surface. Orthologous to human TREML2 (triggering receptor expressed on myeloid cells like 2); INTERACTS WITH alpha-Zearalanol; bisphenol A; acrylamide (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC680844; similar to triggering receptor expressed on myeloid cells-like 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,192,292 - 20,202,981 (-)NCBIGRCr8
mRatBN7.2912,694,453 - 12,705,379 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,694,697 - 12,705,324 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0914,659,967 - 14,668,313 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,660,738 - 14,668,297 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0913,581,327 - 13,590,040 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,107,688 - 8,115,759 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera910,468,458 - 10,476,804 (-)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
T cell activation  (IBA,ISO)

Cellular Component
cell surface  (IBA,ISO)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18650384  


Genomics

Comparative Map Data
Treml2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,192,292 - 20,202,981 (-)NCBIGRCr8
mRatBN7.2912,694,453 - 12,705,379 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,694,697 - 12,705,324 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0914,659,967 - 14,668,313 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,660,738 - 14,668,297 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0913,581,327 - 13,590,040 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,107,688 - 8,115,759 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera910,468,458 - 10,476,804 (-)NCBICelera
Cytogenetic Map9q12NCBI
TREML2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,189,749 - 41,201,149 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,189,749 - 41,201,149 (-)EnsemblGRCh38hg38GRCh38
GRCh37641,157,487 - 41,168,887 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,266,206 - 41,276,902 (-)NCBINCBI36Build 36hg18NCBI36
Build 34641,266,205 - 41,276,902NCBI
Celera642,710,254 - 42,721,629 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef640,875,346 - 40,886,723 (-)NCBIHuRef
CHM1_1641,160,464 - 41,171,828 (-)NCBICHM1_1
T2T-CHM13v2.0641,018,309 - 41,029,701 (-)NCBIT2T-CHM13v2.0
AW049306
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,606,419 - 48,619,562 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1748,606,526 - 48,619,561 (+)EnsemblGRCm39 Ensembl
GRCm381748,299,390 - 48,312,534 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,299,498 - 48,312,533 (+)EnsemblGRCm38mm10GRCm38
MGSCv371748,439,363 - 48,451,859 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361747,765,507 - 47,776,716 (+)NCBIMGSCv36mm8
Celera1751,729,007 - 51,741,509 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.99NCBI
Treml2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554377,812,005 - 7,824,344 (-)NCBIChiLan1.0ChiLan1.0
TREML2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2555,674,472 - 55,685,958 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1651,544,432 - 51,555,915 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0640,766,713 - 40,778,115 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,075,101 - 42,086,477 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,075,101 - 42,086,477 (-)Ensemblpanpan1.1panPan2
TREML2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1129,948,309 - 9,958,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl129,950,133 - 9,959,478 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha129,978,286 - 9,988,881 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01210,427,899 - 10,438,498 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1210,428,677 - 10,438,672 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1129,959,997 - 9,970,595 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01210,041,737 - 10,052,263 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01210,136,772 - 10,147,368 (-)NCBIUU_Cfam_GSD_1.0
Treml2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,326,414 - 45,335,058 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647618,625,573 - 18,632,228 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647618,625,573 - 18,632,228 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TREML2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,482,058 - 36,493,906 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1736,478,339 - 36,494,348 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2741,779,258 - 41,786,511 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TREML2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,949,709 - 30,962,348 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1730,950,860 - 30,959,703 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604441,197,970 - 41,209,962 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Treml2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475417,613,812 - 17,623,436 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Treml2
186 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:54
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000042404
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9336865213533896Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 12 73 52 64 52 6
Low 51 111 80 5 80 9 3 98 45 120 41 3
Below cutoff 5 75 24 39 140 70 22 18

Sequence


Ensembl Acc Id: ENSRNOT00000042404   ⟹   ENSRNOP00000043394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl912,694,697 - 12,705,324 (-)Ensembl
Rnor_6.0 Ensembl914,660,738 - 14,668,297 (-)Ensembl
RefSeq Acc Id: XM_001059150   ⟹   XP_001059150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,192,292 - 20,202,981 (-)NCBI
mRatBN7.2912,694,453 - 12,705,379 (-)NCBI
Rnor_6.0914,659,967 - 14,668,313 (-)NCBI
Rnor_5.0913,581,327 - 13,590,040 (-)NCBI
RGSC_v3.498,107,688 - 8,115,759 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084467   ⟹   XP_038940395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,192,292 - 20,202,981 (-)NCBI
mRatBN7.2912,694,453 - 12,705,379 (-)NCBI
RefSeq Acc Id: XM_039084468   ⟹   XP_038940396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,192,292 - 20,202,003 (-)NCBI
mRatBN7.2912,694,453 - 12,704,399 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001420259 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420260 (Get FASTA)   NCBI Sequence Viewer  
  XP_001059150 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940395 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940396 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043394.5
RefSeq Acc Id: XP_001059150   ⟸   XM_001059150
- Peptide Label: isoform X1
- UniProtKB: D3ZF32 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043394   ⟸   ENSRNOT00000042404
RefSeq Acc Id: XP_038940395   ⟸   XM_039084467
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940396   ⟸   XM_039084468
- Peptide Label: isoform X2
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZF32-F1-model_v2 AlphaFold D3ZF32 1-322 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587039 AgrOrtholog
BioCyc Gene G2FUF-28299 BioCyc
Ensembl Genes ENSRNOG00000013554 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042404.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  Immune_rcpt_domain UniProtKB/TrEMBL
KEGG Report rno:680844 UniProtKB/TrEMBL
NCBI Gene 680844 ENTREZGENE
PANTHER TREM-LIKE TRANSCRIPT 2 PROTEIN UniProtKB/TrEMBL
  TREM-LIKE TRANSCRIPT PROTEIN UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Treml2 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013554 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt D3ZF32 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Treml2  triggering receptor expressed on myeloid cells-like 2  LOC680844  similar to triggering receptor expressed on myeloid cells-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680844  similar to triggering receptor expressed on myeloid cells-like 2  LOC682922  similar to triggering receptor expressed on myeloid cells-like 2  Data merged from RGD:1592821 1643240 APPROVED
2006-11-20 LOC682922  similar to triggering receptor expressed on myeloid cells-like 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC680844  similar to triggering receptor expressed on myeloid cells-like 2      Symbol and Name status set to provisional 70820 PROVISIONAL