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Gene: Sox30 (SRY-box transcription factor 30) Rattus norvegicus

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Symbol:

Sox30

Name:

SRY-box transcription factor 30

RGD ID:

1586382

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Predicted to be involved in several processes, including negative regulation of Wnt signaling pathway; proacrosomal vesicle fusion; and regulation of transcription by RNA polymerase II. Predicted to be located in chromocenter and cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung cancer. Orthologous to human SOX30 (SRY-box transcription factor 30); INTERACTS WITH 2,6-dinitrotoluene; bisphenol A; cocaine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC689918; similar to SRY-box containing gene 30; SRY (sex determining region Y)-box 30; SRY box 30; transcription factor SOX-30

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SOX30 (SRY-box transcription factor 30)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Sox30 (SRY (sex determining region Y)-box 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sox30 (SRY-box transcription factor 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SOX30 (SRY-box transcription factor 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SOX30 (SRY-box transcription factor 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sox30 (SRY-box transcription factor 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SOX30 (SRY-box transcription factor 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SOX30 (SRY-box transcription factor 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sox30 (SRY-box transcription factor 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Sox30 (SRY-box transcription factor 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Sox30 (SRY (sex determining region Y)-box 30)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SOX30 (SRY-box transcription factor 30)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC116409531	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sox30	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	30,918,707 - 30,948,415 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	30,919,778 - 30,948,415 (+)	Ensembl				GRCr8
mRatBN7.2	10	30,417,499 - 30,446,441 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	30,418,473 - 30,446,453 (+)	Ensembl				mRatBN7.2
Rnor_6.0	10	31,074,251 - 31,102,211 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	31,074,251 - 31,102,169 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	30,895,749 - 30,923,086 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	31,116,928 - 31,144,665 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	29,871,335 - 29,900,535 (+)	NCBI		Celera
Cytogenetic Map	10	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hepatocellular carcinoma (ISO)

Liver Metastasis (ISO)

lung adenocarcinoma (ISO)

lung cancer (ISO)

lung metastasis (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

lung squamous cell carcinoma (ISO)

male infertility (ISO)

Neoplasm Metastasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (EXP)

5-aza-2'-deoxycytidine (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

cocaine (EXP)

deguelin (ISO)

diarsenic trioxide (ISO)

lipopolysaccharide (ISO)

pifithrin-alpha hydrobromide (ISO)

quercetin (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

Theaflavin 3,3'-digallate (ISO)

toluene (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA-templated transcription (IEA)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

negative regulation of Wnt signaling pathway (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

proacrosomal vesicle fusion (IEA,ISO)

regulation of transcription by RNA polymerase II (IBA,ISO)

response to corticosteroid (IEA,ISO)

spermatid development (IEA,ISO)

Cellular Component

chromocenter (IEA,ISO)

cytoplasm (IEA,ISO)

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

beta-catenin binding (IEA,ISO)

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA,ISO)

DNA-binding transcription factor activity (IEA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA,ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA,ISO)

sequence-specific double-stranded DNA binding (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of β-Catenin in Lung Cancer.	Han F, etal., EBioMedicine. 2018 May;31:253-266. doi: 10.1016/j.ebiom.2018.04.026. Epub 2018 May 5.
3.	SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer.	Han F, etal., Oncogene. 2015 Aug 13;34(33):4391-402. doi: 10.1038/onc.2014.370. Epub 2014 Dec 1.
4.	High expression of SOX30 is associated with favorable survival in human lung adenocarcinoma.	Han F, etal., Sci Rep. 2015 Sep 2;5:13630. doi: 10.1038/srep13630.
5.	High expression of SRY-box transcription factor 30 associates with well differentiation, absent lymph node metastasis and predicts longer survival in nonsmall-cell lung cancer patients.	Liu C, etal., Medicine (Baltimore). 2020 May;99(20):e20122. doi: 10.1097/MD.0000000000020122.
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	MicroRNA-645 represses hepatocellular carcinoma progression by inhibiting SOX30-mediated p53 transcriptional activation.	Tao J, etal., Int J Biol Macromol. 2019 Jan;121:214-222. doi: 10.1016/j.ijbiomac.2018.10.032. Epub 2018 Oct 9.

