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Gene: Brap (BRCA1 associated protein) Rattus norvegicus

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Symbol:

Brap

Name:

BRCA1 associated protein

RGD ID:

1586551

Description:

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in Ras protein signal transduction and protein ubiquitination. Predicted to be active in cytoplasm. Orthologous to human BRAP (BRCA1 associated protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; paracetamol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC687346; similar to BRCA1-associated protein (BRAP2) (Impedes mitogenic signal propagation) (IMP)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BRAP (BRCA1 associated protein)	HGNC	Ensembl, HomoloGene, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Brap (BRCA1 associated protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Brap (BRCA1 associated protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BRAP (BRCA1 associated protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BRAP (BRCA1 associated protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Brap (BRCA1-associated protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BRAP (BRCA1 associated protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BRAP (BRCA1 associated protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Brap (BRCA1 associated protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Brap (BRCA1 associated protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	BRAP (BRCA1 associated protein)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Brap (BRCA1 associated protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	brap (BRCA1 associated protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5555	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5555	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ETP1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ETP1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	brap-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	brap-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	brap	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	brap	Alliance	DIOPT (OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	40,535,232 - 40,561,726 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	40,535,232 - 40,561,726 (-)	Ensembl				GRCr8
mRatBN7.2	12	34,874,533 - 34,901,030 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	34,874,533 - 34,901,030 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	36,047,411 - 36,073,910 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	36,658,624 - 36,685,121 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	35,711,077 - 35,737,572 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	12	41,811,090 - 41,837,591 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	12	41,723,315 - 41,749,793 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	12	40,601,300 - 40,627,797 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	12	51,053,175 - 51,079,674 (-)	NCBI		F344_StmMcwi
Rnor_6.0	12	40,381,892 - 40,417,764 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	40,383,577 - 40,417,654 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	42,253,695 - 42,285,637 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	12	36,539,105 - 36,565,594 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

myocardial infarction (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

arsenite(3-) (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

ciguatoxin CTX1B (ISO)

clofibrate (ISO)

coumarin (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dimethyl sulfoxide (ISO)

ethyl methanesulfonate (ISO)

fenofibrate (ISO)

FR900359 (ISO)

glyphosate (ISO)

inulin (ISO)

methyl methanesulfonate (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

quercetin (EXP)

rac-lactic acid (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triptonide (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

MAPK cascade (ISO)

negative regulation of signal transduction (IEA,ISO)

protein ubiquitination (IBA,IEA,ISO)

Ras protein signal transduction (IBA,ISO)

Cellular Component

cytoplasm (IBA,IEA,ISO)

cytosol (IEA,ISO)

ubiquitin ligase complex (IEA,ISO)

Molecular Function

identical protein binding (IEA,ISO)

metal ion binding (IEA)

nuclear localization sequence binding (IEA,ISO)

nucleic acid binding (IEA)

protein binding (ISO)

transferase activity (IEA)

ubiquitin protein ligase activity (IBA,IEA,ISO)

ubiquitin-protein transferase activity (IEA,ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9497340	PMID:14724641	PMID:25820252	PMID:37647369

Genomics

Comparative Map Data

Brap
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	40,535,232 - 40,561,726 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	40,535,232 - 40,561,726 (-)	Ensembl				GRCr8
mRatBN7.2	12	34,874,533 - 34,901,030 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	34,874,533 - 34,901,030 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	36,047,411 - 36,073,910 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	36,658,624 - 36,685,121 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	35,711,077 - 35,737,572 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	12	41,811,090 - 41,837,591 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	12	41,723,315 - 41,749,793 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	12	40,601,300 - 40,627,797 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	12	51,053,175 - 51,079,674 (-)	NCBI		F344_StmMcwi
Rnor_6.0	12	40,381,892 - 40,417,764 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	40,383,577 - 40,417,654 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	42,253,695 - 42,285,637 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	12	36,539,105 - 36,565,594 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

BRAP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	111,642,146 - 111,685,956 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	111,642,146 - 111,685,991 (-)	Ensembl			hg38	GRCh38
GRCh37	12	112,079,950 - 112,123,760 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	110,566,280 - 110,608,122 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	110,544,615 - 110,586,459	NCBI
Celera	12	111,705,482 - 111,749,255 (-)	NCBI		Celera
Cytogenetic Map	12	q24.12	NCBI
HuRef	12	109,093,402 - 109,137,289 (-)	NCBI		HuRef
CHM1_1	12	112,047,902 - 112,091,753 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	111,619,068 - 111,662,902 (-)	NCBI		T2T-CHM13v2.0

