Dppa1 (developmental pluripotency associated 1) - Rat Genome Database

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Gene: Dppa1 (developmental pluripotency associated 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Dppa1
Name: developmental pluripotency associated 1
RGD ID: 1586325
Description: Predicted to enable phosphatidylserine binding activity and virus receptor activity. Predicted to be involved in phagocytosis, engulfment and positive regulation of mast cell activation. Predicted to be located in plasma membrane. Predicted to be active in cell surface; INTERACTS WITH bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC689975; similar to developmental pluripotency associated 1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Related Pseudogenes: Dppa1-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: On July 18, 2008, RefSeq staff corrected the association of sequences between the gene (Rno10) and the pseudogene (Rno12)for Dppa1. [18 Jul 2008]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81031,499,311 - 31,519,016 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl127,606,395 - 7,606,751 (-)EnsemblGRCr8
GRCr8 Ensembl1031,499,311 - 31,519,016 (-)EnsemblGRCr8
mRatBN7.21030,998,049 - 31,017,756 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,808,569 - 2,808,925 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1030,998,049 - 31,017,756 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1035,713,584 - 35,733,354 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0104,251,949 - 4,271,721 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01030,699,193 - 30,718,924 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01031,693,219 - 31,712,924 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,693,219 - 31,712,924 (-)Ensemblrn6Rnor6.0
Rnor_5.01031,505,874 - 31,525,617 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41031,702,427 - 31,722,132 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1030,443,208 - 30,462,767 (-)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090  


Genomics

Variants

.
Variants in Dppa1
78 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:41
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000067312
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102342212132490778Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
5 2 10 29 30 18 16 18 63 23 7 4 16 54 12

Sequence


Ensembl Acc Id: ENSRNOT00000037099   ⟹   ENSRNOP00000085733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl127,606,395 - 7,606,751 (-)Ensembl
mRatBN7.2 Ensembl122,808,569 - 2,808,925 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000067312   ⟹   ENSRNOP00000061051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1031,499,311 - 31,519,016 (-)Ensembl
mRatBN7.2 Ensembl1030,998,049 - 31,017,756 (-)Ensembl
Rnor_6.0 Ensembl1031,693,219 - 31,712,924 (-)Ensembl
RefSeq Acc Id: NM_001105905   ⟹   NP_001099375
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81031,499,311 - 31,519,016 (-)NCBI
mRatBN7.21030,998,049 - 31,017,756 (-)NCBI
Rnor_6.01031,693,219 - 31,712,924 (-)NCBI
Rnor_5.01031,505,874 - 31,525,617 (-)NCBI
RGSC_v3.41031,702,427 - 31,722,132 (-)RGD
Celera1030,443,208 - 30,462,767 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099375 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM04178 (Get FASTA)   NCBI Sequence Viewer  
  EDM04179 (Get FASTA)   NCBI Sequence Viewer  
  EDM04180 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061051
  ENSRNOP00000061051.1
  ENSRNOP00000085733.1
RefSeq Acc Id: NP_001099375   ⟸   NM_001105905
- Peptide Label: precursor
- UniProtKB: D4A1B7 (UniProtKB/TrEMBL),   A6HDS4 (UniProtKB/TrEMBL),   A0A8I6A2Z7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061051   ⟸   ENSRNOT00000067312
Ensembl Acc Id: ENSRNOP00000085733   ⟸   ENSRNOT00000037099

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1B7-F1-model_v2 AlphaFold D4A1B7 1-118 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586325 AgrOrtholog
BioCyc Gene G2FUF-25361 BioCyc
Ensembl Genes ENSRNOG00000028544 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000043293 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037099.4 UniProtKB/TrEMBL
  ENSRNOT00000067312 ENTREZGENE
  ENSRNOT00000067312.3 UniProtKB/TrEMBL
InterPro TIM_domain-containing_protein UniProtKB/TrEMBL
KEGG Report rno:689975 UniProtKB/TrEMBL
NCBI Gene 689975 ENTREZGENE
PANTHER DPPA1 UniProtKB/TrEMBL
  HEPATITIS A VIRUS CELLULAR RECEPTOR 1 HOMOLOG UniProtKB/TrEMBL
PhenoGen Dppa1 PhenoGen
RatGTEx ENSRNOG00000028544 RatGTEx
  ENSRNOG00000043293 RatGTEx
UniProt A0A8I6A2Z7 ENTREZGENE, UniProtKB/TrEMBL
  A6HDS4 ENTREZGENE, UniProtKB/TrEMBL
  D4A1B7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Dppa1  developmental pluripotency associated 1  LOC684172  similar to developmental pluripotency associated 1  Data merged from RGD:1593884 1643240 APPROVED
2008-09-19 Dppa1  developmental pluripotency associated 1  LOC689975  similar to developmental pluripotency associated 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-11-20 LOC684172  similar to developmental pluripotency associated 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC689975  similar to developmental pluripotency associated 1      Symbol and Name status set to provisional 70820 PROVISIONAL