Additional References at PubMed

PMID:10359848	PMID:18436822	PMID:29848638	PMID:29866902

Genomics

Comparative Map Data

Sox30
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	30,918,707 - 30,948,415 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	30,919,778 - 30,948,415 (+)	Ensembl				GRCr8
mRatBN7.2	10	30,417,499 - 30,446,441 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	30,418,473 - 30,446,453 (+)	Ensembl				mRatBN7.2
Rnor_6.0	10	31,074,251 - 31,102,211 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	31,074,251 - 31,102,169 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	30,895,749 - 30,923,086 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	31,116,928 - 31,144,665 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	29,871,335 - 29,900,535 (+)	NCBI		Celera
Cytogenetic Map	10	q21	NCBI

SOX30
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	157,625,679 - 157,671,480 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	157,625,679 - 157,671,480 (-)	Ensembl			hg38	GRCh38
GRCh37	5	157,052,687 - 157,098,488 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	156,985,265 - 157,012,006 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	5	153,079,301 - 153,106,027 (-)	NCBI		Celera
Cytogenetic Map	5	q33.3	NCBI
HuRef	5	152,141,308 - 152,168,043 (-)	NCBI		HuRef
CHM1_1	5	156,485,413 - 156,512,148 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	158,144,714 - 158,190,505 (-)	NCBI		T2T-CHM13v2.0

Sox30
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	45,869,873 - 45,908,824 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	45,871,137 - 45,908,821 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	45,979,069 - 46,017,992 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	45,980,310 - 46,017,994 (+)	Ensembl			mm10	GRCm38
MGSCv37	11	45,793,812 - 45,831,494 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	45,823,733 - 45,861,417 (+)	NCBI		MGSCv36	mm8
Celera	11	50,569,188 - 50,580,989 (+)	NCBI		Celera
Cytogenetic Map	11	B1.1	NCBI
cM Map	11	27.49	NCBI

Sox30
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	11,790,079 - 11,828,962 (-)	Ensembl
ChiLan1.0	NW_004955408	11,790,145 - 11,830,426 (-)	NCBI	ChiLan1.0	ChiLan1.0

SOX30
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	152,814,686 - 152,862,324 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	150,954,233 - 151,001,871 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	153,022,109 - 153,067,734 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	159,642,895 - 159,688,473 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	159,640,126 - 159,737,776 (-)	Ensembl			panPan2	panpan1.1

SOX30
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	52,587,163 - 52,615,945 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	52,587,355 - 52,615,945 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	52,478,213 - 52,507,510 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	53,021,730 - 53,051,044 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	53,022,045 - 53,051,044 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	52,849,219 - 52,878,517 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	52,955,552 - 52,984,862 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	53,473,267 - 53,502,568 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sox30
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	107,051,963 - 107,087,980 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936515	5,458,393 - 5,537,946 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936515	5,501,315 - 5,537,946 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SOX30
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	65,642,223 - 65,678,047 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	16	65,642,107 - 65,677,693 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	71,494,089 - 71,532,303 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SOX30
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	60,013,384 - 60,038,682 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	60,014,046 - 60,037,997 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666034	17,546,899 - 17,616,449 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sox30
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	31,774,616 - 31,807,516 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624733	31,774,341 - 31,855,539 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sox30
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	28,705,734 - 28,733,517 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sox30
422 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	150
Count of miRNA genes:	115
Interacting mature miRNAs:	126
Transcripts:	ENSRNOT00000007978
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15776754	60776754	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	27023535	98502431	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22931373	91127454	Rat
2293669	Bmd33	Bone mineral density QTL 33	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	10	27443787	72443787	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6660923	73950353	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5893811	50893811	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1250554	64349221	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5893811	50893811	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293679	Bmd30	Bone mineral density QTL 30	3.5	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	14653541	59653541	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15533012	73695498	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	24662123	73695339	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6877142	51877142	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	27023535	61843633	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35730538	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	19939207	64939207	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	18035782	63035782	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	922197	45922197	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	2103708	47103708	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5893811	50893811	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29800910	91417879	Rat
2298495	Eae23	Experimental allergic encephalomyelitis QTL 23	16.93		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis duration (CMO:0001424)	10	16175525	61175525	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18668419	63668419	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	20110614	65110614	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38832698	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21833758	61843633	Rat
631531	Iresp2	Immunoglobin response QTL2	6.3		blood immunoglobulin E amount (VT:0002492)	serum immunoglobulin E level (CMO:0002101)	10	23422121	32490778	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	27587226	96099902	Rat
2289985	Bp305	Blood pressure QTL 305			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	29076978	74076978	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28950353	73950353	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6661118	35509383	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	18035782	63035782	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29800910	64653589	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	27443787	72443787	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293705	Bmd25	Bone mineral density QTL 25	7.1	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	27443787	72443787	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	29377046	52699134	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14991535	86964295	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
2293652	Bmd22	Bone mineral density QTL 22	4.9	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	20110614	65110614	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	27023535	99451848	Rat