Brap
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	121,798,626 - 121,825,312 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	121,798,626 - 121,825,319 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	121,660,563 - 121,687,249 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	121,660,563 - 121,687,256 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	122,110,595 - 122,137,257 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	121,921,203 - 121,947,865 (+)	NCBI		MGSCv36	mm8
Celera	5	118,750,469 - 118,777,666 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	61.9	NCBI

Brap
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	8,254,709 - 8,282,416 (-)	Ensembl
ChiLan1.0	NW_004955482	8,254,709 - 8,282,416 (-)	NCBI	ChiLan1.0	ChiLan1.0

BRAP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	119,710,107 - 119,757,195 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	119,706,496 - 119,753,586 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	109,216,171 - 109,263,160 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	112,610,179 - 112,654,017 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	112,610,179 - 112,654,017 (-)	Ensembl			panPan2	panpan1.1

BRAP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	9,223,929 - 9,250,985 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	9,224,077 - 9,251,003 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	9,384,554 - 9,413,441 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	9,483,009 - 9,510,405 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	9,481,418 - 9,510,461 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	9,439,088 - 9,466,139 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	9,499,992 - 9,528,875 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	9,454,886 - 9,481,940 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Brap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	155,185,318 - 155,219,571 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936558	4,259,799 - 4,294,191 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936558	4,259,854 - 4,294,131 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BRAP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	32,800,749 - 32,841,743 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	32,800,742 - 32,841,884 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

BRAP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	106,899,512 - 106,938,606 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	138,157,078 - 138,202,510 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Brap
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	20,526,321 - 20,558,040 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	20,526,216 - 20,557,019 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Brap
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	32,145,400 - 32,172,448 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Brap
449 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	163
Count of miRNA genes:	123
Interacting mature miRNAs:	134
Transcripts:	ENSRNOT00000072481
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	29775522	42298555	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	34243475	43352593	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat

Markers in Region

RH129542

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	34,874,573 - 34,874,767 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	40,381,933 - 40,382,126	NCBI	Rnor6.0
Rnor_5.0	12	42,253,736 - 42,253,929	UniSTS	Rnor5.0
Celera	12	36,539,146 - 36,539,339	UniSTS
RH 3.4 Map	12	615.4	UniSTS

BI288042

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Celera	12	36,540,751 - 36,540,956	UniSTS
RH 3.4 Map	12	616.4	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	92	59	6	356	192	11	140	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001271194	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000072481 ⟹ ENSRNOP00000067090

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	40,536,909 - 40,561,726 (-)	Ensembl
mRatBN7.2 Ensembl	12	34,876,210 - 34,901,030 (-)	Ensembl
Rnor_6.0 Ensembl	12	40,383,577 - 40,417,654 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100924 ⟹ ENSRNOP00000082409

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	34,874,533 - 34,900,019 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104886 ⟹ ENSRNOP00000076998

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	40,535,232 - 40,561,726 (-)	Ensembl
mRatBN7.2 Ensembl	12	34,874,533 - 34,901,030 (-)	Ensembl

RefSeq Acc Id:

NM_001271194 ⟹ NP_001258123

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	40,535,232 - 40,561,726 (-)	NCBI
mRatBN7.2	12	34,874,533 - 34,901,030 (-)	NCBI
Dahl_SR_JrHsd	12	41,811,090 - 41,837,591 (-)	NCBI
Lyon_Normotensive	12	41,723,315 - 41,749,793 (-)	NCBI
Lyon_Hypertensive	12	40,601,300 - 40,627,797 (-)	NCBI
F344_StmMcwi	12	51,053,175 - 51,079,674 (-)	NCBI
Rnor_6.0	12	40,381,892 - 40,417,764 (-)	NCBI
Rnor_5.0	12	42,253,695 - 42,285,637 (-)	NCBI
Celera	12	36,539,105 - 36,565,594 (-)	NCBI

