Casq1 (calsequestrin 1) - Rat Genome Database

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Gene: Casq1 (calsequestrin 1) Rattus norvegicus
Analyze
Symbol: Casq1
Name: calsequestrin 1
RGD ID: 1586677
Description: Enables calcium ion binding activity. Involved in regulation of sequestering of calcium ion; response to denervation involved in regulation of muscle adaptation; and skeletal muscle tissue development. Located in I band; T-tubule; and terminal cisterna lumen. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CASQ1 (calsequestrin 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aspartactin; calsequestrin 1 (fast-twitch, skeletal muscle); calsequestrin, skeletal muscle isoform; Calsequestrin-1; Laminin-binding protein; LOC686019; similar to Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,203,021 - 87,212,710 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1387,202,485 - 87,213,463 (-)EnsemblGRCr8
mRatBN7.21384,670,648 - 84,680,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,670,649 - 84,680,339 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1387,173,972 - 87,183,660 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01388,574,232 - 88,583,921 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,758,977 - 85,768,666 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01390,592,676 - 90,602,365 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,592,681 - 90,602,365 (-)Ensemblrn6Rnor6.0
Rnor_5.01395,113,781 - 95,123,470 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41388,200,506 - 88,210,418 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1384,282,072 - 84,291,712 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout mice. Dainese M, etal., FASEB J. 2009 Jun;23(6):1710-20. doi: 10.1096/fj.08-121335. Epub 2009 Feb 23.
2. Calsquestrin 1 (CASQ1) gene polymorphisms under chromosome 1q21 linkage peak are associated with type 2 diabetes in Northern European Caucasians. Das SK, etal., Diabetes. 2004 Dec;53(12):3300-6.
3. Early effects of denervation on Ca(2+)-handling proteins in skeletal muscle. Donoghue P, etal., Int J Mol Med. 2004 Jun;13(6):767-72.
4. Polymorphism in the calsequestrin 1 (CASQ1) gene on chromosome 1q21 is associated with type 2 diabetes in the old order Amish. Fu M, etal., Diabetes. 2004 Dec;53(12):3292-9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Taurine supplementation increases skeletal muscle force production and protects muscle function during and after high-frequency in vitro stimulation. Goodman CA, etal., J Appl Physiol. 2009 Jul;107(1):144-54. Epub 2009 May 7.
7. Assembly of the sarcoplasmic reticulum. Synthesis of calsequestrin and the Ca2+ + Mg2+ -adenosine triphosphatase on membrane-bound polyribosomes. Greenway DC and MacLennan DH, Can J Biochem. 1978 Jun;56(6):452-6.
8. Type 2 diabetes susceptibility genes on chromosome 1q21-24. Hasstedt SJ, etal., Ann Hum Genet. 2008 Mar;72(Pt 2):163-9.
9. Calsequestrin expression and calcium binding is increased in streptozotocin-induced diabetic rat skeletal muscle though not in cardiac muscle. Howarth FC, etal., Pflugers Arch. 2002 May;444(1-2):52-8. Epub 2002 Feb 7.
10. Expression of endoplasmic reticulum stress proteins during skeletal muscle disuse atrophy. Hunter RB, etal., Am J Physiol Cell Physiol. 2001 Oct;281(4):C1285-90.
11. Ultrastructural localization of calsequestrin in rat skeletal muscle by immunoferritin labeling of ultrathin frozen sections. Jorgensen AO, etal., J Cell Biol. 1983 Nov;97(5 Pt 1):1573-81.
12. Membrane associated Ca2+ buffers in the heart. Lee D and Michalak M, BMB Rep. 2010 Mar;43(3):151-7.
13. Calsequestrin content and SERCA determine normal and maximal Ca2+ storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of rat. Murphy RM, etal., J Physiol. 2009 Jan 15;587(Pt 2):443-60. Epub 2008 Nov 24.
14. Restricted distribution of mRNAs encoding a sarcoplasmic reticulum or transverse tubule protein in skeletal myofibers. Nissinen M, etal., J Histochem Cytochem. 2005 Feb;53(2):217-27.