Markers in Region

SOX30

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	10	30,922,556 - 30,922,655 (+)	Marker Load Pipeline
mRatBN7.2	10	30,421,195 - 30,421,293 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	31,076,966 - 31,077,063	NCBI	Rnor6.0
Rnor_5.0	10	30,897,841 - 30,897,938	UniSTS	Rnor5.0
RGSC_v3.4	10	31,119,420 - 31,119,517	UniSTS	RGSC3.4
Celera	10	29,875,296 - 29,875,393	UniSTS
Cytogenetic Map	10	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	4	55	110	43	47	21	54	21	6	207	125	4	101	49	78	26	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063269881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000007978 ⟹ ENSRNOP00000007978

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	30,919,778 - 30,948,415 (+)	Ensembl
mRatBN7.2 Ensembl	10	30,418,473 - 30,446,453 (+)	Ensembl
Rnor_6.0 Ensembl	10	31,074,251 - 31,102,169 (+)	Ensembl

RefSeq Acc Id:

NM_001427190 ⟹ NP_001414119

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	30,919,778 - 30,948,415 (+)	NCBI

RefSeq Acc Id:

XM_039087152 ⟹ XP_038943080

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	30,918,718 - 30,948,415 (+)	NCBI
mRatBN7.2	10	30,417,499 - 30,446,441 (+)	NCBI

RefSeq Acc Id:

XM_063269881 ⟹ XP_063125951

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	30,918,707 - 30,947,497 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001414119	(Get FASTA)	NCBI Sequence Viewer
	XP_038943080	(Get FASTA)	NCBI Sequence Viewer
	XP_063125951	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000007978
	ENSRNOP00000007978.7

Ensembl Acc Id:

ENSRNOP00000007978 ⟸ ENSRNOT00000007978

RefSeq Acc Id:	XP_038943080 ⟸ XM_039087152
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063125951 ⟸ XM_063269881
- Peptide Label:	isoform X2

RefSeq Acc Id:	NP_001414119 ⟸ NM_001427190
- UniProtKB:	F1M453 (UniProtKB/TrEMBL)

Protein Domains

HMG box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M453-F1-model_v2	AlphaFold	F1M453	1-764	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1586382	AgrOrtholog
BioCyc Gene	G2FUF-25380	BioCyc
Ensembl Genes	ENSRNOG00000006098	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007978	ENTREZGENE
	ENSRNOT00000007978.8	UniProtKB/TrEMBL
Gene3D-CATH	1.10.30.10	UniProtKB/TrEMBL
InterPro	HMG_box_dom	UniProtKB/TrEMBL
	HMG_box_dom_sf	UniProtKB/TrEMBL
	SOX30_TF	UniProtKB/TrEMBL
NCBI Gene	689918	ENTREZGENE
PANTHER	TRANSCRIPTION FACTOR SOX-30	UniProtKB/TrEMBL
	TRANSCRIPTION FACTOR SOX-30	UniProtKB/TrEMBL
Pfam	HMG_box	UniProtKB/TrEMBL
PhenoGen	Sox30	PhenoGen
PROSITE	HMG_BOX_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006098	RatGTEx
SMART	HMG	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47095	UniProtKB/TrEMBL
UniProt	F1M453	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-05	Sox30	SRY-box transcription factor 30	Sox30	SRY box 30	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-11-12	Sox30	SRY box 30	Sox30	SRY (sex determining region Y)-box 30	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-05-24	Sox30	SRY (sex determining region Y)-box 30	LOC684093	similar to SRY-box containing gene 30	Data merged from RGD:1595155	1643240	APPROVED
2008-03-06	Sox30	SRY (sex determining region Y)-box 30	LOC689918	similar to SRY-box containing gene 30	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC684093	similar to SRY-box containing gene 30			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC689918	similar to SRY-box containing gene 30			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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