Sequence:

show sequence

GCGGCTCTGAGGCGGTGGCGGGGCTGCCGACCGCGGGCCGCTCGGCCTCTGGGCTCGGCCCGCA
GCCTTCCGTCAGCCAGCCGGAGCCCACGCCGACCAGCGCCTATCCTATGAGTGTGTCACTGGTG
GTCATCCGACTGGAGCTCGCGGGTCACTCGCCGGTCCCCGCCGATTTCGGCTTCAGCGCTGCCG
CTGGAGAGATGTCCAATGAGGAGATCAAAAAGAAGACGTTGGCTTCAGCAGCCGCCTGCCTCGA
AGGGAAGTCGCCAGGGGAAAAAGCAGCAATCATCCACCAGCACCTTGGCCGTCGGGAAATGACT
GACGTGATCATTGAGACCATGAAGGCCAGTGCAGATGAGTTTCGAGACACGTCGGAAGAAAAGA
CGTCTTCAGCAGCCCCCAGCTCTGCACAGAGAAGTAGAGAGCAGAGTGAGTCTGTGAACACGGT
CCCGGATTCTCCGTCCAAACAGCTCCCAGACCAGATTTCCTTCTTCAGTGGCAACCCTTCCGTT
GAAATAGTCCACGGCATTATGCACCTGTACAAGACAAATAAGATGACCTCCCTAAAAGAAGACG
TGCGGCGCAGTGCCATGCTGTGTGTCCTCACCGTCCCGGCCACCATGACCAGCCATGACCTTAT
GAAGTTTGTTGCCCCGTTTAATGACGTAATTGAACAAATGAAAATTATCAGGGACTCAACTCCG
AATCAGTACATGGTGCTGGTCAAGTTCAGTGCACAGGCTGATGCTGATAGTTTCTACATGGCAT
GCAACGGCCGCCAGTTCAACTCAATCGAAGATGACGTGTGCCAGCTGGTCTATGTGGAGAGGGC
CGAAGTGCTCAAGTCCGAAGATGGCGCCAGCCTTCCTGTGATGGACCTGACGGAGCTCCCCAAG
TGCACTGTGTGTCTGGAGCGAATGGACGAGTCTGTGAATGGCATCCTCACCACCCTATGCAACC
ACAGCTTCCATAGTCAGTGTCTGCAGCGGTGGGATGACACAACGTGTCCTGTGTGCCGGTACTG
TCAAACGCCAGAGCCAGTGGAAGAAAACAAGTGTTTCGAGTGTGGTGTTCAGGAAAACCTCTGG
ATTTGTTTAATATGCGGCCACATAGGCTGTGGGCGGTACGTAAGCCGACATGCGTACAAGCACT
TTGAGGAGACCCAGCACACATACGCCATGCAGCTCACCAACCATCGGGTCTGGGACTATGCTGG
AGATAATTATGTCCATCGACTGGTGGCCAGCAAGACGGATGGGAAGATTGTTCAGTACGAGTGT
GAGGGCGATACCTGCCAAGAAGAAAAGATTGATGCCTTACAATTAGAGTATTCATACCTGCTGA
CGAGCCAGCTGGAATCGCAGCGGGTATACTGGGAAAACAAAATTGTGCGCATAGAGAAGGACAC
GGCAGAGGAGATTAATAACATGAAGAGCAAGTTTAAAGAGACCATTGAAAAGTGTGACAGCCTG
GAGCTCAGGCTCAGTGACCTCCTGAAGGAGAAGCAGTCTGTGGAAAGGAAGTGCACTCAGCTGA
GCACCAGAGTGGCCAAGCTGAGCACGGAGCTCCAGGAGGAGCAGGAGCTGAACAAGTGTCTGCG
CGCCAACCAGCTGCTGCTGCAGAACAAGCTGAAGGAGGAGGAGAGGCTGCTGAAGGAGACCTGT
GCCCAGAAGGACCTGCAGATCACAGAGATCCAGGAGCAGCTGCGTGACGTCATGTTCTACCTGG
AGACGCAGCAGCAAATCAGCCATCTGCCTGCAGAGACGAGGCAGGAGATCCAGGAAGGGCAGAT
