C9h2orf66 (similar to human chromosome 2 open reading frame 66) - Rat Genome Database

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Gene: C9h2orf66 (similar to human chromosome 2 open reading frame 66) Rattus norvegicus
Analyze
Symbol: C9h2orf66
Name: similar to human chromosome 2 open reading frame 66
RGD ID: 1586666
Description: Orthologous to human C2orf66 (chromosome 2 open reading frame 66); INTERACTS WITH 1-Hydroxypyrene (ortholog); acrylamide (ortholog); aristolochic acid A (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC100365551; hypothetical protein LOC686030; LOC686030; uncharacterized protein C2orf66 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8963,440,494 - 63,444,210 (-)NCBIGRCr8
mRatBN7.2955,945,806 - 55,949,855 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl955,948,303 - 55,949,643 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0961,036,435 - 61,040,225 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0960,722,946 - 60,738,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4953,225,166 - 53,226,502 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera953,435,638 - 53,439,428 (-)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
C9h2orf66RatNeurodevelopmental Disorders  ISORGD:16023998554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
C9h2orf66Rat1-Hydroxypyrene decreases expressionISORGD:160239964804641-hydroxypyrene results in decreased expression of C2ORF66 mRNACTDPMID:21854004
C9h2orf66Ratacrylamide increases expressionISORGD:16023996480464Acrylamide results in increased expression of C2ORF66 mRNACTDPMID:32763439
C9h2orf66Rataristolochic acid A increases expressionISORGD:16023996480464aristolochic acid I results in increased expression of C2ORF66 mRNACTDPMID:33212167
C9h2orf66Ratbenzo[a]pyrene decreases methylationISORGD:16023996480464Benzo(a)pyrene results in decreased methylation of C2ORF66 exonCTDPMID:27901495
C9h2orf66Ratbenzo[a]pyrene affects methylationISORGD:16023996480464Benzo(a)pyrene affects the methylation of C2ORF66 promoterCTDPMID:27901495
C9h2orf66Ratcisplatin increases expressionISORGD:16023996480464Cisplatin results in increased expression of C2ORF66 mRNACTDPMID:27392435
C9h2orf66Ratresveratrol multiple interactionsISORGD:16023996480464[Plant Extracts co-treated with Resveratrol] results in decreased expression of C2ORF66 mRNACTDPMID:23557933


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Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


C9h2orf66
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8963,440,494 - 63,444,210 (-)NCBIGRCr8
mRatBN7.2955,945,806 - 55,949,855 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl955,948,303 - 55,949,643 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0961,036,435 - 61,040,225 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0960,722,946 - 60,738,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4953,225,166 - 53,226,502 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera953,435,638 - 53,439,428 (-)NCBICelera
Cytogenetic Map9q31NCBI
C2orf66
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382196,804,417 - 196,832,139 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2196,804,417 - 196,809,355 (-)EnsemblGRCh38hg38GRCh38
GRCh372197,669,141 - 197,674,079 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362197,378,254 - 197,383,245 (-)NCBINCBI36Build 36hg18NCBI36
Celera2191,425,877 - 191,430,868 (-)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2189,521,761 - 189,527,630 (-)NCBIHuRef
CHM1_12197,674,991 - 197,680,852 (-)NCBICHM1_1
T2T-CHM13v2.02197,288,090 - 197,315,820 (-)NCBIT2T-CHM13v2.0
Gm34066
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39154,481,731 - 54,495,945 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl154,482,563 - 54,495,922 (-)EnsemblGRCm39 Ensembl
GRCm38154,442,572 - 54,456,786 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl154,443,404 - 54,456,763 (-)EnsemblGRCm38mm10GRCm38
MGSCv37154,501,638 - 54,503,022 (-)MERGEGRCm37MGSCv37mm9NCBIm37
Celera154,967,465 - 54,981,716 (-)NCBICelera
Cytogenetic Map1C1.2NCBI
CUNH2orf66
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554033,600,567 - 3,604,378 (+)NCBIChiLan1.0ChiLan1.0
C13H2orf66
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21399,424,004 - 99,439,884 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B99,438,995 - 99,448,905 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B84,048,089 - 84,055,991 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B201,949,363 - 201,951,884 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B201,949,363 - 201,951,310 (-)Ensemblpanpan1.1panPan2
C37H2orf66
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1376,403,572 - 6,407,464 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl376,403,548 - 6,407,323 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha377,350,789 - 7,356,240 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0376,293,422 - 6,298,868 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl376,295,814 - 6,297,663 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1376,293,023 - 6,298,472 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0376,262,642 - 6,265,833 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0376,284,397 - 6,287,994 (-)NCBIUU_Cfam_GSD_1.0
CUNH2orf66
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303154,502,516 - 154,507,591 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365062,323,711 - 2,333,346 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C15H2orf66
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15100,704,641 - 100,713,581 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115100,704,142 - 100,708,876 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215111,764,058 - 111,768,293 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CUNH2orf66
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11082,327,616 - 82,332,630 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1082,327,626 - 82,334,450 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040117,105,614 - 117,128,820 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in C9h2orf66
31 total Variants

1 to 10 of 27 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat

1 to 10 of 27 rows






Ensembl Acc Id: ENSRNOT00000098126   ⟹   ENSRNOP00000088114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl955,948,303 - 55,949,643 (-)Ensembl
RefSeq Acc Id: XM_063268122   ⟹   XP_063124192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8963,440,494 - 63,444,210 (-)NCBI
RefSeq Acc Id: XR_005489144
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8963,440,494 - 63,441,795 (-)NCBI
mRatBN7.2955,945,806 - 55,949,007 (-)NCBI
RefSeq Acc Id: XR_010054984
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8963,440,494 - 63,441,799 (-)NCBI
Protein RefSeqs NP_001420272 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124192 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088114.1
Ensembl Acc Id: ENSRNOP00000088114   ⟸   ENSRNOT00000098126
RefSeq Acc Id: XP_063124192   ⟸   XM_063268122


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 11 of 11 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-27543 BioCyc
Ensembl Genes ENSRNOG00000067303 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000098126.1 UniProtKB/TrEMBL
InterPro DUF4720 UniProtKB/TrEMBL
NCBI Gene 686030 ENTREZGENE
PANTHER GENE, 34066-RELATED UniProtKB/TrEMBL
  PTHR47620 UniProtKB/TrEMBL
Pfam DUF4720 UniProtKB/TrEMBL
PhenoGen C9h2orf66 PhenoGen
RatGTEx ENSRNOG00000067303 RatGTEx
UniProt A0A8I6A4F4 ENTREZGENE, UniProtKB/TrEMBL
1 to 11 of 11 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 C9h2orf66  similar to human chromosome 2 open reading frame 66  LOC686030  hypothetical protein LOC686030  Symbol and Name Changed 1299863 APPROVED
2013-05-24 LOC686030  hypothetical protein LOC686030  LOC100365551  hypothetical protein LOC100365551  Data merged from RGD:2318831 1643240 APPROVED
2010-05-05 LOC100365551  hypothetical protein LOC100365551      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC686030  hypothetical protein LOC686030  LOC683525  hypothetical protein LOC683525  Data merged from RGD:1585668 1643240 APPROVED
2006-11-19 LOC686030  hypothetical protein LOC686030      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683525  hypothetical protein LOC683525      Symbol and Name status set to provisional 70820 PROVISIONAL