Prss55 (serine protease 55) - Rat Genome Database

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Gene: Prss55 (serine protease 55) Rattus norvegicus
Analyze
Symbol: Prss55
Name: serine protease 55
RGD ID: 1586875
Description: Predicted to enable serine-type peptidase activity. Predicted to be involved in binding activity of sperm to zona pellucida; flagellated sperm motility; and protein processing. Predicted to be located in acrosomal vesicle and cytosol. Predicted to be active in plasma membrane. Orthologous to human PRSS55 (serine protease 55); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC683415; protease, serine, 55; similar to adrenal mitochondrial protease
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81542,489,022 - 42,507,310 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1542,488,038 - 42,521,021 (-)EnsemblGRCr8
mRatBN7.21538,297,674 - 38,345,059 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1538,312,982 - 38,323,103 (-)EnsemblmRatBN7.2
Rnor_6.01547,433,575 - 47,470,809 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1547,433,566 - 47,442,664 (-)Ensemblrn6Rnor6.0
Rnor_5.01551,170,257 - 51,201,168 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1537,993,684 - 38,029,468 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18844450   PMID:30032357  


Genomics

Comparative Map Data
Prss55
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81542,489,022 - 42,507,310 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1542,488,038 - 42,521,021 (-)EnsemblGRCr8
mRatBN7.21538,297,674 - 38,345,059 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1538,312,982 - 38,323,103 (-)EnsemblmRatBN7.2
Rnor_6.01547,433,575 - 47,470,809 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1547,433,566 - 47,442,664 (-)Ensemblrn6Rnor6.0
Rnor_5.01551,170,257 - 51,201,168 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1537,993,684 - 38,029,468 (-)NCBICelera
Cytogenetic Map15p12NCBI
PRSS55
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38810,525,532 - 10,554,166 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl810,525,532 - 10,554,166 (+)Ensemblhg38GRCh38
GRCh37810,383,042 - 10,411,676 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36810,420,491 - 10,433,738 (+)NCBIBuild 36Build 36hg18NCBI36
Celera89,510,226 - 9,523,469 (+)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef89,313,584 - 9,342,227 (+)NCBIHuRef
CHM1_1810,448,797 - 10,477,412 (+)NCBICHM1_1
T2T-CHM13v2.089,184,962 - 9,213,620 (-)NCBIT2T-CHM13v2.0
Prss55
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391464,312,884 - 64,338,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1464,312,887 - 64,327,611 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381464,075,435 - 64,085,449 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1464,075,438 - 64,090,162 (-)Ensemblmm10GRCm38
MGSCv371464,694,280 - 64,704,226 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361463,029,553 - 63,039,499 (-)NCBIMGSCv36mm8
Celera1461,852,974 - 61,862,928 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.35NCBI
PRSS55
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2726,978,803 - 27,007,361 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan183,011,250 - 3,024,572 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v088,656,519 - 8,685,039 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRSS55
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12527,419,326 - 27,436,925 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2527,419,326 - 27,436,864 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2528,079,241 - 28,096,851 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02527,577,172 - 27,594,782 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2527,577,172 - 27,595,225 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12527,531,883 - 27,549,492 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02527,427,228 - 27,444,829 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02527,580,452 - 27,598,058 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prss55
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049436,096,735 - 6,109,075 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366752,479,210 - 2,489,398 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366752,479,210 - 2,499,440 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS55
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1413,335,420 - 13,778,619 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11413,767,574 - 13,777,871 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21415,104,639 - 15,119,408 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRSS55
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.188,549,461 - 8,579,003 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl88,565,279 - 8,578,680 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605233,845,799 - 33,875,418 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prss55
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475824,432,099 - 24,450,759 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475824,421,629 - 24,450,563 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Prss55
121 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:71
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000072994
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
4 5 32 130 54 50 25 25 25 4 187 82 7 114 72 81 25 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000072994   ⟹   ENSRNOP00000067083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,489,012 - 42,495,502 (-)Ensembl
mRatBN7.2 Ensembl1538,312,982 - 38,323,103 (-)Ensembl
Rnor_6.0 Ensembl1547,433,566 - 47,442,664 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123783   ⟹   ENSRNOP00000112403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,488,648 - 42,513,645 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000133903   ⟹   ENSRNOP00000099716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,488,038 - 42,521,021 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140592   ⟹   ENSRNOP00000101566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,489,012 - 42,515,420 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145614   ⟹   ENSRNOP00000103614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,489,012 - 42,501,546 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000146203   ⟹   ENSRNOP00000105433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,488,038 - 42,496,031 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000165197   ⟹   ENSRNOP00000108585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,489,319 - 42,498,793 (-)Ensembl
RefSeq Acc Id: XM_008770800   ⟹   XP_008769022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,489,022 - 42,498,968 (-)NCBI
mRatBN7.21538,311,389 - 38,323,754 (-)NCBI
Rnor_6.01547,433,575 - 47,442,663 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093918   ⟹   XP_038949846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,489,022 - 42,501,386 (-)NCBI
mRatBN7.21538,311,389 - 38,326,553 (-)NCBI
RefSeq Acc Id: XM_039093920   ⟹   XP_038949848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,489,022 - 42,503,221 (-)NCBI
mRatBN7.21538,311,389 - 38,327,346 (-)NCBI
RefSeq Acc Id: XM_063274876   ⟹   XP_063130946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,489,022 - 42,507,310 (-)NCBI
RefSeq Acc Id: XM_063274877   ⟹   XP_063130947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,489,022 - 42,498,574 (-)NCBI
RefSeq Acc Id: XM_063274878   ⟹   XP_063130948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,489,022 - 42,494,983 (-)NCBI
RefSeq Acc Id: XP_008769022   ⟸   XM_008770800
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000067083   ⟸   ENSRNOT00000072994
RefSeq Acc Id: XP_038949848   ⟸   XM_039093920
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038949846   ⟸   XM_039093918
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130946   ⟸   XM_063274876
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130947   ⟸   XM_063274877
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130948   ⟸   XM_063274878
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000099716   ⟸   ENSRNOT00000133903
Ensembl Acc Id: ENSRNOP00000108585   ⟸   ENSRNOT00000165197
Ensembl Acc Id: ENSRNOP00000112403   ⟸   ENSRNOT00000123783
Ensembl Acc Id: ENSRNOP00000105433   ⟸   ENSRNOT00000146203
Ensembl Acc Id: ENSRNOP00000103614   ⟸   ENSRNOT00000145614
Ensembl Acc Id: ENSRNOP00000101566   ⟸   ENSRNOT00000140592
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RBY1-F1-model_v2 AlphaFold M0RBY1 1-321 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699785
Promoter ID:EPDNEW_R10306
Type:multiple initiation site
Name:Prss55_1
Description:protease, serine, 55
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01547,442,598 - 47,442,658EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586875 AgrOrtholog
BioCyc Gene G2FUF-13389 BioCyc
Ensembl Genes ENSRNOG00000047258 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072994.4 UniProtKB/TrEMBL
  ENSRNOT00000123783.1 UniProtKB/TrEMBL
  ENSRNOT00000133903.1 UniProtKB/TrEMBL
  ENSRNOT00000140592.1 UniProtKB/TrEMBL
  ENSRNOT00000145614 ENTREZGENE
  ENSRNOT00000145614.1 UniProtKB/TrEMBL
  ENSRNOT00000146203.1 UniProtKB/TrEMBL
  ENSRNOT00000165197.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1 UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin-like_Pept_dom UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:683415 UniProtKB/TrEMBL
NCBI Gene 683415 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/TrEMBL
  HYALIN UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Prss55 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047258 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A0ABK0KXZ0_RAT UniProtKB/TrEMBL
  A0ABK0L995_RAT UniProtKB/TrEMBL
  A0ABK0LD42_RAT UniProtKB/TrEMBL
  A0ABK0LDS7_RAT UniProtKB/TrEMBL
  A0ABK0LU30_RAT UniProtKB/TrEMBL
  A0ABK0M500_RAT UniProtKB/TrEMBL
  A6K6H1 ENTREZGENE, UniProtKB/TrEMBL
  M0RBY1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Prss55  serine protease 55  Prss55  protease, serine, 55  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-13 Prss55  protease, serine, 55  LOC683415  similar to adrenal mitochondrial protease  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC683415  similar to adrenal mitochondrial protease      Symbol and Name status set to provisional 70820 PROVISIONAL