CAACATTGCCATGGCCTCAGCCCCCAACCCACCCTCTTCAGGTGCCGGTGGGAAGCTGCAGTCT
AGGAAGGGCCGCAGCAAAAGGGGCAAGTGACCTTGAGAGACTTGTCCCAGAGACTTCCTGGGCA
CCACAGGGTGTGCTGGGACCTTTGCTGAGTGGGAGGGTGGGCCCTAATAAGTACGTCTGAGGAC
GAACTGCGGTCGGTCGTGTGGCTCCTTCATTTGTTGCGTGTGGTGTGAGGAGACTAAAAGTGGG
GGAGACGCTGGCAGCATTTCACAAGGGCAAGCCACAGCTTGCCATTCTGCCTTCCAGCTGGGTA
GCCTCCGGCCTGTGCAATTTTCCGTGTATTTATTCAGTTGGAGCACTTGCAGTTGGGTTCCAGG
GTAAATCTATGACATGATGCGACCTTCCTAGCACTAAAGGAATTCCAGCATTACTTAGCACTAA
AGCACAGTGCCTCCCTGAGGCCCTAGCTGCCTTCAGGAGAGGAGCCTGCCGCCCACTGCAGAGG
ATCTCCCCTCCATCCCTCCCTCCCTTCCCCTGCAGGGTTGAAGAGCTGCTTGCATGTCAGAGCG
AAAGGGGCTAAGTTGTAAACCAGGCATAGGCTTGTCCTCAGCAGCCTGACTTGGGGACAGGAAG
AACGAGCAGCTGGGGCAGATGGGGTAGACTCAGTTTAGGGAAGATGGTGACAGCTCTCTTCATT
TTTGATGACTCCATACGAAATGTGCCTGTCATGTAAGAAAAGCCTTACTGGCTCCTCCTCTGCT
CGCTGGGGTAACTGAGTGTCCTCCACCTAGCAGGAGTCAGGCAAGCCTGGTGAGAGGCCTCGGT
GGCGAGCTGACGTGTGGCTGGGTCAGTGTGTACTGACTGTTACAGGCCGAATGTTCAGGTCGCA
GCTAGAGGGAGCTTGGGCAGATTTCAGTTGCTCTTTTCTGATAGTTTCAAAGGCTGCTTCACAC
TCCAGAAAATGGCTTCAGCAGGCCCTCTTTCAAACAGCCATACAATACTTACTGTGACCAACAG
AGGGGCTGTGTGCCTCTCTCTAGAGCCAGGAACGTCAGGTAACTTGTAACAAATTAATTGAACA
AAATTGCGGGACACCATGTTGGGATTTAGCTTTTAGTAGAGCCTGGGCACTTGGCAGCGGTGTG
TGCTGTAGTTTAATTTTTTGCTTTATCATCAGCCAAAGGTTTAAAATGTCATACTTTAGGGACT
TTTTTTTTCCAACTGACTGGACCTCGTCCTTTGACCGGAGTGTCTGACATGTCACCACGTTGCC
TGTGTTGCTGATCACCATCCAGTTCTGTGGAACGGGCTGTGGCATTTCCCAAAATCCCCACCTG
TGGCTGCAGACTGAGTGCTGGCCTGCTCAGACCCCTCGGCTCTCAGCAGGCTGTACTCCACCCT
CAGGCCTGAGCCACACAGGAGCTTCTAGAACCGTTTTACACTGTCACGGTCTTGCCGGCTCAGC
CCTGCTTGTCTTGCACATCTGACCTAGCAGAGGCTGGGGTGGGTGGTAGCATGCTAACTAAGAG
AATCGGAAGAAGTTCCCAAAGCTGGCCCCTCACTCCAGTACAATCCAGAGCAGCCCTCCTGCCC
AGACGAGAGCAGCGCTCCACAGCACAGGTTGGGGAAACGCCTGCGAAGGCCGTGGCCGGAGGAA
GCAGCCGATGGGCAGAGGTTTCCAAACTACTTGAAGGTCTTTAAAAAAATGTCCCAGGACAACA
AAAATCAAGATGTGTAAATAAAATGTTATTTTAAAAGGTCAAA