15. Site-directed mutagenesis and deletion of three phosphorylation sites of calsequestrin of skeletal muscle sarcoplasmic reticulum. Effects on intracellular targeting. Nori A, etal., Exp Cell Res. 2000 Oct 10;260(1):40-9.
16. Ca2+-regulatory muscle proteins in the alcohol-fed rat. Ohlendieck K, etal., Metabolism. 2003 Sep;52(9):1102-12.
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites. Sparso T, etal., Mol Genet Metab. 2007 Nov;92(3):278-82. Epub 2007 Aug 2.
20. Regulation of calcium binding proteins calreticulin and calsequestrin during differentiation in the myogenic cell line L6. Tharin S, etal., J Cell Physiol. 1996 Mar;166(3):547-60.
Additional References at PubMed
PMID:3417768   PMID:7945294   PMID:8042990   PMID:8889548   PMID:12419813   PMID:14651853   PMID:14728599   PMID:15057822   PMID:15489334   PMID:16600288   PMID:17627988   PMID:20833797  
PMID:22049211   PMID:22337878   PMID:25084748   PMID:27185316   PMID:28895244   PMID:37589058  


Genomics

Comparative Map Data
Casq1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,203,021 - 87,212,710 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1387,202,485 - 87,213,463 (-)EnsemblGRCr8
mRatBN7.21384,670,648 - 84,680,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,670,649 - 84,680,339 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1387,173,972 - 87,183,660 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01388,574,232 - 88,583,921 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,758,977 - 85,768,666 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01390,592,676 - 90,602,365 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,592,681 - 90,602,365 (-)Ensemblrn6Rnor6.0
Rnor_5.01395,113,781 - 95,123,470 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41388,200,506 - 88,210,418 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1384,282,072 - 84,291,712 (-)NCBICelera
Cytogenetic Map13q24NCBI
CASQ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,190,575 - 160,201,886 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,190,385 - 160,201,886 (+)Ensemblhg38GRCh38
GRCh371160,160,365 - 160,171,676 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,426,989 - 158,438,300 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341156,973,468 - 156,984,752NCBI
Celera1133,229,049 - 133,240,436 (+)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,517,001 - 131,528,390 (+)NCBIHuRef
CHM1_11161,555,636 - 161,567,025 (+)NCBICHM1_1
T2T-CHM13v2.01159,327,652 - 159,338,962 (+)NCBIT2T-CHM13v2.0
Casq1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,037,461 - 172,047,462 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,037,461 - 172,047,435 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381172,209,894 - 172,219,895 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,209,894 - 172,219,868 (-)Ensemblmm10GRCm38
MGSCv371174,140,025 - 174,150,026 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361174,047,013 - 174,056,514 (-)NCBIMGSCv36mm8
Celera1175,065,863 - 175,075,868 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.54NCBI
Casq1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546811,967,678 - 11,978,836 (+)Ensembl
ChiLan1.0NW_00495546811,967,678 - 11,978,836 (+)NCBIChiLan1.0ChiLan1.0
CASQ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2189,650,462 - 89,662,740 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,390,428 - 89,402,899 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,544,249 - 135,555,545 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11139,465,605 - 139,476,969 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1139,465,605 - 139,476,969 (+)EnsemblpanPan2panpan1.1
CASQ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13822,012,060 - 22,020,430 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3822,011,060 - 22,020,383 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3822,084,775 - 22,093,156 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03822,128,163 - 22,136,607 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3822,128,165 - 22,134,332 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13822,032,897 - 22,041,272 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03822,429,210 - 22,437,626 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,838,952 - 22,847,496 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Casq1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050586,312,524 - 6,324,146 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936740430,026 - 442,539 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936740430,367 - 442,468 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASQ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,276,757 - 90,288,250 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1490,276,752 - 90,288,990 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,218,225 - 98,228,665 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASQ1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,744,921 - 3,759,220 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl203,744,780 - 3,756,435 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660382,802,575 - 2,814,309 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casq1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247941,050,955 - 1,065,287 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247941,054,119 - 1,064,652 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Casq1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11051,322,655 - 51,331,987 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Casq1
90 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:63
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000009344
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
RH133764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21384,670,663 - 84,670,843 (+)MAPPERmRatBN7.2
Rnor_6.01390,592,692 - 90,592,871NCBIRnor6.0
Rnor_5.01395,113,797 - 95,113,976UniSTSRnor5.0
RGSC_v3.41388,200,522 - 88,200,701UniSTSRGSC3.4
Celera1384,282,088 - 84,282,267UniSTS
RH 3.4 Map13554.8UniSTS
Cytogenetic Map13q24UniSTS
G64925  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21384,681,014 - 84,681,174 (+)MAPPERmRatBN7.2
Rnor_6.01390,603,041 - 90,603,200NCBIRnor6.0
Rnor_5.01395,124,146 - 95,124,305UniSTSRnor5.0
RGSC_v3.41388,211,094 - 88,211,253UniSTSRGSC3.4
Celera1384,292,388 - 84,292,547UniSTS
Cytogenetic Map13q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 88 87 56 83 56 6 344 183 10 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009344   ⟹   ENSRNOP00000009344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1387,203,022 - 87,213,463 (-)Ensembl
mRatBN7.2 Ensembl1384,670,649 - 84,680,339 (-)Ensembl
Rnor_6.0 Ensembl1390,592,681 - 90,602,365 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000152763   ⟹   ENSRNOP00000110096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1387,202,485 - 87,212,710 (-)Ensembl
RefSeq Acc Id: NM_001159594   ⟹   NP_001153066
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81387,203,021 - 87,212,710 (-)NCBI
mRatBN7.21384,670,648 - 84,680,339 (-)NCBI
Rnor_6.01390,592,676 - 90,602,365 (-)NCBI
Rnor_5.01395,113,781 - 95,123,470 (-)NCBI
RGSC_v3.41388,200,506 - 88,210,418 (-)RGD
Celera1384,282,072 - 84,291,712 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001153066 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94693 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009344
  ENSRNOP00000009344.5
GenBank Protein P19633 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001153066   ⟸   NM_001159594
- Peptide Label: precursor
- UniProtKB: P19633 (UniProtKB/Swiss-Prot),   A6JG37 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009344   ⟸   ENSRNOT00000009344
Ensembl Acc Id: ENSRNOP00000110096   ⟸   ENSRNOT00000152763

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19633-F1-model_v2 AlphaFold P19633 1-406 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699022
Promoter ID:EPDNEW_R9547
Type:multiple initiation site
Name:Casq1_1
Description:calsequestrin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01390,602,369 - 90,602,429EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586677 AgrOrtholog
BioCyc Gene G2FUF-17328 BioCyc
Ensembl Genes ENSRNOG00000006930 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009344 ENTREZGENE
  ENSRNOT00000009344.7 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
InterPro Calsequestrin UniProtKB/Swiss-Prot
  Calsequestrin_C UniProtKB/Swiss-Prot
  Calsequestrin_CS UniProtKB/Swiss-Prot
  Calsequestrin_middle_dom UniProtKB/Swiss-Prot
  Calsequestrin_N UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:686019 UniProtKB/Swiss-Prot
NCBI Gene 686019 ENTREZGENE
PANTHER CALSEQUESTRIN UniProtKB/Swiss-Prot
  CALSEQUESTRIN-1 UniProtKB/Swiss-Prot
Pfam Calsequestrin UniProtKB/Swiss-Prot
PharmGKB CASQ1 RGD
PhenoGen Casq1 PhenoGen
PRINTS CALSEQUESTRN UniProtKB/Swiss-Prot
PROSITE CALSEQUESTRIN_1 UniProtKB/Swiss-Prot
  CALSEQUESTRIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006930 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A0ABK0M445_RAT UniProtKB/TrEMBL
  A6JG37 ENTREZGENE, UniProtKB/TrEMBL
  CASQ1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Casq1  calsequestrin 1  Casq1  calsequestrin 1 (fast-twitch, skeletal muscle)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Casq1  calsequestrin 1 (fast-twitch, skeletal muscle)  Casq1  calsequestrin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Casq1  calsequestrin 1  LOC679341  similar to Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform)  Data merged from RGD:1589531 1643240 APPROVED
2008-03-05 Casq1  calsequestrin 1  LOC686019  similar to Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC686019  similar to Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC679341  similar to Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform)      Symbol and Name status set to provisional 70820 PROVISIONAL