hide sequence

RefSeq Acc Id:

XM_039089756 ⟹ XP_038945684

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	40,535,232 - 40,561,395 (-)	NCBI
mRatBN7.2	12	34,876,210 - 34,900,678 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001258123	(Get FASTA)	NCBI Sequence Viewer
	XP_038945684	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM13721	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000067090.3
	ENSRNOP00000076998
	ENSRNOP00000076998.1

RefSeq Acc Id:

NP_001258123 ⟸ NM_001271194

- UniProtKB:

A0A8I5Y120 (UniProtKB/TrEMBL), A6J1D1 (UniProtKB/TrEMBL), A0A8I5ZU33 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSVSLVVIRLELAGHSPVPADFGFSAAAGEMSNEEIKKKTLASAAACLEGKSPGEKAAIIHQHL
GRREMTDVIIETMKASADEFRDTSEEKTSSAAPSSAQRSREQSESVNTVPDSPSKQLPDQISFF
SGNPSVEIVHGIMHLYKTNKMTSLKEDVRRSAMLCVLTVPATMTSHDLMKFVAPFNDVIEQMKI
IRDSTPNQYMVLVKFSAQADADSFYMACNGRQFNSIEDDVCQLVYVERAEVLKSEDGASLPVMD
LTELPKCTVCLERMDESVNGILTTLCNHSFHSQCLQRWDDTTCPVCRYCQTPEPVEENKCFECG
VQENLWICLICGHIGCGRYVSRHAYKHFEETQHTYAMQLTNHRVWDYAGDNYVHRLVASKTDGK
IVQYECEGDTCQEEKIDALQLEYSYLLTSQLESQRVYWENKIVRIEKDTAEEINNMKSKFKETI
EKCDSLELRLSDLLKEKQSVERKCTQLSTRVAKLSTELQEEQELNKCLRANQLLLQNKLKEEER
LLKETCAQKDLQITEIQEQLRDVMFYLETQQQISHLPAETRQEIQEGQINIAMASAPNPPSSGA
GGKLQSRKGRSKRGK

hide sequence

Ensembl Acc Id:

ENSRNOP00000067090 ⟸ ENSRNOT00000072481

RefSeq Acc Id:	XP_038945684 ⟸ XM_039089756
- Peptide Label:	isoform X1
- UniProtKB:	A6J1D2 (UniProtKB/TrEMBL), A0A8I5ZU33 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000082409 ⟸ ENSRNOT00000100924

Ensembl Acc Id:

ENSRNOP00000076998 ⟸ ENSRNOT00000104886

Protein Domains

RING-type UBP-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0RBY8-F1-model_v2	AlphaFold	M0RBY8	1-587	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1586551	AgrOrtholog
BioCyc Gene	G2FUF-19218	BioCyc
Ensembl Genes	ENSRNOG00000046497	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000072481.4	UniProtKB/TrEMBL
	ENSRNOT00000104886	ENTREZGENE
	ENSRNOT00000104886.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.40.10	UniProtKB/TrEMBL
	3.30.70.330	UniProtKB/TrEMBL
InterPro	BRAP2	UniProtKB/TrEMBL
	BRAP2_RRM	UniProtKB/TrEMBL
	Nucleotide-bd_a/b_plait_sf	UniProtKB/TrEMBL
	RBD_domain_sf	UniProtKB/TrEMBL
	RING-H2_BRAP2	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_UBP	UniProtKB/TrEMBL
KEGG Report	rno:687346	UniProtKB/TrEMBL
NCBI Gene	687346	ENTREZGENE
PANTHER	BRCA1-ASSOCIATED PROTEIN	UniProtKB/TrEMBL
	BRCA1-ASSOCIATED PROTEIN	UniProtKB/TrEMBL
Pfam	BRAP2	UniProtKB/TrEMBL
	zf-RING_2	UniProtKB/TrEMBL
	zf-UBP	UniProtKB/TrEMBL
PhenoGen	Brap	PhenoGen
PROSITE	ZF_RING_2	UniProtKB/TrEMBL
	ZF_UBP	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000046497	RatGTEx
SMART	RING	UniProtKB/TrEMBL
	ZnF_UBP	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
	SSF54928	UniProtKB/TrEMBL
UniProt	A0A8I5Y120	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZU33	ENTREZGENE
	A6J1D1	ENTREZGENE, UniProtKB/TrEMBL
	A6J1D2	ENTREZGENE, UniProtKB/TrEMBL
	M0RBY8_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-16	Brap	BRCA1 associated protein	LOC687346	similar to BRCA1-associated protein (BRAP2) (Impedes mitogenic signal propagation) (IMP)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC687346	similar to BRCA1-associated protein (BRAP2) (Impedes mitogenic signal propagation) (IMP)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD